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Citations to this article

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent
Alessio Mazzoni, … , Francesco Annunziato, Lorenzo Cosmi
Alessio Mazzoni, … , Francesco Annunziato, Lorenzo Cosmi
Published May 28, 2020
Citation Information: J Clin Invest. 2020;130(9):4694-4703. https://doi.org/10.1172/JCI138554.
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Clinical Research and Public Health Immunology Infectious disease Article has an altmetric score of 91

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

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Abstract

BACKGROUND Coronavirus disease 19 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen clearance; however, in some patients an excessive and aberrant host immune response can lead to an acute respiratory distress syndrome. The comprehension of the mechanisms that regulate pathogen elimination, immunity, and pathology is essential to better characterize disease progression and widen the spectrum of therapeutic options.METHODS We performed a flow cytometric characterization of immune cell subsets from 30 patients with COVID-19 and correlated these data with clinical outcomes.RESULTS Patients with COVID-19 showed decreased numbers of circulating T, B, and NK cells and exhibited a skewing of CD8+ T cells toward a terminally differentiated/senescent phenotype. In agreement, CD4+ T and CD8+ T, but also NK cells, displayed reduced antiviral cytokine production capability. Moreover, a reduced cytotoxic potential was identified in patients with COVID-19, particularly in those who required intensive care. The latter group of patients also showed increased serum IL-6 levels that inversely correlated to the frequency of granzyme A–expressing NK cells. Off-label treatment with tocilizumab restored the cytotoxic potential of NK cells.CONCLUSION The association between IL-6 serum levels and the impairment of cytotoxic activity suggests the possibility that targeting this cytokine may restore antiviral mechanisms.FUNDING This study was supported by funds from the Department of Experimental and Clinical Medicine of University of Florence (the ex-60% fund and the “Excellence Departments 2018–2022 Project”) derived from Ministero dell’Istruzione, dell’Università e della Ricerca (Italy).

Authors

Alessio Mazzoni, Lorenzo Salvati, Laura Maggi, Manuela Capone, Anna Vanni, Michele Spinicci, Jessica Mencarini, Roberto Caporale, Benedetta Peruzzi, Alberto Antonelli, Michele Trotta, Lorenzo Zammarchi, Luca Ciani, Leonardo Gori, Chiara Lazzeri, Andrea Matucci, Alessandra Vultaggio, Oliviero Rossi, Fabio Almerigogna, Paola Parronchi, Paolo Fontanari, Federico Lavorini, Adriano Peris, Gian Maria Rossolini, Alessandro Bartoloni, Sergio Romagnani, Francesco Liotta, Francesco Annunziato, Lorenzo Cosmi

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M Sedegah, C Porter, M Hollingdale, H Ganeshan, J Huang, C Goforth, M Belmonte, A Belmonte, D Weir, R Lizewski, S Lizewski, S Sealfon, V Jani, Y Cheng, S Inoue, R Velasco, E Villasante, P Sun, A Letizia, J Bhattacharya
PloS one 2022
Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?
T Theoharides
Molecular Neurobiology 2022
Pharmaco-immunomodulatory interventions for averting cytokine storm-linked disease severity in SARS-CoV-2 infection
A Kumar, A Sharma, N Tirpude, S Sharma, Y Padwad, S Kumar
Inflammopharmacology 2022
Immunoediting in SARS-CoV-2: Mutual relationship between the virus and the host
N Kheshtchin, P Bakhshi, S Arab, M Nourizadeh
International Immunopharmacology 2022
COVID-19 Pandemic and Periodontal Practice: The Immunological, Clinical, and Economic Points of View
M Darestani, A Akbari, S Yaghobee, M Taheri, S Akbari, Y Guven
BioMed Research International 2022
Dynamics of Peripheral Blood T-lymphocytes Have Predictive Values for the Clinical Outcome of COVID-19 Patients in Intensive Care Unit
D Wu, X Zhang, Y Ziemba, N Haghi, J Brody, P Hsu
2022
The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus
W Dong, H Mead, L Tian, J Park, J Garcia, S Jaramillo, T Barr, D Kollath, V Coyne, N Stone, A Jones, J Zhang, A Li, L Wang, M Milanes-Yearsley, J Torrelles, L Martinez-Sobrido, P Keim, B Barker, M Caligiuri, J Yu, T Gallagher
Journal of virology 2022
Thrombocytopenia in COVID‑19 and vaccine‑induced thrombotic thrombocytopenia
S Geronikolou, I Takan, A Pavlopoulou, M Mantzourani, G Chrousos
International journal of molecular medicine 2022
Advances in clinical outcomes: What we have learned during the COVID-19 pandemic
A Al-Musa, B LaBere, S Habiballah, A Nguyen, J Chou
Journal of Allergy and Clinical Immunology 2022
Are NKT cells a useful predictor of COVID-19 severity?
