BACKGROUND Initial reports from the severe acute respiratory coronavirus 2 (SARS–CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology.METHODS We prospectively enrolled hospitalized patients with evidence of SARS–CoV-2 infection and classified them as having MIS-C or COVID-19. Patients with COVID-19 were classified as having either minimal or severe disease. Cytokine profiles, viral cycle thresholds (Cts), blood smears, and soluble C5b-9 values were analyzed with clinical data.RESULTS Twenty patients were enrolled (9 severe COVID-19, 5 minimal COVID-19, and 6 MIS-C). Five cytokines (IFN-γ, IL-10, IL-6, IL-8, and TNF-α) contributed to the analysis. TNF-α and IL-10 discriminated between patients with MIS-C and severe COVID-19. The presence of burr cells on blood smears, as well as Cts, differentiated between patients with severe COVID-19 and those with MIS-C.CONCLUSION Pediatric patients with SARS–CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19.FUNDING Financial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex’s Lemonade Stand Foundation for Childhood Cancer; Children’s Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics.
Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, Hamid Bassiri
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S Lapp, J Abrams, A Lu, L Hussaini, C Kao, D Hunstad, R Rosenberg, M Zafferani, K Ede, W Ballan, F Laham, Y Beltran, H Hsiao, W Sherry, E Jenkins, K Jones, A Horner, A Brooks, B Bryant, L Meng, T Hammett, M Oster, S Bamrah-Morris, S Godfred-Cato, E Belay, A Chahroudi, E Anderson, P Jaggi, C Rostad |
Open Forum Infectious Diseases | 2022 |
ACE2 overexpressing mesenchymal stem cells alleviates COVID-19 lung injury by inhibiting pyroptosis
J Wei, R Shang, J Wang, S Zhu, J Yin, Y Chen, Y Zhao, G Chen |
iScience | 2022 |
New-onset ocular myasthenia after multisystem inflammatory syndrome in children
P Yavuz, O Demir, Y Ozsurekci, S Ozen, B Anlar, G Haliloglu |
The Journal of Pediatrics | 2022 |
The difference of the inflammatory milieu in MIS-C and severe COVID-19
S Gurlevik, Y Ozsurekci, E Sağ, P Oygar, S Kesici, Ü Akca, M Cuceoglu, O Basaran, S Göncü, J Karakaya, A Cengiz, S Özen |
Pediatric Research | 2022 |
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19
N Veraldi, R Vivès, G Blanchard-Rohner, A LHuillier, N Wagner, M Rohr, M Beghetti, A Agostini, S Grazioli |
Journal of Molecular Medicine | 2022 |
Therapeutic Strategies for COVID-19 Lung Disease in Children
E Gatti, M Piotto, M Lelii, M Pensabene, B Madini, L Cerrato, V Hassan, S Aliberti, S Bosis, P Marchisio, M Patria |
Frontiers in Pediatrics | 2022 |
A Case of Multisystem Inflammatory Syndrome Due to SARS-CoV-2 Presenting With Acute Appendicitis Symptoms
C Uğur, U Mete, E Ömeroğlu |
Cureus | 2022 |
Targeting TNF-α for COVID-19: Recent Advanced and Controversies
Y Guo, K Hu, Y Li, C Lu, K Ling, C Cai, W Wang, D Ye |
Frontiers in public health | 2022 |
Neurological complications of COVID-19 in children and the associated immunological responses
R Siddique, S Khan, Shabana, M Li, M Xue, K Ghanim, Z Kaimkhani, S Mahboob |
Journal of King Saud University - Science | 2022 |
Focal Seizures in a Child Following COVID-19 Infection: A Case Report
J Mydam, S Midivelly, P Chennakesavulu, A Mydam, H Allepalli, K Depala |
Cureus | 2022 |
Arrhythmic myocarditis in an adolescent male: A unique presentation of multi-organ inflammatory syndrome (MIS-C)
G Casavecchia, M Corbo, M Gravina, R Barone, M Magnesa, M Mele, D D'Alessandro, R Ieva, M Iacoviello, L Macarini, N Brunetti |
The American Journal of Emergency Medicine | 2022 |
Multisystem Inflammatory Syndrome after Ad26.COV2.S vaccination
C Bova, E Vigna, M Gentile |
IDCases | 2022 |
Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children
Talal A Chatila, Mehdi Benamar, Qian Chen, Janet Chou, Amelie Julé, Rafik Boudra, Paola Contini, Elena Crestani, Muyun Wang, Jason Fong, Peggy Lai, Shira Rockwitz, Pui Lee, Tsz Man Fion Chan, Ekin Zeynep Altun, Eda Kepenekli, Elif Karakoc-Aydiner, Ahmet Ozen, Perran Boran, Fatih Aygun, Pinar Onal, Ayse Ayzit Kilinc Sakalli, Haluk Cokugras, Metin Gelmez, Fatma Öktelik, Esin Aktaş Cetin, Yuelin Zhong, Maria Taylor, Katherine Irby, Natasha Halasa, Sara Signa, Ignazia Prigione, Marco Gattorno, Nicola Cotugno, Donato Amodio, Raif Geha, Mary Beth Son, Jane Newburger, Pankaj Agrawal, Stefano Volpi, Paolo Palma, Ayca Kiykim, Adrienne Randolph, Gunnur Deniz, Safa Baris, Raffaele De Palma, Klaus Schmitz-Abe, Louis-Marie Charbonnier, Lauren Henderson |
Research square | 2022 |
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 3
L Henderson, S Canna, K Friedman, M Gorelik, S Lapidus, H Bassiri, E Behrens, K Kernan, G Schulert, P Seo, M Son, A Tremoulet, C VanderPluym, R Yeung, A Mudano, A Turner, D Karp, J Mehta |
Arthritis & Rheumatology | 2022 |
Implications of SARS-CoV-2 Infection in Systemic Juvenile Idiopathic Arthritis
L Ailioaie, C Ailioaie, G Litscher |
International journal of molecular sciences | 2022 |
Distinctive Phenotype of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 According to Patients’ Age: A Monocentric Experience
A Giannattasio, F Orlando, C DAnna, S Muzzica, F Angrisani, S Acierno, F Paciello, F Savoia, M Tardi, A Mauro, L Martemucci, V Tipo |
Children | 2022 |
Multisystem inflammatory syndrome in children (MIS-C) possibly secondary to COVID-19 mRNA vaccination
Z Wangu, H Swartz, M Doherty |
BMJ case reports | 2022 |
Multisystem Inflammatory Syndrome and Autoimmune Diseases Following COVID-19: Molecular Mechanisms and Therapeutic Opportunities
P Hosseini, M Fallahi, G Erabi, M Pakdin, S Zarezadeh, A Faridzadeh, S Entezari, A Ansari, M Poudineh, N Deravi |
Frontiers in Molecular Biosciences | 2022 |
Mechanisms of Immune Dysregulation in COVID-19 Are Different From SARS and MERS: A Perspective in Context of Kawasaki Disease and MIS-C
M Dhaliwal, R Tyagi, P Malhotra, P Barman, S Loganathan, J Sharma, K Sharma, S Mondal, A Rawat, S Singh |
