Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
Fabio Candotti, … , Roberta Visconti, John O’Shea
Fabio Candotti, … , Roberta Visconti, John O’Shea
Published May 15, 2002
Citation Information: J Clin Invest. 2002;109(10):1261-1269. https://doi.org/10.1172/JCI15769.
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Perspective

Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways

Abstract

Authors

Fabio Candotti, Luigi Notarangelo, Roberta Visconti, John O’Shea

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The development of lymphoid cells is dependent upon the expression and s...
The development of lymphoid cells is dependent upon the expression and signaling by cytokine receptors, antigen receptors, and adhesion/accessory molecules. Mutations of many different genes can interfere with proper lymphoid development and function and, consequently, can lead to immunodeficiency.