Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg, … , Rudolph L. Leibel, Anthony W. Ferrante Jr.
Stuart P. Weisberg, … , Rudolph L. Leibel, Anthony W. Ferrante Jr.
Published December 15, 2003
Citation Information: J Clin Invest. 2003;112(12):1796-1808. https://doi.org/10.1172/JCI19246.
View: Text | PDF
Article Metabolism

Obesity is associated with macrophage accumulation in adipose tissue

  • Text
  • PDF
Abstract

Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications. To further characterize the changes that occur in adipose tissue with increasing adiposity, we profiled transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob). We found that the expression of 1,304 transcripts correlated significantly with body mass. Of the 100 most significantly correlated genes, 30% encoded proteins that are characteristic of macrophages and are positively correlated with body mass. Immunohistochemical analysis of perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue revealed that the percentage of cells expressing the macrophage marker F4/80 (F4/80+) was significantly and positively correlated with both adipocyte size and body mass. Similar relationships were found in human subcutaneous adipose tissue stained for the macrophage antigen CD68. Bone marrow transplant studies and quantitation of macrophage number in adipose tissue from macrophage-deficient (Csf1op/op) mice suggest that these F4/80+ cells are CSF-1 dependent, bone marrow–derived adipose tissue macrophages. Expression analysis of macrophage and nonmacrophage cell populations isolated from adipose tissue demonstrates that adipose tissue macrophages are responsible for almost all adipose tissue TNF-α expression and significant amounts of iNOS and IL-6 expression. Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals.

Authors

Stuart P. Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L. Leibel, Anthony W. Ferrante Jr.

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 1975 Total
Citations: 88 246 218 295 324 306 233 264 245 258 227 244 280 231 200 173 140 135 48 45 22 14 1 3 4240
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2022 (295)

Title and authors Publication Year
Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters
Lindsey A Muir, Kae W Cho, Lynn M. Geletka, Nicki A Baker, Carmen G. Flesher, Anne P Ehlers, Niko Kaciroti, Stephen Lindsly, Scott Ronquist, Indika Rajapakse, Robert W. O’Rourke, Carey N Lumeng
JCI Insight 2022
Metabolic Changes in Aging Humans: Current Evidence and Therapeutic Strategies
Allyson Palmer, Michael Jensen
Journal of Clinical Investigation 2022
The TBK1/IKKe inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
Peng Zhao, Xiaoli Sun, Zhongji Liao, Hong Yu, Dan Li, Zeyang Shen, Christopher Glass, Joseph L Witztum, Alan R. Saltiel
JCI Insight 2022
T cells dominate peripheral inflammation in obesity-associated diabetes
Gabriella Pugh, Sajjad Fouladvand, Sara SantaCruz-Calvo, Madhur Agrawal, Xiaohua Zhang, Jin Chen, Philip Kern, Barbara Nikolajczyk
Obesity (Silver Spring, Md.) 2022
Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity
Bastian Ramms, Dennis P Pollow, Han Zhu, Chelsea Nora, Austin R Harrington, Ibrahim Omar, Philip Gordts, Matthew Wortham, Maike Sander
Diabetes 2022
The Impact of Obesity, Adipose Tissue, and Tumor Microenvironment on Macrophage Polarization and Metastasis
O Habanjar, M Diab-Assaf, F Caldefie-Chezet, L Delort
Biology : open access journal 2022
Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity
A Matz, L Qu, K Karlinsey, B Zhou
Cells 2022
An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches
M Araújo, S Soczek, J Pontes, L Marques, G Santos, G Simão, L Bueno, D Maria-Ferreira, M Muscará, E Fernandes
Cells 2022
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions
S Georas, R Wright, A Ivanova, E Israel, L LaVange, P Akuthota, T Carr, L Denlinger, M Fajt, R Kumar, W ONeal, W Phipatanakul, S Szefler, M Aronica, L Bacharier, A Burbank, M Castro, L Alexander, J Bamdad, J Cardet, S Comhair, R Covar, E DiMango, K Erwin, S Erzurum, J Fahy, J Gaffin, B Gaston, L Gerald, E Hoffman, F Holguin, D Jackson, J James, N Jarjour, N Kenyon, S Khatri, J Kirwan, M Kraft, J Krishnan, A Liu, M Liu, M Marquis, F Martinez, J Mey, W Moore, J Moy, V Ortega, D Peden, E Pennington, M Peters, K Ross, M Sanchez, L Smith, R Sorkness, M Wechsler, S Wenzel, S White, J Zein, A Zeki, P Noel, D Billheimer, E Bleecker, E Branch, M Conway, C Daines, I Deaton, A Evans, P Field, D Francisco, A Hastie, B Hmieleski, J Krings, Y Liu, J Merchen, D Meyers, N Narendran, S Peters, A Pippins, M Rank, R Schunk, R Skeps, B Wright, T Banzon, L Bartnikas, S Baxi, V Betapudi, I Brick, C Brockway, T Casale, K Castillo-Ruano, M Cinelli, E Crestani, A Cunningham, M Day-Lewis, N Diaz-Cabrera, A DiMango, B Esty, E Fandozzi, J Fernandez, E Fitzpatrick, V Forth, K Gentile, D Gubernick, S Gueye-Ndiaye, S Gunnlaagsson, M Hauptmann, S Hudey, D Imanirad, T Kaage, N Kolinsky, B LaBere, P Lai, M Le, D Ledford, R Lockey, M Louisias, A Macginnitie, M Maciag, A ONeill, A Pepper, P Permaul, M Pugh, D Queheillalt, T Saroya, W Sheehan, C Smith, C Socolovsky, E Treffeisen, L Trippa, A Tulchinsky, C Yee, T Carter, J Fu, V Garcia, J Hixon, C Jackson, Y Ji, R Kalhan, O Kaur, G Li, M Makhija, S Maleckar, E Naureckas, A Peters, V Press, M Qureshi, P Reyfman, S Rosenberg, D Ryba, J Sheng, B Xu, R Alam, D Anderson, S Belimezova, J Bitzan, G Chupp, B Clark, L Cohn, M Cruse, J Estrom, L Freid, J Villalobos, N Grant, V Guntur, C Holm, C Kolakowski, L Manka, N Miyazawa, J Pak, D Pruitt, S Sharma, A Stevens, K Thomas, B Tippin, K Valente, C Wainscoat, M White, D Winnica, S Ye, P Zeitlin, J Bach, J Brownell, L Castro, J DeLisa, S Fain, P Fichtinger, H Floerke, J Gern, V Goswamy, J Grogan, W Hasse, R Kelley, D Klaus, S LaBedz, P Lowell, A Maddox, S Mathur, A McIntyre, L Norwick, S Nyenhuis, M OBrien, T Palas, A Pappalardo, M Potter, S Ramratnam, D Rosenberg, E Schauberger, M Schiebler, A Schraml, R Sorkness, M Taki, M Tattersall, J Torres, L Wollet, S Abi-Saleh, L Bendy, L Borish, J Chmiel, A Dix, L France, R Gammell, A Gluvna, B Hirth, B Hu, E Hyser, K Kloepfer, M Koo, N Krupp, M Labadia, J Lawrence, L Logan, A Marko, B Matuska, D Murphy, R Owensby, E Roesch, D Sanders, J Sharp, W Teague, L Veri, K Shifflett, M Camiolo, S Collins, J Demas, C Elvin, M Gauthier, M Ilnicki, J Ingram, L Lane, S Nouraie, J Trudeau, M Zhang, J Barry, H Brickner, J Celso, M Cernelc-Kohan, D Diaz, A Du, S Jain, N Liu, Y Nazir, J Ryu, P Vijayanand, R Almario, A Baum, K Brown, M Chan, B Gale, A Haczku, R Harper, R Heromin, C Kivler, B Kuhn, N Ly, P McCourt, X Orain, A Plough, K Ramirez, E Roberts, M Schivo, A Singapuri, C Smith, T Tham, D Tompkins, P Twitmyer, , J Atha, J Bedard, J Boomer, A Chung, V Curtis, C Hall, E Hart, F Jackson, P Kemp, S Maxwell, M Messplay, C Ramirez, B Thompson, A Britt, H Bryan, N Gotman, Y Jiang, M Kosorok, D Mauger, K Meekins, J Mollenhauer, S Moody, C Ritz, S Schwartz, C Thomlinson, N Wilson
Journal of Allergy and Clinical Immunology 2022
Inflammation in obesity, diabetes, and related disorders
T Rohm, D Meier, J Olefsky, M Donath
Immunity 2022
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
G Fahed, L Aoun, M Zerdan, S Allam, M Zerdan, Y Bouferraa, H Assi
International journal of molecular sciences 2022
Adipose tissue microenvironments during aging: Effects on stimulated lipolysis
C Camell
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2022
Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge
K Lipke, A Kubis-Kubiak, A Piwowar
Cells 2022
Mechanisms contributing to adverse outcomes of COVID-19 in obesity
M Sudhakar, S Winfred, G Meiyazhagan, D Venkatachalam
Molecular and Cellular Biochemistry 2022
TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target
R Li, Q Qin, H Yang, Y Wang, Y Mi, Y Yin, M Wang, C Yu, Y Tang
Molecular Neurodegeneration 2022
Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics
Z Wei, F Li, G Pi
Frontiers in Cellular and Infection Microbiology 2022
Insulin Resistance: From Mechanisms to Therapeutic Strategies
S Lee, S Park, C Choi
Diabetes & Metabolism Journal 2022
The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy
J Assumpção, G Pasquarelli-do-Nascimento, M Duarte, M Bonamino, K Magalhães
Journal of Biomedical Science 2022
Why does obesity cause diabetes?
