JCI - Concerns over functional experiments, interpretation, and required controls. Reply.

Concerns over functional experiments, interpretation, and required controls. Reply.

Wan-Chen Hsieh, Shih-Yu Chen

Published March 1, 2022
Citation Information: J Clin Invest. 2022;132(5):e158155. https://doi.org/10.1172/JCI158155.

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Letter to the Editor COVID-19 Immunology

Figure 1

Additional evidence to support the involvement of DNAM1-CD155 interactions in the clearance of SARS-CoV-2.

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(A) Representative histogram of CD155 intensity in SARS-CoV-2 N protein–positive and –negative cells. (B) Efficiencies of killing of pseudovirus-infected A549 cells (target [T]) by NK cells (effector [E]) from a healthy donor at 3 effector/target (E/T) ratios with or without anti-DNAM1 antibody. (C) Killing efficiency of mock-infected Calu-1 cells by primary NK cells with or without TIGIT-Fc.

Concerns over functional experiments, interpretation, and required controls. Reply.

Concerns over functional experiments, interpretation, and required controls. Reply.

Abstract

Authors

Figure 1

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