Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
Manuela Neumann, Philipp J. Kahle, Benoit I. Giasson, Laurence Ozmen, Edilio Borroni, Will Spooren, Veronika Müller, Sabine Odoy, Hideo Fujiwara, Masato Hasegawa, Takeshi Iwatsubo, John Q. Trojanowski, Hans A. Kretzschmar, Christian Haass
Manuela Neumann, Philipp J. Kahle, Benoit I. Giasson, Laurence Ozmen, Edilio Borroni, Will Spooren, Veronika Müller, Sabine Odoy, Hideo Fujiwara, Masato Hasegawa, Takeshi Iwatsubo, John Q. Trojanowski, Hans A. Kretzschmar, Christian Haass
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Article Neuroscience

Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

Abstract

Research Article

Authors

Manuela Neumann, Philipp J. Kahle, Benoit I. Giasson, Laurence Ozmen, Edilio Borroni, Will Spooren, Veronika Müller, Sabine Odoy, Hideo Fujiwara, Masato Hasegawa, Takeshi Iwatsubo, John Q. Trojanowski, Hans A. Kretzschmar, Christian Haass

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“Amyloid” pathology in aged transgenic mice. (a and b) Gallyas silver st...
“Amyloid” pathology in aged transgenic mice. (a and b) Gallyas silver stain revealed numerous argyrophilic dystrophic neurites and some inclusions in cell bodies in the pontine reticular field (a) and the motor cortex (b) of a 9-month-old homozygous mouse. (c and d) TS stained numerous LB-like cytoplasmic inclusions (arrow in c) and dystrophic neurites (arrowheads in c), some of which were hugely inflated (d). (e and f) Transmission electron microscopy showing a spherical inclusion composed of the typical 9- to 12-nm straight filaments within a swollen neurite. m, mitochondria; nu, nucleus. Scale bar in a corresponds to 100 μm in a and 50 μm in b–d. Scale bar in e, 400 nm; in f, 125 nm.