S Klein, A Gastaldelli, H Yki-Järvinen, P Scherer
Cell Metabolism 2022
Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review
S Camastra, E Ferrannini
Reviews in Endocrine and Metabolic Disorders 2022
The shades of grey in adipose tissue reprogramming
Y Qi, X Hui
Bioscience Reports 2022
Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance
V Pellegrinelli, S Rodriguez-Cuenca, C Rouault, E Figueroa-Juarez, H Schilbert, S Virtue, J Moreno-Navarrete, G Bidault, M Vázquez-Borrego, A Dias, B Pucker, M Dale, M Campbell, S Carobbio, Y Lin, M Vacca, J Aron-Wisnewsky, S Mora, M Masiero, A Emmanouilidou, S Mukhopadhyay, G Dougan, M den Hoed, R Loos, J Fernández-Real, D Chiarugi, K Clément, A Vidal-Puig
Nature metabolism 2022
Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome
R Hachiya, M Tanaka, M Itoh, T Suganami
Inflammation and Regeneration 2022
Associations of Dietary Inflammatory Index With Prediabetes and Insulin Resistance
Y Shu, X Wu, J Wang, X Ma, H Li, Y Xiang
Frontiers in Endocrinology 2022
Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss
C Ahn, B Ryan, M Schleh, P Varshney, A Ludzki, J Gillen, D Pelt, L Pitchford, S Howton, T Rode, S Hummel, C Burant, J Little, J Horowitz
The Journal of Physiology 2022
Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis
B Dai, J Xu, X Li, L Huang, C Hopkins, H Wang, H Yao, J Mi, L Zheng, J Wang, W Tong, D Chow, Y Li, X He, P Hu, Z Chen, H Zu, Y Li, Y Yao, Q Jiang, L Qin
Nature Communications 2022
Organokines and Exosomes: Integrators of Adipose Tissue Macrophage Polarization and Recruitment in Obesity
Y Wang, Y Wang, X Qi, Z Liao, Y Mai, X Xiao
Frontiers in Endocrinology 2022
IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice
W Liu, H Zhou, H Wang, Q Zhang, R Zhang, B Willard, C Liu, Z Kang, X Li, X Li
Nature Communications 2022
New Insights into Adipose Tissue Macrophages in Obesity and Insulin Resistance
Z Cai, Y Huang, B He
Cells 2022
Sulforaphane reduces obesity by reversing leptin resistance
I Çakır, P Pan, C Hadley, A El-Gamal, A Fadel, D Elsayegh, O Mohamed, N Rizk, M Ghamari-Langroudi
eLife 2022
Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry
J Lee, K Ealey, Y Patel, N Verma, N Thakkar, S Park, J Kim, H Sung
iScience 2022
Adipocyte-specific deletion of PIP5K1c reduces diet-induced obesity and insulin resistance by increasing energy expenditure
G Huang, C Yang, S Guo, M Huang, L Deng, Y Huang, P Chen, F Chen, X Huang
Lipids in Health and Disease 2022
Deconstructing Adipose Tissue Heterogeneity One Cell at a Time
D Duerre, A Galmozzi
Frontiers in Endocrinology 2022
Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor–Toll-like Receptor 4–Proinflammatory Cytokine Signaling
T Nozu, T Okumura
Journal of Neurogastroenterology and Motility 2022
Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies
M Mamtimin, A Pinarci, C Han, A Braun, H Anders, T Gudermann, E Mammadova-Bach
Frontiers in Oncology 2022
Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus?
Q Wu, M Xia, X Gao
World journal of diabetes 2022
Myeloid cell TBK1 restricts inflammatory responses
T Gao, T Liu, C Ko, L Zhang, D Joo, X Xie, L Zhu, Y Li, X Cheng, S Sun
Proceedings of the National Academy of Sciences 2022
Obesity, Adipose Tissue, and Inflammation Answered in Questions
V Guerreiro, D Carvalho, P Freitas, N Velotti
Journal of Obesity 2022
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation
Y Higuchi, T Ogata, N Nakanishi, M Nishi, A Sakamoto, Y Tsuji, S Tomita, S Matoba
Molecular Metabolism 2022
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse
A Müller-Eigner, A Sanz-Moreno, I de-Diego, A Venkatasubramani, M Langhammer, R Gerlini, B Rathkolb, A Aguilar-Pimentel, T Klein-Rodewald, J Calzada-Wack, L Becker, S Palma-Vera, B Gille, I Forne, A Imhof, C Meng, C Ludwig, F Koch, J Heiker, A Kuhla, V Caton, J Brenmoehl, H Reyer, J Schoen, H Fuchs, V Gailus-Durner, A Hoeflich, M de Angelis, S Peleg
2022
You aren't IMMUNE to the ceramides that accumulate in cardiometabolic disease
J Varre, W Holland, S Summers
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2022
Electroacupuncture Stimulation Regulates Adipose Lipolysis via Catecholamine Signaling Mediated by NLRP3 Suppression in Obese Rats
Lu M, Yu Z, Li Q, Gong M, An L, Xu T, Yuan M, Liang C, Yu Z, Xu B
Frontiers in Endocrinology 2022
Maternal Obesity Programming of Perivascular Adipose Tissue and Associated Immune Cells: An Understudied Area With Few Answers and Many Questions
Corken A, Thakali KM
Frontiers in physiology 2022
Moderate l-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance
Cai H, Wang X, Zhang Z, Chen J, Wang F, Wang L, Liu J
The Journal of biological chemistry 2022
Novel Biomarkers of Inflammation for the Management of Diabetes: Immunoglobulin-Free Light Chains
Matsumori A
Biomedicines 2022
The Adipose Tissue Macrophages Central to Adaptive Thermoregulation
Rahman MS, Jun H
Frontiers in immunology 2022
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
Duan H, Jing L, Xiang J, Ju C, Wu Z, Liu J, Ma X, Chen X, Liu Z, Feng J, Yan X
Advanced Science 2022
An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation
Díaz de León-Guerrero S, Salazar-León J, Meza-Sosa KF, Valle-Garcia D, Aguilar-León D, Pedraza-Alva G, Pérez-Martínez L
Disease models & mechanisms 2022
Dietary fat: a potent microglial influencer.
Ceasrine AM, Bilbo SD
Trends in endocrinology and metabolism: TEM 2022
Myristic Acid Supplementation Aggravates High Fat Diet-Induced Adipose Inflammation and Systemic Insulin Resistance in Mice
Saraswathi V, Kumar N, Ai W, Gopal T, Bhatt S, Harris EN, Talmon GA, Desouza CV
Biomolecules 2022
The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and Immunometabolism.
Gálvez I, Navarro MC, Martín-Cordero L, Otero E, Hinchado MD, Ortega E
Nutrients 2022
RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.
Mota RF, Cavalcanti de Araújo PH, Cezine MER, Matsuo FS, Metzner RJM, Oliveira de Biagi Junior CA, Peronni KC, Hayashi H, Shimamura M, Nakagami H, Osako MK
BioMed Research International 2022
Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes
Biondi G, Marrano N, Borrelli A, Rella M, Palma G, Calderoni I, Siciliano E, Lops P, Giorgino F, Natalicchio A
International journal of molecular sciences 2022
Extracellular Vesicles from Adipose Tissue Could Promote Metabolic Adaptation through PI3K/Akt/mTOR
Delgadillo-Velázquez J, Mendivil-Alvarado H, Coronado-Alvarado CD, Astiazaran-Garcia H
Cells 2022
Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation.