Frontiers in Pediatrics | 2022 |
The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections
Hsu RJ, Yu WC, Peng GR, Ye CH, Hu S, Chong PC, Yap KY, Lee JY, Lin WC, Yu SH |
Frontiers in immunology | 2022 |
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4− CD8− Double-Negative T Cells
Hsieh LE, Song J, Grifoni A, Shimizu C, Tremoulet AH, Dummer KB, Burns JC, Sette A, Franco A |
International journal of molecular sciences | 2022 |
The immunopathogenesis of SARS‐CoV‐2 infection in children: diagnostics, treatment and prevention
Patel H, McArdle A, Seaby E, Levin M, Whittaker E |
IBMS BoneKEy | 2022 |
Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic
Ailioaie LM, Ailioaie C, Litscher G, Chiran DA |
International journal of molecular sciences | 2022 |
Extracellular ATP and Imbalance of CD4+ T Cell Compartment in Pediatric COVID-19
Russo C, Raiden S, Algieri S, De Carli N, Davenport C, Sarli M, Bruera MJ, Seery V, Sananez I, Simaz N, Bayle C, Nivela V, Ferrero F, Geffner J, Arruvito L |
Frontiers in Cellular and Infection Microbiology | 2022 |
Effectiveness of BNT162b2 vaccine against SARS-CoV-2 infection and severe COVID-19 in children aged 5–11 years in Italy: a retrospective analysis of January–April, 2022
Sacco C, Del Manso M, Mateo-Urdiales A, Rota MC, Petrone D, Riccardo F, Bella A, Siddu A, Battilomo S, Proietti V, Popoli P, Menniti Ippolito F, Palamara AT, Brusaferro S, Rezza G, Pezzotti P, Fabiani M |
2022 | |
Biomarkers of Endothelial Damage in Distinct Phases of Multisystem Inflammatory Syndrome in Children
Gelzo M, Giannattasio A, Maglione M, Muzzica S, D\u2019Anna C, Scialò F, Gagliardo T, Grieco M, Tipo V, Castaldo G |
Metabolites | 2022 |
Hyperinflammation, apoptosis, and organ damage
Kuypers FA |
Experimental Biology and Medicine | 2022 |
Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells
Hsieh LE, Song J, Tremoulet AH, Burns JC, Franco A |
Clinical & Experimental Immunology | 2022 |
A Diagnosis You Cannot Afford to MIS-C: Multisystem Inflammatory Syndrome in Children Within the Active Duty Population.
Attonito J, Edwards I, Monson M |
2022 | |
Imaging findings in acute pediatric coronavirus disease 2019 (COVID-19) pneumonia and multisystem inflammatory syndrome in children (MIS-C).
Kurian J, Blumfield E, Levin TL, Liszewski MC |
Pediatric Radiology | 2022 |
Severe COVID-19 and Multisystem Inflammatory Syndrome in Children in Children and Adolescents.
Blatz AM, Randolph AG |
Critical Care Clinics | 2022 |
Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP).
Zama D, Baccelli F, Colombini A, Contino A, Calore E, Petris MG, Meneghello L, Mercolini F, Lo Vecchio A, Montalto S, Meazza C, Barone A, Compagno F, Muggeo P, Soncini E, Brescia L, Giraldi E, Giurici N, Mura RM, Cellini M, Perruccio K, Petroni V, La Spina M, Ziino O, Burnelli R, De Santis R, Mascarin M, Barretta V, Tridello G, Cesaro S |
Annals of Hematology | 2022 |
A Mysterious Fever and Retropharyngeal Edema on a Previously Healthy 10-Year-Old Boy Without Known Exposure to COVID-19.
Zhou C, Cheng M, Hong H |
Cureus | 2022 |
COVID-19-associated secondary hemophagocytic lymphohistiocytosis requiring hematopoietic cell transplant.
Greenmyer JR, Wyatt KD, Milanovich S, Kohorst MA, Ferdjallah A |
2022 | |
Complanatuside alleviates inflammatory cell damage induced by pro-inflammatory cytokines in skin keratinocytes
Wang X, Xu X, Wu P, Wu M, Gan L, Jin J, Wu R, Liu W, Zhang K, Li D, Zheng X |
Frontiers in Chemistry | 2022 |
Thromboembolic complications in children with COVID-19 and MIS-C: A narrative review
Trapani S, Rubino C, Lasagni D, Pegoraro F, Resti M, Simonini G, Indolfi G |
Frontiers in Pediatrics | 2022 |
Immunophenotyping of peripheral blood cells allows to discriminate MIS-C and Kawasaki disease
Castaldo A, D\u2019Anna C, Gelzo M, Giannattasio A, Maglione M, Muzzica S, Raia M, Scalia G, Tripodi L, Castaldo G, Tipo V, Grieco D, Grieco M |
Translational Medicine Communications | 2022 |
Hemoadsorption for severe MIS-C in critically ill children, should we consider it as a therapeutic opportunity?
Bottari G, Severini F, Markowich AH, Lorenzetti G, Ruiz Rodriguez JC, Ferrer R, Francalanci P, Ammirati A, Palma P, Cecchetti C |
The International Journal of Artificial Organs | 2022 |
Multisystemic Inflammatory Syndrome in Children, A Disease with Too Many Faces: A Single-Center Experience
Grama A, Căinap SS, Mititelu A, Blag C, Simu C, Burac L, Simionescu B, Mărgescu C, Sur G, Spârchez M, Bota M, Tănasă B, Pop TL |
Journal of Clinical Medicine | 2022 |
Common bone marrow signature in COVID‐19‐associated multisystem inflammatory syndrome in children: A first‐wave small case series experience
De Ioris MA, Scarselli A, Bracaglia C, Perrotta D, Bernardi S, Santilli V, Ceglie G, Fabozzi F, Agrati C, Prencipe G, Alaggio R, Mastronuzzi A, De Vito R |
Pediatric Blood & Cancer | 2022 |
Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome in Children After SARS-CoV-2 Infection
Zambrano LD, Ly KN, Link-Gelles R, Newhams MM, Akande M, Wu MJ, Feldstein LR, Tarquinio KM, Sahni LC, Riggs BJ, Singh AR, Fitzgerald JC, Schuster JE, Giuliano JS Jr, Englund JA, Hume JR, Hall MW, Osborne CM, Doymaz S, Rowan CM, Babbitt CJ, Clouser KN, Horwitz SM, Chou J, Patel MM, Hobbs C, Randolph AG, Campbell AP |
The Pediatric Infectious Disease Journal | 2022 |
MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunity
Gelzo M, Castaldo A, Giannattasio A, Scalia G, Raia M, Esposito MV, Maglione M, Muzzica S, D\u2019Anna C, Grieco M, Tipo V, La Cava A, Castaldo G |
Frontiers in immunology | 2022 |
Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters.
Yuan L, Zhu H, Chen P, Zhou M, Ma J, Liu X, Wu K, Chen R, Liu Q, Yu H, Li L, Wang J, Zhang Y, Ge S, Yuan Q, Tang Q, Cheng T, Guan Y, Xia N |
Cellular & molecular immunology | 2022 |
The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARSCoV2 infection and multisystem inflammatory syndrome in children.
