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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Akiyoshi Uemura, … , George D. Yancopoulos, Shin-Ichi Nishikawa
Akiyoshi Uemura, … , George D. Yancopoulos, Shin-Ichi Nishikawa
Published December 1, 2002
Citation Information: J Clin Invest. 2002;110(11):1619-1628. https://doi.org/10.1172/JCI15621.
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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

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Abstract

Research Article

Authors

Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa

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Figure 5

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Effects of Ang1 on retinal vascular development. (a–g) P4 retinal vascul...
Effects of Ang1 on retinal vascular development. (a–g) P4 retinal vasculature stained with Tie2 (a and e) or with PECAM-1 (b–d, f, and g). Normally, Tie2 is expressed in all retinal vessels (a). Intraocular injections of Tie2-Fc (c) and Ang1* (d) displayed clear contrasts in effects on vascular remodeling, especially in generation of trunk vessels. In the APB5-treated mice, Tie2 is still expressed in all retinal vessels even in the absence of MCs (e). Disorganized vascular architecture induced by systemic APB5 treatment (f) was ameliorated to a great extent by intraocular injections of Ang1* (g). (h) Scanning electron microscopy demonstrating complete absence of MCs in the retina treated with APB5 + Ang1*. (i–m) Quantitative analysis of the radius (i), density (j), arterial diameter (k), venous diameter (l), and capillary diameter (m) of retinal vasculature at P4. Data (mean ± SD) are expressed as percentages relative to the normal retina. *P < 0.05 versus normal (Student t test).

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