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Cheryl L. Day, … , Paul Klenerman, Kai W. Wucherpfennig
Published September 15, 2003
Citation Information: J Clin Invest. 2003;112(6):831-842. https://doi.org/10.1172/JCI18509.
Citation Information: J Clin Invest. 2003;112(6):831-842. https://doi.org/10.1172/JCI18509.
Abstract
Containment of hepatitis C virus (HCV) and other chronic human viral infections is associated with persistence of virus-specific CD4 T cells, but ex vivo characterization of circulating CD4 T cells has not been achieved. To further define the phenotype and function of these cells, we developed a novel approach for the generation of tetrameric forms of MHC class II/peptide complexes that is based on the cellular peptide-exchange mechanism. HLA-DR molecules were expressed as precursors with a covalently linked CLIP peptide, which could be efficiently exchanged with viral peptides following linker cleavage. In subjects who spontaneously resolved HCV viremia, but not in those with chronic progressive infection, HCV tetramer–labeled cells could be isolated by magnetic bead capture despite very low frequencies (1:1,200 to 1:111,000) among circulating CD4 T cells. These T cells expressed a set of surface receptors (CCR7+CD45RA–CD27+) indicative of a surveillance function for secondary lymphoid structures and had undergone significant in vivo selection since they utilized a restricted Vβ repertoire. These studies demonstrate a relationship between clinical outcome and the presence of circulating CD4 T cells directed against this virus. Moreover, they show that rare populations of memory CD4 T cells can be studied ex vivo in human diseases.
Authors
Cheryl L. Day, Nilufer P. Seth, Michaela Lucas, Heiner Appel, Laurent Gauthier, Georg M. Lauer, Gregory K. Robbins, Zbigniew M. Szczepiorkowski, Deborah R. Casson, Raymond T. Chung, Shannon Bell, Gillian Harcourt, Bruce D. Walker, Paul Klenerman, Kai W. Wucherpfennig
Total citations by year
Citation information
Citations to this article (143)
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Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium
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PLoS pathogens | 2016 |
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Tetramers reveal IL-17–secreting CD4 + T cells that are specific for U1-70 in lupus and mixed connective tissue disease
NH Kattah, EW Newell, JA Jarrell, AD Chu, J Xie, MG Kattah, O Goldberger, J Ye, EF Chakravarty, MM Davis, PJ Utz |
Proceedings of the National Academy of Sciences | 2015 |
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T cell responses in hepatitis C virus infection: Historical overview and goals for future research
L Holz, B Rehermann |
Antiviral Research | 2015 |
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Homo-β-amino acid containing MBP(85–99) analogs alleviate experimental autoimmune encephalomyelitis
R Kant, S Pasi, A Surolia |
Scientific Reports | 2015 |
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Broadening the repertoire of melanoma-associated T-cell epitopes
TM Frøsig, R Lyngaa, Ö Met, SK Larsen, M Donia, IM Svane, P Straten, SR Hadrup |
Cancer Immunology, Immunotherapy | 2015 |
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Methodologies for the Analysis of HCV-Specific CD4+ T Cells
MU Lokhande, R Thimme, P Klenerman, N Semmo |
Frontiers in immunology | 2015 |
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Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis
LM Roesner, A Heratizadeh, G Begemann, P Kienlin, S Hradetzky, M Niebuhr, B Eiz-Vesper, C Hennig, G Hansen, V Baron-Bodo, P Moingeon, T Werfel |
Journal of Investigative Dermatology | 2015 |
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Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation
N Bhattarai, JH McLinden, J Xiang, TM Kaufman, JT Stapleton, TL Tellinghuisen |
PLoS pathogens | 2015 |
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Automatic Generation of Validated Specific Epitope Sets
SC Pro, J Sidney, S Paul, CL Arlehamn, D Weiskopf, B Peters, A Sette |
Journal of Immunology Research | 2015 |
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Major Histocompatibility Complex Class II Dextramers: New Tools for the Detection of antigen-Specific, CD4 T Cells in Basic and Clinical Research
C Massilamany, B Krishnan, J Reddy |
Scandinavian Journal of Immunology | 2015 |
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Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers
CJ Holland, G Dolton, M Scurr, K Ladell, AJ Schauenburg, K Miners, F Madura, AK Sewell, DA Price, DK Cole, AJ Godkin |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells
EW Newell, MM Davis |
Nature Biotechnology | 2014 |
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Protective Immunity Against Hepatitis C: Many Shades of Gray
MS Abdel-Hakeem, NH Shoukry |
Frontiers in immunology | 2014 |
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Identification and retrospective validation of T-cell epitopes in the hepatitis C virus genotype 4 proteome: An accelerated approach toward epitope-driven vaccine development
KM Abdel-Hady, AH Gutierrez, F Terry, J Desrosiers, AS de Groot, HM Azzazy |
Human Vaccines & Immunotherapeutics | 2014 |
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Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules
B Raziorrouh, M Heeg, P Kurktschiev, W Schraut, R Zachoval, C Wendtner, M Wächtler, M Spannagl, G Denk, A Ulsenheimer, B Bengsch, H Pircher, HM Diepolder, NH Grüner, MC Jung |
PloS one | 2014 |
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Immune control and failure in HCV infection--tipping the balance
LB Dustin, SB Cashman, SM Laidlaw |
Journal of leukocyte biology | 2014 |
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MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response
HM Long, OL Chagoury, AM Leese, GB Ryan, E James, LT Morton, RJ Abbott, S Sabbah, W Kwok, AB Rickinson |
Journal of Experimental Medicine | 2013 |
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Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
EW Newell, N Sigal, N Nair, BA Kidd, HB Greenberg, MM Davis |
Nature Biotechnology | 2013 |
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Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease
MT Falta, C Pinilla, DG Mack, AN Tinega, F Crawford, M Giulianotti, R Santos, GM Clayton, Y Wang, X Zhang, LA Maier, P Marrack, JW Kappler, AP Fontenot |
Journal of Experimental Medicine | 2013 |
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T-cell responses in hepatitis B and C virus infection: similarities and differences
J Schmidt, HE Blum, R Thimme |
Emerging Microbes & Infections | 2013 |
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Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections
CT Ng, LM Snell, DG Brooks, MB Oldstone |
Cell Host & Microbe | 2013 |
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Analysis, Isolation, and Activation of Antigen-Specific CD4(+) and CD8(+) T Cells by Soluble MHC-Peptide Complexes
J Schmidt, D Dojcinovic, P Guillaume, I Luescher |
Frontiers in immunology | 2013 |
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CD27 expression discriminates porcine T helper cells with functionally distinct properties
K Reutner, J Leitner, A Müllebner, A Ladinig, SE Essler, JC Duvigneau, M Ritzmann, P Steinberger, A Saalmüller, W Gerner |
Veterinary Research | 2013 |
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Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults
LF Su, BA Kidd, A Han, JJ Kotzin, MM Davis |
Immunity | 2013 |
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MHC Class II Tetramers Made from Isolated Recombinant α and β Chains Refolded with Affinity-Tagged Peptides
P Braendstrup, S Justesen, T Østerbye, LL Nielsen, R Mallone, L Vindeløv, A Stryhn, S Buus, F Dieli |
PloS one | 2013 |
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Human CD4+ T cell response to human herpesvirus 6
MD Nastke, A Becerra, L Yin, O Dominguez-Amorocho, L Gibson, LJ Stern, JM Calvo-Calle |
Journal of virology | 2012 |
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Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes
EW Newell, N Sigal, SC Bendall, GP Nolan, MM Davis |
Immunity | 2012 |
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Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence
JS Wiesch, D Ciuffreda, L Lewis-Ximenez, V Kasprowicz, BE Nolan, H Streeck, J Aneja, LL Reyor, TM Allen, AW Lohse, B McGovern, RT Chung, WW Kwok, AY Kim, GM Lauer |
Journal of Experimental Medicine | 2012 |
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Self-reactive human CD4 T cell clones form unusual immunological synapses
DA Schubert, S Gordo, JJ Sabatino, S Vardhana, E Gagnon, DK Sethi, NP Seth, K Choudhuri, H Reijonen, GT Nepom, BD Evavold, ML Dustin, KW Wucherpfennig |
Journal of Experimental Medicine | 2012 |
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Insights into T Cell Recognition of Antigen: Significance of Two-Dimensional Kinetic Parameters
LJ Edwards, VI Zarnitsyna, JD Hood, BD Evavold, C Zhu |
Frontiers in immunology | 2012 |
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Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain
E Gagnon, DA Schubert, S Gordo, HH Chu, KW Wucherpfennig |
Journal of Experimental Medicine | 2012 |
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Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers:
M Angin, M King, M Altfeld, BD Walker, KW Wucherpfennig, MM Addo |
AIDS | 2012 |
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MHC Class II Tetramers
GT Nepom |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
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The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude
MK Jenkins, JJ Moon |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
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Frequency of Epitope-Specific Naive CD4 + T Cells Correlates with Immunodominance in the Human Memory Repertoire
WW Kwok, V Tan, L Gillette, CT Littell, MA Soltis, RB LaFond, J Yang, EA James, JH DeLong |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
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Ara h 1-Reactive T Cells in Peanut Allergic Individuals
JH DeLong, KH Simpson, E Wambre, EA James, D Robinson, WW Kwok |
Journal of Allergy and Clinical Immunology | 2011 |
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A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC
DK Sethi, DA Schubert, AK Anders, A Heroux, DA Bonsor, CP Thomas, EJ Sundberg, J Pyrdol, KW Wucherpfennig |
Journal of Experimental Medicine | 2011 |
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Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis
MM Davis, JD Altman, EW Newell |
Nature Reviews Immunology | 2011 |
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CD4+ T Cell Effects on CD8+ T Cell Location Defined Using Bioluminescence
M Azadniv, WJ Bowers, DJ Topham, IN Crispe, D Unutmaz |
PloS one | 2011 |
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Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection
MF Kotturi, JA Swann, B Peters, CL Arlehamn, J Sidney, RV Kolla, EA James, RS Akondy, R Ahmed, WW Kwok, MJ Buchmeier, A Sette |
Journal of virology | 2011 |
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Mechanisms of Tolerance to Parental Parathyroid Tissue when Combined with Human Allogeneic Thymus Transplantation
IK Chinn, JA Olson, MA Skinner, EA McCarthy, SE Gupton, DF Chen, FA Bonilla, RL Roberts, MG Kanariou, BH Devlin, ML Markert |
Journal of Allergy and Clinical Immunology | 2010 |
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Adaptive immunity to the hepatitis C virus
Christopher M Walker |
Advances in virus research | 2010 |
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Progress in Molecular Biology and Translational Science
PJ Ebert, QJ Li, JB Huppa, MM Davis |
Progress in molecular biology and translational science | 2010 |
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IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
DG Brooks, KB Walsh, H Elsaesser, MB Oldstone |
Proceedings of the National Academy of Sciences | 2010 |
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Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection
VM Fleming, G Harcourt, E Barnes, P Klenerman |
Journal of General Virology | 2010 |
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HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide
AK Anders, MJ Call, MS Schulze, KD Fowler, DA Schubert, NP Seth, EJ Sundberg, KW Wucherpfennig |
Nature Immunology | 2010 |
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A new insight into hepatitis C vaccine development
CI Yu, BL Chiang |
Journal of biomedicine & biotechnology | 2010 |
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Direct ex vivo analysis of allergen-specific CD4+ T cells
WW Kwok, M Roti, JH DeLong, V Tan, E Wambre, EA James, D Robinson |
Journal of Allergy and Clinical Immunology | 2010 |
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Immune Dysregulation by the Rheumatoid Arthritis Shared Epitope
DE Almeida, S Ling, X Pi, AM Hartmann-Scruggs, P Pumpens, J Holoshitz |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
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Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
MJ Fuller, NH Shoukry, T Gushima, DG Bowen, B Callendret, KJ Campbell, DL Hasselschwert, AL Hughes, CM Walker |
Hepatology | 2009 |
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Simultaneous detection of many T-cell specificities using combinatorial tetramer staining
EW Newell, LO Klein, W Yu, MM Davis |
Nature Methods | 2009 |
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Tracking epitope-specific T cells
JJ Moon, HH Chu, J Hataye, AJ Pagán, M Pepper, JB McLachlan, T Zell, MK Jenkins |
Nature Protocols | 2009 |
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CD4 memory T cells: What are they and what can they do?
