JCI - Citations to Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

Peter Sazani, Ryszard Kole

Peter Sazani, Ryszard Kole

Published August 15, 2003
Citation Information: J Clin Invest. 2003;112(4):481-486. https://doi.org/10.1172/JCI19547.

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Citations to this article (196)

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Clinical Reasoning: A 2-Day-Old Boy With Sudden Cardiac Arrest and Encephalopathy. Holmes BB, Russ JB, Wu YW, Gallagher RC, Gano D	Neurology	2021
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Polyglutamine Disorders C Nóbrega, LP de Almeida		2018
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Potential of Peptide Nucleic Acids in Future Therapeutic Applications S Montazersaheb, MS Hejazi, HN Charoudeh	Advanced pharmaceutical bulletin	2018
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RNA and Cancer JY Wu		2013
RNA and Cancer JY Wu		2013
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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System SL DeVos, TM Miller	Journal of visualized experiments : JoVE	2013
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Encyclopedia of Life Sciences B Dahlbäck	Encyclopedia of Life Sciences	2011
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Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs MJ Crawford, S Rapireddy, R Bahal, I Sacui, DH Ly	Journal of nucleic acids	2011
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation K Ezzat, SE Andaloussi, EM Zaghloul, T Lehto, S Lindberg, PM Moreno, JR Viola, T Magdy, R Abdo, P Guterstam, R Sillard, SM Hammond, MJ Wood, AA Arzumanov, MJ Gait, CI Smith, M Hällbrink, Ü Langel	Nucleic Acids Research	2011
Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugated with gold nanoparticles DW Kim, JH Kim, M Park, JH Yeom, H Go, S Kim, MS Han, K Lee, J Bae	Biomaterials	2011
Challenges in Delivery of Therapeutic Genomics and Proteomics M Kumar, A Misra	Challenges in Delivery of Therapeutic Genomics and Proteomics	2011
Use of fully modified 2′-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos PN Schneider, JT Olthoff, AJ Matthews, DW Houston	genesis	2011
Oligonucleotide Analogs with Peptide Internucleotide Linkages A Varizhuk, S Kochetkova, N Kolganova, E Timofeev, V Florentiev	Nucleosides, Nucleotides and Nucleic Acids	2011
Genetic therapies for RNA mis-splicing diseases SM Hammond, MJ Wood	Trends in Genetics	2011
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Cell-Penetrating Peptides Ü Langel	Cell-Penetrating Peptides	2010
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Cell-Penetrating Peptides Ü Langel	Cell-Penetrating Peptides	2010
Potential therapeutic applications of antisense morpholino oligonucleotides in modulation of splicing in primary immunodeficiency diseases L Du, RA Gatti	Journal of Immunological Methods	2010
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Future alternative therapies for β-thalassemia S Rivella, E Rachmilewitz	Expert Review of Hematology	2009
Gene therapy in thalassemia and hemoglobinopathies L Breda, R Gambari, S Rivella	Mediterranean journal of hematology and infectious diseases	2009
RNA and Disease TA Cooper, L Wan, G Dreyfuss	Cell	2009
RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice S Svasti, T Suwanmanee, S Fucharoen, HM Moulton, MH Nelson, N Maeda, O Smithies, R Kole	Proceedings of the National Academy of Sciences	2009
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Progress toward therapy with antisense-mediated splicing modulation L Du, RA Gatti	Current opinion in molecular therapeutics	2009
Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon V Anquetil, CL Sommer, A Méreau, S Hamon, H Lerivray, S Hardy	The Journal of biological chemistry	2009
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Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma J Abubaker, P Bavi, W Al-Haqawi, M Sultana, S Al-Harbi, N Al-Sanea, A Abduljabbar, LH Ashari, S Alhomoud, F Al-Dayel, S Uddin, KS Al-Kuraya	The Journal of Pathology	2009
Effect of chirality of l/d-proline and prochiral glycine as the linker amino acid in five-atom linked thymidinyl-(α-amino acid)-thymidine dimers S Bagmare, M D’Costa, VA Kumar	Chemical Communications	2009