Aurora T, Joseph N, Bhoopalan SV, Caniza MA, Flerlage T, Ghafoor S, Hankins J, Hijano DR, Jesudas R, Kirkham J, Martinez H, Alfaro GM, Sharma A, Hines M |
Haematologica | 2022 |
Drugs for the prevention and treatment of COVID-19 and its complications: An update on what we learned in the past 2 years.
Remuzzi G, Schiaffino S, Santoro MG, FitzGerald GA, Melino G, Patrono C |
Frontiers in pharmacology | 2022 |
Patient-Guided Talking Points to Address COVID-19 and General Vaccine Hesitancy.
Nguyen E, Wright M, Oliphant C, Cleveland K, Holmes J, Nies M, Robinson R |
2022 | |
Clinical and Laboratory Characteristics of Pediatric COVID-19 Population-A Bibliometric Analysis.
Maniu I, Maniu G, Totan M |
Journal of Clinical Medicine | 2022 |
Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications.
Jiang C, Jiang K, Li X, Zhang N, Zhu W, Meng L, Zhang Y, Lu S |
Journal of Pharmaceutical Analysis | 2022 |
Unique Complications of MIS-C and Its Treatment: Encephalopathy in a Child with MIS-C Who Developed Life-Threatening Gastrointestinal Hemorrhage.
Burton L, Manchikalapati A, Rutledge C, Loberger JM, Rockwell N, Cooper J, Lawrence M, Sasser WC |
Case Reports in Critical Care | 2022 |
Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children.
Sinkovits G, Schnur J, Hurler L, Kiszel P, Prohászka ZZ, Sík P, Kajdácsi E, Cervenak L, Maráczi V, Dávid M, Zsigmond B, Rimanóczy É, Bereczki C, Willems L, Toonen EJM, Prohászka Z |
Scientific Reports | 2022 |
The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARS-CoV2 infection and multisystem inflammatory syndrome in children
Aurora T, Joseph N, Bhoopalan SV, Caniza MA, Flerlage T, Ghafoor S, Hankins J, Hijano DR, Jesudas R, Kirkham J, Martinez H, Alfaro GM, Sharma A, Hines M |
Haematologica | 2022 |
Multisystem inflammatory syndrome (MIS-C) with SARS-CoV-2 omicron variant BA.2.38 in a four-year-old Chinese girl: A case report
Wang WY, Wang YJ, An CX, Zhao QJ, Wang SY, Li WY, Yi B, Li H |
Frontiers in public health | 2022 |
Innate immunity, cytokine storm, and inflammatory cell death in COVID-19
Karki R, Kanneganti TD |
Journal of Translational Medicine | 2022 |
Global Coinfections with Bacteria, Fungi, and Respiratory Viruses in Children with SARS-CoV-2: A Systematic Review and Meta-Analysis
Alhumaid S, Alabdulqader M, Al Dossary N, Al Alawi Z, Alnaim AA, Al Mutared KM, Al Noaim K, Al Ghamdi MA, Albahrani SJ, Alahmari AA, Al Hajji Mohammed SM, Almatawah YA, Bayameen OM, Alismaeel AA, Alzamil SK, Alturki SA, Albrahim ZR, Al Bagshi NA, Alshawareb HY, Alhudar JA, Algurairy QA, Alghadeer SM, Alhadab HA, Aljubran TN, Alabdulaly YA, Al Mutair A, Rabaan AA |
Tropical Medicine and Infectious Disease | 2022 |
Circulating sTREM-1 as a predictive biomarker of pediatric multisystemic inflammatory syndrome (MIS-C)
Gonçalves GS, Correa-Silva S, Zheng Y, Avelar I, Montenegro MM, Ferreira AE, Bain V, Fink TT, Suguita P, Astley C, Lindoso L, Martins F, Matsuo OM, Ferreira JC, Firigato I, de Toledo Gonçalves F, Fernanda B. Pereira M, Artur A. da Silva C, Carneiro-Sampaio M, Marques HH, Palmeira P |
Cytokine | 2022 |
Covid-19 infection in children and adolescents and its association with type 1 diabetes mellitus (T1d) presentation and management.
Karavanaki K, Rodolaki K, Soldatou A, Karanasios S, Kakleas K |
Endocrine | 2022 |
Pediatric endocrinopathies related to COVID-19: an update
Memar EH, Mohsenipour R, Sadrosadat ST, Rostami P |
World Journal of Pediatrics | 2022 |
Role of matrix metalloproteinases in multi-system inflammatory syndrome and acute COVID-19 in children
Pavan Kumar N, Venkataraman A, Varadarjan P, Nancy A, Rajamanickam A, Selladurai E, Sankaralingam T, Thiruvengadam K, Selvam R, Thimmaiah A, Natarajan S, Ramaswamy G, Putlibai S, Sadasivam K, Sundaram B, Hissar S, Ranganathan UD, Nutman TB, Babu S |
Frontiers in Medicine | 2022 |
Methylprednisolone pulses as an initial treatment in hyperinflammatory syndrome after COVID-19 in children: evaluation of laboratory data, serial echocardiography and outcome: a case series
Sadeghi P, Gorji M, Assari R, Tahghighi F, Raeeskarami SR, Ziaee V |
Intensive Care Medicine Experimental | 2022 |
Multisystem inflammatory syndrome in children (MIS‐C) and the prothrombotic state: Coagulation profiles and rotational thromboelastometry in a MIS‐C cohort
Al\u2010Ghafry M, Vagrecha A, Malik M, Levine C, Uster E, Aygun B, Appiah\u2010Kubi A, Vlachos A, Capone CA, Rajan S, Palumbo N, Misra N, Mitchell EC, Wolfe LC, Lipton JM, Shore\u2010Lesserson L, Acharya SS |
Journal of Thrombosis and Haemostasis | 2022 |
Similarities and differences between the immunopathogenesis of COVID-19-related pediatric inflammatory multisystem syndrome and Kawasaki disease
Ana Esteve-Sole, Jordi Anton, Rosa M Pino-Ramírez, Judith Sanchez-Manubens, Victoria Fumadó, Clàudia Fortuny, María Rios-Barnes, Joan Sanchez-de-Toledo, Mónica Girona-Alarcón, Juan M. Mosquera, Silvia Ricart, Cristian Launes, Mariona F de Sevilla, Cristina Jou, Carmen Muñoz-Almagro, Eva González-Roca, Andrea Vergara, Jorge Carrillo, Manel Juan, Daniel Cuadras, Antoni Noguera-Julian, Iolanda Jordan, Laia Alsina- |
Journal of Clinical Investigation | 2021 |
Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C
Yanfang P. Zhu, Isaac Shamie, Jamie Casey Lee, Cameron J Nowell, Weiqi Peng, Shiela Angulo, Linh N. Le, Yushan Liu, Huilai Miao, Hainan Xiong, Cathleen J Pena, Elizabeth Moreno, Eric Griffis, Stephanie Labou, Alessandra Franco, Lori Broderick, Hal M. Hoffman, Chisato Shimizu, Nathan E Lewis, John T. Kanegaye, Adriana Tremoulet, Jane C. Burns, Ben A Croker |
Journal of Clinical Investigation | 2021 |
Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
FA Kuypers, CA Rostad, EJ Anderson, A Chahroudi, P Jaggi, J Wrammert, G Mantus, R Basu, F Harris, B Hanberry, A Camacho-Gonzalez, S Manoranjithan, M Vos, LA Brown, CR Morris |
Experimental biology and medicine (Maywood, N.J.) | 2021 |
Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children
NP Kumar, A Venkataraman, LE Hanna, S Putlibai, M Karthick, A Rajamanikam, K Sadasivam, B Sundaram, S Babu |
Open Forum Infectious Diseases | 2021 |
The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
