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Citations to this article

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Terry P. Combs, … , Philipp E. Scherer, Luciano Rossetti
Terry P. Combs, … , Philipp E. Scherer, Luciano Rossetti
Published December 15, 2001
Citation Information: J Clin Invest. 2001;108(12):1875-1881. https://doi.org/10.1172/JCI14120.
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Article

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

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Abstract

Intraperitoneal injection of purified recombinant Acrp30 lowers glucose levels in mice. To gain insight into the mechanism(s) of this hypoglycemic effect, purified recombinant Acrp30 was infused in conscious mice during a pancreatic euglycemic clamp. In the presence of physiological hyperinsulinemia, this treatment increased circulating Acrp30 levels by approximately twofold and stimulated glucose metabolism. The effect of Acrp30 on in vivo insulin action was completely accounted for by a 65% reduction in the rate of glucose production. Similarly, glucose flux through glucose-6-phosphatase (G6Pase) decreased with Acrp30, whereas the activity of the direct pathway of glucose-6-phosphate biosynthesis, an index of hepatic glucose phosphorylation, increased significantly. Acrp30 did not affect the rates of glucose uptake, glycolysis, or glycogen synthesis. These results indicate that an acute increase in circulating Acrp30 levels lowers hepatic glucose production without affecting peripheral glucose uptake. Hepatic expression of the gluconeogenic enzymes phosphoenolpyruvate carboxykinase and G6Pase mRNAs was reduced by more than 50% following Acrp30 infusion compared with vehicle infusion. Thus, a moderate rise in circulating levels of the adipose-derived protein Acrp30 inhibits both the expression of hepatic gluconeogenic enzymes and the rate of endogenous glucose production.

Authors

Terry P. Combs, Anders H. Berg, Silvana Obici, Philipp E. Scherer, Luciano Rossetti

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Total
Citations: 5 9 8 11 16 11 8 5 10 9 16 15 17 8 17 11 15 12 12 11 5 7 10 1 249
Citation information
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Citations to this article in year 2007 (12)

Title and authors Publication Year
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2
M Ishikawa, J Kitayama, T Yamauchi, T Kadowaki, T Maki, H Miyato, H Yamashita, H Nagawa
Cancer Science 2007
Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus
M Bajaj, S Suraamornkul, LJ Hardies, L Glass, N Musi, RA DeFronzo
Diabetologia 2007
Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
JK Nien, S Mazaki-Tovi, R Romero, O Erez, JP Kusanovic, F Gotsch, BL Pineles, R Gomez, S Edwin, M Mazor, J Espinoza, BH Yoon, SS Hassan
Journal of Perinatal Medicine 2007
Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells
I Kanazawa, T Yamaguchi, S Yano, M Yamauchi, M Yamamoto, T Sugimoto
BMC cell biology 2007
Adiponectin in severe preeclampsia
JK Nien, S Mazaki-Tovi, R Romero, O Erez, JP Kusanovic, F Gotsch, BL Pineles, R Gomez, S Edwin, M Mazor, J Espinoza, BH Yoon, SS Hassan
Journal of Perinatal Medicine 2007
Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis
LJ Zhao, H Jiang, CJ Papasian, D Maulik, B Drees, J Hamilton, HW Deng
Journal of Bone and Mineral Research 2007
Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes
L Cong, K Chen, J Li, P Gao, Q Li, S Mi, X Wu, AZ Zhao
Biochemical Journal 2007
Adipokines and vascular disease in diabetes
BJ Goldstein, R Scalia
Current Diabetes Reports 2007
Pathophysiological significance of adiponectin
M Nishida, T Funahashi, I Shimomura
Medical Molecular Morphology 2007
Relationship among Adiponectin, Adiponectin Gene Expression and Fatty Acids Composition in Morbidly Obese Patients
JJ Hernandez-Morante, FI Milagro, E Larque, J Lujan, JA Martinez, S Zamora, M Garaulet
Obesity Surgery 2007
Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo
L Wang, B Balas, CY Christ-Roberts, RY Kim, FJ Ramos, CK Kikani, C Li, C Deng, S Reyna, N Musi, LQ Dong, RA DeFronzo, F Liu
Molecular and cellular biology 2007
Nutrigenomics, beta-cell function and type 2 diabetes.
Nino-Fong R, Collins T, Chan C
Current genomics 2007

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