Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor
Shouhong Xuan, … , Domenico Accili, Argiris Efstratiadis
Shouhong Xuan, … , Domenico Accili, Argiris Efstratiadis
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):1011-1019. https://doi.org/10.1172/JCI15276.
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Article Endocrinology

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor

Abstract

Research Article

Authors

Shouhong Xuan, Tadahiro Kitamura, Jun Nakae, Katerina Politi, Yoshiaki Kido, Peter E. Fisher, Manrico Morroni, Saverio Cinti, Morris F. White, Pedro L. Herrera, Domenico Accili, Argiris Efstratiadis

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Intraperitoneal glucose tolerance tests in mice lacking IGF1R in β cells...
Intraperitoneal glucose tolerance tests in mice lacking IGF1R in β cells. Tests were performed in overnight-fasted mice as indicated in Methods. The difference between Igf1rΔlox/– and Igf1rΔlox/+ is significant at all time points except 0. The difference between Igf1rΔlox/– and Igf1rlox/– is statistically significant at times 90 and 120. The difference between Igf1rΔlox/+ and Igf1rlox/– is statistically significant at times 30, 60, and 90 (P < 0.05 by ANOVA). Bars represent SEM.