H Koay, N Gherardin, T Nguyen, W Zhang, J Habel, R Seneviratna, F James, N Holmes, O Smibert, C Gordon, J Trubiano, K Kedzierska, D Godfrey
Immunity 2022
The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome
R Ganesh, S Grach, A Ghosh, D Bierle, B Salonen, N Collins, A Joshi, N Boeder, C Anstine, M Mueller, E Wight, I Croghan, A Badley, R Carter, R Hurt
Mayo Clinic Proceedings 2022
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications
M Al-Nesf, H Abdesselem, I Bensmail, S Ibrahim, W Saeed, S Mohammed, A Razok, H Alhussain, R Aly, M Maslamani, K Ouararhni, M Khatib, A Hssain, A Omrani, S Al-Kaabi, A Khal, A Al-Thani, W Samsam, A Farooq, J Al-Suwaidi, M Al-Maadheed, H Al-Siddiqi, A Butler, J Decock, V Mohamed-Ali, F Al-Ejeh
Nature Communications 2022
The crucial role of prolactin-lactogenic hormone in Covid-19
H Al-Kuraishy, A Al-Gareeb, M Butnariu, G Batiha
Molecular and Cellular Biochemistry 2022
New Discovery of Myeloid-Derived Suppressor Cell’s Tale on Viral Infection and COVID-19
S Park, D Nam, H Seong, Y Hahn
Frontiers in immunology 2022
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19
, M Xu, D Song, T Yue, Y Wang, P Zhang, Y Zhong, M Zhang, T Lam, N Faria, E Clercq, G Li
Immunity & Ageing 2022
SARS-CoV-2 Immunization Orchestrates the Amplification of IFNγ-Producing T Cell and NK Cell Persistence
L Sala, S Gandini, A Bruno, R Allevi, M Gallazzi, P Senesi, M Palano, P Meregalli, E Longhi, C Sommese, L Luzi, E Trabucchi
Frontiers in immunology 2022
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Q Hammer, J Dunst, W Christ, F Picarazzi, M Wendorff, P Momayyezi, O Huhn, H Netskar, K Maleki, M García, T Sekine, E Sohlberg, V Azzimato, M Aouadi, F Degenhardt, A Franke, F Spallotta, M Mori, J Michaëlsson, N Björkström, T Rückert, C Romagnani, A Horowitz, J Klingström, H Ljunggren, K Malmberg
Cell Reports 2022
Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2
K Piadel, A Haybatollahi, A Dalgleish, P Smith
Journal of General Virology 2022
Hematopoietic responses to SARS-CoV-2 infection
S Elahi
Cellular and Molecular Life Sciences 2022
Open-label use of an aliphatic polyamine immunomodulator in patients hospitalized with COVID-19
S Efimov, N Matsiyeuskaya, O Boytsova, L Akhieva, E Kuntsevich, A Troshina, E Kvasova, A Tikhonov, N Khomyakova, F Harrison, J Rossi, T Hardman
Drugs in Context 2022
SARS-CoV-2 Associated Immune Dysregulation and COVID-Associated Pulmonary Aspergilliosis (CAPA): A Cautionary Tale
D Worku
International journal of molecular sciences 2022
SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine
S Gupta, S Agrawal, A Sandoval, H Su, M Tran, Y Demirdag
Journal of Clinical Immunology 2022
Long‐term SARS‐CoV‐2‐specific and cross‐reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology
I Laurén, S Havervall, H Ng, Martin, A Pettke, N GreilertNorin, L Gabrielsson, A Chourlia, C AmoêdoLeite, V Josyula, M Eltahir, I Kerzeli, A Falk, J Hober, W Christ, A Wiberg, M Hedhammar, H Tegel, J Burman, F Xu, E Pin, A Månberg, J Klingström, G Christoffersson, S Hober, P Nilsson, M Philipson, P Dönnes, R Lindsay, C Thålin, S Mangsbo
Immunity, Inflammation and Disease 2022
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
J Sabbatinelli, G Matacchione, A Giuliani, D Ramini, M Rippo, A Procopio, M Bonafè, F Olivieri
Mechanisms of Ageing and Development 2022
COVID-19 infection as a new risk factor for penile Mondor disease
K Balawender, A Pliszka, A Surowiec, S Rajda
BMC urology 2022
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques
M Aid, S Vidal, C Piedra-Mora, S Ducat, C Chan, S Bondoc, A Colarusso, C Starke, M Nekorchuk, K Busman-Sahay, J Estes, A Martinot, D Barouch, A Bukreyev
PLoS pathogens 2022
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection
A Romano, N Parrinello, M Barchitta, R Manuele, F Puglisi, A Maugeri, A Barbato, A Triolo, C Giallongo, D Tibullo, L Ferla, C Botta, S Siragusa, C Iacobello, A Montineri, G Volti, A Agodi, G Palumbo, F Raimondo
Scientific Reports 2022
Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection
N Albayrak, C Cano, S Karimi, D Dogahe, A Praet, A Godefroid, V Marmol, D Grimaldi, B Bondue, J Vooren, F Mascart, V Corbière
Frontiers in immunology 2022
