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Citations to this article

Clonal hematopoiesis and atherosclerosis
Ohad Oren, … , Aeron M. Small, Peter Libby
Ohad Oren, … , Aeron M. Small, Peter Libby
Published October 1, 2024
Citation Information: J Clin Invest. 2024;134(19):e180066. https://doi.org/10.1172/JCI180066.
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Review Series Article has an altmetric score of 14

Clonal hematopoiesis and atherosclerosis

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Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic mutations in certain known leukemia driver genes give rise to clones of mutant cells in peripheral blood. The increased risk of developing hematologic malignancy does not, on its own, explain excess mortality in individuals with CHIP. Cardiovascular disease accounts for much of this gap. Experimental evidence supports the causality of certain CHIP mutations in accelerated atherosclerosis. CHIP due to mutations in different driver genes varies in their promotion of atherosclerotic events and in the region of augmented atherosclerotic involvement. For example, CHIP due to mutations in DNMT3a appears less atherogenic than CHIP that arises from TET2 or JAK2, forms of CHIP that incite inflammation. The recognition of certain CHIP mutations as promoters of atherosclerotic risk has opened new insights into understanding of the pathophysiology of this disease. The accentuated cardiovascular risk and involvement of distinct pathways of various forms of CHIP also inform novel approaches to allocation of targeted therapies, affording a step toward personalized medicine.

Authors

Ohad Oren, Aeron M. Small, Peter Libby

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Total citations by year

Year: 2025 2024 Total
Citations: 6 3 9
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (9)

Title and authors Publication Year
Deciphering the Complexities of Adult Human Steady State and Stress-Induced Hematopoiesis: Progress and Challenges
Watt SM, Roubelakis MG
International Journal of Molecular Sciences 2025
Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research
Jiang H, Liao Y, Zhu M, Jiramonai L, Wu H, Zhong Y, Xie Z, Liang XJ
Research 2025
Autophagy and Its Association with Macrophages in Clonal Hematopoiesis Leading to Atherosclerosis
Li S, Zhou X, Duan Q, Niu S, Li P, Feng Y, Zhang Y, Xu X, Gong SP, Cao H
International Journal of Molecular Sciences 2025
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID).
Kallai A, Ungvari A, Csaban D, Orfi Z, Lehoczki A, Harasztdombi J, Yabluchanskiy A, Benyó Z, Szappanos Á, Tarantini S, Sorond F, Sótonyi P, Andrikovics H, Ungvari Z
GeroScience 2025
Global trends and research status in clonal hematopoiesis: a bibliometric analysis of the last 10 years.
Luo Q, Yu L
Discover oncology 2025
Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment
Arnold N, Koenig W
European Journal of Clinical Investigation 2025
The emergence of clonal hematopoiesis as a disease determinant
Kenneth Walsh
Journal of Clinical Investigation 2024
JAK2-V617F mutation among blood donors: A meta-analysis
Alsharif MH, Mansory EM, Alharazi AA, Badawi MA
Saudi Medical Journal 2024
PCSK9 Inhibitors: Focus on Evolocumab and Its Impact on Atherosclerosis Progression
Abduljabbar MH
Pharmaceuticals 2024

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Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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