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Ildefonso Sánchez-Cerrillo, … , Enrique Martín-Gayo, the REINMUN-COVID and EDEPIMIC groups
Published August 12, 2020
Citation Information: J Clin Invest. 2020;130(12):6290-6300. https://doi.org/10.1172/JCI140335.
Citation Information: J Clin Invest. 2020;130(12):6290-6300. https://doi.org/10.1172/JCI140335.
Abstract
SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in infected individuals, who can either exhibit mild symptoms or progress toward a life-threatening acute respiratory distress syndrome (ARDS). Exacerbated inflammation and dysregulated immune responses involving T and myeloid cells occur in COVID-19 patients with severe clinical progression. However, the differential contribution of specific subsets of dendritic cells and monocytes to ARDS is still poorly understood. In addition, the role of CD8+ T cells present in the lung of COVID-19 patients and relevant for viral control has not been characterized. Here, we have studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood and lung of COVID-19 patients with different clinical severity in comparison with healthy individuals. Furthermore, these subpopulations and their association with antiviral effector CD8+ T cell subsets were also characterized in lung infiltrates from critical COVID-19 patients. Our results indicate that inflammatory transitional and nonclassical monocytes and CD1c+ conventional dendritic cells preferentially migrate from blood to lungs in patients with severe COVID-19. Thus, this study increases the knowledge of specific myeloid subsets involved in the pathogenesis of COVID-19 disease and could be useful for the design of therapeutic strategies for fighting SARS-CoV-2 infection.
Authors
Ildefonso Sánchez-Cerrillo, Pedro Landete, Beatriz Aldave, Santiago Sánchez-Alonso, Ana Sánchez-Azofra, Ana Marcos-Jiménez, Elena Ávalos, Ana Alcaraz-Serna, Ignacio de los Santos, Tamara Mateu-Albero, Laura Esparcia, Celia López-Sanz, Pedro Martínez-Fleta, Ligia Gabrie, Luciana del Campo Guerola, Hortensia de la Fuente, María J. Calzada, Isidoro González-Álvaro, Arantzazu Alfranca, Francisco Sánchez-Madrid, Cecilia Muñoz-Calleja, Joan B. Soriano, Julio Ancochea, Enrique Martín-Gayo, the REINMUN-COVID and EDEPIMIC groups
Citation information
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Gisby JS, Buang NB, Papadaki A, Clarke CL, Malik TH, Medjeral-Thomas N, Pinheiro D, Mortimer PM, Lewis S, Sandhu E, McAdoo SP, Prendecki MF, Willicombe M, Pickering MC, Botto M, Thomas DC, Peters JE |
Nature Communications | 2022 |
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Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae.
Thompson RC, Simons NW, Wilkins L, Cheng E, Del Valle DM, Hoffman GE, Cervia C, Fennessy B, Mouskas K, Francoeur NJ, Johnson JS, Lepow L, Le Berichel J, Chang C, Beckmann AG, Wang YC, Nie K, Zaki N, Tuballes K, Barcessat V, Cedillo MA, Yuan D, Huckins L, Roussos P, Marron TU, Glicksberg BS, Nadkarni G, Heath JR, Gonzalez-Kozlova E, Boyman O, Kim-Schulze S, Sebra R, Merad M, Gnjatic S, Schadt EE, Charney AW, Beckmann ND |
Nature Medicine | 2022 |
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Flavanol Consumption in Healthy Men Preserves Integrity of Immunological-Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis.