MK MacLeod, ET Clambey, JW Kappler, P Marrack |
Seminars in Immunology | 2009 |
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Rare Birds in North America: Acute Hepatitis C Cohorts
AL Cox, K Page, J Bruneau, NH Shoukry, GM Lauer, AY Kim, HR Rosen, H Radziewicz, A Grakoui, DS Fierer, AD Branch, DE Kaplan, KM Chang |
Gastroenterology | 2009 |
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In Vivo Enhancement of Peptide Display by MHC Class II Molecules with Small Molecule Catalysts of Peptide Exchange
MJ Call, X Xing, GD Cuny, NP Seth, DM Altmann, L Fugger, M Krogsgaard, RL Stein, KW Wucherpfennig |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
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Defining the directionality and quality of CD8+ T cell heterologous immunity in hepatitis C virus infection
Scott M. Ward, Victoria Kasprowicz, Alison Turner, Alexandros Grammatikos, Brian Nolan, Charles Sharp, Jenny Woodruff, Vicki Fleming, Stuart Sims, Bruce D Walker, Andrew Sewell, Georg M. Lauer, Paul Klenerman |
Journal of Clinical Investigation | 2008 |
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Identification of CD4 T-Cell Epitopes in Soluble Liver Antigen/Liver Pancreas Autoantigen in Autoimmune Hepatitis
H Mix, C Weiler-Normann, R Thimme, G Ahlenstiel, EC Shin, J Herkel, CS David, AW Lohse, B Rehermann |
Gastroenterology | 2008 |
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Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR
BA Cobb, DL Kasper |
Glycobiology | 2008 |
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Class II major histocompatibility complex tetramer staining: progress, problems, and prospects
SS Vollers, LJ Stern |
Immunology | 2008 |
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Human immunodeficiency virus (HIV)-specific T helper responses fail to predict CD4+ T cell decline following short-course treatment at primary HIV-1 infection: T h responses do not predict clinical outcome
J Fox, TJ Scriba, N Robinson, JN Weber, RE Phillips, S Fidler |
Clinical & Experimental Immunology | 2008 |
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Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors: Varicella gE-specific CD4+ T cell responses
GN Malavige, L Jones, AP Black, GS Ogg |
Clinical & Experimental Immunology | 2008 |
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Identification and In Vitro Expansion of Functional Antigen-Specific CD25 + FoxP3 + Regulatory T Cells in Hepatitis C Virus Infection
H Ebinuma, N Nakamoto, Y Li, DA Price, E Gostick, BL Levine, J Tobias, WW Kwok, KM Chang |
Journal of virology | 2008 |
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Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection
DG Bowen, NH Shoukry, A Grakoui, MJ Fuller, AG Cawthon, C Dong, DL Hasselschwert, KM Brasky, GJ Freeman, NP Seth, KW Wucherpfennig, M Houghton, CM Walker |
Journal of virology | 2008 |
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High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 + and CD4 + T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
V Kasprowicz, JS zur Wiesch, T Kuntzen, BE Nolan, S Longworth, A Berical, J Blum, C McMahon, LL Reyor, N Elias, WW Kwok, BG McGovern, G Freeman, RT Chung, P Klenerman, L Lewis-Ximenez, BD Walker, TM Allen, AY Kim, GM Lauer |
Journal of virology | 2008 |
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The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine-mediated anti-oxidative pathway
S Ling, Z Li, O Borschukova, L Xiao, P Pumpens, J Holoshitz |
Arthritis Research & Therapy | 2007 |
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Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
M Ráki, LE Fallang, M Brottveit, E Bergseng, H Quarsten, KE Lundin, LM Sollid |
Proceedings of the National Academy of Sciences | 2007 |
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Antigen-Specific CD4 + T Cells Recognize Epitopes of Protective Antigen following Vaccination with an Anthrax Vaccine