Ramírez-Moreno E, Arias-Rico J, Jiménez-Sánchez RC, Estrada-Luna D, Jiménez-Osorio AS, Zafra-Rojas QY, Ariza-Ortega JA, Flores-Chávez OR, Morales-Castillejos L, Sandoval-Gallegos EM
2022
Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration.
Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F
Nature Communications 2022
Neuroimmune contributions to Alzheimer's disease: a focus on human data.
Haage V, De Jager PL
Molecular Psychiatry 2022
Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice
Vilela VR, Samson N, Nachbar R, Perazza LR, Lachance G, Rokatoarivelo V, Centano-Baez C, Zancan P, Sola-Penna M, Bellmann K, Di Marzo V, Laplante M, Marette A
Molecular Metabolism 2022
The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease
Park CS, Shastri N
Immune Network 2022
Subtype-Specific Surface Proteins on Adipose Tissue Macrophages and Their Association to Obesity-Induced Insulin Resistance
Strand K, Stiglund N, Haugstøyl ME, Kamyab Z, Langhelle V, Lawrence-Archer L, Busch C, Cornillet M, Hjellestad ID, Nielsen HJ, Njølstad PR, Mellgren G, Björkström NK, Fernø J
Frontiers in Endocrinology 2022
Role of Innate lymphoid Cells in Obesity and Insulin Resistance
Chen H, Sun L, Feng L, Yin Y, Zhang W
Frontiers in Endocrinology 2022
Role of adipose tissue macrophages in obesity-related disorders
Chakarov S, Blériot C, Ginhoux F
Journal of Experimental Medicine 2022
Neutrophils Actively Contribute to Obesity-Associated Inflammation and Pathological Complications
Uribe-Querol E, Rosales C
Cells 2022
The Roles of Adipose Tissue Macrophages in Human Disease
Liang W, Qi Y, Yi H, Mao C, Meng Q, Wang H, Zheng C
Frontiers in immunology 2022
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation.
Sugimoto S, Mena HA, Sansbury BE, Kobayashi S, Tsuji T, Wang CH, Yin X, Huang TL, Kusuyama J, Kodani SD, Darcy J, Profeta G, Pereira N, Tanzi RE, Zhang C, Serwold T, Kokkotou E, Goodyear LJ, Cypess AM, Leiria LO, Spite M, Tseng YH
Nature metabolism 2022
Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia
Wang N, Liu BW, Ma CM, Yan Y, Su QW, Yin FZ
World journal of clinical cases 2022
Role of Inflammaging on the Reproductive Function and Pregnancy
Zavatta A, Parisi F, Mandò C, Scaccabarozzi C, Savasi VM, Cetin I
Clinical Reviews in Allergy & Immunology 2022
The endocrine adipose organ
Cinti S
Reviews in endocrine & metabolic disorders 2022
Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria
Cox FF, Misiou A, Vierkant A, Ale-Agha N, Grandoch M, Haendeler J, Altschmied J
Cells 2022
SIRT6 stabilization and cytoplasmic localization in macrophages regulates acute and chronic inflammation in mice
Bresque M, Cal K, Pérez-Torrado V, Colman L, Rodríguez-Duarte J, Vilaseca C, Santos L, Garat MP, Ruiz S, Evans F, Dapueto R, Contreras P, Calliari A, Escande C
The Journal of biological chemistry 2022
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
Zeidler JD, Hogan KA, Agorrody G, Peclat TR, Kashyap S, Kanamori KS, Gomez LS, Mazdeh DZ, Warner GM, Thompson KL, Chini CC, Chini EN
AJP Cell Physiology 2022
Near-roadway air pollution, immune cells and adipokines among obese young adults
Rahman MM, Liu FF, Eckel SP, Sankaranarayanan I, Shafiei-Jahani P, Howard E, Baronikian L, Sattler F, Lurmann FW, Allayee H, Akbari O, McConnell R
Environmental Health 2022
Human umbilical cord-derived mesenchymal stem cells alleviate insulin resistance in diet-induced obese mice via an interaction with splenocytes
Xue J, Gao J, Gu Y, Wang A, Yu S, Li B, Yin Y, Wang J, Su W, Zhang H, Ren W, Gu W, Lv Z, Mu Y, Cheng Y
Stem Cell Research & Therapy 2022
Association between Telomere Length and Pediatric Obesity: A Systematic Review
Raftopoulou C, Paltoglou G, Charmandari E
Nutrients 2022
Transcriptome analysis of adipocytokines and their-related LncRNAs in lung adenocarcinoma revealing the association with prognosis, immune infiltration, and metabolic characteristics
Ren J, Zhang H, Wang J, Xu Y, Zhao L, Yuan Q
Adipocyte 2022
Obesity modulates the immune macroenvironment associated with breast cancer development
Núñez-Ruiz A, Sánchez-Brena F, López-Pacheco C, Acevedo-Domínguez NA, Soldevila G
PloS one 2022
CTRP11 contributes modestly to systemic metabolism and energy balance
Sarver DC, Xu C, Carreno D, Arking A, Terrillion CE, Aja S, Wong GW
The FASEB Journal 2022
Monocyte Trafficking and Polarization Contribute to Sex Differences in Meta-Inflammation.
Varghese M, Clemente J, Lerner A, Abrishami S, Islam M, Subbaiah P, Singer K
Frontiers in Endocrinology 2022
Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging
Barbu E, Popescu MR, Popescu AC, Balanescu SM
International journal of molecular sciences 2022
The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?
Szymczak-Pajor I, Miazek K, Selmi A, Balcerczyk A, Śliwińska A
International journal of molecular sciences 2022
The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?
Ramires LC, Santos GS, Ramires RP, da Fonseca LF, Jeyaraman M, Muthu S, Lana AV, Azzini G, Smith CS, Lana JF
International journal of molecular sciences 2022
Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress
Pereira EN, de Araujo BP, Rodrigues KL, Silvares RR, Martins CS, Flores EE, Fernandes-Santos C, Daliry A
Nutrients 2022
The Interplay of Obesity, Dyslipidemia and Immune Dysfunction: A Brief Overview on Pathophysiology, Animal Models, and Nutritional Modulation
She Y, Mangat R, Tsai S, Proctor SD, Richard C
Frontiers in Nutrition 2022
Gastric bypass regulates early inflammatory responses in high-fat diet-induced obese mice
Xu R, Zhu C, Li Y, Andrade M, Yin DP
The Journal of surgical research 2022
Obesity: A Chronic Low-Grade Inflammation and Its Markers
Khanna D, Khanna S, Khanna P, Kahar P, Patel BM
Cureus 2022
The effect of BMI on long-term outcomes after operatively treated ankle fractures: a study with up to 16 years of follow-up
Cardoso DV, Paccaud J, Dubois-Ferrière V, Barea C, Hannouche D, Veljkovic A, Lübbeke A
BMC musculoskeletal disorders 2022
Adipocyte-derived serum amyloid A promotes angiotensin II-induced abdominal aortic aneurysms in obese C57BL/6J mice
Shridas P, Ji A, Trumbauer AC, Noffsinger VP, Leung SW, Dugan AJ, Thatcher SE, Cassis LA, De Beer FC, Webb NR, Tannock LR
Arteriosclerosis, thrombosis, and vascular biology 2022
The duration of chronic low back pain is associated with acute postoperative pain intensity in lumbar fusion surgery: a prospective observational study
Qian MP, Dong MR, Li J, Kang F
BMC Anesthesiology 2022
Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity
Pincu Y, Yoel U, Haim Y, Makarenkov N, Maixner N, Shaco-Levy R, Bashan N, Dicker D, Rudich A
Frontiers in Endocrinology 2022
The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator
Jovanovic F, Sudhakar A, Knezevic NN
International journal of tryptophan research : IJTR 2022
Inflammatory Mechanisms of Diabetes and Its Vascular Complications
Nedosugova LV, Markina YV, Bochkareva LA, Kuzina IA, Petunina NA, Yudina IY, Kirichenko TV
Biomedicines 2022
Current Development of Nano-Drug Delivery to Target Macrophages
Cai D, Gao W, Li Z, Zhang Y, Xiao L, Xiao Y
Biomedicines 2022
Use of Physical Activity and Exercise to Reduce Inflammation in Children and Adolescents with Obesity
Calcaterra V, Vandoni M, Rossi V, Berardo C, Grazi R, Cordaro E, Tranfaglia V, Carnevale Pellino V, Cereda C, Zuccotti G
International journal of environmental research and public health 2022
ASK1-Interacting Protein 1 Acts as a Novel Predictor of Type 2 Diabetes
Song Z, Chen C, He J, Liu B, Ji W, Wu L, He L
Frontiers in Endocrinology 2022
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
Bruno ME, Mukherjee S, Powell WL, Mori SF, Wallace FK, Balasuriya BK, Su LC, Stromberg AJ, Cohen DA, Starr ME
GeroScience 2022
Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
Kempf K, Röhling M, Banzer W, Braumann KM, Halle M, Schaller N, McCarthy D, Predel HG, Schenkenberger I, Tan S, Toplak H, Martin S, Berg A
Nutrients 2022
Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs.
