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PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
Dipak Panigrahy, … , Judah Folkman, Arja Kaipainen
Dipak Panigrahy, … , Judah Folkman, Arja Kaipainen
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):923-932. https://doi.org/10.1172/JCI15634.
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Article Development Article has an altmetric score of 6

PPARγ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis

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Abstract

Research Article

Authors

Dipak Panigrahy, Samuel Singer, Lucy Q. Shen, Catherine E. Butterfield, Deborah A. Freedman, Emy J. Chen, Marsha A. Moses, Susan Kilroy, Stefan Duensing, Christopher Fletcher, Jonathan A. Fletcher, Lynn Hlatky, Philip Hahnfeldt, Judah Folkman, Arja Kaipainen

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Figure 4

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PPARγ ligands inhibit in vivo angiogenesis in the CAM and bFGF-induced c...
PPARγ ligands inhibit in vivo angiogenesis in the CAM and bFGF-induced corneal neovascularization. (a) A normal CAM implanted with a methylcellulose disk. (b) After a 48-hour exposure to rosiglitazone (2.5 μg), avascular zones free of capillaries and small vessels were observed around the disc (arrows point to a 3-mm avascular zone). Scale bar, 22.5 mm. (c) bFGF-induced neovascularization in control cornea on day 6. (d–f) Systemic treatment with rosiglitazone at 50 mg/kg/d (d), 100 mg/kg/d (e), and 400 mg/kg/d (f). (g) Area of inhibition (percent) by various doses of daily and twice-daily rosiglitazone administration. Inhibition was determined on day 6 by the formula 0.2 × π × neovessel length × clock hours of neovessels (n = 6 eyes per group; experiment was performed three times). Lines are fitted to the data assuming a Gaussian distribution.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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