Apparent Association of Insulin With Interleukin-6 (IL-6) in Severe COVID-19 Patients Having Chronic Disease Comorbidities
F Nouh, H Othman, E Gwarsha, A Elbadry, A Alabdali, I Barassi, S Elamary, A Elbadry, F Elshaari
Cureus 2022
Dynamic response landscape of immune cells identified immune dysfunction which predicts disease progression in COVID-19 infected patients
X Deng, Y Zhang, M Li, X Tang, J Shen, Y Chen, Y Zhao, Q Wen, X Wu, M Li, J Li, W Xu, W Li, Z Xiao, D Xian, F Du
International journal of biological sciences 2022
Antibody profiles in COVID ‐19 convalescent plasma prepared with amotosalen/ UVA pathogen reduction treatment
A Bagri, R Assis, C Tsai, G Simmons, Z Mei, M Goetz, M Gatmaitan, M Stone, C Germanio, R Martinelli, O Darst, J Rioveros, P Robinson, D Ward, A Ziman, D Seftel, S Khan, M Busch, P Felgner, L Corash
Transfusion 2022
Differences in Characteristics of T-Cell Immunity to SARS-CoV-2 in Clinically Healthy Subjects
N Sushentseva, O Popov, I Polkovnikova, S Alpako, S Shcherbak
Bulletin of Experimental Biology and Medicine 2022
From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
Zhao M, Tian C, Cong S, Di X, Wang K
Frontiers in immunology 2022
Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors
Rovito R, Augello M, Ben-Haim A, Bono V, d\u2019Arminio Monforte A, Marchetti G
Frontiers in immunology 2022
Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2
Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A, Devadas S
Frontiers in immunology 2022
Exploring the Utility of NK Cells in COVID-19
Deng X, Terunuma H, Nieda M
Biomedicines 2022
Adaptive Immune Responses and Immunity to SARS-CoV-2
Primorac D, Vrdoljak K, Brlek P, Pavelić E, Molnar V, Matišić V, Erceg Ivkošić I, Parčina M
Frontiers in immunology 2022
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness
Morrell ED, Bhatraju PK, Sathe NA, Lawson J, Mabrey L, Holton SE, Presnell SR, Wiedeman A, Acosta-Vega C, Mitchem MA, Liu T, Chai XY, Sahi S, Brager C, Orlov M, Sakr SS, Sader A, Lum DM, Koetje N, Garay A, Barnes E, Cromer G, Bray MK, Pipavath S, Fink SL, Evans L, Long SA, West TE, Wurfel MM, Mikacenic C
AJP Lung Cellular and Molecular Physiology 2022
Molecular mechanisms involved in pathogenicity of SARS-CoV-2: Immune evasion and implications for therapeutic strategies
Latifi-Pupovci H
Biomedicine & Pharmacotherapy 2022
What Inhibits Natural Killers’ Performance in Tumour
Papak I, Chruściel E, Dziubek K, Kurkowiak M, Urban-Wójciuk Z, Marjański T, Rzyman W, Marek-Trzonkowska N
International journal of molecular sciences 2022
NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients
Dizaji Asl K, Mazloumi Z, Majidi G, Kalarestaghi H, Sabetkam S, Rafat A
Cell Biochemistry and Function 2022
The deciphering of the immune cells and marker signature in COVID‐19 pathogenesis: An update
Jasim SA, Mahdi RS, Bokov DO, Najm MA, Sobirova GN, Bafoyeva ZO, Taifi A, Alkadir OK, Mustafa YF, Mirzaei R, Karampoor S
Journal of Medical Virology 2022
Tocilizumab Accelerates Recovery in Patients With Severe COVID-19 Pneumonia on Venovenous Extracorporeal Membrane Oxygenation
Lewis TC, Arnouk S, Toy B, Geraci TC, Carillo JA, Chang SH, Moazami N, Kon ZN, Smith DE
ASAIO Journal 2022
Connecting the dots between inflammatory cascades of obesity and COVID-19 in light of mortal consequences—a review
Mal P, Mukherjee T, Upadhyay AK, Mohanty S, Pattnaik AK
Environmental Science and Pollution Research 2022
Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
Medeiros T, Guimarães GM, Carvalho FR, Alves LS, Faustino R, Campi-Azevedo AC, Peruhype-Magalhães V, Teixeira-Carvalho A, de Souza Gomes M, Rodrigues do Amaral L, Martins-Filho OA, Lugon JR, Almeida JR, Silva AA
Cytokine 2022
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA Vaccine
Al-Attiyah R, Safar HA, Botras L, Botras M, Al-Kandari F, Chehadeh W, Mustafa AS
Frontiers in immunology 2022
Lymphocyte Population Changes at Two Time Points during the Acute Period of COVID-19 Infection
Scalia G, Raia M, Gelzo M, Cacciapuoti S, Rosa AD, Pinchera B, Scotto R, Tripodi L, Mormile M, Fabbrocini G, Gentile I, Parrella R, Castaldo G, Scialò F
Journal of Clinical Medicine 2022
Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 Evolution