Pitere RR, van Heerden MB, Pepper MS, Ambele MA
Biology 2022
The Preliminary Evaluation of Epigenetic Modifications Regulating the Expression of IL10 in Insulin-Resistant Adipocytes.
Cierzniak A, Kaliszewski K, Małodobra-Mazur M
Genes & development 2022
Ocimum basilicum L. Methanol Extract Enhances Mitochondrial Efficiency and Decreases Adipokine Levels in Maturing Adipocytes Which Regulate Macrophage Systemic Inflammation.
Subash-Babu P, Mohammed Alowaidh H, Al-Harbi LN, Shamlan G, Aloud AA, AlSedairy SA, Alshatwi AA
Molecules (Basel, Switzerland) 2022
The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn's Disease.
Hayashi Y, Nakase H
Frontiers in physiology 2022
Acetate-mediated-obestatin modulation attenuates adipose-hepatic dysmetabolism in high fat diet-induced obese rat model.
Olaniyi KS, Atuma CL, Sabinari IW, Mahmud H, Saidi AO, Fafure AA, Olatunji LA
Endocrine 2022
Sodium butyrate reduces endoplasmic reticulum stress by modulating CHOP and empowers favorable anti-inflammatory adipose tissue immune-metabolism in HFD fed mice model of obesity.
Kushwaha V, Rai P, Varshney S, Gupta S, Khandelwal N, Kumar D, Nilkanth Gaikwad A
2022
Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology.
Anderson ZT, Dawson AD, Slominski AT, Harris ML
Frontiers in Endocrinology 2022
Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding.
Müller C, Zidek LM, Eichwald S, Kortman G, Koster MH, Calkhoven CF
eLife 2022
Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases.
Yi YS
International journal of molecular sciences 2022
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.
El-Sayed Moustafa JS, Jackson AU, Brotman SM, Guan L, Villicaña S, Roberts AL, Zito A, Bonnycastle L, Erdos MR, Narisu N, Stringham HM, Welch R, Yan T, Lakka T, Parker S, Tuomilehto J, Seow J, Graham C, Huettner I, Acors S, Kouphou N, Wadge S, Duncan EL, Steves CJ, Doores KJ, Malim MH, Collins FS, Pajukanta P, Boehnke M, Koistinen HA, Laakso M, Falchi M, Bell JT, Scott LJ, Mohlke KL, Small KS
International Journal of Obesity 2022
The influence of gastric bypass surgery on the concentration of high mobility group box 1, nuclear factor erythroid 2-related factor 2 and the genes expression of high mobility group box 1, nuclear factor erythroid2-related factor 2, interleukin 6, and tumor necrosis factor-alpha in the peripheral blood mononuclear cells of patients with morbid obesity.
Khanaghaei M, Ziamajidi N, Poorolajal J, Asadikaram G, Nikoyan P, Bajian M, Abbasalipourkabir R
Molecular Biology Reports 2022
Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ.
Deng H, Konopka CJ, Prabhu S, Sarkar S, Medina NG, Fayyaz M, Arogundade OH, Vidana Gamage HE, Shahoei SH, Nall D, Youn Y, Dobrucka IT, Audu CO, Joshi A, Melvin WJ, Gallagher KA, Selvin PR, Nelson ER, Dobrucki LW, Swanson KS, Smith AM
ACS Nano 2022
Low density, high impact? Neutrophil changes in obesity and bariatric surgery
Roberts CF, Sheu EG
EBioMedicine 2022
Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages
Howe AM, Burke S, O\u2019Reilly ME, McGillicuddy FC, Costello DA
Molecular Neurobiology 2022
Dual Relationship Between Stromal Cells and Immune Cells in the Tumor Microenvironment
Mun JY, Leem SH, Lee JH, Kim HS
Frontiers in immunology 2022
Extracellular Vesicles in Pathogenesis and Treatment of Metabolic Associated Fatty Liver Disease
Sun J, Zhang D, Li Y
Frontiers in physiology 2022
Inhaled or Ingested, Which Is Worse, E-Vaping or High-Fat Diet?
Chen H, Chan YL, Thorpe AE, Pollock CA, Saad S, Oliver BG
Frontiers in immunology 2022
Metabolic risk factors of ovarian cancer: a review.
Khanlarkhani N, Azizi E, Amidi F, Khodarahmian M, Salehi E, Pazhohan A, Farhood B, Mortezae K, Goradel NH, Nashtaei MS
JBRA Assisted Reproduction 2022
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry.
Thylur DS, Goldsmith DR
Harvard Review of Psychiatry 2022
The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.
Bagherniya M, Mahdavi A, Abbasi E, Iranshahy M, Sathyapalan T, Sahebkar A
InflammoPharmacology 2022
A Straightforward Method for Adipocyte Size and Count Analysis Using Open-source Software QuPath.
Palomäki VA, Koivukangas V, Meriläinen S, Lehenkari P, Karttunen TJ
Adipocyte 2022
The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19
Cinti F, Cinti S
Cells 2022
A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle
Sabaratnam R, Skov V, Paulsen SK, Juhl S, Kruse R, Hansen T, Halkier C, Kristensen JM, Vind BF, Richelsen B, Knudsen S, Dahlgaard J, Beck-Nielsen H, Kruse TA, Højlund K
Cells 2022
Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells
Zheng H, Qiu Z, Chai T, He J, Zhang Y, Wang C, Ye J, Wu X, Li Y, Zhang L, Chen L
Frontiers in Cardiovascular Medicine 2022
Differential Effects of Exercise Programs on Neuregulin 4, Body Composition and Cardiometabolic Risk Factors in Men With Obesity
Saeidi A, Shishvan SR, Soltani M, Tarazi F, Doyle-Baker PK, Shahrbanian S, Mollabashi SS, Khosravi N, Laher I, Moriarty TA, Johnson KE, VanDusseldorp TA, Zouhal H
Frontiers in physiology 2022
Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention
Terkawi MA, Ebata T, Yokota S, Takahashi D, Endo T, Matsumae G, Shimizu T, Kadoya K, Iwasaki N
Biomedicines 2022
Integrated Omics Analysis Reveals Alterations in the Intestinal Microbiota and Metabolites of Piglets After Starvation
Ma Y, Lu C, Ji B, Qin J, Cai C, Yang Y, Zhao Y, Liang G, Guo X, Cao G, Li B, Gao P
Frontiers in microbiology 2022
ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead
Misawa T, Wagner M, Koyasu S
Frontiers in immunology 2022
Adipocyte-Specific Ablation of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome in Aging Mice
Chen KY, De Angulo A, Guo X, More A, Ochsner SA, Lopez E, Saul D, Pang W, Sun Y, McKenna NJ, Tong Q
2022
Adipocyte differentiation between obese and lean conditions depends on changes in miRNA expression
Heo Y, Kim H, Lim J, Choi SS
Scientific Reports 2022
Effects of exercise and microbiota transplant on the memory of obesity-induced mice
Park SS, Kim SH, Kim CJ, Shin MS, Park YJ, Kim TW
Journal of Exercise Rehabilitation 2022
Regulation of Adipose Tissue Biology by Long-Chain Fatty Acids: Metabolic Effects and Molecular Mechanisms
Shin S
Journal of Obesity & Metabolic Syndrome 2022
Translating MSC Therapy in the Age of Obesity
Boland L, Bitterlich LM, Hogan AE, Ankrum JA, English K
Frontiers in immunology 2022
Obesity, Inflammation, and Immune System in Osteoarthritis
Nedunchezhiyan U, Varughese I, Sun AR, Wu X, Crawford R, Prasadam I
Frontiers in immunology 2022
Hepatic Insulin Resistance in Hyperthyroid Rat Liver: Vitamin E Supplementation Highlights a Possible Role of ROS
Fasciolo G, Napolitano G, Aprile M, Cataldi S, Costa V, Ciccodicola A, Di Meo S, Venditti P
Antioxidants 2022
Correlation of Body Mass Index and Proinflammatory Cytokine Levels with Hematopoietic Stem Cell Mobilization
Wang TF, Liou YS, Chang HH, Yang SH, Li CC, Wang JH, Sun DS
Journal of Clinical Medicine 2022
Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice
Ushakumari CJ, Zhou QL, Wang YH, Na S, Rigor MC, Zhou CY, Kroll MK, Lin BD, Jiang ZY
Cells 2022
Identification of key genes and their association with immune infiltration in adipose tissue of obese patients: a bioinformatic analysis
Wen J, Wang L
Adipocyte 2022
IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation
Akhter N, Kochumon S, Hasan A, Wilson A, Nizam R, Al Madhoun A, Al-Rashed F, Arefanian H, Alzaid F, Sindhu S, Al-Mulla F, Ahmad R
Journal of inflammation research 2022
From Obesity to Diabetes: The Role of the Adipose Organ.
