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ResearchIn-Press PreviewCell biologyOncology
Open Access | 
10.1172/JCI183531
Kinesin-like protein KIFC2 stabilizes CDK4 to accelerate growth and confer resistance in HR+/HER2- breast cancer
Shao-Ying Yang,1 Ming-Liang Jin,2 Lisa Andriani,2 Qian Zhao,1 Yun-Xiao Ling,1 Cai-Jin Lin,2 Min-Ying Huang,3 Jia-Yang Cai,2 Yin-Ling Zhang,1 Xin Hu,4 Zhi-Ming Shao,1 Fang-Lin Zhang,1 Xi Jin,2 A Yong Cao,2 and Da-Qiang Li1
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Yang, S. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Jin, M. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Andriani, L. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Zhao, Q. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Lin, C. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Hu, X. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Shao, Z. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Zhang, F. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Jin, X. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
Find articles by Cao, A. in: JCI | PubMed | Google Scholar
1Cancer Institute, Fudan University, Shanghai, China
2Department of Breast Surgery, Fudan University, Shanghai, China
3Institutes of Biomedical Sciences, Fudan University, Shanghai, China
4Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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Published April 29, 2025 - More info
Copyright © 2025, Yang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)