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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Gaël Nicolas, … , Axel Kahn, Sophie Vaulont

Gaël Nicolas, … , Axel Kahn, Sophie Vaulont

Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):1037-1044. https://doi.org/10.1172/JCI15686.

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Article Inflammation

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Citations to this article (522)

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Assessment of ferritin and hepcidin levels in splenectomised and non-splenectomised β-thalassemia major patients and exploring a potential correlation with von Willebrand factor and ADAMTS-13. Al-Awadhi A, Alwehaidah MS, Al-Sabaan K, Al-Ajmi N	Annals of hematology	2025
Hepcidin mediates the disorder of iron homeostasis and mitochondrial function in mice under hypobaric hypoxia exposure. Liu J, Zhao J, He J, Li Y, Xu J, Xiao C, Zhang Y, Chen H, Hu Y, Fan C, Liu X	Apoptosis : an international journal on programmed cell death	2025
Activation of intestinal hif2α ameliorates iron-refractory anemia Yingying Yu, Yunxing Su, Sisi Yang, Nupur Das, Yutong Liu, Zhiting Lin, Qian Wu, Jiahui Zhou, Shumin Sun, Xiaopeng Li, Wuyang Yue, Yatrik Shah, Junxia Min, Fudi Wang	Advanced Science	2024
Measurement of serum hepcidin-25 by latex agglutination in healthy volunteers and patients with hematologic disorders. Kawabata H, Miyazawa N, Matsuda Y, Satobe M, Mizogami Y, Kuriyama Y, Sakai T, Mori M, Sasa M	International Journal of Hematology	2024
The interactions between ineffective erythropoiesis and ferroptosis in β-thalassemia Lin S, Zheng Y, Chen M, Xu L, Huang H	Frontiers in physiology	2024
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Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity F Cui, J Guo, HF Hu, Y Zhang, M Shi	Journal of Inflammation	2020
Iron: An Essential Element of Cancer Metabolism MY Hsu, E Mina, A Roetto, PE Porporato	Cells	2020
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A Novel Choice to Correct Inflammation-Induced Anemia in CKD: Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Z Yan, G Xu	Frontiers in Medicine	2020
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Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior Rowers M Zügel, G Treff, JM Steinacker, B Mayer, K Winkert, U Schumann	Frontiers in physiology	2020
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Hepcidin-to-Ferritin Ratio Is Decreased in Astrocytes With Extracellular Alpha-Synuclein and Iron Exposure J Cui, X Guo, Q Li, N Song, J Xie	Frontiers in cellular neuroscience	2020
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The Role of Iron and Erythropoietin in the Association of Fibroblast Growth Factor 23 with Anemia in Chronic Kidney Disease in Humans B Bielesz, T Reiter, FP Hammerle, W Winnicki, M Bojic, A Gleiss, H Kieweg, F Ratzinger, G Sunder-Plassmann, R Marculescu	Journal of Clinical Medicine	2020
Endothelial Bone Morphogenetic Protein 2 ( Bmp2 ) Knockout Exacerbates Hemochromatosis in Homeostatic Iron Regulator ( Hfe ) Knockout Mice but not Bmp6 Knockout Mice X Xiao, S Dev, S Canali, A Bayer, Y Xu, A Agarwal, CY Wang, JL Babitt	Hepatology	2020
Hypoxia-Inducible Factor-Proline Hydroxylase Inhibitor in the Treatment of Renal Anemia X Hu, J Xie, N Chen	Kidney Diseases	2020
The Action of JAK/STAT3 and BMP/HJV/SMAD Signaling Pathways on Hepcidin Suppression by Tucum-do-Cerrado in a Normal and Iron-Enriched Diets. Arruda SF, Ramos LV, Barbosa JLA, Hankins NAC, Rodrigues PAM, Cunha MSBD	Nutrients	2020
Hepcidin and ferritin levels in restless legs syndrome: a case-control study. Chenini S, Delaby C, Rassu AL, Barateau L, Vialaret J, Hirtz C, Dupuy AM, Lehmann S, Jaussent I, Dauvilliers Y	Scientific Reports	2020
Ferrotoxicity and its amelioration by endogenous vitamin D in experimental acute kidney injury Annamalai C, Ganesh RN, Viswanathan P	Experimental Biology and Medicine	2020
Inherited iron overload disorders. Piperno A, Pelucchi S, Mariani R	Translational Gastroenterology and Hepatology	2020
Determination of mutations in iron regulating genes of beta thalassemia major patients of Khyber Pakhtunkhwa, Pakistan. Shah M, Danish L, Khan NU, Zaman F, Ismail M, Hussain M, Pervaiz R, Iqbal A	Molecular Genetics & Genomic Medicine	2020
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Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity J Mora, C Mertens, JK Meier, DC Fuhrmann, B Brüne, M Jung	Cells	2019
Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis N DeGregorio-Rocasolano, O Martí-Sistac, T Gasull	Frontiers in neuroscience	2019
Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats J Moreno-Fernandez, J Díaz-Castro, M Alférez, I López-Aliaga	Nutrients	2019
Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice J Frýdlová, DW Rogalsky, J Truksa, E Nečas, M Vokurka, J Krijt, K Pantopoulos	PloS one	2019
Iron Supplementation Therapy, A Friend and Foe of Mycobacterial Infections? R Agoro, C Mura	Pharmaceuticals (Basel, Switzerland)	2019
Synergistic osmoregulatory dysfunction during salmon lice ( Lepeophtheirus salmonis ) and infectious hematopoietic necrosis virus co‐infection in sockeye salmon ( Oncorhynchus nerka ) smolts A Long, KA Garver, SR Jones	Journal of Fish Diseases	2019
Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet M Samba-Mondonga, M Constante, G Fragoso, A Calvé, MM Santos, K Pantopoulos	PloS one	2019
A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial T Akizawa, M Nangaku, T Yamaguchi, M Arai, R Koretomo, A Matsui, H Hirakata	American Journal of Nephrology	2019
To induce or not to induce: the fight over hepcidin regulation V Sangkhae, E Nemeth	Haematologica	2019
The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women NU Stoffel, M Lazrak, S Bellitir, NE Mir, AE Hamdouchi, A Barkat, C Zeder, D Moretti, H Aguenaou, MB Zimmermann	Haematologica	2019
Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia D Kiers, LT van Eijk, JG van der Hoeven, DW Swinkels, P Pickkers, M Kox	Haematologica	2019
Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns M Chełchowska, TM Maciejewski, J Mazur, J Gajewska, A Zasimovich, M Ołtarzewski, J Ambroszkiewicz	International journal of environmental research and public health	2019
Extrahepatic hepcidin production: The intriguing outcomes of recent years R Daher, T Lefebvre, H Puy, Z Karim	World journal of clinical cases	2019
Association of Transfusion With Risks of Dementia or Alzheimer’s Disease: A Population-Based Cohort Study SY Lin, WH Hsu, CC Lin, CL Lin, HC Yeh, CH Kao	Frontiers in Psychiatry	2019
Anemia of Inflammation with An Emphasis on Chronic Kidney Disease S Begum, GO Latunde-Dada	Nutrients	2019
Animal Models of Normal and Disturbed Iron and Copper Metabolism X Wang, MD Garrick, JF Collins	The Journal of nutrition	2019
A variant erythroferrone disrupts iron homeostasis in SF3B1 -mutated myelodysplastic syndrome S Bondu, AS Alary, C Lefèvre, A Houy, G Jung, T Lefebvre, D Rombaut, I Boussaid, A Bousta, F Guillonneau, P Perrier, S Alsafadi, M Wassef, R Margueron, A Rousseau, N Droin, N Cagnard, S Kaltenbach, S Winter, AS Kubasch, D Bouscary, V Santini, A Toma, M Hunault, A Stamatoullas, E Gyan, T Cluzeau, U Platzbecker, L Adès, H Puy, MH Stern, Z Karim, P Mayeux, E Nemeth, S Park, T Ganz, L Kautz, O Kosmider, M Fontenay	Science Translational Medicine	2019
Impact of Iron Deficiency on Peripheral Artery Disease After Endovascular Therapy. Otaki Y, Watanabe T, Takahashi H, Sugai T, Yokoyama M, Tamura H, Kato S, Nishiyama S, Arimoto T, Shishido T, Watanabe M		2019
Hepcidin-ferroportin axis in health and disease Ginzburg YZ	Vitamins and hormones	2019
Association between the ferritin level and risk of gestational diabetes mellitus: A meta-analysis of observational studies. Sun C, Wu QJ, Gao SY, Ma ZM, Liu YS, Zhang JY, Zhao YH	Journal of Diabetes Investigation	2019
Liver iron sensing and body iron homeostasis CY Wang, JL Babitt	Blood	2018
Adenine alleviates iron overload by cAMP/PKA mediated hepatic hepcidin in mice Y Zhang, X Wang, Q Wu, H Wang, L Zhao, X Wang, M Mu, E Xie, X He, D Shao, Y Shang, Y Lai, Y Ginzburg, J Min, F Wang	Journal of Cellular Physiology	2018
Erythropoietic regulators of iron metabolism T Ganz	Free radical biology & medicine	2018
Dysregulated iron metabolism in polycythemia vera: etiology and consequences YZ Ginzburg, M Feola, E Zimran, J Varkonyi, T Ganz, R Hoffman	Leukemia	2018
Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver MD Kleven, MM Gomes, AM Wortham, CA Enns, CA Kahl, K Stieger	PloS one	2018
Effects of an Acute Exercise Bout on Serum Hepcidin Levels R Domínguez, A Sánchez-Oliver, F Mata-Ordoñez, A Feria-Madueño, M Grimaldi-Puyana, Á López-Samanes, A Pérez-López	Nutrients	2018
Hypoxia enhances H 2 O 2 -mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation I Silva, V Rausch, T Peccerella, G Millonig, HK Seitz, S Mueller	Redox Biology	2018
Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis BH Hudson, AT Hale, RP Irving, S Li, JD York	Proceedings of the National Academy of Sciences	2018
Hepcidin agonists as therapeutic tools C Casu, E Nemeth, S Rivella	Blood	2018
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish E Tarifeño-Saldivia, A Aguilar, D Contreras, L Mercado, B Morales-Lange, K Márquez, A Henríquez, C Riquelme-Vidal, S Boltana	Frontiers in immunology	2018
Modulation of Iron Metabolism in Response to Infection: Twists for All Tastes A Gomes, A Moreira, G Mesquita, M Gomes	Pharmaceuticals (Basel, Switzerland)	2018
Non-Transfusion-Dependent Thalassemia: An Update on Complications and Management J Sleiman, A Tarhini, R Bou-Fakhredin, A Saliba, M Cappellini, A Taher	International journal of molecular sciences	2018
Hepcidin as a potential predictor for preoperative anemia treatment with intravenous iron—A retrospective pilot study C Wittkamp, L Traeger, I Ellermann, M Eveslage, AU Steinbicker, K Pantopoulos	PloS one	2018
Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs L Knight, R Dilger	Nutrients	2018
What can we learn from ineffective erythropoiesis in thalassemia? PR Oikonomidou, S Rivella	Blood Reviews	2018
Ineffective Erythropoiesis: Anemia and Iron Overload R Gupta, KM Musallam, AT Taher, S Rivella	Hematology/Oncology Clinics of North America	2018
Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease T Lefebvre, N Reihani, R Daher, TB de Villemeur, N Belmatoug, C Rose, Y Colin-Aronovicz, H Puy, CL Kim, M Franco, Z Karim	Haematologica	2018
Plasma hepcidin is associated with future risk of venous thromboembolism TS Ellingsen, J Lappegård, T Ueland, P Aukrust, SK Brækkan, JB Hansen	Blood Advances	2018
Iron Therapy in Heart Failure: Ready for Primetime? IR Mordi, A Tee, CC Lang	Cardiac Failure Review	2018
Association of Colecalciferol, Ferritin, and Anemia among Pregnant Women: Result from Cohort Study on Vitamin D Status and Its Impact during Pregnancy and Childhood in Indonesia RT Judistiani, L Gumilang, SA Nirmala, S Irianti, D Wirhana, I Permana, L Sofjan, H Duhita, LA Tambunan, JI Gurnadi, U Seno, R Ghrahani, AR Indrati, Y Sribudiani, T Yuniati, B Setiabudiawan	Anemia	2018
Hematological responses to iron-folate supplementation and its determinants in pregnant women attending antenatal cares in Mekelle City, Ethiopia E Belay, A Endrias, B Alem, K Endris, X Xue	PloS one	2018
The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value A Roetto, M Mezzanotte, R Pellegrino	Pharmaceuticals (Basel, Switzerland)	2018
Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases V Petzer, I Theurl, G Weiss	Pharmaceuticals (Basel, Switzerland)	2018
Novel Liposome Eencapsulated Guanosine Di Phosphate based Therapeutic Target against Anemia of Inflammation S Angmo, S Rana, K Yadav, R Sandhir, NK Singhal	Scientific Reports	2018
Iron in the Tumor Microenvironment—Connecting the Dots C Pfeifhofer-Obermair, P Tymoszuk, V Petzer, G Weiss, M Nairz	Frontiers in Oncology	2018
Hepcidin mediated iron homoeostasis as immune regulator in visceral leishmaniasis patients B Singh, SS Singh, S Sundar	Parasite Immunology	2018
Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease – a randomized double blind crossover study A Masajtis-Zagajewska, M Nowicki	Renal Failure	2018
Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine AA El-Sheikh, SH Ameen, SS AbdEl-Fatah	Journal of Toxicology	2018
Hepcidin, an Iron Regulatory Hormone of Innate Immunity, is Differentially Expressed in Premature Fetuses with Early-Onset Neonatal Sepsis. Tabbah SM, Buhimschi CS, Rodewald-Millen K, Pierson CR, Bhandari V, Samuels P, Buhimschi IA	American journal of perinatology	2018
Effect of daprodustat on anemia in patients with chronic kidney disease: a meta-analysis. Xie D, Wang J, Wu X, Li M	International Urology and Nephrology	2018
Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology MJ Stevenson, KS Uyeda, NH Harder, MC Heffern	Metallomics	2018
Iron-related markers are associated with infection after liver transplantation JK Chow, T Ganz, R Ruthazer, MA Simpson, EA Pomfret, FD Gordon, ME Westerman, DR Snydman	Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society	2017
Role of Activins in Hepcidin Regulation during Malaria N Spottiswoode, AE Armitage, AR Williams, AJ Fyfe, S Biswas, SH Hodgson, D Llewellyn, P Choudhary, SJ Draper, PE Duffy, H Drakesmith, JH Adams	Infection and immunity	2017
Regulation of the Iron Homeostatic Hormone Hepcidin V Sangkhae, E Nemeth	Advances in nutrition (Bethesda, Md.)	2017
HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism: HIF in erythropoiesis and iron metabolism VH Haase	Hemodialysis International	2017
Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies VH Haase	Experimental Cell Research	2017
Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway S Angmo, N Tripathi, S Abbat, S Sharma, SS Singh, A Halder, K Yadav, G Shukla, R Sandhir, V Rishi, PV Bharatam, H Yadav, NK Singhal	Scientific Reports	2017
Human Antimicrobial Peptides in Bodily Fluids: Current Knowledge and Therapeutic Perspectives in the Postantibiotic Era: HUMAN ANTIMICROBIAL PEPTIDES IN BODILY FLUIDS P Bastos, F Trindade, J Costa, R Ferreira, R Vitorino	Medicinal Research Reviews	2017
Acute-Phase Proteins and Iron Status in Cats with Chronic Kidney Disease R Javard, C Grimes, L Bau-Gaudreault, M Dunn	Journal of Veterinary Internal Medicine	2017
Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress: IG Alamo, KB Kannan, LE Bible, TJ Loftus, H Ramos, PA Efron, AM Mohr	Journal of Trauma and Acute Care Surgery	2017
Elevated Serum Hepcidin Levels during an Intensified Training Period in Well-Trained Female Long-Distance Runners A Ishibashi, N Maeda, D Sumi, K Goto	Nutrients	2017
Hepcidin suppression in β-thalassemia is associated with the down-regulation of atonal homolog 8 S Upanan, AT McKie, GO Latunde-Dada, S Roytrakul, C Uthaipibull, P Pothacharoen, P Kongtawelert, S Fucharoen, S Srichairatanakool	International Journal of Hematology	2017
Change in iron metabolism in rats after renal ischemia/reperfusion injury G Xie, L Zhu, Y Zhang, Q Zhang, Q Yu, K Pantopoulos	PloS one	2017
Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study ST Nikkari, AL Visto, KM Määttä, TA Kunnas	Medicine	2017
Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major AM Kaddah, A Abdel-Salam, MS Farhan, R Ragab	The Indian Journal of Pediatrics	2017
Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice CY Wang, AB Core, S Canali, KB Zumbrennen-Bullough, S Ozer, L Umans, A Zwijsen, JL Babitt	Blood	2017
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 SR Pasricha, PJ Lim, TL Duarte, C Casu, D Oosterhuis, K Mleczko-Sanecka, M Suciu, AR da Silva, K Al-Hourani, J Arezes, K McHugh, S Gooding, JN Frost, K Wray, A Santos, G Porto, E Repapi, N Gray, SJ Draper, N Ashley, E Soilleux, P Olinga, MU Muckenthaler, JR Hughes, S Rivella, TA Milne, AE Armitage, H Drakesmith	Nature Communications	2017
Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels A Ishibashi, N Maeda, A Kamei, K Goto	Nutrients	2017
Ferroportin Is Essential for Iron Absorption During Suckling, But Is Hyporesponsive to the Regulatory Hormone Hepcidin DM Frazer, SJ Wilkins, D Darshan, CS Mirciov, LA Dunn, GJ Anderson	CMGH Cellular and Molecular Gastroenterology and Hepatology	2017
Does Hypoxia Cause Carcinogenic Iron Accumulation in Alcoholic Liver Disease (ALD)? I Silva, V Rausch, HK Seitz, S Mueller	Cancers	2017
Iron and infection T Ganz	International Journal of Hematology	2017
Role of HAMP Genetic Variants on Pathophysiology of Iron Deficiency Anemia S Pandey, SK Pandey, V Shah	Indian Journal of Clinical Biochemistry	2017
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction SL Ross, K Biswas, J Rottman, JR Allen, J Long, LP Miranda, A Winters, TL Arvedson	Frontiers in pharmacology	2017
Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial GD Lewis, R Malhotra, AF Hernandez, SE McNulty, A Smith, GM Felker, WH Tang, SJ LaRue, MM Redfield, MJ Semigran, MM Givertz, PV Buren, D Whellan, KJ Anstrom, MR Shah, P Desvigne-Nickens, J Butler, E Braunwald	Journal of the American Medical Association	2017
The relationship between systemic iron homeostasis and erythropoiesis G Rishi, VN Subramaniam	Bioscience Reports	2017
Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression YS Lee, YH Kim, YS Jung, KS Kim, DK Kim, SY Na, JM Lee, CH Lee, HS Choi	Experimental & molecular medicine	2017
Normalizing serum hepcidin but not α-1-antitrypsin level during effective treatment of chronic hepatitis C M Rogalska-Taranta, J Jaroszewicz, R Flisiak	Clinical and Experimental Hepatology	2017
Iron Overload and Chelation Therapy in Non-Transfusion Dependent Thalassemia R Bou-Fakhredin, AH Bazarbachi, B Chaya, J Sleiman, M Cappellini, A Taher	International journal of molecular sciences	2017