Garcinuño S, Gil-Etayo FJ, Mancebo E, López-Nevado M, Lalueza A, Díaz-Simón R, Pleguezuelo DE, Serrano M, Cabrera-Marante O, Allende LM, Paz-Artal E, Serrano A
International journal of molecular sciences 2022
Age-dependent NK cell dysfunctions in severe COVID-19 patients
Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumé, Mattia Lanfranchi, Isabella Quinti, Cinzia Milito, Paolo Palange, Ilaria Menichini, Silvano Sozzani, Luigi Frati, Angela Gismondi, Angela Santoni, Helena Stabile
Frontiers in immunology 2022
Where do T cell subsets stand in SARS-CoV-2 infection: an update
Tarique M, Suhail M, Naz H, Muhammad N, Tabrez S, Zughaibi TA, Abuzenadah AM, Hashem AM, Shankar H, Saini C, Sharma A
Frontiers in Cellular and Infection Microbiology 2022
SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination
Vespa S, Simeone P, Catitti G, Buca D, De Bellis D, Pierdomenico L, Pieragostino D, Cicalini I, Del Boccio P, Natale L, Owens T, Khorooshi R, De Laurenzi V, Stuppia L, Lanuti P
International journal of molecular sciences 2022
Alum/CpG Adjuvanted Inactivated COVID-19 Vaccine with Protective Efficacy against SARS-CoV-2 and Variants
Zhang Y, Zheng X, Sheng W, Liang H, Zhao Y, Zhu X, Yang R, Zhang Y, Dong X, Li W, Pei F, Ding L, Chang Z, Deng L, Yuan G, Yang Z, Zhu D, Yang X, Wang H
Human vaccines 2022
Clinical Effect of Early administration of Tocilizumab Following the Initiation of Corticosteroid Therapy for Patients with COVID-19
Kawamata ( T, Tanino ( Y, Nikaido ( T, Minemura ( H, Sato ( Y, Togawa ( R, Watanabe ( N, Yamada ( R, Sato ( R, Onuma ( T, Tomita ( H, Saito ( M, Rikimaru ( M, Suzuki ( Y, Tsukada ( Y, Nakamura ( K, Kanemitsu ( K, Iseki ( K, Shibata ( Y
Journal of Infection and Chemotherapy 2022
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key
Khare K, Pandey R
Frontiers in immunology 2022
Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2.
Lee KS, Russ BP, Wong TY, Horspool AM, Winters MT, Barbier M, Bevere JR, Martinez I, Damron FH, Cyphert HA
iScience 2022
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike
Gatineau J, Nidercorne C, Dupont A, Puiffe ML, Cohen JL, Molinier-Frenkel V, Niedergang F, Castellano F
Frontiers in immunology 2022
Heterogenous CD8+ T Cell Maturation and ‘Polarization’ in Acute and Convalescent COVID-19 Patients
Kudryavtsev IV, Arsentieva NA, Korobova ZR, Isakov DV, Rubinstein AA, Batsunov OK, Khamitova IV, Kuznetsova RN, Savin TV, Akisheva TV, Stanevich OV, Lebedeva AA, Vorobyov EA, Vorobyova SV, Kulikov AN, Sharapova MA, Pevtsov DE, Totolian AA
Viruses 2022
SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows
Solimando AG, Marziliano D, Ribatti D
Biomedicines 2022
The function of myeloid-derived suppressor cells in COVID-19 lymphopenia
Li T, Zheng F, Cheng F
International Immunopharmacology 2022
Neutrophil-Lymphocyte Ratio Predicting Case Severity in SARS-CoV-2 Infection: A Review
Agarwal S
Cureus 2022
Impact of SARS-CoV-2 infection on the profiles and responses of innate immune cells after recovery
Ruenjaiman V, Sodsai P, Kueanjinda P, Bunrasmee W, Klinchanhom S, Reantragoon R, Tunvirachaisakul C, Manothummetha K, Mejun N, Liengswangwong K, Torvorapanit P, Paitoonpong L, Putcharoen O, Palaga T, Hirankarn N
Journal of Microbiology, Immunology and Infection 2022
Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19.
Wang M, Chang W, Zhang L, Zhang Y
International journal of biological sciences 2022
Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review
Tziastoudi M, Cholevas C, Stefanidis I, Theoharides TC
Annals of Clinical and Translational Neurology 2022
Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
Bychinin MV, Klypa TV, Mandel IA, Yusubalieva GM, Baklaushev VP, Kolyshkina NA, Troitsky AV
Scientific Reports 2022
Generation of Cytotoxic T Cells and Dysfunctional CD8 T Cells in Severe COVID-19 Patients
Gozzi-Silva SC, Oliveira LD, Alberca RW, Pereira NZ, Yoshikawa FS, Pietrobon AJ, Yendo TM, de Souza Andrade MM, Ramos YA, Brito CA, Oliveira EA, Beserra DR, Orfali RL, Aoki V, Duarte AJ, Sato MN
Cells 2022
Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes
Messing M, Sekhon MS, Hughes MR, Stukas S, Hoiland RL, Cooper J, Ahmed N, Hamer MS, Li Y, Shin SB, Tung LW, Wellington CL, Sin DD, Leslie KB, McNagny KM