E Syrimi, E Fennell, A Richter, P Vrljicak, R Stark, S Ott, PG Murray, E Al-Abadi, A Chikermane, P Dawson, S Hackett, D Jyothish, HK Kanthimathinathan, S Monaghan, P Nagakumar, BR Scholefield, S Welch, N Khan, S Faustini, K Davies, WM Zelek, P Kearns, GS Taylor |
iScience | 2021 |
Characterization of SARS‐CoV‐2 and common cold coronavirus‐specific T‐cell responses in MIS‐C and Kawasaki disease children
LE Hsieh, A Grifoni, J Sidney, C Shimizu, H Shike, N Ramchandar, E Moreno, AH Tremoulet, JC Burns, A Franco |
European Journal of Immunology | 2021 |
Upregulation of Conventional Dendritic Cells type 1 (cDC1) implicates antigen cross presentation in Multisystem Inflammatory Syndrome (MIS-C)
JJ Huang, SB Gaines, ML Amezcua, TR Lubell, PS Dayan, M Dale, AD Boneparth, MD Hicar, R Winchester, M Gorelik |
Journal of Allergy and Clinical Immunology | 2021 |
Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction
C Diorio, R Shraim, LA Vella, JR Giles, AE Baxter, DA Oldridge, SW Canna, SE Henrickson, KO McNerney, F Balamuth, C Burudpakdee, J Lee, T Leng, A Farrel, MP Lambert, KE Sullivan, EJ Wherry, DT Teachey, H Bassiri, EM Behrens |
Nature Communications | 2021 |
The cytokine storm and thyroid hormone changes in COVID-19
L Croce, D Gangemi, G Ancona, F Liboà, G Bendotti, L Minelli, L Chiovato |
Journal of Endocrinological Investigation | 2021 |
The up‐to‐date pathophysiology of Kawasaki disease
T Hara, K Yamamura, Y Sakai |
IBMS BoneKEy | 2021 |
DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia
LK Lam, S Murphy, D Kokkinaki, A Venosa, S Sherrill-Mix, C Casu, S Rivella, A Weiner, J Park, S Shin, AE Vaughan, BH Hahn, AR John, NJ Meyer, CA Hunter, GS Worthen, NS Mangalmurti |
Science Translational Medicine | 2021 |
Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers
V Seery, SC Raiden, SC Algieri, NA Grisolía, D Filippo, ND Carli, SD Lalla, H Cairoli, MJ Chiolo, CN Meregalli, LI Gimenez, G Gregorio, M Sarli, AL Alcalde, C Davenport, MJ Bruera, N Simaz, MF Pérez, V Nivela, C Bayle, P Tuccillo, MT Agosta, H Pérez, SV Nova, P Suárez, EM Takata, M García, J Lattner, MJ Rolón, P Coll, I Sananez, MP Holgado, F Ferrero, J Geffner, L Arruvito |
EBioMedicine | 2021 |
Eosinophil extracellular traps drive asthma progression through neuro-immune signals
Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su |
Nature Cell Biology | 2021 |
Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients
E Balestrieri, A Minutolo, V Petrone, M Fanelli, M Iannetta, V Malagnino, M Zordan, P Vitale, B Charvet, B Horvat, S Bernardini, E Garaci, P di Francesco, PS Vallebona, L Sarmati, S Grelli, M Andreoni, H Perron, C Matteucci |
EBioMedicine | 2021 |
COVID19 and acute lymphoblastic leukemias of children and adolescents: Updated recommendations (Version 2) of the Leukemia Committee of the French Society for the fight against Cancers and leukemias in children and adolescents (SFCE)
J Rouger-Gaudichon, Y Bertrand, N Boissel, B Brethon, S Ducassou, V Gandemer, C Halfon-Domenech, T Leblanc, G Leverger, G Michel, A Petit, AF Ray-Lunven, PS Rohrlich, P Schneider, N Sirvent, M Strullu, A Baruchel |
B CANCER | 2021 |
Embryonic Origin and Subclonal Evolution of Tumor-Associated Macrophages Imply Preventive Care for Cancer
XM Zhang, DG Chen, SC Li, B Zhu, ZJ Li |
Cells | 2021 |
Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children
MR Chen, HC Kuo, YJ Lee, H Chi, SC Li, HC Lee, KD Yang |
Frontiers in immunology | 2021 |
Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2
S Esposito, N Principi |
Pediatric Drugs | 2021 |
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
LA Vella, JR Giles, AE Baxter, DA Oldridge, C Diorio, L Kuri-Cervantes, C Alanio, MB Pampena, JE Wu, Z Chen, YJ Huang, EM Anderson, S Gouma, KO McNerney, J Chase, C Burudpakdee, JH Lee, SA Apostolidis, AC Huang, D Mathew, O Kuthuru, EC Goodwin, ME Weirick, MJ Bolton, CP Arevalo, A Ramos, CJ Jasen, PE Conrey, S Sayed, HM Giannini, K DAndrea, NJ Meyer, EM Behrens, H Bassiri, SE Hensley, SE Henrickson, DT Teachey, MR Betts, EJ Wherry |
Science Immunology | 2021 |
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C
L Hoste, L Roels, L Naesens, V Bosteels, S Vanhee, S Dupont, C Bosteels, R Browaeys, N Vandamme, K Verstaen, J Roels, K Damme, B Maes, E Leeuw, J Declercq, H Aegerter, L Seys, U Smole, S Prijck, M Vanheerswynghels, K Claes, V Debacker, G Isterdael, L Backers, K Claes, P Bastard, E Jouanguy, S Zhang, G Mets, J Dehoorne, K Vandekerckhove, P Schelstraete, J Willems, J Willekens, H Schaballie, S daele, L Dierickx, S David, E Dhont, A Verrijckt, A de Jaeger, E Beel, I Matthijs, A Minne, K Decaestecker, J John, T Crijnen, M Koninckx, J Verbruggen, G Nys, S Akhnikh, K Vanlede, A Coppens, J Thijs, I Ryckaert, A Covents, E Duval, A Verschelde, L Keyzer, T Ackere, A Verbist, C Daeze, C Becue, J Paepe, J Keepers, B Bruylants, S Kuypers, S Daelemans, J van der Werff ten Bosch, G van Berlaer, A Dreesman, B Florkin, C Heijmans, J Papadopoulos, P Stordeur, S Janssens, R Beyaert, Y Saeys, J Casanova, B Lambrecht, F Haerynck, S Tavernier |
Journal of Experimental Medicine | 2021 |
A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children
I Sananez, SC Raiden, SC Algieri, M Uranga, NA Grisolía, D Filippo, ND Carli, SD Lalla, H Cairoli, MJ Chiolo, CN Meregalli, E Cohen, G Mosquera, MM del Pont, LI Giménez, G Gregorio, M Sarli, AL Alcalde, C Davenport, MJ Bruera, N Simaz, MF Pérez, V Nivela, C Bayle, L Alvarez, M Revetria, P Tuccillo, MT Agosta, H Pérez, SV Nova, P Suárez, EM Takata, M García, J Lattner, MJ Rolón, P Coll, M Salvatori, C Piccardo, C Russo, A Varese, V Seery, MP Holgado, ML Polo, A Ceballos, M Nuñez, JM Penedo, F Ferrero, J Geffner, L Arruvito |
EBioMedicine | 2021 |
The Journal of Clinical Investigation in the time of COVID-19
A Casadevall, S Jackson, GL Semenza, GF Tomaselli, RS Ahima |
Journal of Clinical Investigation | 2021 |
The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved
F Coperchini, L Chiovato, G Ricci, L Croce, F Magri, M Rotondi |
Cytokine & Growth Factor Reviews | 2021 |
The intersection of COVID-19 and autoimmunity: What is our current understanding?
