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Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways
Robert Dinser, … , Mats Paulsson, Patrik Maurer
Robert Dinser, … , Mats Paulsson, Patrik Maurer
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):505-513. https://doi.org/10.1172/JCI14386.
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Article Genetics

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

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Abstract

Research Article

Authors

Robert Dinser, Frank Zaucke, Florian Kreppel, Kjell Hultenby, Stefan Kochanek, Mats Paulsson, Patrik Maurer

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Figure 1

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Overexpression of mutant COMP decreases the viability of chondrocytes. (...
Overexpression of mutant COMP decreases the viability of chondrocytes. (a) Monolayer cells were transduced with different infectious titers of adenovirus, and viable cells were quantified 3 days later. Viable cells are indicated relative to untransduced control cultures. Filled circles, cultures expressing mutant COMP; open circles, cultures expressing wild-type COMP. The composite result of two independent experiments is shown, with each point representing nine measurements. Error bars indicate 1 SD; **P < 0.01 in the two-sided student t test. (b) The supernatants of cultures were analyzed for LDH activity 3 days after gene transfer with 200 MOI. Values were corrected for the background activity of the culture medium and related to the LDH activity of a total cell lysate obtained by sonication of an equivalent cell number. Measurements were performed in triplicate, error bars indicate 1 SD. NS, no significant difference; *P < 0.05 in the two-sided student t test. Mu, cultures overexpressing mutant COMP; Wt, cultures overexpressing wild-type COMP; C, untransduced control cultures.

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