Milenkovic D, Rodriguez-Mateos A, Lucosz M, Istas G, Declerck K, Sansone R, Deenen R, Köhrer K, Corral-Jara KF, Altschmied J, Haendeler J, Kelm M, Berghe WV, Heiss C |
Molecular Nutrition & Food Research | 2022 |
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Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
Laurent P, Yang C, Rendeiro AF, Nilsson-Payant BE, Carrau L, Chandar V, Bram Y, tenOever BR, Elemento O, Ivashkiv LB, Schwartz RE, Barrat FJ |
Science Immunology | 2022 |
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Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients
G Riva, S Castellano, V Nasillo, AM Ottomano, G Bergonzini, A Paolini, B Lusenti, J Milić, SD Biasi, L Gibellini, A Cossarizza, S Busani, M Girardis, G Guaraldi, C Mussini, R Manfredini, M Luppi, E Tagliafico, T Trenti |
Scientific Reports | 2021 |
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Impaired function and delayed regeneration of dendritic cells in COVID-19
E Winheim, L Rinke, K Lutz, A Reischer, A Leutbecher, L Wolfram, L Rausch, J Kranich, PR Wratil, JE Huber, D Baumjohann, S Rothenfusser, B Schubert, A Hilgendorff, JC Hellmuth, C Scherer, M Muenchhoff, M von Bergwelt-Baildon, K Stark, T Straub, T Brocker, OT Keppler, M Subklewe, AB Krug, M Suthar |
PLoS pathogens | 2021 |
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T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19
O Zenarruzabeitia, G Astarloa-Pando, I Terrén, A Orrantia, R Pérez-Garay, I Seijas-Betolaza, J Nieto-Arana, N Imaz-Ayo, S Pérez-Fernández, E Arana-Arri, F Borrego |
Frontiers in immunology | 2021 |
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Similarities and Differences in the Acute-Phase Response to SARS-CoV-2 in Rhesus Macaques and African Green Monkeys
C Coleman, LA Doyle-Meyers, KE Russell-Lodrigue, N Golden, B Threeton, K Song, G Pierre, C Baribault, RP Bohm, NJ Maness, JK Kolls, J Rappaport, JC Mudd |
Frontiers in immunology | 2021 |
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Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019
F Qi, W Zhang, J Huang, L Fu, J Zhao |
Frontiers in immunology | 2021 |
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Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic Landscape
K Mukund, P Nayak, C Ashokkumar, S Rao, J Almeda, MM Betancourt-Garcia, R Sindhi, S Subramaniam |
Frontiers in immunology | 2021 |
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Aging versus youth: Endocrine aspects of vulnerability for COVID-19
SH Oguz, M Koca, BO Yildiz |
Reviews in Endocrine and Metabolic Disorders | 2021 |
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Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19
A Paolini, R Borella, SD Biasi, A Neroni, M Mattioli, DL Tartaro, C Simonini, L Franceschini, G Cicco, AM Piparo, A Cossarizza, L Gibellini |
Cells | 2021 |
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Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype
AC Trombetta, GB Farias, AM Gomes, A Godinho-Santos, P Rosmaninho, CM Conceição, J Laia, DF Santos, AR Almeida, C Mota, A Gomes, M Serrano, M Veldhoen, AE Sousa, SM Fernandes |
Frontiers in immunology | 2021 |
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Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers
V Seery, SC Raiden, SC Algieri, NA Grisolía, D Filippo, ND Carli, SD Lalla, H Cairoli, MJ Chiolo, CN Meregalli, LI Gimenez, G Gregorio, M Sarli, AL Alcalde, C Davenport, MJ Bruera, N Simaz, MF Pérez, V Nivela, C Bayle, P Tuccillo, MT Agosta, H Pérez, SV Nova, P Suárez, EM Takata, M García, J Lattner, MJ Rolón, P Coll, I Sananez, MP Holgado, F Ferrero, J Geffner, L Arruvito |
EBioMedicine | 2021 |
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A hitchhiker's guide through the COVID-19 galaxy
S Felsenstein, AO Reiff |
Clinical Immunology | 2021 |
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Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic options
SR Dyavar, R Singh, R Emani, GP Pawar, VD Chaudhari, AT Podany, SN Avedissian, CV Fletcher, DB Salunke |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2021 |
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The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19?
