Sequence alignment of lipoprotein lipase (lpl), hepatic lipase (hl), and endothelial lipase (el) from human (h) and pufferfish Takifugu rubripes (f). Amino acids that are identical in all three genes in both species are shaded in grey. The serine, aspartic acid, and histidine resides of the catalytic triad, as well as the lipase motif (GXSXG) are boxed. The conserved cysteine residues are denoted with closed circles. The lid domain is indicated with a single line, and the conserved heparin-binding region (BBXB) is indicated with a double line.