Colleluori G, Perugini J, Giordano A, Cinti S
Handbook of experimental pharmacology 2022
Brown Adipose Tissue: A Short Historical Perspective.
Trayhurn P
Methods in molecular biology (Clifton, N.J.) 2022
Adipose Tissue Inflammation and Cardiovascular Disease: An Update.
Rana MN, Neeland IJ
Current Diabetes Reports 2022
A single-cell atlas of human and mouse white adipose tissue.
Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen ED
Nature 2022
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation.
Ren Y, Zhao H, Yin C, Lan X, Wu L, Du X, Griffiths HR, Gao D
Frontiers in Endocrinology 2022
White adipose tissue-derived factors and prostate cancer progression: mechanisms and targets for interventions.
Saha A, Hamilton-Reeves J, DiGiovanni J
Cancer metastasis reviews 2022
An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload
Ameka MK, Beavers WN, Shaver CM, Ware LB, Kerchberger VE, Schoenfelt KQ, Sun L, Koyama T, Skaar EP, Becker L, Hasty AH
International journal of molecular sciences 2022
Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis.
Etienne Q, Lebrun V, Komuta M, Navez B, Thissen JP, Leclercq IA, Lanthier N
Metabolites 2022
Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology
Lecoutre S, Lambert M, Drygalski K, Dugail I, Maqdasy S, Hautefeuille M, Clément K
Cells 2022
Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in Type 2 diabetes - mediation by pigment epithelium-derived factor.
Low S, Pek S, Moh A, Ang K, Khoo J, Shao YM, Tang WE, Lim Z, Subramaniam T, Sum CF, Lim SC
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2022
The adipocyte microenvironment and cancer.
Mukherjee A, Bilecz AJ, Lengyel E
Cancer metastasis reviews 2022
Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip
Rogal J, Roosz J, Teufel C, Cipriano M, Xu R, Eisler W, Weiss M, Schenke\u2010Layland K, Loskill P
Advanced Science 2022
Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation
Zhang C, Zhang B, Zhang X, Wang M, Sun X, Sun G
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2022
Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells
Schielke L, Zimmermann N, Hobelsberger S, Steininger J, Strunk A, Blau K, Hernandez J, Künzel S, Ziegenbalg R, Rösing S, Beissert S, Abraham S, Günther C
Frontiers in immunology 2022
Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction
Raheem J, Sliz E, Shin J, Holmes MV, Pike GB, Richer L, Gaudet D, Paus T, Pausova Z
2022
Resveratrol pre-treatment alleviated caerulein-induced acute pancreatitis in high-fat diet-feeding mice via suppressing the NF-κB proinflammatory signaling and improving the gut microbiota
Zhang X, Yang G, Chen Y, Mu Z, Zhou H, Zhang L
2022
Early introduction of exercise prevents insulin resistance in postnatal overfed rats
Fischer SV, Appel MH, Naliwaiko K, Pagliosa DD, Araújo DN, Capote AE, Oliveira BA, Fernandes LC
Brazilian Journal of Medical and Biological Research 2022
Expression of adipokines and adipocytokines by epidural adipose tissue in cauda equina syndrome in dogs
Leisengang S, Gluding D, Hörster J, Peek V, Ott D, Rummel C, Schmidt MJ
Journal of Veterinary Internal Medicine 2022
Cutoff Points of Waist Circumference for Predicting Incident Non-Alcoholic Fatty Liver Disease in Middle-Aged and Older Korean Adults
Lee JH, Jeon S, Lee HS, Kwon YJ
Nutrients 2022
T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity
Hägglöf T, Vanz C, Kumagai A, Dudley E, Ortega V, Siller M, Parthasarathy R, Keegan J, Koenigs A, Shute T, Leadbetter EA
Cell Metabolism 2022
Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain
Woo A, Botta A, Shi SS, Paus T, Pausova Z
International journal of molecular sciences 2022
Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases
Püschel GP, Klauder J, Henkel J
Journal of Clinical Medicine 2022
Endothelial Cell Insulin Signaling Regulates CXCR4 and Limits Leukocyte Adhesion to Endothelium
Rathjen T, Kunkemoeller B, Cederquist CT, Wang X, Lockhart SM, Patti JC, Willenbrock H, Olsen GS, Povlsen GK, Beck HC, Rasmussen LM, Li Q, Park K, King GL, Rask-Madsen C
Arteriosclerosis, thrombosis, and vascular biology 2022
A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
Wang M, Xu R, Liu X, Zhang L, Qiu S, Lu Y, Zhang P, Yan M, Zhu J
2022
The purinergic signalling and inflammation in the pathogenesis and progression of diabetes: key factors and therapeutic targets.
de Lima AC, Chaves LM, Prestes SN, Mânica A, Cardoso AM
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022
The obesity-breast cancer link: a multidisciplinary perspective.
Devericks EN, Carson MS, McCullough LE, Coleman MF, Hursting SD
Cancer metastasis reviews 2022
IL-25 directly modulates adipocyte function and inflammation through the regulation of adiponectin.
Jeerawattanawart S, Siripurkpong P, Roytrakul S, Angkasekwinai P
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022
Placental diabesity: placental VEGF and CD31 expression according to pregestational BMI and gestational weight gain in women with gestational diabetes.
Sirico A, Rossi ED, Degennaro VA, Arena V, Rizzi A, Tartaglione L, Di Leo M, Pitocco D, Lanzone A
Archives of Gynecology and Obstetrics 2022
The role of obesity and bariatric surgery-induced weight loss in breast cancer.
Bohm MS, Sipe LM, Pye ME, Davis MJ, Pierre JF, Makowski L
Cancer metastasis reviews 2022
14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling.
Chen JL, Feng ZL, Zhou F, Lou RH, Peng C, Ye Y, Lin LG
Acta Pharmacologica Sinica 2022
The dark side of Tregs during aging
Palatella M, Guillaume SM, Linterman MA, Huehn J
Frontiers in immunology 2022
Protective role of zinc in the pathogenesis of respiratory diseases
Luan R, Ding D, Xue Q, Li H, Wang Y, Yang J
European Journal of Clinical Nutrition 2022
Macrophage Polarization Mediated by Mitochondrial Dysfunction Induces Adipose Tissue Inflammation in Obesity
Xu L, Yan X, Zhao Y, Wang J, Liu B, Yu S, Fu J, Liu Y, Su J
International journal of molecular sciences 2022
Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption
Mackert O, Wirth EK, Sun R, Winkler J, Liu A, Renko K, Kunz S, Spranger J, Brachs S
Molecular Metabolism 2022
Adipose tissue regulatory T cells: differentiation and function.
Fooks AN, Beppu LY, Frias AB, D'Cruz LM
International Reviews of Immunology 2022
20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology.
Tews D, Brenner RE, Siebert R, Debatin KM, Fischer-Posovszky P, Wabitsch M
International Journal of Obesity 2022
Altered adipose tissue macrophage populations in people with HIV on integrase inhibitor-containing antiretroviral therapy.
Vakili S, Paneru B, Guerrier CM, Miller J, Baumrin E, Forrestel A, Lynn K, Frank I, Lo Re V 3rd, Collman RG, Hill DA
AIDS 2022
Lipid Peroxidation in Obesity: Can Bariatric Surgery Help?
Soldo AM, Soldo I, Karačić A, Konjevod M, Perkovic MN, Glavan TM, Luksic M, Žarković N, Jaganjac M
Antioxidants 2022
Obesity: a perfect storm for carcinogenesis.