X Wang, P Yi, Y Liang |
Frontiers in immunology | 2021 |
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Deregulated cellular circuits driving immunoglobulins and complement consumption associate with the severity of COVID‐19 patients
A MarcosJiménez, S SánchezAlonso, A AlcarazSerna, L Esparcia, C LópezSanz, M SampedroNúñez, T MateuAlbero, I SánchezCerrillo, P MartínezFleta, L Gabrie, LC Guerola, JM RodríguezFrade, JM Casasnovas, HT Reyburn, M ValésGómez, M LópezTrascasa, E MartínGayo, MJ Calzada, S Castañeda, H Fuente, I GonzálezÁlvaro, F SánchezMadrid, C MuñozCalleja, A Alfranca |
European Journal of Immunology | 2021 |
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Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen, Z Chong, SJ Zost, H Jang, Y Huang, JD Allen, JB Case, RE Sutton, RH Carnahan, TL Darling, AC Boon, M Mack, RD Head, TM Ross, JE Crowe, MS Diamond |
Cell | 2021 |
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Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice
TR Karhadkar, D Pilling, RH Gomer, H Fehrenbach |
PloS one | 2021 |
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A bird's eye view on the role of dendritic cells in SARS‐CoV‐2 infection: Perspectives for immune‐based vaccines
D Galati, S Zanotta, L Capitelli, M Bocchino |
Allergy | 2021 |
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Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19
C Liu, AJ Martins, WW Lau, N Rachmaninoff, J Chen, L Imberti, D Mostaghimi, DL Fink, PD Burbelo, K Dobbs, OM Delmonte, N Bansal, L Failla, A Sottini, E Quiros-Roldan, KL Han, BA Sellers, F Cheung, R Sparks, TW Chun, S Moir, MS Lionakis, C Rossi, HC Su, DB Kuhns, JI Cohen, LD Notarangelo, JS Tsang, MS Abers, R Apps, M Bosticardo, P Milanez-Almeida, MP Mulè, E Shaw, Y Zhang, F Castelli, ML Muiesan, G Tomasoni, F Scolari, A Tucci |
Cell | 2021 |
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Maturation signatures of conventional dendritic cell subtypes in COVID‐19 suggest direct viral sensing
L Marongiu, G Protti, FA Facchini, M Valache, F Mingozzi, V Ranzani, AR Putignano, L Salviati, V Bevilacqua, S Curti, M Crosti, ML Sarnicola, M D'Angiò, LR Bettini, A Biondi, L Nespoli, N Tamini, N Clementi, N Mancini, S Abrignani, R Spreafico, F Granucci |
European Journal of Immunology | 2021 |
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Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19
V Chilunda, P Martinez-Aguado, LC Xia, L Cheney, A Murphy, V Veksler, V Ruiz, TM Calderon, JW Berman |
Frontiers in immunology | 2021 |
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Monocytes and Macrophages in COVID-19
R Knoll, JL Schultze, J Schulte-Schrepping |
Frontiers in immunology | 2021 |
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SARS‐CoV‐2 sculpts the immune system to induce sustained virus‐specific naïve‐like and memory B‐cell responses
L de CamposMata, ST Vaquero, R TachóPiñot, J Piñero, EK Grasset, IA Aldea, NR Melero, C Carolis, JP Horcajada, A Cerutti, J VillarGarcía, G Magri |
IBMS BoneKEy | 2021 |
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COVID-19 illness and autoimmune diseases: recent insights
J Li, HH Liu, XD Yin, CC Li, J Wang |
Inflammation Research | 2021 |
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Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
A Mazzoni, L Salvati, L Maggi, F Annunziato, L Cosmi |
Seminars in Immunology | 2021 |