Frontiers in immunology 2022
Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives
Zhu Q, Xu Y, Wang T, Xie F
Frontiers in immunology 2022
Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19
Valenzuela-Fernández A, Cabrera-Rodriguez R, Ciuffreda L, Perez-Yanes S, Estevez-Herrera J, González-Montelongo R, Alcoba-Florez J, Trujillo-González R, García-Martínez de Artola D, Gil-Campesino H, Díez-Gil O, Lorenzo-Salazar JM, Flores C, Garcia-Luis J
Frontiers in Bioengineering and Biotechnology 2022
Immunosenescence and inflamm-ageing in COVID-19
Zinatizadeh MR, Zarandi PK, Ghiasi M, Kooshki H, Mohammadi M, Amani J, Rezaei N
Ageing Research Reviews 2022
Impact of fluvoxamine on outpatient treatment of COVID-19 in Honduras in a prospective observational real-world study
Pineda E, Singh J, Pineda MV, Umanzor JG, Baires F, Benitez LG, Burgos C, Sekhon AK, Crisp N, Lewis AS, Radwanski J, Bermudez M, Barjun KS, Diaz O, Palou E, Escalante RE, Hernandez CI, Stevens ML, Eberhard D, Sierra M, Alvarado T, Videa O, Sierra-Hoffman M, Valerio-Pascua F
Frontiers in pharmacology 2022
Current Developments in the Preclinical and Clinical use of Natural Killer T cells
Kratzmeier C, Singh S, Asiedu EB, Webb TJ
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2022
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Khoo WH, Jackson K, Phetsouphanh C, Zaunders JJ, Alquicira-Hernandez J, Yazar S, Ruiz-Diaz S, Singh M, Dhenni R, Kyaw W, Tea F, Merheb V, Lee FX, Burrell R, Howard-Jones A, Koirala A, Zhou L, Yuksel A, Catchpoole DR, Lai CL, Vitagliano TL, Rouet R, Christ D, Tang B, West NP, George S, Gerrard J, Croucher PI, Kelleher AD, Goodnow CG, Sprent JD, Powell JE, Brilot F, Nanan R, Hsu PS, Deenick EK, Britton PN, Phan TG
Clinical Immunology 2022
CD4+ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1–Dependent
Popescu I, Snyder ME, Iasella CJ, Hannan SJ, Koshy R, Burke R, Das A, Brown MJ, Lyons EJ, Lieber SC, Chen X, Sembrat JC, Bhatt P, Deng E, An X, Linstrum K, Kitsios G, Konstantinidis I, Saul M, Kass DJ, Alder JK, Chen BB, Lendermon EA, Kilaru S, Johnson B, Pilewski JM, Kiss JE, Wells AH, Morris A, McVerry BJ, McMahon DK, Triulzi DJ, Chen K, Sanchez PG, McDyer JF
American journal of respiratory and critical care medicine 2022
High activation levels maintained in receptor‐binding domain–specific memory B cells in people with severe coronavirus disease 2019
Gupta M, Balachandran H, Louie RH, Li H, Agapiou D, Keoshkerian E, Christ D, Rawlinson W, Mina MM, Post JJ, Hudson B, Gilroy N, Konecny P, Bartlett AW, Sasson SC, Ahlenstiel G, Dwyer D, Lloyd AR, Martinello M, Luciani F, Bull RA
Immunology and Cell Biology 2022
Immune profile of children diagnosed with multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C)
Gowin E, Dworacki G, Siewert B, Wysocki J, Januszkiewicz-Lewandowska D
2022
High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56+CD57+PD-1+ Natural Killer Cells, SARS-CoV-2-Specific Memory CD4+ and CD8+ T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients
Srivastava R, Dhanushkodi N, Prakash S, Coulon PG, Vahed H, Zayou L, Quadiri A, BenMohamed L
2022
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of healthcare workers
Magali Noval Rivas, Joseph E. Ebinger, Min Wu, Nancy Sun, Jonathan Braun, Kimia Sobhani, Jennifer E. Van Eyk, Susan Cheng, Moshe Arditi
Journal of Clinical Investigation 2021
An immune-based biomarker signature is associated with mortality in COVID-19 patients
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle Fink, Adriana A. de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura R. Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily Gliniewicz, Elana R. Shaw, Dana Kahle, Andre T. Rastegar, Michael A Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S Lionakis, Luigi D Notarangelo
JCI Insight 2021
Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19
B Liao, Z Liu, L Tang, L Li, Q Gan, H Shi, Q Jiao, Y Guan, M Xie, , H Zhao, W Chen, Y Liu, L Li, Y Wang, Y Cao, Y Shi, Y Li, C Lei
International journal of medical sciences 2021
Major reduction of NKT cells in patients with severe COVID-19 pneumonia
