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The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
Junichi Sadoshima, … , Dorothy E. Vatner, Stephen F. Vatner
Junichi Sadoshima, … , Dorothy E. Vatner, Stephen F. Vatner
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):271-279. https://doi.org/10.1172/JCI14938.
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Article Genetics

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy

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Abstract

Research Article

Authors

Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner

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Figure 7

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Upregulation of TNF-α and TGF-β expression by pressure overload is impai...
Upregulation of TNF-α and TGF-β expression by pressure overload is impaired in MEKK1–/– mice. MEKK1+/+ (control) and MEKK1–/– mice were subjected to either aortic banding or sham operation. After 7 days of pressure overload, animals were sacrificed and total RNA was isolated from the apex. mRNA expression of TNF-α and TGF-β was determined by RT-PCR. Expression of GAPDH was determined as an internal control. Representative ethidium bromide staining of the products of RT-PCR is shown. n = 5.

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