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The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki, S Cajander, M Shankar-Hari, G Lachmann, G Monneret, F Venet, M Bauer, FM Brunkhorst, S Weis, A Garcia-Salido, M Kox, JM Cavaillon, F Uhle, MA Weigand, SB Flohé, WJ Wiersinga, R Almansa, A de la Fuente, I Martin-Loeches, C Meisel, T Spinetti, JC Schefold, C Cilloniz, A Torres, EJ Giamarellos-Bourboulis, R Ferrer, M Girardis, A Cossarizza, MG Netea, T van der Poll, JF Bermejo-Martín, I Rubio |
The lancet. Respiratory medicine | 2021 |
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Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
J Lim, KJ Puan, LW Wang, KW Teng, CY Loh, KP Tan, G Carissimo, YH Chan, CM Poh, CY Lee, SW Fong, NK Yeo, RS Chee, SN Amrun, ZW Chang, MZ Tay, A Torres-Ruesta, NL Fernandez, W How, AK Andiappan, W Lee, K Duan, SY Tan, G Yan, S Kalimuddin, DC Lye, YS Leo, SW Ong, BE Young, L Renia, LF Ng, B Lee, O Rötzschke |
Frontiers in immunology | 2021 |
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Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients
A Sacconi, CD Vitis, L de Latouliere, S di Martino, FD Nicola, F Goeman, C Mottini, F Paolini, M DAscanio, A Ricci, A Tafuri, P Marchetti, AD Napoli, LD Biase, A Negro, C Napoli, P Anibaldi, V Salvati, D Duffy, B Terrier, M Fanciulli, C Capalbo, S Sciacchitano, G Blandino, G Piaggio, R Mancini, G Ciliberto |
Cell Death and Disease | 2021 |
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Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients
DA Rodríguez-Serrano, E Roy-Vallejo, ND Cruz, AM Ramírez, SC Rodríguez-García, N Arevalillo-Fernández, JM Galván-Román, LF García-Rodrigo, L Vega-Piris, MC Llano, DA Méndez, BG de Marcos, JH Santos, AS Azofra, EÁ Pérez-Urria, P Rodriguez-Cortes, L Esparcia, A Marcos-Jimenez, S Sánchez-Alonso, I Llorente, J Soriano, CS Fernández, R García-Vicuña, J Ancochea, J Sanz, C Muñoz-Calleja, R de la Cámara, AC Berlanga, I González-Álvaro, L Cardeñoso, RM Hernández, M Orts, C Figueroa, C Román, A Planas, LD Arganda, PM Vives, GD Nieto, A Cecconi, A Benedicto, AR González, J Jiménez-Borreguero, C del Arco, JM Aguilar, N Villalba, M Negro, E Contreras, A del Rey, C Santiago, M Junquera, R Caminero, FJ Val, S González, M Caño, I López, A von Wernitz, I Guerra, J Sorando, L Chao, MJ Cárdenas, V Espiga, A Pizarro, ÁF Álvarez, B Aguado, J Cannata, J Ortiz, A Morell, E Ramírez, AI Zurriaga, MP Abanades, SR García, TG Aranda, M Ruiz, CM Nieto, JM Serra, F Sánchez-Madrid, I Sánchez-Cerrillo, P Martínez-Fleta, C López-Sanz, L Gabrie, L del Campo Guerola, E Fernández, R Tejedor, PA Haro, MT Genao, BQ Dorado, DJ Jiménez, MA González, P Villamayor, I de los Santos, E Sánchez, F Moldenhauer, P Casado, J Curbelo, A Gutiérrez, A Bautista, NR Giménez, A Fernández, LG Fraile, P Parra, B Moyano, A Barrios, P Gil, IG Polo, DR de Asúa, B Sánchez, C Sáez, M Ciudad, MF Rico, CA Román, EM Rodríguez, D Navas, M del Carmen Cuevas Torresano, DD García, TA Cavero, AG Blanco, MA Chong, AG Cobos, AM Torres, T Alonso, P Landete, J Soriano, C Cisneros, EG Castillo, C Valenzuela, FJ Pérez, RM Girón, J Aspa, C Marcos, E Zamora, G Iturricastillo, MB Mayo, ER Garrido, S Castañeda, C Fernández-Díaz, EG Tomero, NG Castañeda, AM Ortiz, C Valero, M Uriarte, N Montes, IG Sanz, FE Viamontes, JD Valdueza |
Scientific Reports | 2021 |
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Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology
A Codd, S Hanna, E Compeer, F Richter, E Pring, E Gea-Mallorquí, M Borsa, O Moon, D Scourfield, D Ahern, H Almuttaqi, D Alonzi, A Alrubayyi, G Alsaleh, V Bart, V Batchelor, R Bayliss, D Berthold, J Bezbradica, T Bharuchq, H Borrmann, M Borsa, R Borst, J Brun, S Burnell, L Capitani, A Cavounidis, L Chapman, A Chauveau, L Cifuentes, A Codd, E Compeer, C Coveney, A Cross, S Danielli, L Davies, C Dendrou, S Dimonte, R Durairaj, L Dustin, A Dyer, C Fielding, F Fischer, A Gallimore, S Galloway, A Gammage, E Gea-Mallorquí, A Godkin, S Hanna, C Heuberger, S Hulin-Curtis, F Issa, E Jones, R Jones, K Ladell, S Lauder, K Liddiard, P Ligoxygakis, F Lu, B MacLachlan, S Maleki-Toyserkani, E Mann, A Marzeda, R Matthews, J Mazet, A Milicic, E Mitchell, O Moon, V Nguyen, M O'Hanlon, C Pavillet, D Peppa, A Pires, E Pring, M Quastel, S Reed, J Rehwinkel, N Richmond, F Richter, A Robinson, P Rodrigues, P Sabberwal, A Sami, R Peres, Q Sattentau, B Schonfeldova, D Scourfield, T Selvakumar, F Shepherd, C Shorten, A Simon, A Smith, A Crespo, M Tellier, E Thornton, L Uhl, E van Grinsven, A Wann, R Williams, J Wilson, D Zhou, Z Zhu, A Gallimore, A Milicic |
2021 | |
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Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity
Wuji Zhang, Brendon Chua, Kevin Selva, Lukasz Kedzierski, Thomas Ashhurst, Ebene Haycroft, Suzanne Shoffner, Luca Hensen, David Boyd, Fiona James, Effie Mouhtouris, Jason Kwong, Kyra Chua, George Drewett, Ana Copaescu, Julie Dobson, Louise Rowntree, Jennifer Habel, Lilith Allen, Hui-Fern Koay, Jessica Neil, Matthew Gartner, Christina Lee, Patiyan Andersson, Torsten Seemann, Norelle Sherry, Fatima Amanat, Florian Krammer, Sarah Londrigan, Linda Wakim, Nicholas King, Dale Godfrey, Laura Mackay, Paul Thomas, Suellen Nicholson, Kelly Arnold, Amy Chung, Natasha Holmes, Olivia Smibert, Jason Trubiano, Claire Gordon, Thi Nguyen, Katherine Kedzierska |
Research square | 2021 |
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Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk loci
CY Moon, BM Schilder, T Raj, K Huang |
iScience | 2021 |
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COVID-19, what could sepsis, severe acute pancreatitis, gender differences, and aging teach us?
CG Gallo, S Fiorino, G Posabella, D Antonacci, A Tropeano, E Pausini, C Pausini, T Guarniero, W Hong, E Giampieri, I Corazza, L Federico, D de Biase, M Zippi, M Zancanaro |
Cytokine | 2021 |
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Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells
I Nikitopoulou, D Fanidis, K Ntatsoulis, P Moulos, G Mpekoulis, M Evangelidou, AG Vassiliou, V Dimakopoulou, E Jahaj, S Tsipilis, SE Orfanos, I Dimopoulou, E Angelakis, K Akinosoglou, N Vassilaki, A Tzouvelekis, A Kotanidou, V Aidinis |
International journal of molecular sciences | 2021 |
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Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection
N Bozorgmehr, S Mashhouri, EP Rosero, L Xu, S Shahbaz, W Sligl, M Osman, DJ Kutsogiannis, E MacIntyre, CR ONeil, S Elahi, D Paraskevis |
mBio | 2021 |
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Circulating Type I Interferon Levels and COVID-19 Severity: A Systematic Review and Meta-Analysis
RP da Silva, JI Gonçalves, RF Zanin, FB Schuch, AP de Souza |
Frontiers in immunology | 2021 |
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SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care
C Gutmann, K Takov, SA Burnap, B Singh, H Ali, K Theofilatos, E Reed, M Hasman, A Nabeebaccus, M Fish, MJ McPhail, K OGallagher, LE Schmidt, C Cassel, M Rienks, X Yin, G Auzinger, S Napoli, SF Mujib, F Trovato, B Sanderson, B Merrick, U Niazi, M Saqi, K Dimitrakopoulou, R Fernández-Leiro, S Braun, R Kronstein-Wiedemann, KJ Doores, JD Edgeworth, AM Shah, SR Bornstein, T Tonn, AC Hayday, M Giacca, M Shankar-Hari, M Mayr |
