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Thrombopoietin expands hematopoietic stem cells after transplantation

Norma Fox, … , Thalia Papayannopoulou, Kenneth Kaushansky

Norma Fox, … , Thalia Papayannopoulou, Kenneth Kaushansky

Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):389-394. https://doi.org/10.1172/JCI15430.

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Citations to this article (82)

Title and authors	Publication	Year
TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling Yang Y, Cathelin S, Liu AC, Subedi A, Maher A, Hosseini M, Manikoth Ayyathan D, Vanner R, Chan SM	Nature Communications	2025
Lymphopoiesis is attenuated upon hepatocyte-specific deletion of the cytochrome c oxidase assembly factor Sco1 Pioli KT, Ghosh S, Boulet A, Leary SC, Pioli PD	iScience	2025
Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution Huang Y, Liu X, Li S, Li C, Wang HY, Liu Q, Chen JY, Zhang Y, Li Y, Zhang X, Wang Q, Liu K, Liu YY, Pang Y, Liu S, Fan G, Shao C	Nature Communications	2024
Sox17 and Other SoxF-Family Proteins Play Key Roles in the Hematopoiesis of Mouse Embryos Nobuhisa I, Melig G, Taga T	Cells	2024
In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation Bozhilov YK, Hsu I, Brown EJ, Wilkinson AC	Cells	2023
Angelica sinensis polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells. Niu Y, Xiao H, Wang B, Wang Z, Du K, Wang Y, Wang L	Pharmaceutical Biology	2023
Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia Shin J, Kim MJ, Quan X, Kim JW, Lee S, Park S, Jeong JY, Yea K	BMC Cancer	2023
Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers. Defour JP, Leroy E, Dass S, Balligand T, Levy G, Brett IC, Papadopoulos N, Mouton C, Genet L, Pecquet C, Staerk J, Smith SO, Constantinescu SN	eLife	2023
The role of GATA2 in adult hematopoiesis and cell fate determination Peters IJ, de Pater E, Zhang W	Frontiers in Cell and Developmental Biology	2023
Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells I Mayer, A Hoelbl-Kovacic, V Sexl, E Doma	Cancers	2022
Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease Sargur Madabushi S, Fouda R, Ghimire H, Abdelhamid AM, Lim JE, Vishwasrao P, Kiven S, Brooks J, Zuro D, Rosenthal J, Guha C, Gupta K, Hui SK	Frontiers in Oncology	2022
Hematopoietic Stem Cells and Regeneration Biermann M, Reya T	Cold Spring Harbor perspectives in biology	2022
Building the Next Generation of Humanized Hemato-Lymphoid System Mice T Martinov, KM McKenna, WH Tan, EJ Collins, AR Kehret, JD Linton, TM Olsen, N Shobaki, A Rongvaux	Frontiers in immunology	2021
Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions I Lyadova, T Gerasimova, T Nenasheva	Frontiers in Cell and Developmental Biology	2021
In vitro expansion of fetal liver hematopoietic stem cells R Bhardwaj, L Kumar, D Chhabra, NK Mehra, A sharma, S Mohanty, V Kochupillai	Scientific Reports	2021
Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish J Chen, G Li, J Lian, N Ma, Z Huang, J Li, Z Wen, W Zhang, Y Zhang	Science China Life Sciences	2021
Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells JT Zoine, C Prince, JY Story, GM Branella, AM Lytle, A Fedanov, JS Alexander, CC Porter, CB Doering, HT Spencer, S Chandrakasan	Gene Therapy	2021
Natural Receptor- and Ligand-Based Chimeric Antigen Receptors: Strategies Using Natural Ligands and Receptors for Targeted Cell Killing Branella GM, Spencer HT	Cells	2021
Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression Y Liu, L Ding, B Zhang, Z Deng, Y Han, S Wang, S Yang, Z Fan, J Zhang, H Yan, D Han, L He, W Yue, H Wang, Y Li, X Pei	Stem Cells Translational Medicine	2020
Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development F Soares-da-Silva, M Peixoto, A Cumano, P Pinto-do-Ó	Frontiers in Cell and Developmental Biology	2020
C‐Cbl regulates c‐MPL receptor trafficking and its internalization M Märklin, C Tandler, HG Kopp, KL Hoehn, L QuintanillaMartinez, O Borst, MR Müller, SJ Saur	Journal of Cellular and Molecular Medicine	2020
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors L Cui, I Moraga, T Lerbs, CV Neste, S Wilmes, N Tsutsumi, AC Trotman-Grant, M Gakovic, S Andrews, J Gotlib, S Darmanis, M Enge, S Quake, IS Hitchcock, J Piehler, KC Garcia, G Wernig	Proceedings of the National Academy of Sciences	2020
Rebound Thrombocytosis after Induction Chemotherapy is a Strong Biomarker for Favorable Outcome in AML Patients: BR Schnell, K Seipel, U Bacher, B Jeker, BU Mueller, Y Banz, U Novak, T Pabst		2019
Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ LJ Alvarado, HD Huntsman, H Cheng, DM Townsley, T Winkler, X Feng, CE Dunbar, NS Young, A Larochelle	Blood	2019