NE Winchester, C Calabrese, L Calabrese |
Pathogens and Immunity | 2021 |
Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research
PA Verhoef, S Kannan, JL Sturgill, EW Tucker, PE Morris, AC Miller, TR Sexton, JL Koyner, R Hejal, SC Brakenridge, LL Moldawer, RS Hotchkiss, TM Blood, MB Mazer, S Bolesta, SA Alexander, DL Armaignac, SL Shein, C Jones, CD Hoemann, A Doctor, SH Friess, RI Parker, AT Rotta, KE Remy |
2021 | |
Consequences of coronavirus infections for primitive and mature hematopoietic cells: new insights and why it matters
J Ropa, T Trinh, A Aljoufi, HE Broxmeyer |
Current Opinion in Hematology | 2021 |
Immune response to SARS‐CoV‐2 in children: A review of the current knowledge
F Filippatos, EB Tatsi, A Michos |
2021 | |
Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure
HM Rando, AL MacLean, AJ Lee, R Lordan, S Ray, V Bansal, AN Skelly, E Sell, JJ Dziak, L Shinholster, LD McGowan, MB Guebila, N Wellhausen, S Knyazev, SM Boca, S Capone, Y Qi, YS Park, D Mai, Y Sun, JD Boerckel, C Brueffer, JB Byrd, JP Kamil, J Wang, R Velazquez, GL Szeto, JP Barton, RR Goel, S Mangul, T Lubiana, A Gitter, CS Greene, JA Gilbert |
mSystems | 2021 |
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children
A Ramaswamy, NN Brodsky, TS Sumida, M Comi, H Asashima, KB Hoehn, N Li, Y Liu, A Shah, NG Ravindra, J Bishai, A Khan, W Lau, B Sellers, N Bansal, P Guerrerio, A Unterman, V Habet, AJ Rice, J Catanzaro, H Chandnani, M Lopez, N Kaminski, CS Cruz, JS Tsang, Z Wang, X Yan, SH Kleinstein, D van Dijk, RW Pierce, DA Hafler, CL Lucas |
Immunity | 2021 |
Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India
A Venkataraman, NP Kumar, LE Hanna, S Putlibai, M Karthick, A Rajamanikam, K Sadasivam, B Sundaram, S Babu |
EBioMedicine | 2021 |
Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Children: One Year after the Onset of the Pandemic in a High-Incidence Area
M Fabi, E Filice, C Biagi, L Andreozzi, D Palleri, BE Mattesini, A Rizzello, L Gabrielli, C Ghizzi, DD Luca, F Caramelli, AD Fanti, M Lanari |
Viruses | 2021 |
Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison
C Sharma, M Ganigara, C Galeotti, J Burns, FM Berganza, DA Hayes, D Singh-Grewal, S Bharath, S Sajjan, J Bayry |
Nature Reviews Rheumatology | 2021 |
Humoral signatures of protective and pathological SARS-CoV-2 infection in children
YC Bartsch, C Wang, T Zohar, S Fischinger, C Atyeo, JS Burke, J Kang, AG Edlow, A Fasano, LR Baden, EJ Nilles, AE Woolley, EW Karlson, AR Hopke, D Irimia, ES Fischer, ET Ryan, RC Charles, BD Julg, DA Lauffenburger, LM Yonker, G Alter |
Nature Medicine | 2021 |
Immunotherapy of multisystem inflammatory syndrome in children (MIS-C) following COVID-19 through mesenchymal stem cells
W Suksatan, S Chupradit, AV Yumashev, S Ravali, MN Shalaby, YF Mustafa, A Kurochkin, H Siahmansouri |
International Immunopharmacology | 2021 |
Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection
AZ Berna, EH Akaho, RM Harris, M Congdon, E Korn, S Neher, M MFarrej, J Burns, AR John |
ACS Infectious Diseases | 2021 |
Learning about Kawasaki disease from COVID-19 and the Multisystem Inflammatory Syndrome in Children
M Gorelik |
Current Opinion in Pediatrics | 2021 |
Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children
GS Schulert, SA Blum, RQ Cron |
Current Opinion in Pediatrics | 2021 |
Current Understanding of Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 and Its Distinction from Kawasaki Disease
H Bukulmez |
Current Rheumatology Reports | 2021 |
Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation
TM Bigley, MA Cooper |
Current Opinion in Immunology | 2021 |
PIMS-TS, the New Paediatric Systemic Inflammatory Disease Related to Previous Exposure to SARS-CoV-2 Infection—“Rheumatic Fever” of the 21st Century?
