High power view of the basal half of a podocyte attached to the lamina rara externs (LRE) of the glomerular basement membrane. The slit diaphragms (SD) insert laterally into the podocyte cell membrane. Three membrane domains are marked: green indicates the apical cell membrane above the slit diaphragm; blue marks the membrane of the slit diaphragm domain; red indicates the cell membrane at the base, or “sole” of the foot process. LD: lamina densa. ×140,000.