EM Laughlin, JD Miller, E James, D Fillos, CC Ibegbu, RS Mittler, R Akondy, W Kwok, R Ahmed, G Nepom |
Infection and immunity | 2007 |
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Identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine
T Mashiba, K Udaka, Y Hirachi, Y Hiasa, T Miyakawa, Y Satta, T Osoda, S Kataoka, M Kohara, M Onji |
Immunogenetics | 2007 |
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Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1
B Moza, AK Varma, RA Buonpane, P Zhu, CA Herfst, MJ Nicholson, AK Wilbuer, NP Seth, KW Wucherpfennig, JK McCormick, DM Kranz, EJ Sundberg |
The EMBO Journal | 2007 |
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Ex Vivo Analysis of Human T Lymphotropic Virus Type 1–Specific CD4 + Cells by Use of a Major Histocompatibility Complex Class II Tetramer Composed of a Neurological Disease–Susceptibility Allele and Its Immunodominant Peptide
H Nose, R Kubota, NP Seth, PK Goon, Y Tanaka, S Izumo, K Usuku, Y Ohara, KW Wucherpfennig, CR Bangham, M Osame, M Saito |
The Journal of Infectious Diseases | 2007 |
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Empty Class II Major Histocompatibility Complex Created by Peptide Photolysis Establishes the Role of DM in Peptide Association*S
GM Grotenbreg, MJ Nicholson, KD Fowler, K Wilbuer, L Octavio, M Yang, AK Chakraborty, HL Ploegh, KW Wucherpfennig |
The Journal of biological chemistry | 2007 |
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Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection
M Lucas, A Ulsenheimer, K Pfafferot, MH Heeg, S Gaudieri, N Grüner, A Rauch, JT Gerlach, MC Jung, R Zachoval, GR Pape, W Schraut, T Santantonio, H Nitschko, M Obermeier, R Phillips, TJ Scriba, N Semmo, C Day, JN Weber, S Fidler, R Thimme, A Haberstroh, TF Baumert, P Klenerman, HM Diepolder, S Bowyer |
PloS one | 2007 |
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Ex Vivo Monitoring of Antigen-Specific CD4 + T Cells after Recall Immunization with Tetanus Toxoid
C Barbey, E Pradervand, N Barbier, F Spertini |
Clinical and vaccine immunology : CVI | 2007 |
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CD4+ T cell responses in hepatitis C virus infection
Semmo N, Klenerman P |
World journal of gastroenterology : WJG | 2007 |
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Host and viral factors contributing to CD8+ T cell failure in hepatitis C virus infection
Neumann-Haefelin C, Spangenberg HC, Blum HE, Thimme R |
World journal of gastroenterology : WJG | 2007 |
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Acquisition of direct antiviral effector functions by CMV-specific CD4 + T lymphocytes with cellular maturation
JP Casazza, MR Betts, DA Price, ML Precopio, LE Ruff, JM Brenchley, BJ Hill, M Roederer, DC Douek, RA Koup |
Journal of Experimental Medicine | 2006 |
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The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
SA Islam, SY Thomas, C Hess, BD Medoff, TK Means, C Brander, CM Lilly, AM Tager, AD Luster |
Blood | 2006 |
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Cellular immune responses against persistent hepatitis C virus: gone but not forgotten
P Klenerman, N Semmo |
Gut | 2006 |
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Cellular immune responses associated with occult hepatitis C virus infection of the liver
JA Quiroga, S Llorente, I Castillo, E Rodríguez-Iñigo, M Pardo, V Carreño |
Journal of virology | 2006 |
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Identification of key peptide-specific CD4+ T cell responses to human cytomegalovirus: implications for tracking antiviral populations
GC Harcourt, TJ Scriba, N Semmo, S Bounds, E Taylor, P Klenerman |
Clinical & Experimental Immunology | 2006 |
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Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses
A Ulsenheimer, M Lucas, NP Seth, JT Gerlach, NH Gruener, A Loughry, GR Pape, KW Wucherpfennig, HM Diepolder, P Klenerman |
Journal of Viral Hepatitis | 2006 |
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Preferential Infection Shortens the Life Span of Human ImmunodeficiencyVirus-Specific CD4+ T Cells In Vivo
JM Brenchley, LE Ruff, JP Casazza, RA Koup, DA Price, DC Douek |
Journal of virology | 2006 |
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Tracking of Peptide-Specific CD4 + T-Cell Responses after an Acute Resolving Viral Infection: a Study of Parvovirus B19
V Kasprowicz, A Isa, T Tolfvenstam, K Jeffery, P Bowness, P Klenerman |
Journal of virology | 2006 |
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Small Molecules That Enhance the Catalytic Efficiency of HLA-DM
Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
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HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound
Thomas J. Scriba, Hua-Tang Zhang, Helen L. Brown, Annette Oxenius, Norbert Tamm, Sarah Fidler, Julie Fox, Jonathan N. Weber, Paul Klenerman, Cheryl L. Day, Michaela Lucas, and Rodney E. Phillips |
Journal of Clinical Investigation | 2005 |
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Prolonged activation of virus-specific CD8+T cells after acute B19 infection
A Isa, V Kasprowicz, O Norbeck, A Loughry, K Jeffery, K Broliden, P Klenerman, T Tolfvenstam, P Bowness |
PLoS Medicine | 2005 |
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Expansion and Contraction of HIV-Specific CD4 T Cells with Short Bursts of Viremia, but Physical Loss of the Majority of These Cells with Sustained Viral Replication
Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
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Virus Specific T-Cell Responses
Appay V |
2005 | |
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Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes.
Mallone R, Nepom GT |
American Journal of Therapeutics | 2005 |
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Autoreactive T cell responses show pro-inflammatory polarization in diabetes but a regulatory phenotype in health
Sefina Arif, Timothy I Tree, Thomas P Astill, Jennifer M Tremble, Colin M Dayan, Bart O Roep, Mark Peakman |
Journal of Clinical Investigation | 2004 |
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Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis
H Appel, W Kuon, M Kuhne, P Wu, S Kuhlmann, S Kollnberger, A Thiel, P Bowness, J Sieper |
Arthritis Research & Therapy | 2004 |
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CD8 epitope escape and reversion in acute HCV infection
J Timm, GM Lauer, DG Kavanagh, I Sheridan, AY Kim, M Lucas, T Pillay, K Ouchi, LL Reyor, JS Wiesch, RT Gandhi, RT Chung, N Bhardwaj, P Klenerman, BD Walker, TM Allen |
Journal of Experimental Medicine | 2004 |
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Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cells
M Lucas, CL Day, JR Wyer, SL Cunliffe, A Loughry, AJ McMichael, P Klenerman |
Journal of virology | 2004 |
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The physiological role of cytotoxic CD4(+) T-cells: the holy grail?
V Appay |
Clinical & Experimental Immunology | 2004 |
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Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load
A Harari, F Vallelian, G Pantaleo |
European Journal of Immunology | 2004 |
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Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation
WN Haining, JW Evans, NP Seth, GD Callaway, KW Wucherpfennig, LM Nadler, EC Guinan |
British Journal of Haematology | 2004 |
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Progress in Defining CD4 Helper Cell Responses in Chronic Viral Infections: Figure 1
CL Day, BD Walker |
Journal of Experimental Medicine | 2003 |
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