V Opoka-Winiarska, E Grywalska, J Roliński |
International journal of molecular sciences | 2021 |
IgG Epitopes Processed and Presented by IgG + B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells
LE Hsieh, J Sidney, JC Burns, DL Boyle, GS Firestein, Y Altman, A Sette, A Franco |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data
TP Vogel, KA Top, C Karatzios, DC Hilmers, LI Tapia, P Moceri, L Giovannini-Chami, N Wood, RE Chandler, NP Klein, EP Schlaudecker, MC Poli, E Muscal, FM Munoz |
Vaccine | 2021 |
Current Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome in Children
LA Vella, AH Rowley |
Current Pediatrics Reports | 2021 |
Cardiovascular Magnetic Resonance for Patients With COVID-19
SE Petersen, MG Friedrich, T Leiner, MD Elias, VM Ferreira, M Fenski, SD Flamm, M Fogel, R Garg, MK Halushka, AG Hays, N Kawel-Boehm, CM Kramer, E Nagel, NA Ntusi, E Ostenfeld, DJ Pennell, Z Raisi-Estabragh, SB Reeder, CE Rochitte, J Starekova, D Suchá, Q Tao, J Schulz-Menger, DA Bluemke |
JACC: Cardiovascular Imaging | 2021 |
Immune determinants of COVID-19 disease presentation and severity
P Brodin |
Nature Medicine | 2021 |
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
V Sancho-Shimizu, P Brodin, A Cobat, CM Biggs, J Toubiana, CL Lucas, SE Henrickson, A Belot, E Haddad, K Beland, A Pujol, A Schlüter, L Planas-Serra, S Aguilera-Albesa, J Valencia-Ramos, A Rodríguez-Palmero, M Gut, JG Rivière, R Colobran, P Soler-Palacin, C Rodriguez-Gallego, RP Diego, C Flores, L Alsina, D Blazquez-Gamero, I Jordan, S Keles, M Emiroglu, OM Akcan, G Alkan, SE Aytekin, Y Gul, ŞK Öz, SE Bozdemir, GI Bayhan, SK Yüksek, AÖ Parlakay, B Gülhan, A Yahşi, AO Kilic, A Karbuz, EH Erdeniz, EA Özkan, Z Orbak, Ş Aydemir, JB Celik, B Kandemir, G Aytekin, H Kapakli, V Yarar, A Yosunkaya, H Vatansev, C Aytekin, SH Torun, S Nepesov, T Coskuner, B Sözeri, YK Demirkol, O Kasapcopur, M Yıldız, E Sevketoglu, N Hatipoğlu, T Özçelik, O Yesilbas, ZG Aydin, A Sediva, A Klocperk, M Bloomfield, I Meyts, S Delafontaine, F Haerynck, L Hoste, M Shahrooei, L Marque, JF Neves, G Novelli, A Novelli, A Aiuti, G Casari, AA Bousfiha, SZ Almuhsen, A Sobh, A Gagro, F Bajolle, D Bonnet, P Lebon, W Lei, D Lee, Y Seeleuthner, P Zhang, M Maglorius, Q Philippot, S Pelham, P Bastard, Q Zhang, E Jouanguy, A Puel, J Herberg, TW Kuijpers, E Bellos, M Kaforou, S Menikou, Q Pan-Hammarström, L Hammarström, H Abolhassani, Y Bryceson, A Condino-Neto, C Prando, SY Bando, A Cavalcanti, J Fellay, G Blanchard-Rohner, D Mansouri, S Mahmoudi, O Boyarchuk, A Volokha, A Bondarenko, Y Stepanovskiy, T Mogensen, D van de Beek, E Andreakos, M Papadaki, AA Tayoun, R Halwani, F Al-Mulla, JL Franco, YL Lau, M Kwan, K Imai, S Okada, A Bolze, MJ Butte, E Hsieh, BA Drolet, L Arkin, Y Itan, T Maniatis, M Arditi, M Cooper, E Schmitt, S Chakravorty, MS Anderson, HC Su, LD Notarangelo, SG Tangye, JD Milner, M Levin, L Abel, D Bogunovic, JL Casanova, SY Zhang |
Journal of Experimental Medicine | 2021 |
Pediatric COVID-19: Immunopathogenesis, Transmission and Prevention
G Blanchard-Rohner, A Didierlaurent, A Tilmanne, P Smeesters, A Marchant |
Human vaccines | 2021 |
MultiInflammatory Syndrome in Children: A View into Immune Pathogenesis from a Laboratory Perspective
MK Bohn, P Yousef, S Steele, L Sepiashvili, K Adeli |
2021 | |
Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children With Acute Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome With Similar Levels of Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 Shedding
NP Akindele, T Kouo, AH Karaba, O Gordon, KZ Fenstermacher, J Beaudry, JH Rubens, CC Atik, W Zhou, H Ji, X Tao, D Vaidya, H Mostafa, P Caturegli, PW Blair, L Sauer, AL Cox, D Persaud |
The Journal of Infectious Diseases | 2021 |
Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study
JJ Rodriguez-Smith, EL Verweyen, GM Clay, YM Esteban, SR de Loizaga, EJ Baker, T Do, S Dhakal, SM Lang, AA Grom, D Grier, GS Schulert |
2021 | |
SARS-CoV-2 and the Brain: What Do We Know about the Causality of ‘Cognitive COVID?
HA Awan, MN Diwan, A Aamir, M Ali, MD Giannantonio, I Ullah, S Shoib, DD Berardis |
Journal of Clinical Medicine | 2021 |
ABO blood types and sepsis mortality
TS Itenov, DI Sessler, AK Khanna, SR Ostrowski, PI Johansson, C Erikstrup, OB Pedersen, SL Rygård, LB Holst, MH Bestle, L Hein, A Lindhardt, H Tousi, MH Andersen, T Mohr, JD Lundgren, JU Jensen |
Annals of Intensive Care | 2021 |
Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis
JG Wang, ZJ Zhong, M Li, J Fu, YH Su, YM Ping, ZJ Xu, H Li, YH Chen, YL Huang, D Zheng |
Biochemistry Research International | 2021 |
Best Practice Recommendations for the Diagnosis and Management of Children With Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 (PIMS-TS; Multisystem Inflammatory Syndrome in Children, MIS-C) in Switzerland
LJ Schlapbach, MC Andre, S Grazioli, N Schöbi, N Ritz, C Aebi, P Agyeman, M Albisetti, DG Bailey, C Berger, G Blanchard-Rohner, S Bressieux-Degueldre, M Hofer, AG L'Huillier, M Marston, PM Sauteur, JP Schmid, MH Perez, B Rogdo, J Trück, A Woerner, D Wütz, P Zimmermann, M Levin, E Whittaker, PC Rimensberger |
Frontiers in Pediatrics | 2021 |
Progress in the Diagnosis and Treatment of COVID-19 in Children: A Review
L Wang, G Li, C Yuan, Y Yang, G Ling, J Zheng, Y Zhou, T Zhang, W Lin, Z Lin |
International journal of general medicine | 2021 |
COVID-19 in Pediatrics
SM Case, MB Son |
Rheumatic diseases clinics of North America | 2021 |
The clinical course and short-term health outcomes of multisystem inflammatory syndrome in children in the single pediatric rheumatology center
B Sözeri, Ş Çağlayan, V Atasayan, K Ulu, T Coşkuner, ÖP Akbay, CH Akkuş, G Atay, E Salı, M Karacan, T Öner, S Erdoğan, F Demir |
Postgraduate Medicine | 2021 |
Differences and similarities of multisystem inflammatory syndrome in children, Kawasaki disease and macrophage activating syndrome due to systemic juvenile idiopathic arthritis: a comparative study
