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Citations to this article

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Terry P. Combs, … , Philipp E. Scherer, Luciano Rossetti
Terry P. Combs, … , Philipp E. Scherer, Luciano Rossetti
Published December 15, 2001
Citation Information: J Clin Invest. 2001;108(12):1875-1881. https://doi.org/10.1172/JCI14120.
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Article

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

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Abstract

Intraperitoneal injection of purified recombinant Acrp30 lowers glucose levels in mice. To gain insight into the mechanism(s) of this hypoglycemic effect, purified recombinant Acrp30 was infused in conscious mice during a pancreatic euglycemic clamp. In the presence of physiological hyperinsulinemia, this treatment increased circulating Acrp30 levels by approximately twofold and stimulated glucose metabolism. The effect of Acrp30 on in vivo insulin action was completely accounted for by a 65% reduction in the rate of glucose production. Similarly, glucose flux through glucose-6-phosphatase (G6Pase) decreased with Acrp30, whereas the activity of the direct pathway of glucose-6-phosphate biosynthesis, an index of hepatic glucose phosphorylation, increased significantly. Acrp30 did not affect the rates of glucose uptake, glycolysis, or glycogen synthesis. These results indicate that an acute increase in circulating Acrp30 levels lowers hepatic glucose production without affecting peripheral glucose uptake. Hepatic expression of the gluconeogenic enzymes phosphoenolpyruvate carboxykinase and G6Pase mRNAs was reduced by more than 50% following Acrp30 infusion compared with vehicle infusion. Thus, a moderate rise in circulating levels of the adipose-derived protein Acrp30 inhibits both the expression of hepatic gluconeogenic enzymes and the rate of endogenous glucose production.

Authors

Terry P. Combs, Anders H. Berg, Silvana Obici, Philipp E. Scherer, Luciano Rossetti

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Total
Citations: 5 9 8 11 16 11 8 5 10 9 16 15 17 8 17 11 15 12 12 11 5 7 10 1 249
Citation information
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Citations to this article in year 2010 (11)

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Ryoichi Banno, Derek Zimmer, Bart De Jonghe, Marybless Atienza, Kimberly Rak, Wentian Yang, Kendra Bence
Journal of Clinical Investigation 2010
Adiponectin resistance and vascular dysfunction in the hyperlipidemic state
R Li, WB Lau, XL Ma
Acta Pharmacologica Sinica 2010
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
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Nature Medicine 2010
Adiponectin Lowers Glucose Production by Increasing SOGA
RB Cowherd, RB Cowerd, MM Asmar, JM Alderman, EA Alderman, AL Garland, WH Busby, WM Bodnar, I Rusyn, BD Medoff, R Tisch, E Mayer-Davis, JA Swenberg, SH Zeisel, TP Combs
The American Journal of Pathology 2010
The Physiological Deadlock between AMPK and Gluconeogenesis
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The American Journal of Pathology 2010
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P Singla, A Bardoloi, AA Parkash
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Q Liu, MS Gauthier, L Sun, N Ruderman, H Lodish
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Adiponectin and bone mass density: The InCHIANTI study
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Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus
I Kanazawa, T Yamaguchi, M Yamauchi, M Yamamoto, S Kurioka, S Yano, T Sugimoto
Osteoporosis International 2010

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