Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
Hong Xiao, … , Ronald J. Falk, J. Charles Jennette
Hong Xiao, … , Ronald J. Falk, J. Charles Jennette
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):955-963. https://doi.org/10.1172/JCI15918.
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Article Immunology

Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice

Abstract

Research Article

Authors

Hong Xiao, Peter Heeringa, Peiqi Hu, Zhi Liu, Minglang Zhao, Yasuaki Aratani, Nobuyo Maeda, Ronald J. Falk, J. Charles Jennette

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Figure 1

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Anti-MPO antibody ELISA titers in Rag2–/– mice that received 1 × 108 ant...
Anti-MPO antibody ELISA titers in Rag2–/– mice that received 1 × 108 anti-MPO splenocytes (closed diamonds), 5 × 107 anti-MPO splenocytes (filled squares), 1 × 107 anti-MPO splenocytes (filled triangles), 1 × 108 anti-BSA splenocytes (open triangles), or 1 × 108 splenocytes from nonimmunized mice (open circles). Mice that received 5 × 107 or 1 × 107 anti-BSA splenocytes had no values above 15 (data not shown).