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Stem cell factor stimulates neurogenesis in vitro and in vivo
Kunlin Jin, … , Lin Xie, David A. Greenberg
Kunlin Jin, … , Lin Xie, David A. Greenberg
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):311-319. https://doi.org/10.1172/JCI15251.
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Article Genetics

Stem cell factor stimulates neurogenesis in vitro and in vivo

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Abstract

Research Article

Authors

Kunlin Jin, Xiao Ou Mao, Yunjuan Sun, Lin Xie, David A. Greenberg

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Figure 7

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Intraventricular SCF stimulates BrdU incorporation in SGZ and SVZ in viv...
Intraventricular SCF stimulates BrdU incorporation in SGZ and SVZ in vivo. (a) Brain sections through SGZ and SVZ were immunostained with anti-BrdU Ab 1 week after intraventricular infusion of SCF or aCSF vehicle (n = 6). Compared with aCSF (control), SCF increased the number of BrdU-positive cells in SGZ and SVZ. Proliferation was more pronounced on the cannula side, as compared with the contralateral side. (b) BrdU-labeled cells in SGZ (top) and SVZ (bottom) were counted in control brain (n = 6) and both ipsilateral (cannula side) and contralateral to SCF infusion (n = 6). In some experiments, SCF was infused together with anti–c-kit Ab (n = 4). Bars (left to right) represent control; SCF-treated, cannula side; SCF-treated, control side; and SCF- and anti–c-kit-treated, cannula side. BrdU-positive cells were increased in SVZ on both the infused and contralateral sides and in SGZ on the infused side.The effect of SCF was partially blocked by coadministration of anti–c-kit Ab (*P < 0.05, Student t test). (c) Rat brain sections through SGZ, obtained 1 week after SCF infusion, were double-labeled for BrdU (red) and NeuN or Neuro D (green). Merged images show that BrdU labeling colocalized with Neuro D and, in some cases, NeuN. Data shown are representative fields from the number of experiments given above (a and c), or mean ± SEM (n = 3) (b).

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