Harris BHL, Macaulay VM, Harris DA, Klenerman P, Karpe F, Lord SR, Harris AL, Buffa FM
Cancer metastasis reviews 2022
Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
Orliaguet L, Ejlalmanesh T, Humbert A, Ballaire R, Diedisheim M, Julla JB, Chokr D, Cuenco J, Michieletto J, Charbit J, Lindén D, Boucher J, Potier C, Hamimi A, Lemoine S, Blugeon C, Legoix P, Lameiras S, Baudrin LG, Baulande S, Soprani A, Castelli FA, Fenaille F, Riveline JP, Dalmas E, Rieusset J, Gautier JF, Venteclef N, Alzaid F
Nature Communications 2022
Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase.
Zapata RC, Carretero M, Reis FCG, Chaudry BS, Ofrecio J, Zhang D, Sasik R, Ciaraldi T, Petrascheck M, Osborn O
Nature Communications 2022
Food for thought - ILC metabolism in the context of helminth infections.
Michla M, Wilhelm C
Mucosal Immunology 2022
Anti-inflammatory agents as modulators of the inflammation in adipose tissue: A systematic review
da Cruz Nascimento SS, Carvalho de Queiroz JL, Fernandes de Medeiros A, de França Nunes AC, Piuvezam G, Lima Maciel BL, Souza Passos T, Morais AH
PloS one 2022
Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids.
Raj RR, Lofquist S, Lee MJ
Pharmaceutical Research 2022
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CK, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X
Nature Communications 2022
Analytical performance of a canine ELISA monocyte chemoattractant protein-1 assay for use in cats and evaluation of circulating levels in normal weight and obese cats
Stenberg K, Gensby L, Cremer SE, Nielsen MM, Bjørnvad CR
Acta veterinaria Scandinavica 2022
Adipose tissue macrophages in remote modulation of hepatic glucose production
Tao Y, Jiang Q, Wang Q
Frontiers in immunology 2022
Sex-specific effects of maternal weight loss on offspring cardiometabolic outcomes in the obese preeclamptic-like mouse model, BPH/5.
Beckers KF, Schulz CJ, Flanagan JP, Adams DM, Gomes VCL, Liu CC, Childers GW, Sones JL
Physiological Reports 2022
Breast cancer microenvironment and obesity: challenges for therapy.
Hillers-Ziemer LE, Kuziel G, Williams AE, Moore BN, Arendt LM
Cancer metastasis reviews 2022
Fibrosis in fat: From other diseases to Crohn's disease.
Xiong S, Tan J, Wang Y, He J, Hu F, Wu X, Liu Z, Lin S, Li X, Chen Z, Mao R
Frontiers in immunology 2022
Examination of the role of necroptotic damage-associated molecular patterns in tissue fibrosis.
Liu X, Lu F, Chen X
Frontiers in immunology 2022
Adipose tissue macrophage in obesity-associated metabolic diseases
Yao J, Wu D, Qiu Y
Frontiers in immunology 2022
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging.
Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD
Immunity 2022
A nexus of lipid and O-Glcnac metabolism in physiology and disease.
Lockridge A, Hanover JA
Frontiers in Endocrinology 2022
Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review.
Lv W, Xu D
2022
A modified standard American diet induces physiological parameters associated with metabolic syndrome in C57BL/6J mice.
Chehade SB, Green GBH, Graham CD, Chakraborti A, Vashai B, Moon A, Williams MB, Vickers B, Berryhill T, Van Der Pol W, Wilson L, Powell ML, Smith DL Jr, Barnes S, Morrow C, Mukhtar MS, Kennedy GD, Bibb JA, Watts SA
Frontiers in Nutrition 2022
Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice
Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, Okazaki H, Ebihara K, Yagyu H, Takayanagi Y, Onaka T, Goldberg IJ, Ishibashi S
The Journal of biological chemistry 2022
Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
Patel S, Haider A, Alvarez-Guaita A, Bidault G, El-Sayed Moustafa JS, Guiu-Jurado E, Tadross JA, Warner J, Harrison J, Virtue S, Scurria F, Zvetkova I, Blüher M, Small KS, O\u2019Rahilly S, Savage DB
Molecular Metabolism 2022
The Role of Diet in Regulation of Macrophages Functioning
Varaeva YR, Kirichenko TV, Shaposhnikova NN, Nikityuk DB, Starodubova AV
Biomedicines 2022
The Adipose Organ Is a Unitary Structure in Mice and Humans
Giordano A, Cinti F, Canese R, Carpinelli G, Colleluori G, Di Vincenzo A, Palombelli G, Severi I, Moretti M, Redaelli C, Partridge J, Zingaretti MC, Agostini A, Sternardi F, Giovagnoni A, Castorina S, Cinti S
Biomedicines 2022
Effects of adrenergic-stimulated lipolysis and cytokine production on in vitro mouse adipose tissue–islet interactions
Oquendo MB, Lorza-Gil E, Juarez-Lopez D, Wagner R, Birkenfeld AL, Ullrich S, Gerst F
Scientific Reports 2022
Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-κB/AMPK Activation in Obese Mice Fed a High-Fat Diet
Chang E
International journal of molecular sciences 2022
Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity.
Bradley D, Smith AJ, Blaszczak A, Shantaram D, Bergin SM, Jalilvand A, Wright V, Wyne KL, Dewal RS, Baer LA, Wright KR, Stanford KI, Needleman B, Brethauer S, Noria S, Renton D, Joseph JJ, Lovett-Racke A, Liu J, Hsueh WA
Nature Communications 2022
Immune Cell Activation in Obesity and Cardiovascular Disease
Garcia JN, Wanjalla CN, Mashayekhi M, Hasty AH
Current Hypertension Reports 2022
Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
Boroumand P, Prescott DC, Mukherjee T, Bilan PJ, Wong M, Shen J, Tattoli I, Zhou Y, Li A, Sivasubramaniyam T, Shi N, Zhu LY, Liu Z, Robbins C, Philpott DJ, Girardin SE, Klip A
eLife 2022
The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women
Damani JJ, De Souza MJ, VanEvery HL, Strock NC, Rogers CJ
Advances in Nutrition 2022
Comparison of perinephric fat measurements between malignant and benign renal tumours
Tsai JP, Lin DC, Huang WM, Chen M, Chen YH
2022
Reciprocal signaling between adipose tissue depots and the central nervous system
Puente-Ruiz SC, Jais A
Frontiers in Cell and Developmental Biology 2022
Macrophages, Chronic Inflammation, and Insulin Resistance
Li H, Meng Y, He S, Tan X, Zhang Y, Zhang X, Wang L, Zheng W
Cells 2022
Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice
Frieler RA, Vigil TM, Song J, Leung C, Goldstein DR, Lumeng CN, Mortensen RM
Obesity (Silver Spring, Md.) 2022
Modeling Obesity-Driven Pancreatic Carcinogenesis—A Review of Current In Vivo and In Vitro Models of Obesity and Pancreatic Carcinogenesis
Kfoury S, Michl P, Roth L
Cells 2022
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2022
REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation.
Lee DK, Kim T, Byeon J, Park M, Kim S, Kim J, Choi S, Lee G, Park C, Lee KW, Kwon YJ, Lee JH, Kwon YG, Kim YM
Nature Communications 2022
The gut microbiota: a double-edged sword in endometriosis†.
Talwar C, Singh V, Kommagani R
Biology of reproduction 2022
Estradiol treatment increases M2-like visceral adipose tissue macrophages in obese ovariectomized mice regardless of its anorectic action.
Kim KD, Choe JM, Myoung S, Lee SH, Kim M, Choi JH, Park HT
Animal Cells and Systems 2022
Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity.
Ruggiero AD, Vemuri R, Block M, DeStephanis D, Davis M, Chou J, Williams A, Brock A, Das SK, Kavanagh K
International journal of molecular sciences 2022
Obesity-Related Cross-Talk between Prostate Cancer and Peripheral Fat: Potential Role of Exosomes.
Feng S, Lou K, Luo C, Zou J, Zou X, Zhang G
Cancers 2022
Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance.
Mentxaka A, Gómez-Ambrosi J, Ramírez B, Rodríguez A, Becerril S, Neira G, Valentí V, Moncada R, Silva C, Unamuno X, Cienfuegos JA, Escalada J, Frühbeck G, Catalán V
Nutrients 2022
Palmitoleic Acid Acts on Adipose-Derived Stromal Cells and Promotes Anti-Hypertrophic and Anti-Inflammatory Effects in Obese Mice.