MA Zingaropoli, V Perri, P Pasculli, FC Dezza, P Nijhawan, G Savelloni, GL Torre, C D'Agostino, F Mengoni, M Lichtner, MR Ciardi, CM Mastroianni
Clinical Immunology 2021
Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
G Meoni, V Ghini, L Maggi, A Vignoli, A Mazzoni, L Salvati, M Capone, A Vanni, L Tenori, P Fontanari, F Lavorini, A Peris, A Bartoloni, F Liotta, L Cosmi, C Luchinat, F Annunziato, P Turano, K Subbarao
PLoS pathogens 2021
SARS‐CoV‐2‐specific serological and functional T cell immune responses during acute and early COVID‐19 convalescence in solid organ transplant patients
A Favà, L Donadeu, N Sabé, V Pernin, J GonzálezCostello, L Lladó, M Meneghini, X Charmetant, E GarcíaRomero, A Cachero, A Torija, R RodriguezUrquia, E Crespo, I Teubel, E Melilli, N Montero, A Manonelles, R Preyer, K Strecker, A Ovize, JJ Lozano, J Sidorova, JM Cruzado, ML Quintrec, O Thaunat, O Bestard
American Journal of Transplantation 2021
The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes
G Tang, M Huang, Y Luo, W Liu, Q Lin, L Mao, S Wu, Z Xiong, H Hou, Z Sun, F Wang
Frontiers in immunology 2021
Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
JD Matute, B Finander, D Pepin, X Ai, NP Smith, JZ Li, AG Edlow, AC Villani, PH Lerou, BT Kalish
Pediatric Research 2021
T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19
O Zenarruzabeitia, G Astarloa-Pando, I Terrén, A Orrantia, R Pérez-Garay, I Seijas-Betolaza, J Nieto-Arana, N Imaz-Ayo, S Pérez-Fernández, E Arana-Arri, F Borrego
Frontiers in immunology 2021
Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19
J Yang, M Zhong, E Zhang, K Hong, Q Yang, D Zhou, J Xia, YQ Chen, M Sun, B Zhao, J Xiang, Y Liu, Y Han, M Xu, , C Huang, Y Shang, H Yan, J Wu
Journal of Molecular Cell Biology 2021
High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses
M Xie, J Yunis, Y Yao, J Shi, Y Yang, P Zhou, K Liang, Y Wan, A Mehdi, Z Chen, N Wang, S Xu, M Zhou, M Yu, K Wang, Y Tao, Y Zhou, X Li, X Liu, X Yu, Y Wei, Z Liu, J Sprent, D Yu
IBMS BoneKEy 2021
Autoimmunity and COVID-19 – The microbiotal connection
N Katz-Agranov, G Zandman-Goddard
Autoimmunity Reviews 2021
Anti-VEGF agents: As appealing targets in the setting of COVID-19 treatment in critically ill patients
A Sahebnasagh, SM Nabavi, HR Kashani, S Abdollahian, S Habtemariam, A Rezabakhsh
International Immunopharmacology 2021
SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias, D Furman, DA Winer, E Verdin
2021
The Effect of Unconventional Cytokine Combinations on NK-Cell Responses to Viral Infection
DE Ochayon, SN Waggoner
Frontiers in immunology 2021
SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise
R Duerr, KM Crosse, AM Valero-Jimenez, M Dittmann
Microorganisms 2021
Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice
M Ghasemzadeh, A Ghasemzadeh, E Hosseini
Human Immunology 2021
Activation or exhaustion of CD8+ T cells in patients with COVID-19
MS Rha, EC Shin
Cellular and Molecular Immunology 2021
A scoping review of the pathophysiology of COVID-19
PE Marik, J Iglesias, J Varon, P Kory
International journal of immunopathology and pharmacology 2021
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
EA Thompson, K Cascino, AA Ordonez, W Zhou, A Vaghasia, A Hamacher-Brady, NR Brady, IH Sun, R Wang, AZ Rosenberg, M Delannoy, R Rothman, K Fenstermacher, L Sauer, K Shaw-Saliba, EM Bloch, AD Redd, AA Tobian, M Horton, K Smith, A Pekosz, FR DAlessio, S Yegnasubramanian, H Ji, AL Cox, JD Powell
Cell Reports 2021
Edible and Herbal Plants for the Prevention and Management of COVID-19
S Li, CS Cheng, C Zhang, GY Tang, HY Tan, HY Chen, N Wang, AY Lai, Y Feng
Frontiers in pharmacology 2021
Myeloid cells in COVID-19 microenvironment
G Qin, S Liu, L Yang, W Yu, Y Zhang
Signal Transduction and Targeted Therapy 2021
Directing T-Cell Immune Responses for Cancer Vaccination and Immunotherapy
PL Smith, K Piadel, AG Dalgleish
Human vaccines 2021
Immune System Disequilibrium—Neutrophils, Their Extracellular Traps, and COVID-19-Induced Sepsis
C Keane, M Coalter, I Martin-Loeches
Frontiers in Medicine 2021
Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches
A Hasan, E Al-Ozairi, Z Al-Baqsumi, R Ahmad, F Al-Mulla
ImmunoTargets and Therapy 2021
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
J Hazeldine, J M.
