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How the JCI’s most-cited paper sparked the field of lipoprotein research
Michael S. Brown, Joseph L. Goldstein
Michael S. Brown, Joseph L. Goldstein
Published February 15, 2024
Citation Information: J Clin Invest. 2024;134(4):e177475. https://doi.org/10.1172/JCI177475.
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100th Anniversary Viewpoints Article has an altmetric score of 9

How the JCI’s most-cited paper sparked the field of lipoprotein research

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Michael S. Brown, Joseph L. Goldstein

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Figure 1

The most-cited paper in the 100-year history of the JCI.

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The most-cited paper in the 100-year history of the JCI.
(A) A copy of t...
(A) A copy of the title page of the 1955 paper by Havel, Eder, and Bragdon, who described a method that used the ultracentrifuge to isolate plasma lipoproteins. (B) Annual citations from 1955 to 2023. The total number of citations is 8,913, according to data from the Web of Science. Google Scholar, whose citation counts are based on a larger set of publications, including non-peer-reviewed articles and book chapters, lists the total number of citations at 10,012). (C) The late Richard J. Havel, the lead author of the paper. The photograph is reproduced from Kane and Malloy (12). (D) Photographs of the luminal surface of aortas from a cholesterol-fed, wild-type mouse (top) and an Ldlr–/– mouse (bottom). The aortas were stained for lipid with Sudan IV. Mice from both genotypes were fed a diet containing 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% sodium cholate for 8 months and were sacrificed at 13 months. Photographs are reproduced from Ishibashi et al. (11).

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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