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Citations to this article

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
Susan B. Gurley, … , Howard A. Rockman, Thomas M. Coffman
Susan B. Gurley, … , Howard A. Rockman, Thomas M. Coffman
Published August 1, 2006
Citation Information: J Clin Invest. 2006;116(8):2218-2225. https://doi.org/10.1172/JCI16980.
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Research Article Cardiology Article has an altmetric score of 10

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice

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Abstract

The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To clarify the physiological roles of ACE2, we generated mice with targeted disruption of the Ace2 gene. ACE2-deficient mice were viable, fertile, and lacked any gross structural abnormalities. We found normal cardiac dimensions and function in ACE2-deficient animals with mixed or inbred genetic backgrounds. On the C57BL/6 background, ACE2 deficiency was associated with a modest increase in blood pressure, whereas the absence of ACE2 had no effect on baseline blood pressures in 129/SvEv mice. After acute Ang II infusion, plasma concentrations of Ang II increased almost 3-fold higher in ACE2-deficient mice than in controls. In a model of Ang II–dependent hypertension, blood pressures were substantially higher in the ACE2-deficient mice than in WT. Severe hypertension in ACE2-deficient mice was associated with exaggerated accumulation of Ang II in the kidney, as determined by MALDI-TOF mass spectrometry. Although the absence of functional ACE2 causes enhanced susceptibility to Ang II–induced hypertension, we found no evidence for a role of ACE2 in the regulation of cardiac structure or function. Our data suggest that ACE2 is a functional component of the renin-angiotensin system, metabolizing Ang II and thereby contributing to regulation of blood pressure.

Authors

Susan B. Gurley, Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, Mary Donoghue, Roger E. Breitbart, Susan L. Acton, Howard A. Rockman, Thomas M. Coffman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 2 3 3 7 20 21 7 3 3 8 4 11 7 14 8 14 7 16 5 163
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Citations to this article in year 2020 (21)

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ACE2 mouse models: a toolbox for cardiovascular and pulmonary research
H Jia, X Yue, E Lazartigues
Nature Communications 2020
Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2
H Ji, AM de Souza, B Bajaj, W Zheng, X Wu, RC Speth, K Sandberg
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Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity
CA Tavares, MA Bailey, AC Girardi
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Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System
A Brojakowska, J Narula, R Shimony, J Bander
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The ACE2‐deficient mouse: A model for a cytokine storm‐driven inflammation
J Wang, N Kaplan, J Wysocki, W Yang, K Lu, H Peng, D Batlle, RM Lavker
The FASEB Journal 2020
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S Jakhmola, O Indari, D Kashyap, N Varshney, A Rani, C Sonkar, B Baral, S Chatterjee, A Das, R Kumar, HC Jha
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MA Sparks, AM South, AD Badley, CM Baker-Smith, D Batlle, B Bozkurt, R Cattaneo, SD Crowley, LJ DellItalia, AL Ford, K Griendling, SB Gurley, SE Kasner, JA Murray, KA Nath, MA Pfeffer, J Rangaswami, WR Taylor, VD Garovic
Hypertension 2020
ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives
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Implications of renal ACE2 expression in the age of COVID-19
HM Salah, JM Arthur, JL Mehta
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Laboratory Investigation 2020
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
R Amraei, N Rahimi
Cells 2020
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L Song, S Zhao, L Wang, K Yang, W Xiao, SP Clifford, J Huang, X Chen
Frontiers in Cardiovascular Medicine 2020
ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2
RK Sharma, BR Stevens, AG Obukhov, MB Grant, GY Oudit, Q Li, EM Richards, CJ Pepine, MK Raizada
Hypertension 2020
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N Banu, SS Panikar, LR Leal, AR Leal
Life Sciences 2020
Identifying pathophysiological bases of disease in COVID-19
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Translational Medicine Communications 2020
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S de Maat, Q de Mast, AH Danser, FL van de Veerdonk, C Maas
Seminars in thrombosis and hemostasis 2020
Covid‐19, ACE2 and the kidney
JH Hardenberg, FC Luft
Acta physiologica (Oxford, England) 2020
The Genetic Dissection of Ace2 Expression Variation in the Heart of Murine Genetic Reference Population
F Xu, J Gao, U Munkhsaikhan, N Li, Q Gu, JF Pierre, A Starlard-Davenport, JA Towbin, Y Cui, E Purevjav, L Lu
Frontiers in Cardiovascular Medicine 2020
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International journal of molecular sciences 2020

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