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Citations to this article

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
Nives Zimmermann, … , Qutayba Hamid, Marc E. Rothenberg
Nives Zimmermann, … , Qutayba Hamid, Marc E. Rothenberg
Published June 15, 2003
Citation Information: J Clin Invest. 2003;111(12):1863-1874. https://doi.org/10.1172/JCI17912.
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Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

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Abstract

Asthma is on the rise despite intense, ongoing research underscoring the need for new scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an approach involving expression profiling of lung tissue from mice with experimental asthma. Employing asthma models induced by different allergens and protocols, we identified 6.5% of the tested genome whose expression was altered in an asthmatic lung. Notably, two phenotypically similar models of experimental asthma were shown to have distinct transcript profiles. Genes related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes. In situ hybridization demonstrated marked staining of arginase I, predominantly in submucosal inflammatory lesions. Arginase activity was increased in allergen-challenged lungs, as demonstrated by increased enzyme activity, and increased levels of putrescine, a downstream product. Lung arginase activity and mRNA expression were strongly induced by IL-4 and IL-13, and were differentially dependent on signal transducer and activator of transcription 6. Analysis of patients with asthma supported the importance of this pathway in human disease. Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders.

Authors

Nives Zimmermann, Nina E. King, Johanne Laporte, Ming Yang, Anil Mishra, Sam M. Pope, Emily E. Muntel, David P. Witte, Anthony A. Pegg, Paul S. Foster, Qutayba Hamid, Marc E. Rothenberg

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Total
Citations: 3 5 4 2 1 3 4 4 6 5 14 11 8 23 11 18 21 15 9 8 7 6 188
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2024 (3)

Title and authors Publication Year
An integrated metabo-lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD.
Correnti S, Preianò M, Gamboni F, Stephenson D, Pelaia C, Pelaia G, Savino R, D'Alessandro A, Terracciano R
Journal of Translational Medicine 2024
Pathophysiology of Arginases in Cancer and Efforts in Their Pharmacological Inhibition
Marzęta-Assas P, Jacenik D, Zasłona Z
International Journal of Molecular Sciences 2024
Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies.
Tsai J, Malik S, Tjen-A-Looi SC
Life (Basel, Switzerland) 2024

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