Simão JJ, Cruz MM, Abdala FM, Bolsoni-Lopes A, Armelin-Correa L, Alonso-Vale MIC
Pharmaceuticals (Basel, Switzerland) 2022
TSH-SPP1/TRβ-TSH positive feedback loop mediates fat deposition of hepatocyte: Crosstalk between thyroid and liver.
Huang B, Wen W, Ye S
Frontiers in immunology 2022
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations.
Joffin N, Gliniak CM, Funcke JB, Paschoal VA, Crewe C, Chen S, Gordillo R, Kusminski CM, Oh DY, Geldenhuys WJ, Scherer PE
Nature metabolism 2022
Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice.
Hiramoto K, Goto K, Tanaka S, Horikawa T, Ooi K
Biomedicines 2022
Comprehensive analysis of epigenomics and transcriptome data to identify potential target genes associated with obesity.
Wu P, Guo L, Li X, Du Y, Lin X, Ma X, Lin Y, Wen C, Yang C, Liu N, Feng Q, Xue Y, Guan M
Frontiers in Genetics 2022
Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows.
Michelotti TC, Kisby BR, Flores LS, Tegeler AP, Fokar M, Crasto C, Menarim BC, Loux SC, Strieder-Barboza C
Frontiers in Cell and Developmental Biology 2022
Serum plays an important role in reprogramming the seasonal transcriptional profile of brown bear adipocytes.
Saxton MW, Perry BW, Evans Hutzenbiler BD, Trojahn S, Gee A, Brown AP, Merrihew GE, Park J, Cornejo OE, MacCoss MJ, Robbins CT, Jansen HT, Kelley JL
iScience 2022
Obesity: A Doorway to a Molecular Path Leading to Infertility.
Ahmad R, Haque M
Cureus 2022
UCP2 KO mice exhibit ameliorated obesity and inflammation induced by high-fat diet feeding
Kim DH, Kim HJ, Seong JK
BMB Reports 2022
Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity
Mathur N, Severinsen MC, Jensen ME, Naver L, Schrölkamp M, Laye MJ, Watt MJ, Nielsen S, Krogh-Madsen R, Pedersen BK, Scheele C
Frontiers in Cell and Developmental Biology 2022
The critical role of gut microbiota in obesity
Cheng Z, Zhang L, Yang L, Chu H
Frontiers in Endocrinology 2022
A soy-yoghurt-honey product as a therapeutic functional food: mode of action and narrative review
Berg A, McCarthy HD
Heliyon 2022
[Role of metaflammation as a systemic manifestation of metabolic diseases].
Schäffler A
2022
Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ.
Dana N, Ferns GA, Nedaeinia R, Haghjooy Javanmard S
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022
The Role of Crosstalk between Adipose Cells and Myocytes in the Pathogenesis of Sarcopenic Obesity in the Elderly
Zamboni M, Mazzali G, Brunelli A, Saatchi T, Urbani S, Giani A, Rossi AP, Zoico E, Fantin F
Cells 2022
Cross-Sectional Associations of Body Adiposity, Sedentary Behavior, and Physical Activity with Hemoglobin and White Blood Cell Count
Koivula T, Lempiäinen S, Laine S, Sjöros T, Vähä-Ypyä H, Garthwaite T, Löyttyniemi E, Sievänen H, Vasankari T, Knuuti J, Heinonen IH
International journal of environmental research and public health 2022
Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome
Li W, Liu C, Yang Q, Zhou Y, Liu M, Shan H
Frontiers in Nutrition 2022
How Does Lifestyle Affect Hematopoiesis and the Bone Marrow Microenvironment?
Vanhie JJ, De Lisio M
Toxicologic pathology 2022
Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise.
Razi O, Teixeira AM, Tartibian B, Zamani N, Knechtle B
Molecular and Cellular Biochemistry 2022
LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation.
Choi CHJ, Barr W, Zaman S, Model C, Park A, Koenen M, Lin Z, Szwed SK, Marchildon F, Crane A, Carroll TS, Molina H, Cohen P
eLife 2022
Extracellular vesicles biogenesis, isolation, manipulation and genetic engineering for potential in vitro and in vivo therapeutics: An overview.
Hadizadeh N, Bagheri D, Shamsara M, Hamblin MR, Farmany A, Xu M, Liang Z, Razi F, Hashemi E
Frontiers in Bioengineering and Biotechnology 2022
Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response
Jerigova V, Zeman M, Okuliarova M
International journal of molecular sciences 2022
Differential Gene Expression of Subcutaneous Adipose Tissue among Lean, Obese, and after RYGB (Different Timepoints): Systematic Review and Analysis
Cruz-García EM, Frigolet ME, Canizales-Quinteros S, Gutiérrez-Aguilar R
Nutrients 2022
Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System
D\u2019Oria R, Genchi VA, Caccioppoli C, Calderoni I, Marrano N, Biondi G, Borrelli A, Di Gioia L, Giorgino F, Laviola L
International journal of molecular sciences 2022
Rapid Drop in Coronary Heart Disease Mortality in Czech Male Population—What Was Actually behind It?
Poledne R, Kralova A, Bartuskova H, Paukner K, Kauerova S, Fronek J, Lanska V, Kralova Lesna I
Biomedicines 2022
Multiple sclerosis and obesity: The role of adipokines
Correale J, Marrodan M
Frontiers in immunology 2022
Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity
Nance SA, Muir L, Lumeng C
Molecular Metabolism 2022
In vivo corneal confocal microscopy as a non-invasive test to assess obesity induced small fibre nerve damage and inflammation.
Gulkas S, Aydin FO, Turhan SA, Toker AE
Eye 2022
Immune response to arbovirus infection in obesity.
Hameed M, Geerling E, Pinto AK, Miraj I, Weger-Lucarelli J
Frontiers in immunology 2022
Adipocyte coculture induces a pro-inflammatory, fibrotic, angiogenic, and proliferative microenvironment in uterine leiomyoma cells
Afrin S, El Sabah M, Manzoor A, Miyashita-Ishiwata M, Reschke L, Borahay MA
2022
Ferroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system
Zhang S, Sun Z, Jiang X, Lu Z, Ding L, Li C, Tian X, Wang Q
Frontiers in immunology 2022
Essential roles of the cytokine oncostatin M in crosstalk between muscle fibers and immune cells in skeletal muscle after aerobic exercise
Komori T, Morikawa Y
The Journal of biological chemistry 2022
A low carbohydrate diet high in fish oil and soy protein delays inflammation, hematopoietic stem cell depletion, and mortality in miR-146a knock-out mice
Elisia I, Kowalski S, Yeung M, Wong J, Grants JM, Karsan A, Krystal G
Frontiers in Nutrition 2022
Mangiferin Ameliorates Obesity-Associated Inflammation and Autophagy in High-Fat-Diet-Fed Mice: In Silico and In Vivo Approaches
Noh JW, Lee HY, Lee BC
International journal of molecular sciences 2022
Ramulus Mori (Sangzhi) Alkaloids Ameliorate Obesity-Linked Adipose Tissue Metabolism and Inflammation in Mice
Sun QW, Lian CF, Chen YM, Ye J, Chen W, Gao Y, Wang HL, Gao LL, Liu YL, Yang YF
Nutrients 2022
The Role of Adipokines in Inflammatory Mechanisms of Obesity
Kirichenko TV, Markina YV, Bogatyreva AI, Tolstik TV, Varaeva YR, Starodubova AV
International journal of molecular sciences 2022
The PI3K/Akt Pathway in Meta-Inflammation
Acosta-Martinez M, Cabail MZ
International journal of molecular sciences 2022
Developmental endothelial locus-1 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target
Zhao M, Zheng Z, Li C, Wan J, Wang M
Frontiers in immunology 2022
The rheumatoid arthritis drug auranofin lowers leptin levels and exerts anti-diabetic effects in obese mice
Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Li G, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM
Cell Metabolism 2022
MicroRNAs: a crossroad that connects obesity to immunity and aging
Rakib A, Kiran S, Mandal M, Singh UP
Immunity & ageing : I & A 2022
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes
Clement CC, Osan J, Buque A, Nanaware PP, Chang YC, Perino G, Shetty M, Yamazaki T, Tsai WL, Urbanska AM, Calvo-Calle JM, Ramsamooj S, Vergani D, Mieli-Vergani G, Beretta-Piccoli BT, Gadina M, Montagna C, DaSilva Goncalves M, Sallusto F, Galluzzi L, Soni RK, Stern LJ, Santambrogio L
Science Immunology 2022
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
Mikkelsen RB, Arora T, Trošt K, Dmytriyeva O, Jensen SK, Meijnikman AS, Olofsson LE, Lappa D, Aydin Ö, Nielsen J, Gerdes V, Moritz T, van de Laar A, de Brauw M, Nieuwdorp M, Hjorth SA, Schwartz TW, Bäckhed F
iScience 2022
Metabolic syndrome and aberrant immune responses to viral infection and vaccination: Insights from small animal models
Geerling E, Hameed M, Weger-Lucarelli J, Pinto AK
Frontiers in immunology 2022
Creeping fat formation and interaction with intestinal disease in Crohn's disease
Yin Y, Xie Y, Ge W, Li Y
United European gastroenterology journal 2022
Time-restricted feeding reduces monocyte production by controlling hematopoietic stem and progenitor cells in the bone marrow during obesity
Kim Y, Lee Y, Lee MN, Nah J, Yun N, Wu D, Pae M
Frontiers in immunology 2022
Supplementing Diets with Agriophyllum squarrosum Reduced Blood Lipids, Enhanced Immunity and Anti-Inflammatory Capacities, and Mediated Lipid Metabolism in Tan Lambs.