“Hierarchy” and “Holacracy”; A Paradigm of the Hematopoietic System T Yokota	Cells	2019
JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling: TPO/MPL in JAK2V617F MK-Induced Myeloproliferation Y Zhang, CH Lin, K Kaushansky, H Zhan	Stem Cells	2018
Fat-bone interaction within the bone marrow milieu: Impact on hematopoiesis and systemic energy metabolism CP Hawkes, S Mostoufi-Moab	Bone	2018
Activity of eltrombopag in severe aplastic anemia P Scheinberg	Blood Advances	2018
Activity of eltrombopag in severe aplastic anemia P Scheinberg	Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program	2018
C-MPL provides tumor-targeted T cell receptor-transgenic T cells with co-stimulation and cytokine signals CD Nishimura, DA Brenner, M Mukherjee, RA Hirsch, L Ott, MF Wu, H Liu, O Dakhova, JS Orange, MK Brenner, CY Lin, C Arber	Blood	2017
Integrin αvβ3 enhances the suppressive effect of interferon‐γ on hematopoietic stem cells T Umemoto, Y Matsuzaki, Y Shiratsuchi, M Hashimoto, T Yoshimoto, A NakamuraIshizu, B Petrich, M Yamato, T Suda	The EMBO Journal	2017
[Advances on thrombopoietin receptor agonist in severe aplastic anemia] J Du, F K Zhang	Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi	2017
Heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells Bin Zhang, Ling Li, Yin Wei Ho, Sierra Min Li, Guido Marcucci, Wei Tong, Ravi Bhatia	Journal of Clinical Investigation	2016
Hematopoietic stem cells: multiparameter regulation K Song, L Li, Y Wang, T Liu	Human Cell	2016
Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction C Sanada, J Xavier-Ferrucio, YC Lu, E Min, PX Zhang, S Zou, E Kang, M Zhang, G Zerafati, PG Gallagher, DS Krause	Blood	2016
Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery MM Green, N Chao, S Chhabra, K Corbet, C Gasparetto, A Horwitz, Z Li, JK Venkata, G Long, A Mims, D Rizzieri, S Sarantopoulos, R Stuart, AD Sung, KM Sullivan, L Costa, M Horwitz, Y Kang	Journal of Hematology & Oncology	2016
A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells X Wang, D Haylock, CS Hu, W Kowalczyk, T Jiang, J Qiu, G Mosoyan, W He, N Marshall, J Mascarenhas, A Tarasova, J Brody, D Winkler, R Hoffman	Blood	2016
JAK2V617F-mutant vascular niche contributes to JAK2V617F clonal expansion in myeloproliferative neoplasms CH Lin, K Kaushansky, H Zhan	Blood Cells, Molecules, and Diseases	2016
MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling K Rozenova, J Jiang, R Donaghy, B Aressy, RA Greenberg, W Tong	Blood	2015
Eltrombopag in Aplastic Anemia R Desmond, DM Townsley, C Dunbar, NS Young	Seminars in Hematology	2015
Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance S Kohlscheen, S Wintterle, A Schwarzer, C Kamp, MH Brugman, DC Breuer, G Büsche, C Baum, U Modlich, Z Ivanovic	PloS one	2015
Efficient Generation of Megakaryocytes From Human Induced Pluripotent Stem Cells Using Food and Drug Administration-Approved Pharmacological Reagents Y Liu, Y Wang, Y Gao, JA Forbes, R Qayyum, L Becker, L Cheng, ZZ Wang	Stem Cells Translational Medicine	2015
Recombinant human thrombopoietin promotes hematopoietic reconstruction after severe whole body irradiation C Wang, B Zhang, S Wang, J Zhang, Y Liu, J Wang, Z Fan, Y Lv, X Zhang, L He, L Chen, H Xia, Y Li, X Pei	Scientific Reports	2015
Mechanisms of self-renewal in hematopoietic stem cells Z Wang, H Ema	International Journal of Hematology	2015
Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program HJ Park, J Li, R Hannah, S Biddie, AI Leal-Cervantes, K Kirschner, DF Cruz, V Sexl, B Go ttgens, AR Green	The EMBO Journal	2015
Myelodysplastic Syndrome Presenting as Amegakaryocytic Thrombocytopenia in a Collodion Baby MA Pakra, AA Jabri, E Hanafy	Journal of Investigative Medicine High Impact Case Reports	2015
The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm V Sangkhae, SL Etheridge, K Kaushansky, IS Hitchcock	Blood	2014
Obesity-driven disruption of haematopoiesis and the bone marrow niche BJ Adler, K Kaushansky, CT Rubin	Nature Reviews Endocrinology	2014
Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine A Rongvaux, H Takizawa, T Strowig, T Willinger, EE Eynon, RA Flavell, MG Manz	Annual Review of Immunology	2013
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1 B Laval, P Pawlikowska, D Barbieri, C Besnard-Guerin, A Cico, R Kumar, M Gaudry, V Baud, F Porteu	Blood	2013
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival P Holmfeldt, J Pardieck, AC Saulsberry, SK Nandakumar, D Finkelstein, JT Gray, DA Persons, S McKinney-Freeman	Blood	2013