Alternative splicing and disease J Tazi, N Bakkour, S Stamm	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2009
Polypyrimidine Tract Binding Protein Prevents Activity of an Intronic Regulatory Element That Promotes Usage of a Composite 3′-Terminal Exon V Anquetil, CL Sommer, A Méreau, S Hamon, H Lerivray, S Hardy	The Journal of biological chemistry	2009
Handbook of Research on Systems Biology Applications in Medicine: A Daskalaki		2009
Recognition Receptors in Biosensors M Zourob		2009
Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides SR Sirsi, RC Schray, MA Wheatley, GJ Lutz	Journal of nanobiotechnology	2009
Antisense Makes Sense in Engineered Regenerative Medicine Y Yao, C Wang, RR Varshney, DA Wang	Pharmaceutical Research	2008
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides R Juliano, MR Alam, V Dixit, H Kang	Nucleic Acids Research	2008
Alternative splicing and tumor progression C Ghigna, C Valacca, G Biamonti	Current genomics	2008
Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems SD Laufer, T Restle	Current pharmaceutical design	2008
Functional characterization of alternatively spliced human SECISBP2 transcript variants LV Papp, J Wang, D Kennedy, D Boucher, Y Zhang, VN Gladyshev, RN Singh, KK Khanna	Nucleic Acids Research	2008
Dynamics of co-transcriptional pre-mRNA folding influences the induction of dystrophin exon skipping by antisense oligonucleotides KB Wee, ZA Pramono, JL Wang, KF MacDorman, PS Lai, WC Yee	PloS one	2008
Chimeric (α-amino acid + nucleoside-β-amino acid)n peptide oligomers show sequence specific DNA/RNA recognition K Gogoi, VA Kumar	Chemical Communications	2008
Doxycycline-controlled splicing modulation by regulated antisense U7 snRNA expression cassettes J Marquis, SS Kämpfer, L Angehrn, D Schümperli	Gene Therapy	2008
Effective delivery of antisense peptide nucleic acid oligomers into cells by anthrax protective antigen DG Wright, Y Zhang, JR Murphy	Biochemical and Biophysical Research Communications	2008
Controlled delivery of anti-sense oligodeoxynucleotide from multilayered biocompatible phosphorylcholine polymer films Z Zhang, X Cao, X Zhao, CM Holt, AL Lewis, JR Lu	Journal of Controlled Release	2008
Design and development of antisense drugs R Malik, I Roy	Expert Opinion on Drug Discovery	2008
Integrated DNA, cDNA, and protein studies in Becker muscular dystrophy show high exception to the reading frame rule A Kesari, LN Pirra, L Bremadesam, O McIntyre, E Gordon, AL Dubrovsky, V Viswanathan, EP Hoffman	Human Mutation	2008
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Dynamics of Co-Transcriptional Pre-mRNA Folding Influences the Induction of Dystrophin Exon Skipping by Antisense Oligonucleotides KB Wee, ZA Pramono, JL Wang, KF MacDorman, PS Lai, WC Yee, JN Volff	PloS one	2008
Splice-switching efficiency and specificity for oligonucleotides with locked nucleic acid monomers P Guterstam, M Lindgren, H Johansson, U Tedebark, J Wengel, SE Andaloussi, Ü Langel	Biochemical Journal	2008
Distinct Uptake Routes of Cell-Penetrating Peptide Conjugates P Lundin, H Johansson, P Guterstam, T Holm, M Hansen, Ü Langel, SE Andaloussi	Bioconjugate Chemistry	2008
Factors Determining the Efficacy of Nuclear Delivery of Antisense Oligonucleotides by Gold Nanoparticles Y Liu, S Franzen	Bioconjugate Chemistry	2008
Cellular Delivery and Biological Activity of Antisense Oligonucleotides Conjugated to a Targeted Protein Carrier H Kang, R Alam, V Dixit, M Fisher, RL Juliano	Bioconjugate Chemistry	2008
Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB B Khoo, X Roca, SL Chew, AR Krainer	BMC Molecular Biology	2007
New biological therapies from the human genome S Schnieper-Samec, G Feger, TN Wells	Expert Opinion on Drug Discovery	2007
Alternative splicing: an important mechanism for myometrial gene regulation that can be manipulated to target specific genes associated with preterm labour AJ Tyson-Capper	BMC pregnancy and childbirth	2007
Switching on transgene expression by correcting aberrant splicing using multi-targeting steric-blocking oligonucleotides S Resina, R Kole, A Travo, B Lebleu, AR Thierry	The Journal of Gene Medicine	2007
A Novel Cell-penetrating Peptide, M918, for Efficient Delivery of Proteins and Peptide Nucleic Acids S El-Andaloussi, HJ Johansson, T Holm, Ü Langel	Molecular Therapy	2007
Assessing the delivery efficacy and internalization route of cell-penetrating peptides SE Andaloussi, P Guterstam, Ü Langel	Nature Protocols	2007
Alternative splicing: an emerging topic in molecular and clinical oncology MJ Pajares, T Ezponda, R Catena, A Calvo, R Pio, LM Montuenga	The Lancet Oncology	2007
Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos PA Morcos	Biochemical and Biophysical Research Communications	2007
RNA regulation and cancer development E Scholzová, R Malík, J Ševčík, Z Kleibl	Cancer Letters	2007
Pegylation of liposomes favours the endosomal degradation of the delivered phosphodiester oligonucleotides K Remaut, B Lucas, K Braeckmans, J Demeester, SC Smedt	Journal of Controlled Release	2007
Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides S Resina, S Abes, JJ Turner, P Prevot, A Travo, P Clair, MJ Gait, AR Thierry, B Lebleu	International Journal of Pharmaceutics	2007
Alternative Splicing in the Postgenomic Era BJ Blencowe, BR Graveley		2007
Synthesis and RNA Binding Selectivity of Oligonucleotides Modified with Five-Atom Thioacetamido Nucleic Acid Backbone Structures K Gogoi, AD Gunjal, UD Phalgune, VA Kumar	Organic letters	2007
Applications of cell-penetrating peptides in regulation of gene expression P Järver, K Langel, S El-Andaloussi, Ü Langel	Biochemical Society Transactions	2007
Pharmacokinetics, Biodistribution, Stability and Toxicity of a Cell-Penetrating Peptide−Morpholino Oligomer Conjugate A Amantana, HM Moulton, ML Cate, MT Reddy, T Whitehead, JN Hassinger, DS Youngblood, PL Iversen	Bioconjugate Chemistry	2007
Defective splicing, disease and therapy: searching for master checkpoints in exon definition E Buratti, M Baralle, FE Baralle	Nucleic Acids Research	2006
TassDB: a database of alternative tandem splice sites M Hiller, S Nikolajewa, K Huse, K Szafranski, P Rosenstiel, S Schuster, R Backofen, M Platzer	Nucleic Acids Research	2006
Human laminopathies: nuclei gone genetically awry BC Capell, FS Collins	Nature Reviews Genetics	2006
Comparison of basic peptides- and lipid-based strategies for the delivery of splice correcting oligonucleotides AR Thierry, S Abes, S Resina, A Travo, JP Richard, P Prevot, B Lebleu	Biochimica et Biophysica Acta (BBA) - Biomembranes	2006
Analysis of Prostate-Specific Membrane Antigen Splice Variants in LNCap Cells T Williams, R Kole	Oligonucleotides	2006
Induction of splice correction by cell-penetrating peptide nucleic acids S El-Andaloussi, HJ Johansson, P Lundberg, Ü Langel	The Journal of Gene Medicine	2006
Efficient and Persistent Splice Switching by Systemically Delivered LNA Oligonucleotides in Mice J ROBERTS, E PALMA, P SAZANI, H ORUM, M CHO, R KOLE	Molecular Therapy	2006
Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells F Dabertrand, JL Morel, V Sorrentino, J Mironneau, C Mironneau, N Macrez	Cell Calcium	2006
Alternative Splicing and Disease P Jeanteur		2006
Modification of MyD88 mRNA Splicing and Inhibition of IL-1β Signaling in Cell Culture and in Mice with a 2′- O -Methoxyethyl-Modified Oligonucleotide TA Vickers, H Zhang, MJ Graham, KM Lemonidis, C Zhao, NM Dean	Journal of immunology (Baltimore, Md. : 1950)	2006
Overexpression of Caspase-3s Splice Variant in Locally Advanced Breast Carcinoma Is Associated with Poor Response to Neoadjuvant Chemotherapy F Végran, R Boidot, C Oudin, JM Riedinger, F Bonnetain, S Lizard-Nacol	Clinical cancer research	2006
Splicing of a Critical Exon of Human Survival Motor Neuron Is Regulated by a Unique Silencer Element Located in the Last Intron NK Singh, NN Singh, EJ Androphy, RN Singh	Molecular and cellular biology	2006
Delivery of Phosphodiester Oligonucleotides: Can DOTAP/DOPE Liposomes Do the Trick? K Remaut, B Lucas, K Braeckmans, NN Sanders, J Demeester, SC Smedt	Biochemistry	2006
Epigenetic manipulation of gene expression: a toolkit for cell biologists RL Juliano, VR Dixit, H Kang, TY Kim, Y Miyamoto, D Xu	The Journal of Cell Biology	2005
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics D Gauguier	Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics	2005
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome P Scaffidi, T Misteli	Nature Medicine	2005
Predicting RNA secondary structure by free energy minimization DH Mathews	Theoretical Chemistry Accounts	2005
Antibodies as Drug Carriers III: Design of Oligonucleotides with Enhanced Binding Affinity for Immunoglobulin G E Palma, DG Klapper, MJ Cho	Pharmaceutical Research	2005
Avery's Diseases of the Newborn R Chmait, TR Moore	Avery's Diseases of the Newborn	2005
Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy K Remaut, B Lucas, K Braeckmans, NN Sanders, J Demeester, SC Smedt	Journal of Controlled Release	2005
Alternative splicing: A new drug target of the post-genome era M Hagiwara	Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics	2005
Regulation of Apoptosis by Alternative Pre-mRNA Splicing C Schwerk, K Schulze-Osthoff	Molecular Cell	2005
Use of Antisense Oligonucleotides in Functional Genomics and Target Validation LV Ravichandran, NM Dean, EG Marcusson	Oligonucleotides	2004
Modification of Alternative Splicing by Antisense Therapeutics R Kole, M Vacek, T Williams	Oligonucleotides	2004
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas A Watahiki, K Waki, N Hayatsu, T Shiraki, S Kondo, M Nakamura, D Sasaki, T Arakawa, J Kawai, M Harbers, Y Hayashizaki, P Carninci	Nature Methods	2004
Targeted genetic repair: an emerging approach to genetic therapy BA Sullenger	Journal of Clinical Investigation	2003
Mending the message MA Garcia-Blanco	Nature Biotechnology	2003
RNA directed therapeutics: mechanisms and status ST Crooke	Drug Discovery Today: Therapeutic Strategies
Peptide functionalized nanoparticles for nonviral gene delivery RM Levine, CM Scott, E Kokkoli	Soft Matter	2013
Oligonucleotides containing a peptide internucleotide linkage. A novel class of modified oligonucleotides AM Varizhuk, SV Kochetkova, NA Kolganova, EN Timofeev, VL Florentiev	Russian Journal of Bioorganic Chemistry	2010
Spliceosome-Mediated RNA Trans-splicing Y Yang, CE Walsh	Molecular Therapy	2005
Alternatively and Constitutively Spliced Exons Are Subject to Different Evolutionary Forces FC Chen, SS Wang, CJ Chen, WH Li, TJ Chuang	Molecular Biology and Evolution	2005
Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas MD Yan, CC Hong, GM Lai, AL Cheng, YW Lin, SE Chuang	Human Molecular Genetics	2005
Novel Targeting of Cyclooxygenase-2 (COX-2) Pre-mRNA Using Antisense Morpholino Oligonucleotides Directed to the 3′ Acceptor and 5′ Donor Splice Sites of Exon 4: Suppression of COX-2 Activity in Human Amnion-Derived WISH and Myometrial Cells AJ Tyson-Capper, GN Europe-Finner	Molecular pharmacology	2005
Physiochemical Properties of Low and High Molecular Weight Poly(ethylene glycol)-Grafted Poly(ethylene imine) Copolymers and Their Complexes with Oligonucleotides M Glodde, SR Sirsi, GJ Lutz	Biomacromolecules	2005
Épissage alternatif, pathologie et thérapeutique moléculaire L Corcos, S Solier	médecine/sciences	2005
Antibodies as drug carriers III: design of oligonucleotides with enhanced binding affinity for immunoglobulin G. Palma E, Klapper DG, Cho MJ	Pharmaceutical Research	2005
Androgen receptor function is modulated by the tissue-specific AR45 variant: Androgen receptor variant form I Ahrens-Fath, O Politz, C Geserick, B Haendler	FEBS Journal	2004
New paradigms for gene transfer: RNA trans-splicing and small interfering RNA as therapeutic strategies Christopher E Walsh	Seminars in Hematology	2004
Manipulation of Alternative Splicing by a Newly Developed Inhibitor of Clks M Muraki, B Ohkawara, T Hosoya, H Onogi, J Koizumi, T Koizumi, K Sumi, J Yomoda, MV Murray, H Kimura, K Furuichi, H Shibuya, AR Krainer, M Suzuki, M Hagiwara	The Journal of biological chemistry	2004
Alternative splicing in disease and therapy MA Garcia-Blanco, AP Baraniak, EL Lasda	Nature Biotechnology	2004
Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR A Denley, ER Bonython, GW Booker, LJ Cosgrove, BE Forbes, CW Ward, JC Wallace	Molecular Endocrinology	2004
Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives J Tazi, N Bakkour, J Soret, L Zekri, B Hazra, W Laine, B Baldeyrou, A Lansiaux, C Bailly	Molecular pharmacology	2004
Grundlagen der Molekularen Medizin D Ganten, K Ruckpaul		2003

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