DEFERASIROX: OVER A DECADE OF EXPERIENCE IN THALASSEMIA A Taher	Mediterranean journal of hematology and infectious diseases	2017
Role of hepcidin-ferroportin axis in the pathophysiology, diagnosis, and treatment of anemia of chronic inflammation: Hepcidin-ferroportin axis in ACI AL Langer, YZ Ginzburg	Hemodialysis International	2017
Physical exercise intervention at school improved hepcidin, inflammation, and iron metabolism in overweight and obese children and adolescents. Coimbra S, Catarino C, Nascimento H, Inês Alves A, Filipa Medeiros A, Bronze-da-Rocha E, Costa E, Rocha-Pereira P, Aires L, Seabra A, Mota J, Ferreira Mansilha H, Rêgo C, Santos-Silva A, Belo L	Pediatric Research	2017
Clinical iron deficiency disturbs normal human responses to hypoxia Matthew Frise, Hung-Yuan Cheng, Annabel Nickol, Mary Curtis, Karen Pollard, David J. Roberts, Peter Ratcliffe, Keith Dorrington, Peter Robbins	Journal of Clinical Investigation	2016
Liver — guardian, modifier and target of sepsis P Strnad, F Tacke, A Koch, C Trautwein	Nature Reviews Gastroenterology & Hepatology	2016
New strategies to target iron metabolism for the treatment of beta thalassemia: Targeting iron metabolism PR Oikonomidou, C Casu, S Rivella	Annals of the New York Academy of Sciences	2016
Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length M Chełchowska, J Ambroszkiewicz, J Gajewska, E Jabłońska-Głąb, TM Maciejewski, M Ołtarzewski	Biological Trace Element Research	2016
Interferon lambda polymorphisms associate with body iron indices and hepatic expression of interferon-responsive long non-coding RNA in chronic hepatitis C A Wróblewska, A Bernat, A Woziwodzka, J Markiewicz, T Romanowski, KP Bielawski, T Smiatacz, K Sikorska	Clinical and Experimental Medicine	2016
Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin? F Yousaf, B Spinowitz	Current Hypertension Reports	2016
Characterization of erythropoietin and hepcidin in the regulation of persistent injury-associated anemia: IG Alamo, KB Kannan, MA Smith, PA Efron, AM Mohr	Journal of Trauma and Acute Care Surgery	2016
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution L Gasperini, E Meneghetti, G Legname, F Benetti	Frontiers in neuroscience	2016
A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron A Bah, R Wegmuller, C Cerami, L Kendall, SR Pasricha, SE Moore, AM Prentice	BMC pregnancy and childbirth	2016
Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse RM Pellegrino, E Boda, F Montarolo, M Boero, M Mezzanotte, G Saglio, A Buffo, A Roetto	Scientific Reports	2016
Intravenous Iron Carboxymaltose as a Potential Therapeutic in Anemia of Inflammation N Lofruthe, I Gallitz, L Traeger, N Bäumer, I Schulze, T Kuhlmann, C Müller-Tidow, AU Steinbicker, K Pantopoulos	PloS one	2016
Hepcidin-Dependent Regulation of Erythropoiesis during Anemia in a Teleost Fish, Dicentrarchus labrax JV Neves, C Caldas, MF Ramos, PN Rodrigues, TY Chen	PloS one	2016
Laboratory use of hepcidin in renal transplant recipients L Simetic, L Zibar	Biochemia Medica	2016
Comparison of iron status 28 d after provision of antimalarial treatment with iron therapy compared with antimalarial treatment alone in Ugandan children with severe malaria SE Cusick, RO Opoka, AS Ssemata, MK Georgieff, CC John	The American journal of clinical nutrition	2016
Relationship between the Ingestion of a Polyphenol-Rich Drink, Hepcidin Hormone, and Long-Term Training D Villaño, C Vilaplana, S Medina, F Algaba-Chueca, R Cejuela-Anta, J Martínez-Sanz, F Ferreres, A Gil-Izquierdo	Molecules (Basel, Switzerland)	2016
High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation S Sakamoto, H Kawabata, J Kanda, T Uchiyama, C Mizumoto, T Kitano, T Kondo, M Hishizawa, N Tomosugi, A Takaori-Kondo	Cancer Medicine	2016
Expression of Iron Regulatory Protein 1 Is Regulated not only by HIF-1 but also pCREB under Hypoxia QQ Luo, ZM Qian, YF Zhou, MW Zhang, D Wang, L Zhu, Y Ke	International journal of biological sciences	2016
S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway M Wang, W Tang, H Xin, YZ Zhu, P Strnad	PloS one	2016
Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia AE Armitage, PJ Lim, JN Frost, SR Pasricha, EJ Soilleux, E Evans, A Morovat, A Santos, R Diaz, D Biggs, B Davies, U Gileadi, PA Robbins, S Lakhal-Littleton, H Drakesmith	Journal of Innate Immunity	2016
Dilemma: Correlation Between Serum Level of Hepcidin and IL-6 in Anemic Myeloma Patients L IbricevicBalic, E IcindicNakas, S Hasic, E Kiseljakovic, A SofoHafizovic, S Balic	Medical Archives	2016
Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli D Houamel, N Ducrot, T Lefebvre, R Daher, B Moulouel, MA Sari, P Letteron, S Lyoumi, S Millot, J Tourret, O Bouvet, S Vaulont, A Vandewalle, E Denamur, H Puy, C Beaumont, L Gouya, Z Karim	Journal of the American Society of Nephrology : JASN	2015
Factors controlling permeability of the blood–brain barrier MM Almutairi, C Gong, YG Xu, Y Chang, H Shi	Cellular and Molecular Life Sciences	2015
Oxidative stress in B-thalassaemia and sickle cell disease S Voskou, A Mutay, P Fanis, M Phylactides, M Kleanthous	Redox Biology	2015
Hepcidin: regulation of the master iron regulator G Rishi, DF Wallace, VN Subramaniam	Bioscience Reports	2015
Detection of a Novel, Integrative Aging Process Suggests Complex Physiological Integration AA Cohen, E Milot, Q Li, P Bergeron, R Poirier, F Dusseault-Bélanger, T Fülöp, M Leroux, V Legault, EJ Metter, LP Fried, L Ferrucci, RM Anderson	PloS one	2015
Differential effects of basolateral and apical iron supply on iron transport in Caco-2 cells JJ Eady, YM Wormstone, SJ Heaton, B Hilhorst, RM Elliott	Genes & Nutrition	2015
Iron-Hepcidin Dysmetabolism, Anemia and Renal Hypoxia, Inflammation and Fibrosis in the Remnant Kidney Rat Model P Garrido, S Ribeiro, J Fernandes, H Vala, E Bronze-da-Rocha, P Rocha-Pereira, L Belo, E Costa, A Santos-Silva, F Reis, K Pantopoulos	PloS one	2015
Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models S Lu, J Seravalli, D Harrison-Findik	Transgenic Research	2015
Hepcidin-25 in Diabetic Chronic Kidney Disease Is Predictive for Mortality and Progression to End Stage Renal Disease M Wagner, DR Ashby, C Kurtz, A Alam, M Busbridge, U Raff, J Zimmermann, PU Heuschmann, C Wanner, L Schramm, P Fiorina	PloS one	2015
Anaemia in kidney disease: harnessing hypoxia responses for therapy MJ Koury, VH Haase	Nature Reviews Nephrology	2015
Iron homeostasis in host defence and inflammation T Ganz, E Nemeth	Nature Reviews Immunology	2015
Oxidative Stress and the Homeodynamics of Iron Metabolism N Bresgen, P Eckl	Biomolecules	2015
The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro AA Alkhateeb, PD Buckett, AM Gardeck, J Kim, SL Byrne, PG Fraenkel, M Wessling-Resnick	AJP Gastrointestinal and Liver Physiology	2015
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation PJ Schmidt	The Journal of biological chemistry	2015
The Relationship between Iron Dyshomeostasis and Amyloidogenesis in Alzheimer’s Disease: Two Sides of the Same Coin DG Peters, JR Connor, MD Meadowcroft	Neurobiology of Disease	2015
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases A Lyberopoulou, G Chachami, NK Gatselis, E Kyratzopoulou, A Saitis, S Gabeta, P Eliades, E Paraskeva, K Zachou, GK Koukoulis, A Mamalaki, GN Dalekos, G Simos, P Strnad	PloS one	2015
Iron deficiency anemia in inflammatory bowel disease Sindhu Kaitha, Muhammad Bashir, Tauseef Ali	World journal of gastrointestinal pathophysiology	2015
Hepcidin and Host Defense against Infectious Diseases K Michels, E Nemeth, T Ganz, B Mehrad, JB Bliska	PLoS pathogens	2015
The erythroblastic island as an emerging paradigm in the anemia of inflammation J Hom, BM Dulmovits, N Mohandas, L Blanc	Immunologic Research	2015
Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection? A Grandone, P Marzuillo, L Perrone, E Giudice	Nutrients	2015
Effects of Pregnancy and Lactation on Iron Metabolism in Rats G Gao, SY Liu, HJ Wang, TW Zhang, P Yu, XL Duan, SE Zhao, YZ Chang	BioMed Research International	2015
Hepcidin antagonists for potential treatments of disorders with hepcidin excess M Poli, M Asperti, P Ruzzenenti, M Regoni, P Arosio	Frontiers in pharmacology	2014
Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation: Hepcidin-Independent Regulation of Erythropoiesis JM Langdon, SC Yates, LK Femnou, BJ McCranor, C Cheadle, QL Xue, S Vaulont, CI Civin, JD Walston, CN Roy	American Journal of Hematology	2014
Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis YM Shah, L Xie	Gastroenterology	2014
Epithelial Transport in Inflammatory Bowel Diseases: FK Ghishan, PR Kiela	Inflammatory Bowel Diseases	2014
Iron and noncontrast magnetic resonance T2* as a marker of intraplaque iron in human atherosclerosis MW Winner, T Sharkey-Toppen, X Zhang, ML Pennell, OP Simonetti, JL Zweier, PS Vaccaro, SV Raman	Journal of Vascular Surgery	2014
