JCI - Citations to IFNs and STATs in innate immunity to microorganisms

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IFNs and STATs in innate immunity to microorganisms

Thomas Decker, … , Mathias Müller, Pavel Kovarik

Thomas Decker, … , Mathias Müller, Pavel Kovarik

Published May 15, 2002
Citation Information: J Clin Invest. 2002;109(10):1271-1277. https://doi.org/10.1172/JCI15770.

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Citations to this article (100)

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Characterization of microRNA expression in B cells derived from Japanese black cattle naturally infected with bovine leukemia virus by deep sequencing C Ochiai, S Miyauchi, Y Kudo, Y Naruke, S Yoneyama, K Tomita, L Dongze, Y Chiba, T Hirata, T Ichijo, K Nagai, S Kobayashi, S Yamada, H Hikono, K Murakami, FX Donadeu	PloS one	2021
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IFN-β: A Contentious Player in Host–Pathogen Interaction in Tuberculosis Sabir N, Hussain T, Shah SZ, Zhao D, Zhou X	International journal of molecular sciences	2017
Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes: All cells were pre-treated with IFNγ for 16 hr prior investigation ( a ) Left panel. GFP fluorescence intensity ( S G,G ) images of GBP2 -/- MEFs expressing G-mGBP2-WT (G-mGBP2 MEFs), mutants (R48A, K51A, E99A, D182N, C586S) or GFP highlighted with selections of pixels within different cellular compartments. Right panel. MFIS 2D-histograms of GFP anisotropy ( r D ) on x axis vs. photon number per pixel on y axis, the frequency of pixels color coded from white (lowest) to black (highest). This allows the identification and selection of pixel populations with unique fluorescence properties for a detailed subsequent pixel integrated analysis. The pixels with low photon numbers (below 1000) are selected in red boxes (defined as cytosol) and those with more than 1000 photons in green boxes (defined as VLS). Bars, 10 µm. ( b ) Scheme of the principle of homo-FRET assays. Compared to G-mGBP2 monomers, r D in G-mGBP2 multimers decreases due to depolarization of GFP fluorescence while GFP S G,G increases. ( c ) For specific compartments (cytosol and VLS, respectively), the anisotropy values are averaged over all cells generally denoted as r D > loc . r D > loc and S G,G in cytosol and VLS were plotted for G-mGBP2-WT, and the K51A mutant and GFP in the cytosol. ( d ) Mean anisotropy of averages over whole cells r D > cell for G-mGBP2 WT and mutant proteins. GFP expressing cells served as controls (***p E Kravets, D Degrandi, Q Ma, TO Peulen, V Klümpers, S Felekyan, R Kühnemuth, S Weidtkamp-Peters, CA Seidel, K Pfeffer	eLife	2016
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STAT Proteins and Oncogenesis Jacqueline Bromberg	Journal of Clinical Investigation	2002
JAK-STAT signaling in human disease Christian Schindler	Journal of Clinical Investigation	2002

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