Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice
Wouter J. de Jonge, … , Marinus C. Lamers, Wouter H. Lamers
Wouter J. de Jonge, … , Marinus C. Lamers, Wouter H. Lamers
Published November 15, 2002
Citation Information: J Clin Invest. 2002;110(10):1539-1548. https://doi.org/10.1172/JCI16143.
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Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice

Abstract

Research Article

Authors

Wouter J. de Jonge, Karin L. Kwikkers, Anje A. te Velde, Sander J.H. van Deventer, Martijn A. Nolte, Reina E. Mebius, Jan M. Ruijter, Marinus C. Lamers, Wouter H. Lamers

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Serum Ig levels in wild-type and F/A-2+/+ mice. Serum Ig levels in wild-...
Serum Ig levels in wild-type and F/A-2+/+ mice. Serum Ig levels in wild-type (squares) and F/A-2+/+ (diamonds) mice increase with a similar time course after weaning, but IgM levels remain depressed to 30% of that of control in F/A-2+/+ serum (P < 0.01). Furthermore, IgG1 levels do not increase after weaning in the F/A transgenics. For each measurement, serum of three mice was pooled. Values are mean ± SEM and are based on triplicates in two independent analyses.