Frontiers in immunology 2021
Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection
X Wang, G Xu, X Liu, Y Liu, S Zhang, Z Zhang
Cellular and Molecular Immunology 2021
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
P Wang, SY Lau, S Deng, P Chen, BW Mok, AJ Zhang, AC Lee, KH Chan, RC Tam, H Xu, R Zhou, W Song, L Liu, KK To, JF Chan, Z Chen, KY Yuen, H Chen
Nature Communications 2021
COVID-19 in Immunosuppressed Children
E Nicastro, L Verdoni, LR Bettini, G Zuin, A Balduzzi, G Montini, A Biondi, L D'Antiga
Frontiers in Pediatrics 2021
Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects
S Yu, C Di, S Chen, M Guo, J Yan, Z Zhu, L Liu, R Feng, Y Xie, R Zhang, J Chen, M Wang, D Wei, H Fang, T Yin, J Huang, S Chen, H Lu, J Zhu, J Qu
Cell Research 2021
A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
JG Yeo, JY Leong, SH Tay, KD Nadua, DE Anderson, AJ Lim, XW Ng, SL Poh, D Guo, KN Yaung, P Kumar, M Wasser, SN Hazirah, N Sutamam, CJ Chua, M Qui, R Foo, AM Gamage, KT Yeo, L Ramakrishna, T Arkachaisri, BE Young, DC Lye, LF Wang, CY Chong, NW Tan, J Li, KQ Kam, F Ginhoux, KC Thoon, JK Chan, CF Yung, S Albani
Frontiers in immunology 2021
Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 Infection
A Lin, WH Yan
Frontiers in immunology 2021
Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System
J Roberts, AL Pritchard, AT Treweeke, AG Rossi, N Brace, P Cahill, SM MacRury, J Wei, IL Megson
Frontiers in Cardiovascular Medicine 2021
Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial
P Tebas, SP Yang, JD Boyer, EL Reuschel, A Patel, A Christensen-Quick, VM Andrade, MP Morrow, K Kraynyak, J Agnes, M Purwar, A Sylvester, J Pawlicki, E Gillespie, I Maricic, FI Zaidi, KY Kim, Y Dia, D Frase, P Pezzoli, K Schultheis, TR Smith, SJ Ramos, T McMullan, K Buttigieg, MW Carroll, J Ervin, MC Diehl, E Blackwood, MP Mammen, J Lee, MJ Dallas, AS Brown, JE Shea, JJ Kim, DB Weiner, KE Broderick, LM Humeau
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The Journal of Clinical Investigation in the time of COVID-19
A Casadevall, S Jackson, GL Semenza, GF Tomaselli, RS Ahima
Journal of Clinical Investigation 2021
Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
A Mazzoni, L Salvati, L Maggi, F Annunziato, L Cosmi
Seminars in Immunology 2021
T Cells: Warriors of SARS-CoV-2 Infection
P de Candia, F Prattichizzo, S Garavelli, G Matarese
Trends in Immunology 2021
Pattern Recognition Proteins: First Line of Defense Against Coronaviruses
CA Labarrere, GS Kassab
Frontiers in immunology 2021
Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review
A Peddapalli, M Gehani, AM Kalle, SR Peddapalli, AE Peter, S Sharad
Viruses 2021
SARS-CoV-2 and Plasma Hypercoagulability
E Steadman, M Fandaros, W Yin
Cellular and Molecular Bioengineering 2021
Basophils and Mast Cells in COVID-19 Pathogenesis
G Murdaca, MD Gioacchino, M Greco, M Borro, F Paladin, C Petrarca, S Gangemi
Cells 2021
Differential alterations in peripheral lymphocyte subsets in COVID-19 patients: upregulation of double-positive and double-negative T cells
AM Zahran, ZA Zahran, YH Mady, EE Mahran, A Rashad, A Makboul, KA Nasif, AA Abdelmaksoud, O El-Badawy
Multidisciplinary Respiratory Medicine 2021
Implications of Laboratory Tests in Disease Grading and Death Risk Stratification of COVID-19: A Retrospective Study in Wuhan, China
Y Bai, E Wang, S Zhao, J Li, Y Zhu, Y Zhang, L Cao, H Liu, Y Dong, F Wang, G Liang, L Liu
Frontiers in Medicine 2021
T cell response to SARS-CoV-2 infection in humans: A systematic review
M Shrotri, MC van Schalkwyk, N Post, D Eddy, C Huntley, D Leeman, S Rigby, SV Williams, WH Bermingham, P Kellam, J Maher, AM Shields, G Amirthalingam, SJ Peacock, SA Ismail, SR Walsh
PloS one 2021
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
MF Osuchowski, MS Winkler, T Skirecki, S Cajander, M Shankar-Hari, G Lachmann, G Monneret, F Venet, M Bauer, FM Brunkhorst, S Weis, A Garcia-Salido, M Kox, JM Cavaillon, F Uhle, MA Weigand, SB Flohé, WJ Wiersinga, R Almansa, A de la Fuente, I Martin-Loeches, C Meisel, T Spinetti, JC Schefold, C Cilloniz, A Torres, EJ Giamarellos-Bourboulis, R Ferrer, M Girardis, A Cossarizza, MG Netea, T van der Poll, JF Bermejo-Martín, I Rubio
The lancet. Respiratory medicine 2021
T cell counts and IL‐6 concentration in blood of North African COVID‐19 patients are two independent prognostic factors for severe disease and death