The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6 C Mayeur, LK Lohmeyer, P Leyton, SM Kao, AE Pappas, SA Kolodziej, E Spagnolli, B Yu, RL Galdos, PB Yu, RT Peterson, DB Bloch, KD Bloch, AU Steinbicker	Blood	2014
Iron and Atherosclerosis: Nailing Down a Novel Target with Magnetic Resonance TP Sharkey-Toppen, AK Tewari, SV Raman	Journal of Cardiovascular Translational Research	2014
A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression P Foka, A Dimitriadis, E Kyratzopoulou, DA Giannimaras, S Sarno, G Simos, U Georgopoulou, A Mamalaki	Cellular and Molecular Life Sciences	2014
Modulation of Hepcidin as Therapy for Primary and Secondary Iron Overload Disorders PJ Schmidt, MD Fleming	Hematology/Oncology Clinics of North America	2014
Influence of post-exercise hypoxic exposure on hepcidin response in athletes CE Badenhorst, B Dawson, C Goodman, M Sim, GR Cox, CJ Gore, H Tjalsma, DW Swinkels, P Peeling	European Journal of Applied Physiology	2014
Hepcidin and the iron enigma in HCV infection U Georgopoulou, A Dimitriadis, P Foka, E Karamichali, A Mamalaki	Virulence	2014
The pathophysiology and pharmacology of hepcidin P Ruchala, E Nemeth	Trends in Pharmacological Sciences	2014
Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions R Cui, RP Gale, G Zhu, Z Xu, T Qin, Y Zhang, G Huang, B Li, L Fang, H Zhang, L Pan, N Hu, S Qu, Z Xiao	Leukemia Research	2014
Calorie Restriction Down-Regulates Expression of the Iron Regulatory Hormone Hepcidin in Normal and d -Galactose–Induced Aging Mouse Brain S Wei, W Shi, M Li, Q Gao	Rejuvenation Research	2014
Hepcidin and sports anemia WN Kong, G Gao, YZ Chang	Cell & Bioscience	2014
Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases G Gao, YZ Chang	Frontiers in pharmacology	2014
Serum hepcidin following autologous hematopoietic cell transplantation: an illustration of the interplay of iron status, erythropoiesis and inflammation A Jaspers, F Baron, E Willems, L Seidel, ET Wiegerinck, DW Swinkels, Y Beguin	Haematologica	2014
Anemia of Inflammation E Nemeth, T Ganz	Hematology/Oncology Clinics of North America	2014
Identification of erythroferrone as an erythroid regulator of iron metabolism L Kautz, G Jung, EV Valore, S Rivella, E Nemeth, T Ganz	Nature Genetics	2014
Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease M Dostalikova-Cimburova, K Balusikova, K Kratka, J Chmelikova, V Hejda, J Hnanicek, J Neubauerova, J Vranova, J Kovar, J Horak	Journal of Cellular and Molecular Medicine	2014
Iron, anemia and hepcidin in malaria N Spottiswoode, PE Duffy, H Drakesmith	Frontiers in pharmacology	2014
The Potential for Transition Metal-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis DB Lovejoy, GJ Guillemin	Frontiers in aging neuroscience	2014
Iron age: novel targets for iron overload C Casu, S Rivella	Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program	2014
Hepcidin is suppressed by erythropoiesis in hemoglobin E -thalassemia and -thalassemia trait E Jones, SR Pasricha, A Allen, P Evans, CA Fisher, K Wray, A Premawardhena, D Bandara, A Perera, C Webster, P Sturges, NF Olivieri, TS Pierre, AE Armitage, JB Porter, DJ Weatherall, H Drakesmith	Blood	2014
Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice M Pauk, L Grgurevic, J Brkljacic, V Kufner, T Bordukalo-Niksic, K Grabusic, G Razdorov, D Rogic, M Zuvic, H Oppermann, JL Babitt, HY Lin, S Volarevic, S Vukicevic	International Orthopaedics	2014
RAP-011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice: Tg-Hamp mice respond to RAP-011 JM Langdon, S Barkataki, AE Berger, C Cheadle, QL Xue, V Sung, CN Roy	American Journal of Hematology	2014
Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver E Aigner	World journal of hepatology	2014
Duodenal Ferroportin Is Up-Regulated in Patients with Chronic Hepatitis C L Ma, T Zou, Y Yuan, J Lv, X Dong, G Yang, Y Zhu, J Luo, Z Zhang, J Yang, SD Sekaran	PloS one	2014
Mechanism underlying the transient increase of serum iron during FOLFOX/FOLFIRI therapy T Ochiai, K Nishimura, T Watanabe, M Kitajima, A Nakatani, T Sato, K Kishine, S Futagawa, S Mashiko, I Nagaoka	Molecular and Clinical Oncology	2014
The role of hepcidin, ferroportin, HCP1, and DMT1 protein in iron absorption in the human digestive tract J Przybyszewska, E Żekanowska	PRZ GASTROENTEROL	2014
Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats C Cao, CE Thomas, KL Insogna, KO O'Brien	The Journal of nutrition	2014
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly E Gammella, V Diaz, S Recalcati, P Buratti, M Samaja, S Dey, CT Noguchi, M Gassmann, G Cairo	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2014
Mechanistic and regulatory aspects of intestinal iron absorption S Gulec, GJ Anderson, JF Collins	AJP Gastrointestinal and Liver Physiology	2014
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats M Theurl, M Nairz, A Schroll, T Sonnweber, M Asshoff, D Haschka, M Seifert, W Willenbacher, D Wilflingseder, W Posch, AT Murphy, DR Witcher, I Theurl, G Weiss	Haematologica	2014
A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis P Gutschow, PJ Schmidt, H Han, V Ostland, TB Bartnikas, MA Pettiglio, C Herrera, JS Butler, E Nemeth, T Ganz, MD Fleming, M Westerman	Haematologica	2014
Bmp6 Expression Can Be Regulated Independently of Liver Iron in Mice Z Zhang, X Guo, C Herrera, Y Tao, Q Wu, A Wu, H Wang, TB Bartnikas, F Wang, T Rouault	PloS one	2014
Left Ventricular Mass in Dialysis Patients, Determinants and Relation with Outcome. Results from the COnvective TRansport STudy (CONTRAST) IM Mostovaya, ML Bots, MA van Dorpel, R Goldschmeding, CH Hoedt, O Kamp, R Levesque, AH Mazairac, EL Penne, DW Swinkels, NC van der Weerd, PM Wee, MJ Nubé, PJ Blankestijn, MP Grooteman, LR James	PloS one	2014
Lipopolysaccharides upregulate hepcidin in neuron via microglia and the IL-6/STAT3 signaling pathway. Qian ZM, He X, Liang T, Wu KC, Yan YC, Lu LN, Yang G, Luo QQ, Yung WH, Ke Y	Molecular Neurobiology	2014
Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes. Govus AD, Abbiss CR, Garvican-Lewis LA, Swinkels DW, Laarakkers CM, Gore CJ, Peeling P	European Journal of Applied Physiology	2014
Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome. Abakay O, Abakay A, Palanci Y, Yuksel H, Selimoglu Sen H, Evliyaoglu O, Tanrikulu AC	Sleep & breathing = Schlaf & Atmung	2014
Iron regulation by hepcidin Ningning Zhao, An-Sheng Zhang, Caroline Enns	Journal of Clinical Investigation	2013
The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions M Mastrogiannaki, P Matak, C Peyssonnaux	Blood	2013
Iron homeostasis in the liver ER Anderson, YM Shah	Comprehensive Physiology	2013
Effect of Nerium oleander (N.O.) leaves extract on serum hepcidin, total iron, and infiltration of ED1 positive cells in albino rat MH Abbasi, S Fatima, N Naz, IA Malik, N Sheikh	BioMed Research International	2013
Regulation of erythropoiesis by hypoxia-inducible factors VH Haase	Blood Reviews	2013
Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease DS Larson, DW Coyne	Kidney Research and Clinical Practice	2013
Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver SA Bloomer, KC Kregel, KE Brown	Archives of Gerontology and Geriatrics	2013
Retinal iron homeostasis in health and disease D Song, JL Dunaief	Frontiers in aging neuroscience	2013
Role of hepcidin in the pathophysiology and diagnosis of anemia G D'Angelo	Blood Research	2013
Tubular reabsorption and local production of urine hepcidin-25 HP Peters, CM Laarakkers, P Pickkers, R Masereeuw, OC Boerman, A Eek, EA Cornelissen, DW Swinkels, JF Wetzels	BMC Nephrology	2013
Profiling Sirolimus-Induced Inflammatory Syndrome: A Prospective Tricentric Observational Study F Buron, P Malvezzi, E Villar, C Chauvet, B Janbon, L Denis, M Brunet, S Daoud, R Cahen, C Pouteil-Noble, MC Gagnieu, J Bienvenu, F Bayle, E Morelon, O Thaunat	PloS one	2013
The small molecule, genistein, increases hepcidin expression in human hepatocytes: HEPATOLOGY, Vol. 58, No. X, 2013 ZHEN ET AL AW Zhen, NH Nguyen, Y Gibert, S Motola, P Buckett, M Wessling-Resnick, E Fraenkel, PG Fraenkel	Hepatology	2013
Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria B Troxell, HM Hassan	Frontiers in Cellular and Infection Microbiology	2013
The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients K Zumbrennen-Bullough, JL Babitt	Nephrology Dialysis Transplantation	2013
Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients SN Song, M Iwahashi, N Tomosugi, K Uno, J Yamana, S Yamana, T Isobe, H Ito, H Kawabata, K Yoshizaki	Arthritis Research & Therapy	2013
The liver: conductor of systemic iron balance D Meynard, JL Babitt, HY Lin	Blood	2013
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin A Kim, E Fung, SG Parikh, EV Valore, V Gabayan, E Nemeth, T Ganz	Blood	2013
The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels N Patel, J Varghese, P Masaratana, GO Latunde-Dada, M Jacob, RJ Simpson, AT McKie	British Journal of Haematology	2013
Serum iron levels as a new biomarker in chemotherapy with leucovorin and fluorouracil plus oxaliplatin or leucovorin and fluorouracil plus irinotecan, with or without molecularly-targeted drugs T Ochiai, K Nishimura, T Watanabe, M Kitajima, A Nakatani, T Inou, H Shibata, T Sato, K Kishine, S Seo, S Okubo, S Futagawa, S Mashiko, I Nagaoka	Molecular and Clinical Oncology	2013
Manipulation of the hepcidin pathway for therapeutic purposes E Fung, E Nemeth	Haematologica	2013
Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients YP Hsieh, CH Huang, CY Lee, HL Chen, CY Lin, CC Chang	World Journal of Nephrology	2013
Hepcidin-minireview SP M, M Ganesh, T Karthikeyan, AJ Devi, SV Mythili	Journal of Clinical and Diagnostic Research : JCDR	2013
Alterations in expression profile of iron-related genes in colorectal cancer K Hamara, A Bielecka-Kowalska, K Przybylowska-Sygut, A Sygut, A Dziki, J Szemraj	Molecular Biology Reports	2013
Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age BJ McCranor, JM Langdon, OD Prince, LK Femnou, AE Berger, C Cheadle, CI Civin, A Kim, S Rivera, T Ganz, S Vaulont, QL Xue, JD Walston, CN Roy	Haematologica	2013
Hepcidin levels in diabetes mellitus and polycystic ovary syndrome AH Sam, M Busbridge, A Amin, L Webber, D White, S Franks, NM Martin, M Sleeth, NA Ismail, NM Daud, D Papamargaritis, CW le Roux, RS Chapman, G Frost, SR Bloom, KG Murphy	Diabetic Medicine	2013
Hepcidin-25 Concentrations Are Markedly Increased in Patients With Chronic Kidney Disease and Are Inversely Correlated With Estimated Glomerular Filtration Rates: Human Hepcidin-25 in Chronic Kidney Disease JS Troutt, AM Butterfield, RJ Konrad	Journal of Clinical Laboratory Analysis	2013
HFE-Related Hemochromatosis: An Update for the Rheumatologist E Husar-Memmer, A Stadlmayr, C Datz, J Zwerina	Current Rheumatology Reports	2013
Treating iron overload in patients with non-transfusion-dependent thalassemia: Critical Review AT Taher, V Viprakasit, KM Musallam, MD Cappellini	American Journal of Hematology	2013
High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats R Meli, GM Raso, C Irace, R Simeoli, AD Pascale, O Paciello, TB Pagano, A Calignano, A Colonna, R Santamaria, S Gaetani	PloS one	2013
Sequestration and Scavenging of Iron in Infection NL Parrow, RE Fleming, MF Minnick, AT Maurelli	Infection and immunity	2013
Change in serum ferritin concentration in experimentally induced anemia of chronic inflammation in dogs. Chikazawa S, Nakazawa T, Hori Y, Hoshi F, Kanai K, Ito N, Orino K, Watanabe K, Higuchi S	Journal of Veterinary Medical Science	2013
Hypoxia-inducible factor regulates hepcidin via EPO-induced erythropoiesis Qingdu Liu, Olena Davidoff, Knut Niss, Volker H. Haase	Journal of Clinical Investigation	2012
Treatment of erythropoietin deficiency in mice with systemically administered siRNA W Querbes, RL Bogorad, J Moslehi, J Wong, AY Chan, E Bulgakova, S Kuchimanchi, A Akinc, K Fitzgerald, V Koteliansky, WG Kaelin	Blood	2012
Bacterial Cell Wall Constituents Induce Hepcidin Expression in Macrophages Through MyD88 Signaling A Layoun, MM Santos	Inflammation	2012
Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin S Nekhai, M Xu, A Foster, I Kasvosve, S Diaz, RF Machado, OL Castro, GJ Kato, JG 6th, VR Gordeuk	Haematologica	2012
Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation CC Sun, V Vaja, JL Babitt, HY Lin	American Journal of Hematology	2012
Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis T Ganz, E Nemeth	Cold Spring Harbor Perspectives in Medicine	2012
Hepcidin: A useful marker in chronic obstructive pulmonary disease S Duru, E Bilgin, S Ardiç	Annals of thoracic medicine	2012
Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis M Mastrogiannaki, P Matak, JR Mathieu, S Delga, P Mayeux, S Vaulont, C Peyssonnaux	Haematologica	2012
Anaemia in inflammatory rheumatic diseases G Weiss, G Schett	Nature Reviews Rheumatology	2012
Serum Hepcidin Levels and Reticulocyte Hemoglobin Concentrations as Indicators of the Iron Status of Peritoneal Dialysis Patients A Eguchi, T Mochizuki, M Tsukada, K Kataoka, Y Hamaguchi, S Oguni, K Nitta, K Tsuchiya	International Journal of Nephrology	2012
Management of Anemia of Inflammation in the Elderly A Macciò, C Madeddu	Anemia	2012
Erythropoietin, ferritin, haptoglobin, hemoglobin and transferrin receptor in metabolic syndrome: a case control study P Hämäläinen, J Saltevo, H Kautiainen, P Mäntyselkä, M Vanhala	Cardiovascular Diabetology	2012
Tumour necrosis factor alpha downregulates human hemojuvelin expression via a novel response element within its promoter MF Salama, HK Bayele, SS Srai	Journal of Biomedical Science	2012
A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum W Chen, CC Sun, S Chen, D Meynard, JL Babitt, HY Lin	Haematologica	2012
Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods P Lipiński, A Styś, RR Starzyński	Experientia	2012
Late stage erythroid precursor production is impaired in mice with chronic inflammation OD Prince, JM Langdon, AJ Layman, IC Prince, M Sabogal, HH Mak, AE Berger, C Cheadle, FJ Chrest, Q Yu, NC Andrews, QL Xue, CI Civin, JD Walston, CN Roy	Haematologica	2012
Protein Degradation and Iron Homeostasis JW Thompson, RK Bruick	Biochimica et Biophysica Acta	2012
Severe Microcytic Anemia but Increased Erythropoiesis in Mice Lacking Hfe or Tfr2 and Tmprss6 P Lee, MH Hsu, J Welser-Alves, H Peng	Blood cells, molecules & diseases	2012
Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children AM Prentice, CP Doherty, SA Abrams, SE Cox, SH Atkinson, H Verhoef, AE Armitage, H Drakesmith	Blood	2012
The evolving science of detection of 'blood doping' C Lundby, P Robach, B Saltin	British Journal of Pharmacology	2012
Regulation of iron metabolism in Hamp (-/-) mice in response to iron-deficient diet P Masaratana, N Patel, GO Latunde-Dada, S Vaulont, RJ Simpson, AT McKie	Zeitschrift für Ernährungswissenschaft	2012
Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries R Paesano, T Natalizi, F Berlutti, P Valenti	Pathogens and Global Health	2012
Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency M Dostalikova-Cimburova, K Kratka, K Balusikova, J Chmelikova, V Hejda, J Hnanicek, J Neubauerova, J Vranova, J Kovar, J Horak	Journal of Cellular and Molecular Medicine	2012
Current Topics in Membranes N Zhao, CA Enns	Current topics in membranes	2012
The Hypoxia-Inducible Factor-C/EBP Axis Controls Ethanol-Mediated Hepcidin Repression ER Anderson, M Taylor, X Xue, A Martin, DS Moons, MB Omary, YM Shah	Molecular and cellular biology	2012
Iron metabolism: current facts and future directions. Tandara L, Salamunic I	Biochemia Medica	2012
Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice M Taylor, A Qu, ER Anderson, T Matsubara, A Martin, FJ Gonzalez, YM Shah	Gastroenterology	2011
BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice N Patel, P Masaratana, J Diaz-Castro, GO Latunde-Dada, A Qureshi, P Lockyer, M Jacob, M Arno, P Matak, RR Mitry, RD Hughes, A Dhawan, C Patterson, RJ Simpson, AT McKie	The Journal of biological chemistry	2011
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation AU Steinbicker, C Sachidanandan, AJ Vonner, RZ Yusuf, DY Deng, CS Lai, KM Rauwerdink, JC Winn, B Saez, CM Cook, BA Szekely, CN Roy, JS Seehra, GD Cuny, DT Scadden, RT Peterson, KD Bloch, PB Yu	Blood	2011
Gastrins, Iron Homeostasis and Colorectal Cancer S Kovac, GJ Anderson, GS Baldwin	Biochimica et Biophysica Acta	2011
Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology* R Szabo, TH Bugge	Annual Review of Cell and Developmental Biology	2011
The Effect of Altitude Change on Anemia Treatment Response in Hemodialysis Patients MA Brookhart, BD Bradbury, J Avorn, S Schneeweiss, WC Winkelmayer	American Journal of Epidemiology	2011
Duodenal cytochrome b (Cybrd 1) and HIF-2α expression during acute hypoxic exposure in mice GO Latunde-Dada, L Xiang, RJ Simpson, AT McKie	European Journal of Nutrition	2011
Hepcidin expression in human airway epithelial cells is regulated by interferon-γ MD Frazier, LB Mamo, AJ Ghio, JL Turi	Respiratory Research	2011
Iron deficiency anemia: focus on infectious diseases in lesser developed countries JG Shaw, JF Friedman	Anemia	2011
Treatment of chronic periodontitis decreases serum prohepcidin levels in patients with chronic kidney disease EM Vilela, JA Bastos, N Fernandes, AP Ferreira, A Chaoubah, MG Bastos	Clinics (São Paulo, Brazil)	2011
Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice M Hadziahmetovic, Y Song, P Ponnuru, J Iacovelli, A Hunter, N Haddad, J Beard, JR Connor, S Vaulont, JL Dunaief	Investigative ophthalmology & visual science	2011
Hepcidin: A Critical Regulator of Iron Metabolism during Hypoxia KJ Hintze, JP McClung	Advances in Hematology	2011
Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort study A Haase-Fielitz, PR Mertens, M Plass, H Kuppe, R Hetzer, M Westerman, V Ostland, JR Prowle, R Bellomo, M Haase	Critical Care	2011
Exploring Staphylococcus aureus pathways to disease for vaccine development A DeDent, HK Kim, D Missiakas, O Schneewind	Seminars in Immunopathology	2011
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice L Krieg, O Milstein, P Krebs, Y Xia, B Beutler, X Du	Blood	2011
Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo I Theurl, A Schroll, M Nairz, M Seifert, M Theurl, T Sonnweber, H Kulaksiz, G Weiss	Haematologica	2011
Nifedipine Affects the Course of Salmonella enterica Serovar Typhimurium Infection by Modulating Macrophage Iron Homeostasis SM Mair, M Nairz, R Bellmann-Weiler, T Muehlbacher, A Schroll, I Theurl, PL Moser, H Talasz, FC Fang, G Weiss	The Journal of Infectious Diseases	2011
Gastrin-Deficient Mice Have Disturbed Hematopoiesis in Response to Iron Deficiency S Kovac, GJ Anderson, WS Alexander, A Shulkes, GS Baldwin	Endocrinology	2011
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice D Meynard, V Vaja, CC Sun, E Corradini, S Chen, C López-Otín, L Grgurevic, CC Hong, M Stirnberg, M Gütschow, S Vukicevic, JL Babitt, HY Lin	Blood	2011
Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis W Chen, FW Huang, TB de Renshaw, NC Andrews	Blood	2011
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice E Corradini, D Meynard, Q Wu, S Chen, P Ventura, A Pietrangelo, JL Babitt	Hepatology	2011
Iron deficiency in critically ill patients: highlighting the role of hepcidin N Heming, P Montravers, S Lasocki	Critical Care	2011
Hepcidin and iron regulation, 10 years later T Ganz	Blood	2011
Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling TB Chaston, P Matak, K Pourvali, SK Srai, AT McKie, PA Sharp	AJP Cell Physiology	2011
Hepcidin in anemia of chronic heart failure V Divakaran, S Mehta, D Yao, S Hassan, S Simpson, E Wiegerinck, DW Swinkels, DL Mann, V Afshar-Kharghan	American Journal of Hematology	2011
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis P Ramos, E Guy, N Chen, CC Proenca, S Gardenghi, C Casu, A Follenzi, NV Rooijen, RW Grady, M Sousa, S Rivella	Blood	2011
Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression VR Gordeuk, GY Miasnikova, AI Sergueeva, X Niu, M Nouraie, DJ Okhotin, LA Polyakova, T Ammosova, S Nekhai, T Ganz, JT Prchal	Blood	2011
Hereditary Hemochromatosis and Transferrin Receptor 2 J Chen, CA Enns	Biochimica et Biophysica Acta	2011
The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders T Ganz, E Nemeth	Hematology	2011
Mammalian Target of Rapamycin (mTOR) Inhibitors: Potential Uses and a Review of Haematological Adverse Effects S Sofroniadou, D Goldsmith	Drug Safety	2011
Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by a robust LC-MS/MS method SI Hwang, YY Lee, JO Park, HJ Norton, E Clemens, LW Schrum, HL Bonkovsky	Clinica Chimica Acta	2011
Iron deficiency in children with early chronic kidney disease R Baracco, S Saadeh, R Valentini, G Kapur, A Jain, TK Mattoo	Pediatric Nephrology	2011
The prevalence and etiology of anemia among HIV-infected children in India A Shet, K Arumugam, N Rajagopalan, C Dinakar, S Krishnamurthy, S Mehta, AS Shet	European Journal of Pediatrics	2011
Hepcidin Is Involved in Iron Regulation in the Ischemic Brain H Ding, CZ Yan, H Shi, YS Zhao, SY Chang, P Yu, WS Wu, CY Zhao, YZ Chang, XL Duan, DI Finkelstein	PloS one	2011
Hepcidin Is an Antibacterial, Stress-Inducible Peptide of the Biliary System P Strnad, P Schwarz, MC Rasenack, O Kucukoglu, RI Habib, D Heuberger, R Ehehalt, MW Müller, A Stiehl, G Adler, H Kulaksiz, V Uversky	PloS one	2011
Hypoxia Inducible Factor-2α Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats MK Davis, KM Shawron, E Rendina, SK Peterson, EA Lucas, BJ Smith, SL Clarke	The Journal of nutrition	2011
Iron regulation by hepatocytes and free radicals T Takami, I Sakaida	Journal of Clinical Biochemistry and Nutrition	2011
Prohepcidin and iron metabolism parameters in the obese elderly patients with anemia. Przybyszewska J, Zekanowska E, Kedziora-Kornatowska K, Boinska J, Cichon R, Porzych K	The journal of nutrition, health & aging	2011
Ferroportin and erythroid cells: an update L Cianetti, M Gabbianelli, NM Sposi	Advances in Hematology	2010
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice J Gao, J Chen, ID Domenico, DM Koeller, CO Harding, RE Fleming, DD Koeberl, CA Enns	Blood	2010
Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-α and macrophage migration inhibitory factor concentrations in African children I Kasvosve, Z Debebe, S Nekhai, VR Gordeuk	Clinica chimica acta; international journal of clinical chemistry	2010
Iron Homeostasis and the Inflammatory Response M Wessling-Resnick	Annual Review of Nutrition	2010
Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD JL Babitt, HY Lin	American Journal of Kidney Diseases	2010
Iron Loading and Overloading due to Ineffective Erythropoiesis T Tanno, JL Miller	Advances in Hematology	2010
Crosstalk between Iron Metabolism and Erythropoiesis H Li, YZ Ginzburg	Advances in Hematology	2010
Iron: an emerging factor in colorectal carcinogenesis AC Chua, B Klopcic, IC Lawrance, JK Olynyk, D Trinder	World journal of gastroenterology : WJG	2010
Iron overload in sickle cell disease R Raghupathy, D Manwani, JA Little	Advances in Hematology	2010
Hypoxic regulation of erythropoiesis and iron metabolism VH Haase	American journal of physiology. Renal physiology	2010
Increased serum iron levels and infectious complications after liver transplantation JK Chow, BG Werner, R Ruthazer, DR Snydman	Clinical Infectious Diseases	2010
ER Stress and Iron Homeostasis: A New Frontier for the UPR SJ Oliveira, M Sousa, JP Pinto	Biochemistry Research International	2010
Use of hematopoietic growth factor in the management of hematological side effects associated to antiviral treatment for HCV hepatitis P Mancino, K Falasca, C Ucciferri, E Pizzigallo, J Vecchiet	Mediterranean journal of hematology and infectious diseases	2010
Gender-related variations in iron metabolism and liver diseases DD Harrison-Findik	World journal of hepatology	2010
Iron overload induces BMP6 expression in the liver but not in the duodenum L Kautz, C Besson-Fournier, D Meynard, C Latour, MP Roth, H Coppin	Haematologica	2010
Severe iron deficiency blunts the response of the iron regulatory gene Hamp and pro-inflammatory cytokines to lipopolysaccharide D Darshan, DM Frazer, SJ Wilkins, GJ Anderson	Haematologica	2010
beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload L Melchiori, S Gardenghi, S Rivella	Advances in Hematology	2010
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis KE Finberg, RL Whittlesey, MD Fleming, NC Andrews	Blood	2010
Proinflammatory state, hepcidin, and anemia in older persons L Ferrucci, RD Semba, JM Guralnik, WB Ershler, S Bandinelli, KV Patel, K Sun, RC Woodman, NC Andrews, RJ Cotter, T Ganz, E Nemeth, DL Longo	Blood	2010
Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia P Cheng, X Jiao, X Wang, J Lin, Y Cai	Clinical and Experimental Medicine	2010
Validation and Potential Mechanisms of Red Cell Distribution Width as a Prognostic Marker in Heart Failure LA Allen, GM Felker, MR Mehra, JR Chiong, SH Dunlap, JK Ghali, DJ Lenihan, RM Oren, LE Wagoner, TA Schwartz, KF Adams	Journal of Cardiac Failure	2010
Anemia, Ineffective Erythropoiesis and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overload in β-Thalassemia S Gardenghi, RW Grady, S Rivella	Hematology/Oncology Clinics of North America	2010
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors S Lakhal, J Schödel, AR Townsend, CW Pugh, PJ Ratcliffe, DR Mole	The Journal of biological chemistry	2010
Benefits and Risks of Iron Supplementation in Anemic Neonatal Pigs P Lipinski, RR Starzyński, F Canonne-Hergaux, B Tudek, R Oliński, P Kowalczyk, T Dziaman, O Thibaudeau, MA Gralak, E Smuda, J Woliński, A Usińska, R Zabielski	The American Journal of Pathology	2010
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice E Corradini, PJ Schmidt, D Meynard, C Garuti, G Montosi, S Chen, S Vukicevic, A Pietrangelo, HY Lin, JL Babitt	Gastroenterology	2010
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes C Rapisarda, J Puppi, RD Hughes, A Dhawan, S Farnaud, RW Evans, PA Sharp	AJP Gastrointestinal and Liver Physiology	2010
Heme and non-heme iron transporters in non-polarized and polarized cells I Yanatori, M Tabuchi, Y Kawai, Y Yasui, R Akagi, F Kishi	BMC cell biology	2010
Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation: GDF15 AND IRON DEFICIENCY T Tanno, A Rabel, YT Lee, YY Yau, SF Leitman, JL Miller	Transfusion	2010
Hepcidin and Hfe in iron overload in β-thalassemia: Strategies to increase hepcidin in β-thalassemia S Gardenghi, P Ramos, A Follenzi, N Rao, EA Rachmilewitz, PJ Giardina, RW Grady, S Rivella	Annals of the New York Academy of Sciences	2010
Diagnostic accuracy of serum hepcidin for iron deficiency in critically ill patients with anemia S Lasocki, G Baron, F Driss, M Westerman, H Puy, I Boutron, C Beaumont, P Montravers	Intensive Care Medicine	2010
A novel monoclonal antibody immunoassay for the detection of human serum hepcidin P Schwarz, P Strnad, G Figura, A Janetzko, P Krayenbühl, G Adler, H Kulaksiz	Journal of Gastroenterology	2010
Novel assessment of hepatic iron distribution by synchrotron radiation X-ray fluorescence microscopy H Kinoshita, Y Hori, T Fukumoto, T Ohigashi, K Shinohara, Y Hayashi, Y Ku	Medical Molecular Morphology	2010
Prenatal Inflammation-Induced Hypoferremia Alters Dopamine Function in the Adult Offspring in Rat: Relevance for Schizophrenia A Aguilar-Valles, C Flores, GN Luheshi, LF Ng	PloS one	2010
Anemic Copper-Deficient Rats, but Not Mice, Display Low Hepcidin Expression and High Ferroportin Levels S Jenkitkasemwong, M Broderius, H Nam, JR Prohaska, MD Knutson	The Journal of nutrition	2010
Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages EE Johnson, CV Srikanth, A Sandgren, L Harrington, E Trebicka, L Wang, N Borregaard, M Murray, BJ Cherayil	FEMS Immunology and Medical Microbiology	2010
Reduction of Serum Hepcidin by Hemodialysis in Pediatric and Adult Patients J Zaritsky, B Young, B Gales, HJ Wang, A Rastogi, M Westerman, E Nemeth, T Ganz, IB Salusky	Clinical journal of the American Society of Nephrology : CJASN	2010
Role of Ferroportin in Macrophage-Mediated Immunity EE Johnson, A Sandgren, BJ Cherayil, M Murray, M Wessling-Resnick	Infection and immunity	2010
HIF-2 alpha but not HIF-1 alpha is a key regulator of iron absorption Maria Mastrogiannaki, Pavle Matak, Brian Keith, M. Celeste Simon, Sophie Vaulont, Carole Peyssonnaux	Journal of Clinical Investigation	2009
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo S Soe-Lin, SS Apte, B Andriopoulos, MC Andrews, M Schranzhofer, T Kahawita, D Garcia-Santos, P Ponka	Proceedings of the National Academy of Sciences	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases DB Kell	BMC Medical Genomics	2009
Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease? DD Harrison-Findik	World journal of gastroenterology : WJG	2009
Genetic mechanisms and modifying factors in hereditary hemochromatosis G Weiss	Nature Reviews Gastroenterology & Hepatology	2009
The global burden of iron overload MJ Wood, R Skoien, LW Powell	Hepatology International	2009
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency YM Shah, T Matsubara, S Ito, SH Yim, FJ Gonzalez	Cell Metabolism	2009
Mammalian iron transport GJ Anderson, CD Vulpe	Cellular and Molecular Life Sciences	2009
Future alternative therapies for β-thalassemia S Rivella, E Rachmilewitz	Expert Review of Hematology	2009
Iron sequestration and anemia of inflammation T Ganz, E Nemeth	Seminars in Hematology	2009
Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin DR Ashby, DP Gale, M Busbridge, KG Murphy, ND Duncan, TD Cairns, DH Taube, SR Bloom, FW Tam, R Chapman, PH Maxwell, P Choi	Haematologica	2009
Animal models of anemia of inflammation S Rivera, T Ganz	Seminars in Hematology	2009
Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major M Andreani, FC Radio, M Testi, CD Bernardo, M Troiano, S Majore, P Bertucci, P Polchi, R Rosati, P Grammatico	Haematologica	2009
Inflammation and its impact on anaemia in chronic kidney disease: from haemoglobin variability to hyporesponsiveness AL de Francisco, P Stenvinkel, S Vaulont	NDT Plus	2009
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes G Ramey, JC Deschemin, S Vaulont	Haematologica	2009
Expression of iron-related genes in human brain and brain tumors MM Hänninen, J Haapasalo, H Haapasalo, RE Fleming, RS Britton, BR Bacon, S Parkkila	BMC neuroscience	2009
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism B Andriopoulos, E Corradini, Y Xia, SA Faasse, S Chen, L Grgurevic, MD Knutson, A Pietrangelo, S Vukicevic, HY Lin, JL Babitt	Nature Genetics	2009
A novel immunological assay for hepcidin quantification in human serum V Koliaraki, M Marinou, TP Vassilakopoulos, E Vavourakis, E Tsochatzis, GA Pangalis, G Papatheodoridis, A Stamoulakatou, DW Swinkels, G Papanikolaou, A Mamalaki	PloS one	2009
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli H Huang, M Constante, A Layoun, MM Santos	Blood	2009
Malarial anemia and STAT6 KJ Robson, DJ Weatherall	Haematologica	2009
Transferrin-a modulates hepcidin expression in zebrafish embryos PG Fraenkel, Y Gibert, JL Holzheimer, VJ Lattanzi, SF Burnett, KA Dooley, RA Wingert, LI Zon	Blood	2009
Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk AA Salahudeen, RK Bruick	Annals of the New York Academy of Sciences	2009
STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo R Sakamori, T Takehara, T Tatsumi, M Shigekawa, H Hikita, N Hiramatsu, T Kanto, N Hayashi	Journal of Gastroenterology	2009
Role of hepcidin in murine brain iron metabolism SM Wang, LJ Fu, XL Duan, DR Crooks, P Yu, ZM Qian, XJ Di, J Li, TA Rouault, YZ Chang	Cellular and Molecular Life Sciences	2009
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation L Viatte, HJ Gröne, MW Hentze, B Galy	Journal of Molecular Medicine	2009
Decreased serum prohepcidin concentration in patients with polycythemia vera J Kwapisz, E Żekanowska, J Jasiniewska	Journal of Zhejiang University SCIENCE B	2009
Expression of hepcidin and other iron-regulatory genes in human hepatocellular carcinoma and its clinical implications HH Tseng, JG Chang, YH Hwang, KT Yeh, YL Chen, HS Yu	Journal of Cancer Research and Clinical Oncology	2009
Global Transcriptional Response to Hfe Deficiency and Dietary Iron Overload in Mouse Liver and Duodenum A Rodriguez, T Luukkaala, RE Fleming, RS Britton, BR Bacon, S Parkkila, J Valcarcel	PloS one	2009
Immunolocalization of Ferroportin in Healthy and Anemic Mice MC D'Anna, TV Veuthey, ME Roque	Journal of Histochemistry & Cytochemistry	2009
Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors M Volke, DP Gale, U Maegdefrau, G Schley, B Klanke, AK Bosserhoff, PH Maxwell, KU Eckardt, C Warnecke, C Zoccali	PloS one	2009
Iron Loading Increases Ferroportin Heterogeneous Nuclear RNA and mRNA Levels in Murine J774 Macrophages F Aydemir, S Jenkitkasemwong, S Gulec, MD Knutson	The Journal of nutrition	2009
Hepcidin—A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease J Zaritsky, B Young, HJ Wang, M Westerman, G Olbina, E Nemeth, T Ganz, S Rivera, AR Nissenson, IB Salusky	Clinical journal of the American Society of Nephrology : CJASN	2009
Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI	Sleep	2009
Forging a field: the golden age of iron biology NC Andrews	Blood	2008
Function of the hemochromatosis protein HFE: Lessons from animal models K Pantopoulos	World journal of gastroenterology : WJG	2008
Hereditary hemochromatosis in the post-HFE era JK Olynyk, D Trinder, GA Ramm, RS Britton, BR Bacon	Hepatology	2008
Intracellular iron transport and storage: from molecular mechanisms to health implications EL MacKenzie, K Iwasaki, Y Tsuji	Antioxidants & Redox Signaling	2008
Phytate: impact on environment and human nutrition. A challenge for molecular breeding L Bohn, AS Meyer, SK Rasmussen	Journal of Zhejiang University SCIENCE B	2008
The serine protease TMPRSS6 is required to sense iron deficiency X Du, E She, T Gelbart, J Truksa, P Lee, Y Xia, K Khovananth, S Mudd, N Mann, EM Moresco, E Beutler, B Beutler	Science (New York, N.Y.)	2008
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome KE van Zandt, FB Sow, WC Florence, BS Zwilling, AR Satoskar, LS Schlesinger, WP Lafuse	Journal of leukocyte biology	2008
An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study S Cherian, DA Forbes, AG Cook, FM Sanfilippo, EH Kemna, DW Swinkels, DP Burgner	PloS one	2008
The hepcidin-binding site on ferroportin is evolutionarily conserved ID Domenico, E Nemeth, JM Nelson, JD Phillips, RS Ajioka, MS Kay, JP Kushner, T Ganz, DM Ward, J Kaplan	Cell Metabolism	2008
Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma H Kijima, T Sawada, N Tomosugi, K Kubota	BMC Cancer	2008
Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain Q Wang, F Du, ZM Qian, XH Ge, L Zhu, WH Yung, L Yang, Y Ke	Endocrinology	2008
Evolution of the hepcidin gene in primates L Segat, A Pontillo, M Milanese, A Tossi, S Crovella	BMC Genomics	2008
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells Z Li, Z Lai, K Ya, D Fang, YW Ho, Y Lei, QZ Ming	Journal of Cellular and Molecular Medicine	2008
Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice S Liu, RN Suragani, A Han, W Zhao, NC Andrews, JJ Chen	Haematologica	2008
Anemia upregulates lipocalin 2 in the liver and serum W Jiang, M Constante, MM Santos	Blood Cells, Molecules, and Diseases	2008
Serum Pro-hepcidin Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus SS Koca, A Isik, B Ustundag, K Metin, K Aksoy	Inflammation	2008
Genetics of iron regulation and the possible role of iron in Parkinson's disease SL Rhodes, B Ritz	Neurobiology of Disease	2008
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression M Theurl, I Theurl, K Hochegger, P Obrist, N Subramaniam, N van Rooijen, K Schuemann, G Weiss	Journal of Molecular Medicine	2008
Regulation of Iron Absorption in Hemoglobinopathies Rechavi G, Rivella S	Current molecular medicine	2008
Modulation of Bone Morphogenetic Protein Signaling in vivo Regulates Systemic Iron Balance Jodie L. Babitt, Franklin W. Huang, Yin Xia, Yisrael Sidis, Nancy C. Andrews, Herbert Y. Lin	Journal of Clinical Investigation	2007
Regulation of iron homeostasis by the hypoxia inducible transcription factor-1 (HIF-1) Carole Peyssonnaux, Annelies S. Zinkernagel, Reto A. Schuepbach, Erinn Rankin, Sophie Vaulont, Volker H. Haase, Victor Nizet and Randall S. Johnson	Journal of Clinical Investigation	2007
Deficiency of Heme-Regulated eIF2α Kinase Attenuates Macrophage Maturation, Inflammatory Response and Iron Homeostasis Sijin Liu1, Rajasekhar NVS Suragani1, Fudi Wang2, Anping Han1, Wanting Zhao1, Nancy C Andrews2 and Jane-Jane Chen1*	Journal of Clinical Investigation	2007
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 L Lin, EV Valore, E Nemeth, JB Goodnough, V Gabayan, T Ganz	Blood	2007
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation CN Roy, HH Mak, I Akpan, G Losyev, D Zurakowski, NC Andrews	Blood	2007
The relevance of the intestinal crypt and enterocyte in regulating iron absorption PS Oates	Pflügers Archiv - European Journal of Physiology	2007
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin EV Valore, T Ganz	Blood cells, molecules & diseases	2007
Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha M Constante, D Wang, VA Raymond, M Bilodeau, MM Santos	The American Journal of Pathology	2007
Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C N Fujita, R Sugimoto, M Takeo, N Urawa, R Mifuji, H Tanaka, Y Kobayashi, M Iwasa, S Watanabe, Y Adachi, M Kaito	Molecular Medicine	2007
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin S Gardenghi, MF Marongiu, P Ramos, E Guy, L Breda, A Chadburn, YF Liu, N Amariglio, G Rechavi, EA Rachmilewitz, W Breuer, ZI Cabantchik, DM Wrighting, NC Andrews, M Sousa, PJ Giardina, RW Grady, S Rivella	Blood	2007
The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: Lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters J Truksa, P Lee, E Beutler	Blood Cells, Molecules, and Diseases	2007
In vivo imaging of hepcidin promoter stimulation by iron and inflammation JM Flanagan, J Truksa, H Peng, P Lee, E Beutler	Blood Cells, Molecules, and Diseases	2007
Iron homeostasis and toxicity in retinal degeneration X He, P Hahn, J Iacovelli, R Wong, C King, R Bhisitkul, M Massaro-Giordano, JL Dunaief	Progress in Retinal and Eye Research	2007
Role of Gα12 and Gα13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor MK Cho, WD Kim, SH Ki, JI Hwang, S Choi, CH Lee, SG Kim	Molecular and cellular biology	2007
Flatiron mice and ferroportin disease. Johnson EE, Wessling-Resnick M	Nutrition Reviews	2007
Liver iron transport. Graham RM, Chua AC, Herbison CE, Olynyk JK, Trinder D	World Journal of Gastroenterology	2007
Liver-gut axis in the regulation of iron homeostasis. Darshan D, Anderson GJ	World Journal of Gastroenterology	2007
Role of alcohol in the regulation of iron metabolism. Harrison-Findik DD	World Journal of Gastroenterology	2007
Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation M Constante, W Jiang, D Wang, VA Raymond, M Bilodeau, MM Santos	American journal of physiology. Gastrointestinal and liver physiology	2006
Impaired Intestinal Iron Absorption in Crohn's Disease Correlates with Disease Activity and Markers of Inflammation G Semrin, DS Fishman, A Bousvaros, A Zholudev, AC Saunders, CE Correia, E Nemeth, RJ Grand, DA Weinstein	Inflammatory Bowel Diseases	2006
Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression SJ Wilkins, DM Frazer, KN Millard, GD McLaren, GJ Anderson	Blood	2006
Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations G Dallalio, E Law, RT Means	Blood	2006
Suppression of hepcidin during anemia requires erythropoietic activity M Pak, MA Lopez, V Gabayan, T Ganz, S Rivera	Blood	2006
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6 J Truksa, H Peng, P Lee, E Beutler	Proceedings of the National Academy of Sciences	2006
DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis D Pospisilova, MP Mims, E Nemeth, T Ganz, JT Prchal	Blood	2006
Molecular insights into the pathogenesis of hereditary haemochromatosis A Pietrangelo	Gut	2006
The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study E Nemeth, GC Preza, CL Jung, J Kaplan, AJ Waring, T Ganz	Blood	2006
Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis M Nairz, G Weiss	Wiener klinische Wochenschrift	2006
Hemojuvelin Is Essential For Dietary Iron-Sensing and Its Mutation Leads to Severe Iron Overload Vera Niederkofler, Rishard Salie, Silvia Arber	Journal of Clinical Investigation	2005
Requirement of ferroportin1 for normal iron cycling in zebrafish Paula G. Fraenkel, David Traver, Adriana Donovan, David Zahrieh, Leonard I. Zon	Journal of Clinical Investigation	2005
Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading H Makui, RJ Soares, W Jiang, M Constante, MM Santos	Blood	2005
Non-HFE hemochromatosis: Genetics, pathogenesis, and clinical management JE Nelson, KV Kowdley	Current Gastroenterology Reports	2005
Hepcidin in iron overload disorders G Papanikolaou, M Tzilianos, JI Christakis, D Bogdanos, K Tsimirika, J MacFarlane, YP Goldberg, N Sakellaropoulos, T Ganz, E Nemeth	Blood	2005
Recent advances in intestinal iron transport GJ Anderson, DM Frazer	Current Gastroenterology Reports	2005
Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains JJ Ravia, RM Stephen, FK Ghishan, JF Collins	The Journal of biological chemistry	2005
Pathophysiology of hereditary hemochromatosis RE Fleming, RS Britton, A Waheed, WS Sly, BR Bacon	Seminars in liver disease	2005
Of mice and men: the iron age S Vaulont, DQ Lou, L Viatte, A Kahn	Journal of Clinical Investigation	2005
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin DF Wallace, L Summerville, PE Lusby, VN Subramaniam	Gut	2005
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs S Rivera, E Nemeth, V Gabayan, MA Lopez, D Farshidi, T Ganz	Blood	2005
Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression PS Leung, SK Srai, M Mascarenhas, LJ Churchill, ES Debnam	Gut	2005
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin MD Knutson, M Oukka, LM Koss, F Aydemir, M Wessling-Resnick	Proceedings of the National Academy of Sciences	2005
Serum pro-hepcidin: measuring active hepcidin or a non-functional precursor? MJ Brookes, NK Sharma, C Tselepis, TH Iqbal	Gut	2005
Interleukin-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron-regulatory hormone hepcidin Elizabeta Nemeth, Seth Rivera, Victoria Gabayan, Charlotte Keller, Sarah Taudorf, Bente K. Pedersen, Tomas Ganz	Journal of Clinical Investigation	2004
Recent advances in understanding haemochromatosis: a transition state KJ Robson, AT Merryweather-Clarke, E Cadet, V Viprakasit, MG Zaahl, JJ Pointon, DJ Weatherall, J Rochette	Journal of medical genetics	2004
The 16189 variant of mitochondrial DNA occurs more frequently in C282Y homozygotes with haemochromatosis than those without iron loading KJ Livesey, VL Wimhurst, K Carter, M Worwood, E Cadet, J Rochette, AG Roberts, JJ Pointon, AT Merryweather-Clarke, ML Bassett, AM Jouanolle, A Mosser, V David, J Poulton, KJ Robson	Journal of medical genetics	2004
Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability S Ludwiczek, I Theurl, E Artner-Dworzak, M Chorney, G Weiss	Journal of Molecular Medicine	2004
Hepcidin and its role in iron absorption KJ Robson	Gut	2004
The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1) AT McKie, DJ Barlow	Pflügers Archiv - European Journal of Physiology	2004
Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis DM Frazer, HR Inglis, SJ Wilkins, KN Millard, TM Steele, GD McLaren, AT McKie, CD Vulpe, GJ Anderson	Gut	2004
Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis T Kelleher, E Ryan, S Barrett, M Sweeney, V Byrnes, C O'Keane, J Crowe	Gut	2004
Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia H Kulaksiz, SG Gehrke, A Janetzko, D Rost, T Bruckner, B Kallinowski, W Stremmel	Gut	2004
Anemia of inflammation: the cytokine-hepcidin link NC Andrews	Journal of Clinical Investigation	2004
Manipulation of iron to determine survival: competition between host and pathogen. Laham N, Ehrlich R	Immunologic research	2004

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