Jiao D, Liang Y, Zhou S, Wu X, Degen AA, Hickford J, Zhou H, Cong H, Shi X, Ma X, Yang G
2022
Mannose Receptor Deficiency Impacts Bone Marrow and Circulating Immune Cells during High Fat Diet Induced Obesity.
Nour J, Moregola A, Svecla M, Da Dalt L, Bellini R, Neyrolles O, Fadini GP, Rombouts Y, Albiero M, Bonacina F, Norata GD
Metabolites 2022
Macrophage-Conditioned Media Promotes Adipocyte Cancer Association, Which in Turn Stimulates Breast Cancer Proliferation and Migration
Vallega KA, Bosco DB, Ren Y, Sang QX
Biomolecules 2022
Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity
Kochumon S, Arefanian H, Sindhu S, Thomas R, Jacob T, Al-Sayyar A, Shenouda S, Al-Rashed F, Koistinen HA, Al-Mulla F, Tuomilehto J, Ahmad R
Cells 2022
Obesity as a Risk Factor for Breast Cancer-The Role of miRNA.
Hanusek K, Karczmarski J, Litwiniuk A, Urbańska K, Ambrozkiewicz F, Kwiatkowski A, Martyńska L, Domańska A, Bik W, Paziewska A
International journal of molecular sciences 2022
Metabolic impact of adipose tissue macrophages in the early postnatal life
Röszer T
Journal of leukocyte biology 2022
Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes
Zhang X, Gao Y, Liu Z, Li W, Kang Y, Li X, Xu Z, Peng C, Qi Y
International journal of molecular sciences 2022
Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status
Dance YW, Obenreder MC, Seibel AJ, Meshulam T, Ogony JW, Lahiri N, Pacheco-Spann L, Radisky DC, Layne MD, Farmer SR, Nelson CM, Tien J
Cellular and Molecular Bioengineering 2022
Development of a lactic acid bacteria strain that suppresses chronic inflammation and improves glucose and lipid metabolism
TOSHIMITSU T
Bioscience of Microbiota, Food and Health 2022
Dysregulated systemic metabolism in a Down syndrome mouse model
Sarver DC, Xu C, Velez LM, Aja S, Jaffe AE, Seldin MM, Reeves RH, Wong GW
Molecular Metabolism 2022
The NLRP3 inflammasome activation in subcutaneous, epicardial and pericardial adipose tissue in patients with coronary heart disease undergoing coronary by-pass surgery.
Åkra S, Seljeflot I, Braathen B, Bratseth V, Hansen CH, Arnesen H, Tønnessen T, Solheim S
2022
TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling
Lee HH, Jeong GW, Ye BJ, Yoo EJ, Son KS, Kim DK, Park HK, Kang BH, Lee-Kwon W, Kwon HM, Choi SY
Diabetes 2022
Beneficial effects of intermittent fasting: a narrative review
Song DK, Kim YW
2022
Obesity aggravates contact hypersensitivity reaction in mice
Majewska-Szczepanik M, Kowalczyk P, Marcińska K, Strzępa A, Lis GJ, Susan Wong F, Szczepanik M, Wen L
Contact Dermatitis 2022
Obesity and Coronavirus Disease 2019
Fei S, Feng X, Luo J, Guo L, Pan Q
Journal of Translational Internal Medicine 2022
Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation
Nie Q, Li C, Wang Y, Hu Y, Pu W, Zhang Q, Cai J, Lin Y, Li G, Wang C, Li L, Dou Y, Zhang J
Acta pharmaceutica Sinica. B 2022
Extracellular RNAs from immune cells under obesity—a narrative review
Karlinsey K, Matz A, Qu L, Zhou B
2022
DNA damage response signaling: A common link between cancer and cardiovascular diseases.
Nikfarjam S, Singh KK
Cancer Medicine 2022
Revisiting the role of IL-1 signaling in the development of apical periodontitis
Tazawa K, Azuma Presse MM, Furusho H, Stashenko P, Sasaki H
2022
In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications
Huang K, Zapata D, Tang Y, Teng Y, Li Y
Biomaterials 2022
Functional Hallmarks of healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance
Sheu K, Hoffmann A
Annual Review of Immunology 2022
Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome.
Slate-Romano JJ, Yano N, Zhao TC
Molecular and Cellular Endocrinology 2022
Metabolic strategy of macrophages under homeostasis or immune stress in Drosophila
Luo W, Liu S, Zhang F, Zhao L, Su Y
2022
Dynamics of adipose tissue macrophage populations after gastric bypass surgery
Palomäki VA, Lehenkari P, Meriläinen S, Karttunen TJ, Koivukangas V
Obesity (Silver Spring, Md.) 2022
One Week of Overeating Upregulates Angiogenic and Lipolytic Gene Expression in Human Subcutaneous Adipose Tissue from Exercise Trained and Untrained Adults
Ludzki AC, Krueger EM, Gillen JB, Taylor NM, Middlebrook DO, Baldwin TC, Karabetsos KC, Schleh MW, Horowitz JF
2022
Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity
Aaron N, Zahr T, He Y, Yu L, Mayfield B, Pajvani UB, Qiang L
2022
The Influence of Sex, Body Mass Index, and Age on Cellular and Humoral Immune Responses Against Measles After a Third Dose of Measles-Mumps-Rubella Vaccine
Quach HQ, Chen J, Monroe JM, Ratishvili T, Warner ND, Grill DE, Haralambieva IH, Ovsyannikova IG, Poland GA, Kennedy RB
The Journal of Infectious Diseases 2022
Cross-sectional study protocol to assess the environmental exposure of endocrine-disruptive chemicals: bisphenol A and heavy metals in children
Malik VS, Khaiwal R
Pediatric endocrinology, diabetes, and metabolism 2022
Inflammatory potential of diet and risk of mortality in normal-weight adults with central obesity
Choi MK, Mark Park YM, Shivappa N, Hong OK, Han K, Steck SE, Hébert JR, Merchant AT, Sandler DP, Lee SS
Clinical nutrition (Edinburgh, Scotland) 2022
Methanolic fruit extract of Myrica nagi protects the hypothalamus and attenuates inflammation associated with gold thioglucose- and high-fat diet-induced obesity via various adipokines
Prashar Y, Patel NJ
Journal of Ayurveda and integrative medicine 2022
Binge eating disorder, frequency of depression, and systemic inflammatory state in individuals with obesity – A cross sectional study
Caldas ND, Braulio VB, Brasil MA, Furtado VC, de Carvalho DP, Cotrik EM, Dantas JR, Zajdenverg L
Archives of Endocrinology and Metabolism 2022
The immunomodulatory functions of chromogranin A-derived peptide pancreastatin
Ioannidis M, Mahata SK, van den Bogaart G
Peptides 2022
Adipose tissue plasticity in health and disease
Sakers A, De Siqueira MK, Seale P, Villanueva CJ
Cell 2022
Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.
Chiang JJ, Lam PH, Chen E, Miller GE
Psychological bulletin 2022
Impact of Conjugated Linoleic Acid on Obesity and Its Association with Macrophage Recruitment: Experimental and Immunohistochemical Study.
Abdou AG, Bendary MA, Abdou SE, Amer GS
Journal of microscopy and ultrastructure 2022
The Yin-Yang functions of macrophages in metabolic disorders
Bai J, Liu F
Life Medicine 2022
A novel strategy to dissect multifaceted macrophage function in human diseases
Karlinsey K, Qu L, Matz AJ, Zhou B
Journal of leukocyte biology 2022

← Previous 1 2 3 … 11 12 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts