Thyroid hormone action: a binding contract
Mitchell A. Lazar
Mitchell A. Lazar
Published August 15, 2003
Citation Information: J Clin Invest. 2003;112(4):497-499. https://doi.org/10.1172/JCI19479.
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Commentary

Thyroid hormone action: a binding contract

Abstract

Thyroid hormones are critical for differentiation, growth, and metabolism. A new study investigating the biological role of the TH receptor TR-β has demonstrated that DNA binding is critical for most of its functions, but also suggests that novel mechanisms independent of DNA binding may contribute to regulation of auditory function by TR-β.

Authors

Mitchell A. Lazar

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Figure 1

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Paradigm for positive regulation of gene expression by TH. TH binding to...
Paradigm for positive regulation of gene expression by TH. TH binding to TR triggers a switch from corepressor (CoR) to coactivator (CoA) binding on a TRE on DNA.