Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins
Alberto Auricchio, … , Roberto Calcedo, James M. Wilson
Alberto Auricchio, … , Roberto Calcedo, James M. Wilson
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):499-504. https://doi.org/10.1172/JCI15780.
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Article Genetics

Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins

Abstract

Research Article

Authors

Alberto Auricchio, Erin O’Connor, Daniel Weiner, Guang-Ping Gao, Markus Hildinger, Lili Wang, Roberto Calcedo, James M. Wilson

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Serum Epo (a) and hematocrit (b) levels following intranasal administrat...
Serum Epo (a) and hematocrit (b) levels following intranasal administration of vectors based on various AAV serotypes in mice. We intranasally administered 3 × 1011 GCs per mouse of AAV2/1-, AAV2/2-, or AAV2/5-CC10-rhEpo 4 weeks before the measurements. Control animals received the same set of vectors containing lacZ. Values shown are mean ± SD.