Nature Communications | 2021 |
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Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery
A Utrero-Rico, C González-Cuadrado, M Chivite-Lacaba, O Cabrera-Marante, R Laguna-Goya, P Almendro-Vazquez, C Díaz-Pedroche, M Ruiz-Ruigómez, A Lalueza, MD Folgueira, E Vázquez, A Quintas, MJ Berges-Buxeda, M Martín-Rodriguez, A Dopazo, A Serrano-Hernández, JM Aguado, E Paz-Artal |
Biomedicines | 2021 |
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Coronavirus infection: An immunologists' perspective
JB Sanctis, AH García, D Moreno, M Hajduch |
Scandinavian Journal of Immunology | 2021 |
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COVID-19–Associated Acute Respiratory Distress Syndrome
EA Middleton, GA Zimmerman |
Critical Care Clinics | 2021 |
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Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
E Kvedaraite, L Hertwig, I Sinha, A Ponzetta, IH Myrberg, M Lourda, M Dzidic, M Akber, J Klingström, E Folkesson, JR Muvva, P Chen, S Gredmark-Russ, S Brighenti, A Norrby-Teglund, LI Eriksson, O Rooyackers, S Aleman, K Strålin, HG Ljunggren, F Ginhoux, NK Björkström, JI Henter, M Svensson |
Proceedings of the National Academy of Sciences | 2021 |
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Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection
M Roussel, J Ferrant, F Reizine, SL Gallou, J Dulong, S Carl, M Lesouhaitier, M Gregoire, N Bescher, C Verdy, M Latour, I Bézier, M Cornic, A Vinit, C Monvoisin, B Sawitzki, S Leonard, S Paul, J Feuillard, R Jeannet, T Daix, VK Tiwari, JM Tadié, M Cogné, K Tarte |
Cell reports. Medicine | 2021 |
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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
A Pérez-Gómez, J Vitallé, C Gasca-Capote, A Gutierrez-Valencia, M Trujillo-Rodriguez, A Serna-Gallego, E Muñoz-Muela, M de los Reyes Jiménez-Leon, MR Benhnia, I Rivas-Jeremias, C Sotomayor, C Roca-Oporto, N Espinosa, C Infante-Domínguez, JC Crespo-Rivas, A Fernández-Villar, A Pérez-González, LF López-Cortés, E Poveda, E Ruiz-Mateos, JM Cisneros, S Salto-Alejandre, J Berastegui-Cabrera, P Camacho-Martínez, C Infante-Domínguez, M Carretero-Ledesma, JC Crespo-Rivas, E Márquez, JM Lomas, C Bueno, R Amaya, JA Lepe, J Pachón, E Cordero, J Sánchez-Céspedes, M Aguilar-Guisado, A Aguilera, C Aguilera, T Aldabo-Pallas, V Alfaro-Lara, C Amodeo, J Ampuero, MD Avilés, M Asensio, B Barón-Franco, L Barrera-Pulido, R Bellido-Alba, M Bernabeu-Wittel, C Caballero-Eraso, M Cabrera, E Calderón, J Carbajal-Guerrero, M Cid-Cumplido, Y Corcia-Palomo, J Delgado, A Domínguez-Petit, A Deniz, R Dusseck-Brutus, A Escoresca-Ortega, F Espinosa, N Espinosa, M Espinoza, C Ferrándiz-Millón, M Ferrer, T Ferrer, I Gallego-Texeira, R Gámez-Mancera, E García, H García-Delgado, M García-Gutiérrez, ML Gascón-Castillo, A González-Estrada, D González, C Gómez-González, R González-León, C Grande-Cabrerizo, S Gutiérrez, C Hernández-Quiles, IC Herrera-Melero, M Herrero-Romero, L Jara, C Jiménez-Juan, S Jiménez-Jorge, M Jiménez-Sánchez, J Lanseros-Tenllado, C López, I López, Á López-Barrios, LF López-Cortés, R Luque-Márquez, D Macías-García, G Martín-Gutiérrez, L Martín-Villén, J Molina, A Morillo, MD Navarro-Amuedo, D Nieto-Martín, F Ortega, M Paniagua-García, A Peña-Rodríguez, E Pérez, M Poyato, J Praena-Segovia, R Ríos, C Roca-Oporto, JF Rodríguez, MJ Rodríguez-Hernández, S Rodríguez-Suárez, Á Rodríguez-Villodres, N Romero-Rodríguez, R Ruiz, ZR de Azua, C Salamanca, S Sánchez, VM Sánchez-Montagut, C Sotomayor, AS Benjumea, J Toral |
