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Citations to this article

Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
Gillian S. Ashcroft, … , Sharon M. Wahl, Toshinori Nakayama
Gillian S. Ashcroft, … , Sharon M. Wahl, Toshinori Nakayama
Published May 1, 2003
Citation Information: J Clin Invest. 2003;111(9):1309-1318. https://doi.org/10.1172/JCI16288.
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Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor

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Abstract

Characteristic of both chronic wounds and acute wounds that fail to heal are excessive leukocytosis and reduced matrix deposition. Estrogen is a major regulator of wound repair that can reverse age-related impaired wound healing in human and animal models, characterized by a dampened inflammatory response and increased matrix deposited at the wound site. Macrophage migration inhibitory factor (MIF) is a candidate proinflammatory cytokine involved in the hormonal regulation of inflammation. We demonstrate that MIF is upregulated in a distinct spatial and temporal pattern during wound healing and its expression is markedly elevated in wounds of estrogen-deficient mice as compared with intact animals. Wound-healing studies in mice rendered null for the MIF gene have demonstrated that in the absence of MIF, the excessive inflammation and delayed-healing phenotype associated with reduced estrogen is reversed. Moreover, in vitro assays have shown a striking estrogen-mediated decrease in MIF production by activated murine macrophages, a process involving the estrogen receptor. We suggest that estrogen inhibits the local inflammatory response by downregulating MIF, suggesting a specific target for future therapeutic intervention in impaired wound-healing states.

Authors

Gillian S. Ashcroft, Stuart J. Mills, KeJian Lei, Linda Gibbons, Moon-Jin Jeong, Marisu Taniguchi, Matthew Burow, Michael A. Horan, Sharon M. Wahl, Toshinori Nakayama

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 6 3 5 3 11 4 4 3 4 5 5 6 7 6 4 5 5 2 1 1 5 95
Citation information
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Citations to this article in year 2021 (11)

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Frontiers in immunology 2021
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JW Heo, SE Kim, MK Sung
International journal of molecular sciences 2021
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GH Bothamley
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Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses
AH Al-Rikabi, DJ Tobin, K Riches-Suman, MJ Thornton
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Collagen-Containing Fish Sidestream-Derived Protein Hydrolysates Support Skin Repair via Chemokine Induction
I Lapi, O Kolliniati, T Aspevik, EE Deiktakis, K Axarlis, MG Daskalaki, E Dermitzaki, M Tzardi, SC Kampranis, ZE Marsni, KC Kousoulaki, C Tsatsanis, M Venihaki
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H Bai, B Sha, X Xu, L Yu
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Sex and Tamoxifen confound murine experimental studies in cardiovascular tissue engineering
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Estrogen deficiency - a central paradigm in age-related impaired healing?
Mohamed El Mohtadi, Kathryn Whitehead, Nina Dempsey-Hibbert, Amina Belboul, Jason Ashworth
EXCLI J 2021
Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
RA Scappaticci, AA Berretta, EC Torres, AF Buszinski, GL Fernandes, TF dos Reis, FN de Souza-Neto, LF Gorup, ER de Camargo, DB Barbosa
Antibiotics 2021
Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review
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