GO Yener, AP Kısaarslan, K Ulu, E Atalay, F Haşlak, S Özdel, BB Yücel, DG Yıldırım, F Çakmak, K Öztürk, M Çakan, Z Balık, CH Akkuş, M Yıldız, T Erat, BŞ Çetin, M Yılmaz, E Bağlan, SL Gürlevik, V Atasayan, ŞG Karadağ, A Adrovic, Ş Çağlayan, A Tanatar, FG Demirkan, T Coşkuner, Ö Akgün, MK Cüceoğlu, GK Kayaalp, S Şahin, Ö Başaran, F Demir, K Barut, M Çiftel, D Gürses, A Baykan, Y Özsürekçi, T Karagöz, HE Sönmez, Y Bilginer, NA Ayaz, Ö Aydoğ, S Yüksel, B Sözeri, Ö Kasapçopur, S Özen |
Rheumatology International | 2021 |
Skewed Cytokine Responses Rather Than the Magnitude of the Cytokine Storm May Drive Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children
JC Chang, D Matsubara, RW Morgan, C Diorio, S Nadaraj, DT Teachey, H Bassiri, EM Behrens, A Banerjee |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2021 |
Clinical features of multisystem inflammatory syndrome in children
JE Roberts, LA Henderson |
Current Opinion in Rheumatology | 2021 |
Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease
MS Lee, YC Liu, CC Tsai, JH Hsu, JR Wu |
Frontiers in Pediatrics | 2021 |
Ocular and Systemic Manifestations in Paediatric Multisystem Inflammatory Syndrome Associated with COVID-19
TC Lo, YY Chen |
Journal of Clinical Medicine | 2021 |
The impact of the COVID-19 pandemic on the field of pediatric rheumatology
DM Wahezi, M Peskin, T Tanner |
Current Opinion in Rheumatology | 2021 |
Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes
MB Son, N Murray, K Friedman, CC Young, MM Newhams, LR Feldstein, LL Loftis, KM Tarquinio, AR Singh, SM Heidemann, VL Soma, BJ Riggs, JC Fitzgerald, M Kong, S Doymaz, JS Giuliano, MA Keenaghan, JR Hume, CV Hobbs, JE Schuster, KN Clouser, MW Hall, LS Smith, SM Horwitz, SP Schwartz, K Irby, TT Bradford, AB Maddux, CJ Babbitt, CM Rowan, GE McLaughlin, PH Yager, M Maamari, EH Mack, CL Carroll, VL Montgomery, NB Halasa, NZ Cvijanovich, BM Coates, CE Rose, JW Newburger, MM Patel, AG Randolph |
New England Journal of Medicine | 2021 |
Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis
Y Zhao, J Patel, Y Huang, L Yin, L Tang |
The American Journal of Emergency Medicine | 2021 |
Management of COVID-19-associated multisystem inflammatory syndrome in children: A comprehensive literature review
A Kiss, PM Ryan, T Mondal |
Progress in Pediatric Cardiology | 2021 |
The inflammatory markers of multisystem inflammatory syndrome in children (MIS‐C) and adolescents associated with COVID‐19: A meta‐analysis
Y Zhao, L Yin, J Patel, L Tang, Y Huang |
Journal of Medical Virology | 2021 |
Acute kidney injury in pediatric patients hospitalized with acute COVID-19 and multisystem inflammatory syndrome in children associated with COVID-19
A Basalely, S Gurusinghe, J Schneider, SS Shah, LB Siegel, G Pollack, P Singer, LJ Castellanos-Reyes, S Fishbane, KD Jhaveri, E Mitchell, K Merchant, C Capone, AM Gefen, J Steinberg, CB Sethna |
Kidney International | 2021 |
Multisystem inflammatory syndrome in children related to COVID-19: a systematic review
L Hoste, RV Paemel, F Haerynck |
European Journal of Pediatrics | 2021 |
The JANUS of chronic inflammatory and autoimmune diseases onset during COVID-19 – A systematic review of the literature
L Novelli, F Motta, MD Santis, AA Ansari, ME Gershwin, C Selmi |
Journal of Autoimmunity | 2021 |
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 2
LA Henderson, SW Canna, KG Friedman, M Gorelik, SK Lapidus, H Bassiri, EM Behrens, A Ferris, KF Kernan, GS Schulert, P Seo, MB Son, AH Tremoulet, RS Yeung, AS Mudano, AS Turner, DR Karp, JJ Mehta |
Arthritis & Rheumatology | 2021 |
Discriminating Multisystem Inflammatory Syndrome in Children Requiring Treatment from Common Febrile Conditions in Outpatient Settings
RF Carlin, AM Fischer, Z Pitkowsky, D Abel, TB Sewell, EG Landau, S Caddle, L Robbins-Milne, A Boneparth, JD Milner, EW Cheung, P Zachariah, MS Stockwell, BR Anderson, M Gorelik |
The Journal of Pediatrics | 2021 |
Pathophysiology and Clinical Presentation of COVID-19 in Children: Systematic Review of the Literature
G Vidya, M Kalpana, K Roja, John Ashok Nitin, Madhuri Taranikanti |
Mædica | 2021 |
Pediatric COVID-19 Therapeutics: Seizing the Right Research and Development Opportunities to Accelerate Access for Children
S Morin, M Lallemant, A Garcia-Prats, L Lewis, M Watkins, C Giaquinto, M Valentin, M Penazzato, JC Reeder |
The Pediatric Infectious Disease Journal | 2021 |
The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)
S Panaro, M Cattalini |
Frontiers in Medicine | 2021 |
SARS‐CoV‐2 infection coincident with newly diagnosed severe aplastic anemia: A report of two cases
R Chakravarthy, ML Murphy, MA Thompson, HL McDaniel, S ZarnegarLumley, SC Borinstein |
Pediatric Blood & Cancer | 2021 |
Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Children and Expectant Mothers With Inflammatory Bowel Disease
EI Benchimol, MW Carroll, R Geist, AM Griffiths, JG Huang, DR Mack, CN Bernstein, A Bitton, JL Jones, GG Kaplan, ME Kuenzig, K Lee, MS Mukhtar, SK Murthy, P Tandon, LE Targownik, JW Windsor, CH Seow |
2021 | |
Severe acute respiratory syndrome coronavirus 2 and respiratory syncytial virus coinfection in children
M Zandi, S Soltani, M Fani, S Abbasi, S Ebrahimi, A Ramezani |
Osong Public Health and Research Perspectives | 2021 |
Worldwide epidemiology of neuro-coronavirus disease in children: lessons for the next pandemic
AM Alcamo, JL McGuire, HK Kanthimathinathan, JD Roa, EL Fink |
Current Opinion in Pediatrics | 2021 |
Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection
S Dholariya, DN Parchwani, R Singh, M Radadiya, CD Katoch |
Indian Journal of Clinical Biochemistry | 2021 |
Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Following COVID-19
EY Wu, MJ Campbell |
Current Cardiology Reports | 2021 |
SARS-CoV-2 multisystem inflammatory syndrome in an adult presenting with polyarthritis treated with anakinra
V Chalasani, P Parameswaran, A Cherico, V Villgran, H Lowther, J Marco |
Rheumatology | 2021 |
Acute Kidney Injury in Pediatric Acute SARS-CoV-2 Infection and Multisystem Inflammatory Syndrome in Children (MIS-C): Is There a Difference?
