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Citations to this article

IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Min Huang, … , Robert M. Strieter, Steven M. Dubinett
Min Huang, … , Robert M. Strieter, Steven M. Dubinett
Published April 1, 2002
Citation Information: J Clin Invest. 2002;109(7):931-937. https://doi.org/10.1172/JCI14685.
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Article Genetics

IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis

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Abstract

Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic therapeutic potential of IL-7 in both in vitro and in vivo pulmonary fibrosis models. IL-7 inhibited both TGF-β production and signaling in fibroblasts and required an intact JAK1/STAT1 signal transduction pathway. IL-7–mediated inhibition of TGF-β signaling was found to be associated with an increase in Smad7, a major inhibitory regulator in the SMAD family. In the presence of IL-7, Smad7 dominant negative fibroblasts restored TGF-β–induced collagen synthesis, indicating that an IL-7–mediated increase in Smad7 suppressed TGF-β signaling. Consistent with these in vitro findings, recombinant IL-7 decreased bleomycin-induced pulmonary fibrosis in vivo, independent of IFN-γ. The antifibrotic activities of IL-7 merit further basic and clinical investigation for the treatment of pulmonary fibrosis.

Authors

Min Huang, Sherven Sharma, Li X. Zhu, Michael P. Keane, Jie Luo, Ling Zhang, Marie D. Burdick, Ying Q. Lin, Mariam Dohadwala, Brian Gardner, Raj K. Batra, Robert M. Strieter, Steven M. Dubinett

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Total
Citations: 4 3 7 10 2 6 2 1 3 4 3 2 6 2 2 6 1 4 1 1 2 1 73
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