Ex vivo activation of angiogenic property in human peripheral blood-derived monocytes by thrombopoietin T Kawamoto, J Sasajima, Y Sugiyama, K Nakamura, H Tanabe, M Fujiya, T Nata, Y Iuchi, T Ashida, Y Torimoto, Y Mizukami, Y Kohgo	International Journal of Hematology	2013
The TPO/c-MPL Pathway in the Bone Marrow may Protect Leukemia Cells from Chemotherapy in AML Patients Z Dong-Feng, L Ting, Z Yong, C Cheng, , K Pei-Yan	Pathology & Oncology Research	2013
Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling JA Pulikkan, D Madera, L Xue, P Bradley, SF Landrette, YH Kuo, S Abbas, LJ Zhu, P Valk, LH Castilla	Blood	2012
The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO FS Chou, A Griesinger, M Wunderlich, S Lin, KA Link, M Shrestha, S Goyama, B Mizukawa, S Shen, G Marcucci, JC Mulloy	Blood	2012
Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis H Sun, Y Tsai, I Nowak, J Liesveld, Y Chen	Stem Cell Research	2012
Signaling Profiling at the Single-Cell Level Identifies a Distinct Signaling Signature in Murine Hematopoietic Stem Cells J Du, J Wang, G Kong, J Jiang, J Zhang, Y Liu, W Tong, J Zhang	Stem Cells	2012
Genetics of familial forms of thrombocytopenia CL Balduini, A Savoia	Human Genetics	2012
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo A Rongvaux, T Willinger, H Takizawa, C Rathinam, W Auerbach, AJ Murphy, DM Valenzuela, GD Yancopoulos, EE Eynon, S Stevens, MG Manz, RA Flavell	Proceedings of the National Academy of Sciences	2011
Thrombopoietin and hematopoietic stem cells CA de Graaf, D Metcalf	Cell cycle (Georgetown, Tex.)	2011
Megakaryopoiesis AE Geddis	Seminars in Hematology	2010
Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5 G Li, Z Wang, KL Miskimen, Y Zhang, W Tse, KD Bunting	PloS one	2010
Ubiquitination and degradation of the thrombopoietin receptor c-Mpl SJ Saur, V Sangkhae, AE Geddis, K Kaushansky, IS Hitchcock	Blood	2010
Selective Enhancement of Donor Hematopoietic Cell Engraftment by the CXCR4 Antagonist AMD3100 in a Mouse Transplantation Model Y Kang, BJ Chen, D DeOliveira, J Mito, NJ Chao, A Leri	PloS one	2010
Genetic modification of ex-vivo expanded stem cells for clinical application Aggarwal R, Pompili VJ, Das H		2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Increased differentiation of dermal mast cells in mice lacking the Mpl gene B Ghinassi, M Zingariello, F Martelli, R Lorenzini, AM Vannucchi, RA Rana, M Nishikawa, G Migliaccio, J Mascarenhas, AR Migliaccio	Stem Cells and Development	2009
Thrombopoietin in normal and neoplastic stem cell development K Kaushansky, HM Ranney	Best practice & research. Clinical haematology	2009
Lnk Controls Hematopoietic Stem Cell Self-renewal and Quiescence through Direct Interactions with JAK2 Alexey Bersenev 2, Chao Wu 2, Joanna Balcerek 2, and Wei Tong 1,2, 3	Journal of Clinical Investigation	2008
Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression CF Barroga, H Pham, K Kaushansky	Experimental Hematology	2008
YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation IS Hitchcock, MM Chen, JR King, K Kaushansky	Blood	2008
Thrombopoietin (TPO) regulates HIF-1α levels through generation of mitochondrial reactive oxygen species K Yoshida, K Kirito, H Yongzhen, K Ozawa, K Kaushansky, N Komatsu	International Journal of Hematology	2008
AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells Y Satoh, I Matsumura, H Tanaka, S Ezoe, K Fukushima, M Tokunaga, M Yasumi, H Shibayama, M Mizuki, T Era, T Okuda, Y Kanakura	The Journal of biological chemistry	2008
Historical review: megakaryopoiesis and thrombopoiesis K Kaushansky	Blood	2007
Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones JL Abkowitz, J Chen	Blood	2007
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal W Tong, YM Ibarra, HF Lodish	Experimental Hematology	2007
Hematopoietic stem cells RG Hawley, A Ramezani, TS Hawley	Methods in enzymology	2006
The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells JM Ninos, LC Jefferies, CR Cogle, WG Kerr	Journal of Translational Medicine	2006
Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha K Kirito, N Fox, N Komatsu, K Kaushansky	Blood	2005
Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells K Kirito, N Fox, K Kaushansky	Molecular and cellular biology	2004
Deletion of α4 Integrins from Adult Hematopoietic Cells Reveals Roles in Homeostasis, Regeneration, and Homing LM Scott, GV Priestley, T Papayannopoulou	Molecular and cellular biology	2003
Optimizing Hematopoietic stem cell engraftment: a novel role for thrombopoietin Catherine Verfaillie	Journal of Clinical Investigation	2002

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