Cellular and Molecular Immunology | 2021 |
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A distinct innate immune signature marks progression from mild to severe COVID-19
S Chevrier, Y Zurbuchen, C Cervia, S Adamo, ME Raeber, N de Souza, S Sivapatham, A Jacobs, E Bachli, A Rudiger, M Stüssi-Helbling, LC Huber, DJ Schaer, J Nilsson, O Boyman, B Bodenmiller |
Cell reports. Medicine | 2021 |
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A regulatory T cell signature distinguishes the immune landscape of COVID-19 patients from those with other respiratory infections
SC Vick, M Frutoso, F Mair, AJ Konecny, E Greene, CR Wolf, JK Logue, NM Franko, J Boonyaratanakornkit, R Gottardo, JT Schiffer, HY Chu, M Prlic, JM Lund |
Science Advances | 2021 |
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Comprehensive immune cell profiling depicts an early immune response associated with severe coronavirus disease 2019 in cancer patients
PR Tembhare, H Sriram, G Chatterjee, T Khanka, A Gokarn, S Mirgh, A Rajendra, A Chaturvedi, SG Ghogale, N Deshpande, K Girase, K Dalvi, S Rajpal, N Patkar, B Trivedi, A Joshi, V Murthy, N Shetty, S Nair, A More, S Kamtalwar, P Chavan, V Bhat, P Bhat, PG Subramanian, S Gupta, N Khattry |
Immunology and Cell Biology | 2021 |
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A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID
A Utrero-Rico, M Ruiz-Ruigómez, R Laguna-Goya, E Arrieta-Ortubay, M Chivite-Lacaba, C González-Cuadrado, A Lalueza, P Almendro-Vazquez, A Serrano, JM Aguado, C Lumbreras, E Paz-Artal |
Biomedicines | 2021 |
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Myeloid dysregulation and therapeutic intervention in COVID-19
R Gu, T Mao, Q Lu, TT Su, J Wang |
Seminars in Immunology | 2021 |
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Comprehensive Immunologic Evaluation of Bronchoalveolar Lavage Samples from Human Patients with Moderate and Severe Seasonal Influenza and Severe COVID-19
D Reynolds, CV Guillamet, A Day, N Borcherding, RV Guillamet, JA Choreño-Parra, SL House, JA OHalloran, J Zúñiga, AH Ellebedy, DE Byers, PA Mudd |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
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Immune response to SARS‐CoV‐2 in children: A review of the current knowledge
F Filippatos, EB Tatsi, A Michos |
2021 | |
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Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
M Severa, RA Diotti, MP Etna, F Rizzo, S Fiore, D Ricci, M Iannetta, A Sinigaglia, A Lodi, N Mancini, E Criscuolo, M Clementi, M Andreoni, S Balducci, L Barzon, P Stefanelli, N Clementi, EM Coccia, MS Diamond |
PLoS pathogens | 2021 |
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Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
N Nassir, R Tambi, A Bankapur, SA Heialy, N Karuvantevida, HH Khansaheb, B Zehra, G Begum, RA Hameid, A Ahmed, Z Deesi, A Alkhajeh, KM Uddin, H Akter, SA Shabestari, O Almidani, A Islam, M Gaudet, RK Kandasamy, T Loney, AA Tayoun, N Nowotny, M Woodbury-Smith, P Rahman, WM Kuebler, MY Hachim, JL Casanova, BK Berdiev, A Alsheikh-Ali, M Uddin |
iScience | 2021 |
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SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
