Calcineurin inhibitor blocks tolerance by suppressing donor T cell terminal exhaustion after allogeneic hematopoietic cell transplantation
Hajime Senjo, … , Daigo Hashimoto, Takanori Teshima
Hajime Senjo, … , Daigo Hashimoto, Takanori Teshima
Published October 15, 2024
Citation Information: J Clin Invest. 2024;134(20):e184332. https://doi.org/10.1172/JCI184332.
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Figure 1

Donor T cell profile on day 14.

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Donor T cell profile on day 14. CSP (25 mg/kg) was administered on days ...
CSP (25 mg/kg) was administered on days 0–13 after allo-HCT. (A, B, E, and F) scRNA-seq. (C and D) CD62L on 2C-Tg donor T cells (n = 5/group). Box-and-whisker plot shows the median (vehicle vs. CSP: 2.510 vs. 0.990; line in box), IQR (0.57–3.12 vs. 0.86–2.39; box bounds), and minimum/maximum values (0.43/3.47 vs. 0.61/3.41; whiskers). P > 0.99 by 2-tailed Mann-Whitney U test (D).