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Citations to this article

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
Susan B. Gurley, … , Howard A. Rockman, Thomas M. Coffman
Susan B. Gurley, … , Howard A. Rockman, Thomas M. Coffman
Published August 1, 2006
Citation Information: J Clin Invest. 2006;116(8):2218-2225. https://doi.org/10.1172/JCI16980.
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Research Article Cardiology Article has an altmetric score of 10

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice

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Abstract

The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To clarify the physiological roles of ACE2, we generated mice with targeted disruption of the Ace2 gene. ACE2-deficient mice were viable, fertile, and lacked any gross structural abnormalities. We found normal cardiac dimensions and function in ACE2-deficient animals with mixed or inbred genetic backgrounds. On the C57BL/6 background, ACE2 deficiency was associated with a modest increase in blood pressure, whereas the absence of ACE2 had no effect on baseline blood pressures in 129/SvEv mice. After acute Ang II infusion, plasma concentrations of Ang II increased almost 3-fold higher in ACE2-deficient mice than in controls. In a model of Ang II–dependent hypertension, blood pressures were substantially higher in the ACE2-deficient mice than in WT. Severe hypertension in ACE2-deficient mice was associated with exaggerated accumulation of Ang II in the kidney, as determined by MALDI-TOF mass spectrometry. Although the absence of functional ACE2 causes enhanced susceptibility to Ang II–induced hypertension, we found no evidence for a role of ACE2 in the regulation of cardiac structure or function. Our data suggest that ACE2 is a functional component of the renin-angiotensin system, metabolizing Ang II and thereby contributing to regulation of blood pressure.

Authors

Susan B. Gurley, Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, Mary Donoghue, Roger E. Breitbart, Susan L. Acton, Howard A. Rockman, Thomas M. Coffman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 1 3 3 7 20 21 7 3 3 8 4 11 7 14 8 14 7 16 5 162
Citation information
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Citations to this article in year 2009 (7)

Title and authors Publication Year
Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension
J Wysocki, M Ye, E Rodriguez, FR González-Pacheco, C Barrios, K Evora, M Schuster, H Loibner, KB Brosnihan, CM Ferrario, JM Penninger, D Batlle
Hypertension 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
The sweeter side of ACE2: Physiological evidence for a role in diabetes
SM Bindom, E Lazartigues
Molecular and Cellular Endocrinology 2009
Does ACE2 contribute to the development of hypertension?
MC Chappell
Hypertension research : official journal of the Japanese Society of Hypertension 2009
Not just angiotensinases: new roles for the angiotensin-converting enzymes
DW Lambert, NE Clarke, AJ Turner
Cellular and Molecular Life Sciences 2009
The role of ACE2 in pulmonary diseases--relevance for the nephrologist
GY Oudit, Y Imai, K Kuba, JW Scholey, JM Penninger
Nephrology Dialysis Transplantation 2009
Angiotensin-(1-7), Angiotensin-Converting Enzyme 2, and New Components of the Renin Angiotensin System
Trask AJ, Varagic J, Ahmad S, Ferrario CM
2009

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