M Shemesh, TE Aktepe, JM Deerain, JL McAuley, MD Audsley, CT David, DF Purcell, V Urin, R Hartmann, GW Moseley, JM Mackenzie, G Schreiber, D Harari, A Pekosz |
PLoS pathogens | 2021 |
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Critical COVID‐19 is associated with distinct leukocyte phenotypes and transcriptome patterns
EE Christensen, MJ Jørgensen, KG Nore, TB Dahl, K Yang, T Ranheim, C Huse, A Lind, S Nur, B Stiksrud, S Jenum, K Tonby, JC Holter, AR Holten, B Halvorsen, AM DyrholRiise |
Journal of Internal Medicine | 2021 |
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Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response
A Mithal, AJ Hume, J Lindstrom-Vautrin, C Villacorta-Martin, J Olejnik, E Bullitt, A Hinds, E Mühlberger, G Mostoslavsky |
Stem Cell Reports | 2021 |
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Profiles of Peripheral Immune Cells of Uncomplicated COVID-19 Cases with Distinct Viral RNA Shedding Periods
DU Putri, CH Wang, PC Tseng, WS Lee, FL Chen, HP Kuo, CH Lee, CF Lin |
Viruses | 2021 |
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High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19.
De Zuani M, Lazničková P, Tomašková V, Dvončová M, Forte G, Stokin GB, Šrámek V, Helán M, Frič J |
Scandinavian Journal of Immunology | 2021 |
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A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections.
Vick SC, Frutoso M, Mair F, Konecny AJ, Greene E, Wolf CR, Logue JK, Boonyaratanakornkit J, Gottardo R, Schiffer JT, Chu HY, Prlic M, Lund JM |
medRxiv : the preprint server for health sciences | 2021 |
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COVID-19 and myeloid cells: complex interplay correlates with lung severity
Franco R. D'Alessio, Nicola M. Heller |
Journal of Clinical Investigation | 2020 |
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Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeutics
V Kumar |
International Immunopharmacology | 2020 |
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Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19
G Carissimo, W Xu, I Kwok, MY Abdad, YH Chan, SW Fong, KJ Puan, CY Lee, NK Yeo, SN Amrun, RS Chee, W How, S Chan, BE Fan, AK Andiappan, B Lee, O Rötzschke, BE Young, YS Leo, DC Lye, L Renia, LG Ng, A Larbi, LF Ng |
Nature Communications | 2020 |
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The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection
O Gallo, LG Locatello, A Mazzoni, L Novelli, F Annunziato |
Mucosal Immunology | 2020 |
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Quantitative and qualitative alterations of circulating myeloid cells and plasmacytoid DC in SARS‐CoV‐2 infection
B Peruzzi, S Bencini, M Capone, A Mazzoni, L Maggi, L Salvati, A Vanni, C Orazzini, C Nozzoli, A Morettini, L Poggesi, F Pieralli, A Peris, A Bartoloni, AM Vannucchi, F Liotta, R Caporale, L Cosmi, F Annunziato |
Immunology | 2020 |
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Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathology
PR Rodrigues, A Alrubayyi, E Pring, VM Bart, R Jones, C Coveney, F Lu, M Tellier, S Maleki-Toyserkani, FC Richter, DO Scourfield, E Gea-Mallorquí, LC Davies |
2020 | |
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Decrease of Non‐Classical and Intermediate Monocyte Subsets in Severe Acute SARS‐CoV‐2 Infection
Gatti A, Radrizzani D, Viganò P, Mazzone A, Brando B |
Cytometry Part A | 2020 |
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