T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Mark W. Musch, … , Eugene B. Chang, Terrence A. Barrett
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1739-1747. https://doi.org/10.1172/JCI15695.
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Article Inflammation

T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase

Abstract

Research Article

Authors

Mark W. Musch, Lane L. Clarke, Daniel Mamah, Lara R. Gawenis, Zheng Zhang, William Ellsworth, David Shalowitz, Navdha Mittal, Petros Efthimiou, Ziad Alnadjim, Steve D. Hurst, Eugene B. Chang, Terrence A. Barrett

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Effect of anti-CD3 mAb in CFTR-deficient mice. Mice were injected with P...
Effect of anti-CD3 mAb in CFTR-deficient mice. Mice were injected with PBS (Sham-injected) or 0.2 mg anti-CD3 mAb 3 hours before sacrifice. (a) Effect on jejunal wt/l ratio. Values are means ± SE for three mice in each group. *P < 0.5 vs. sham-injected. (b–d) Effect of anti-CD3 mAb ISC, Gt and Jmannitol of intestine from CFTR-deficient murine jejunum. Values are means ± SE for seven sections (four mice). *P < 0.05, **P < 0.1 vs. sham-injected.