MK Grewal, MJ Gregory, A Jain, D Mohammad, K Cashen, JY Ang, RL Thomas, RP Valentini |
Frontiers in Pediatrics | 2021 |
Performance of Cytokine Storm Syndrome Scoring Systems in Pediatric COVID‐19 and Multisystem Inflammatory Syndrome in Children
DD Reiff, RQ Cron |
2021 | |
Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry
US Bhalala, KM Gist, S Tripathi, K Boman, VK Kumar, L Retford, K Chiotos, AM Blatz, H Dapul, S Verma, IA Sayed, VP Gharpure, E Bjornstad, N Tofil, K Irby, RC Sanders, JA Heneghan, M Thomas, MK Gupta, FE Oulds, GM Arteaga, ER Levy, N Gupta, M Kaufman, A Abdelaty, M Shlomovich, SS Medar, AM OMeara, J Kuehne, S Menon, PB Khandhar, AS Miller, SM Barry, VC Danesh, AK Khanna, K Zammit, C Stulce, PW McGonagill, A Bercow, IG Amzuta, S Gupta, MA Almazyad, L Pierre, P Sendi, S Ishaque, HL Anderson, P Nawathe, M Akhter, PG Lyons, C Chen, AJ Walkey, A Bihorac, IW Bello, JB Ari, T Kovacevic, V Bansal, JT Brinton, JJ Zimmerman, R Kashyap |
Critical Care Medicine | 2021 |
Thrombotic risk in children with COVID-19 infection: A systematic review of the literature
M Zaffanello, G Piacentini, L Nosetti, S Ganzarolli, M Franchini |
Thrombosis Research | 2021 |
SARS‐CoV‐2 infection and paediatric endocrine disorders: Risks and management considerations
R Miller, AP Ashraf, E Gourgari, A Gupta, MK Kamboj, B Kohn, A Lahoti, D Mak, S Mehta, D Mitchell, N Patel, V Raman, DG Reynolds, C Yu, S Krishnan |
2021 | |
Assessing the utility of screening electrocardiograms in paediatric patients following COVID-19
AJ Gartenberg, TJ White, K Dang, M Shah, SM Paridon, MD Elias |
Cardiology in the Young | 2021 |
Efficacy of CytoSorb in a Pediatric Case of Severe Multisystem Infammatory Syndrome (MIS-C): A Clinical Case Report
G Bottari, V Confalone, N Cotugno, I Guzzo, S Perdichizzi, EC Manno, F Stoppa, C Cecchetti |
Frontiers in Pediatrics | 2021 |
Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study
ES Goudouris, F Pinto-Mariz, LO Mendonça, CS Aranda, RR Guimarães, C Kokron, MT Barros, F Anísio, ML Alonso, F Marcelino, SO Valle, SD Junior, ID Barreto, JF Ferreira, P Roxo-Junior, AM do Rego Silva, FL Campinhos, C Bonfim, G Loth, JF Fernandes, JL Garcia, A Capelo, OA Takano, MI Nadaf, EC Toledo, LA Cunha, RS Gesu, L Schidlowski, P Fillipo, DC Bichuetti-Silva, G Soldateli, NR Ferraroni, E de Oliveira Dantas, S Pestana, E Mansour, RG Ulaf, C Prando, A Condino-Neto, AS Grumach |
Journal of Clinical Immunology | 2021 |
Multisystem Inflammatory Syndrome in Children and COVID-19 Infections
MW Bultas, K Fuller |
NASN School Nurse | 2021 |
Characteristics and Outcomes of Pediatric COVID-19 Patients in Osaka, Japan
Y Katayama, L Zha, T Kitamura, A Hirayama, T Takeuchi, K Tanaka, S Komukai, T Shimazu, T Sobue |
International journal of environmental research and public health | 2021 |
Multisystem inflammatory syndrome in children during the coronavirus disease pandemic of 2019: a review of clinical features and acute phase management
N Shioji, K Aoyama, M Englesakis, G Annich, JT Maynes |
Journal of Anesthesia | 2021 |
Case Report: Successful Response to Intravenous Immunoglobulin and Steroid Pulses in a Renal Transplant Recipient With Severe Covid-19 Disease and Associated Acute Allograft Failure
P Rosa-Guerrero, A Trujillo-Aguilera, J Molina, A Navas, C López-Martín, A Jurado, A Rodríguez-Benot, Á Torres-De-Rueda |
Frontiers in immunology | 2021 |
Successful Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 (PIMS-TS) with Split Doses of Immunoglobulin G and Estimation of PIMS-TS Incidence in a County District in Southern Germany
G Wehl, J Franke, M Frühwirth, M Edlinger, M Rauchenzauner |
Healthcare | 2021 |
Systemic and organ-specific immune-related manifestations of COVID-19
M Ramos-Casals, P Brito-Zerón, X Mariette |
Nature Reviews Rheumatology | 2021 |
Multisystem inflammatory syndrome in children: a microcosm of challenges and opportunities for translational bioinformatics in pediatric research
LM Jones, P Khatri |
Current Opinion in Pediatrics | 2021 |
COVID‐19 infection in a pediatric kidney transplant population: A single‐center experience
PS Singer, C Sethna, E Molmenti, A Fahmy, E Grodstein, L CastellanosReyes, J Fassano, L Teperman |
Pediatric Transplantation | 2021 |
La place des enfants dans la pandémie et le rôle de la COVID-19 dans leur vie
A Zaloszyc, M Tsimaratos |
Néphrologie & Thérapeutique | 2021 |
Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis
SJ Si, SK Tasian, H Bassiri, BT Fisher, J Atalla, R Patel, N Romberg, MP Lambert, M Paessler, EJ Behrens, DT Teachey, KE Sullivan |
Journal of Clinical Immunology | 2021 |
Therapeutic approaches to pediatric COVID-19: an online survey of pediatric rheumatologists
A Janda, C Schuetz, S Canna, M Gorelik, M Heeg, K Minden, C Hinze, A Schulz, KM Debatin, CM Hedrich, F Speth |
Rheumatology International | 2021 |
Distinguishing active pediatric COVID-19 pneumonia from MIS-C
DD Reiff, ML Mannion, N Samuy, P Scalici, RQ Cron |
Pediatric Rheumatology | 2021 |
Managing children with brain tumors during the COVID-19 era: Don’t stop the care!
MA Capozza, S Triarico, G Attinà, A Romano, S Mastrangelo, P Maurizi, P Frassanito, F Bianchi, T Verdolotti, M Gessi, M Balducci, L Massimi, G Tamburrini, A Ruggiero |
Computational and Structural Biotechnology Journal | 2021 |
Alteration of Auto-CPAP requirements in obstructive sleep apnea patients with COVID-19 history
V Fidan, H Koyuncu, O Akin |
American Journal of Otolaryngology | 2021 |
SARS-CoV-2-associated multisystem inflammatory syndrome in children: clinical manifestations and the role of infliximab treatment
N Abdel-Haq, BI Asmar, MP Leon, EJ McGrath, HS Arora, K Cashen, B Tilford, AC Eddine, U Sethuraman, JY Ang |
European Journal of Pediatrics | 2021 |
Kawasaki or Kawasaki-like disease? A debate on COVID-19 infection in children
MS Hosseini |
Clinical Immunology | 2021 |
Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis
BK Tsankov, JM Allaire, MA Irvine, AA Lopez, LJ Sauvé, BA Vallance, K Jacobson |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | 2021 |
MIS-C: post-infectious syndrome or persistent infection?
M Schwartz |
The Lancet Infectious Diseases | 2021 |
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