B Belaid, LL Mahammad, B Mihi, SY Rahali, A Djidjeli, Z Larab, L Berkani, I Berkane, W Sayah, F Merah, NZ Lazli, L Kheddouci, A Kadi, M Ouali, R Khellafi, D Mekideche, A Kheliouen, S Ayoub, RM Hamidi, F Derrar, M Gharnaout, I Allam, R Djidjik
Journal of leukocyte biology 2021
Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients
I Kos, B Balensiefer, V Lesan, D KadduMulindwa, L Thurner, K Christofyllakis, JT Bittenbring, M Ahlgrimm, M Seiffert, S Wagenpfeil, Y Bewarder, F Neumann, T Rixecker, S Smola, A Link, M Krawczyk, F Lammert, PM Lepper, R Bals, S Stilgenbauer, M Bewarder
European Journal of Immunology 2021
SARS-CoV-2-specific T cells in infection and vaccination
A Bertoletti, NL Bert, M Qui, AT Tan
Cellular and Molecular Immunology 2021
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
MS Rha, AR Kim, EC Shin
Immune Network 2021
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations
B Sun, N Tang, MJ Peluso, NS Iyer, L Torres, JL Donatelli, SE Munter, CC Nixon, RL Rutishauser, I Rodriguez-Barraquer, B Greenhouse, JD Kelly, JN Martin, SG Deeks, TJ Henrich, L Pulliam
Cells 2021
SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells
Y Singh, C Trautwein, R Fendel, N Krickeberg, G Berezhnoy, R Bissinger, S Ossowski, MS Salker, N Casadei, O Riess
Heliyon 2021
Immune checkpoint inhibition in COVID-19: risks and benefits
PS Pezeshki, N Rezaei
Expert Opinion on Biological Therapy 2021
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue
TC Theoharides, C Cholevas, K Polyzoidis, A Politis
BioFactors (Oxford, England) 2021
Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, Including Response to SARS-CoV-2, in Autism Spectrum Disorder
TC Theoharides
Journal of Personalized Medicine 2021
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
M Witkowski, C Tizian, M Ferreira-Gomes, D Niemeyer, TC Jones, F Heinrich, S Frischbutter, S Angermair, T Hohnstein, I Mattiola, P Nawrath, SM Ewen, S Zocche, E Viviano, GA Heinz, M Maurer, U Kölsch, RL Chua, T Aschman, C Meisel, J Radke, B Sawitzki, J Roehmel, K Allers, V Moos, T Schneider, L Hanitsch, MA Mall, C Conrad, H Radbruch, CU Duerr, JA Trapani, E Marcenaro, T Kallinich, VM Corman, F Kurth, LE Sander, C Drosten, S Treskatsch, P Durek, A Kruglov, A Radbruch, MF Mashreghi, A Diefenbach
Nature 2021
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19
DM Kim, Y Kim, JW Seo, J Lee, U Park, NY Ha, J Koh, H Park, JW Lee, HJ Ro, NR Yun, DY Kim, SH Yoon, YS Na, DS Moon, SC Lim, CM Kim, K Jeon, JG Kang, NY Jang, H Jeong, J Kim, S Cheon, KM Sohn, JY Moon, S Kym, SR Han, MS Lee, HJ Kim, WY Park, JY Choi, HW Shin, HY Kim, CH Cho, YK Jeon, YS Kim, NH Cho
Cell Reports 2021
Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients
S Tomić, J Đokić, D Stevanović, N Ilić, A Gruden-Movsesijan, M Dinić, D Radojević, M Bekić, N Mitrović, R Tomašević, D Mikić, D Stojanović, M Čolić
Frontiers in immunology 2021
Abnormality in the NK-cell population is prolonged in severe COVID-19 patients
G Leem, S Cheon, H Lee, SJ Choi, S Jeong, ES Kim, HW Jeong, H Jeong, SH Park, YS Kim, EC Shin
Journal of Allergy and Clinical Immunology 2021
Impaired response to first SARS‐CoV ‐2 dose vaccination in myeloproliferative neoplasm patients receiving ruxolitinib
P Guglielmelli, A Mazzoni, L Maggi, ST Kiros, L Zammarchi, S Pilerci, A Rocca, M Spinicci, M Borella, A Bartoloni, GM Rossolini, F Annunziato, AM Vannucchi
American Journal of Hematology 2021
Regulation of the expression of proinflammatory cytokines induced by SARS-CoV-2
XN Zhang, LJ Wu, X Kong, BY Zheng, Z Zhang, ZW He
World journal of clinical cases 2021
Immune memory in convalescent patients with asymptomatic or mild COVID-19
QX Long, YJ Jia, X Wang, HJ Deng, XX Cao, J Yuan, L Fang, XR Cheng, C Luo, AR He, XJ Tang, J Hu, Y Hu, N Tang, XF Cai, DQ Wang, J Hu, JF Qiu, BZ Liu, J Chen, A Huang
Cell Discovery 2021
Immunological Characteristics of Non-Intensive Care Hospitalized COVID-19 Patients: A Preliminary Report
S Corrao, F Gervasi, FD Bernardo, G Natoli, M Raspanti, N Catalano, C Argano
Journal of Clinical Medicine 2021
Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
AM Khesht, V Karpisheh, BQ Saeed, AO Zekiy, LM Yapanto, MN Afjadi, M Aksoun, MN Esfahani, F Aghakhani, M Movahed, N Joshi, K Abbaszadeh-Goudarzi, S Hallaj, M Ahmadi, S Dolati, A Mahmoodpoor, V Hashemi, F Jadidi-Niaragh
International Immunopharmacology 2021
SARS-CoV-2-Associated T-Cell Responses in the Presence of Humoral Immunodeficiency
S Gupta, H Su, T Narsai, S Agrawal
International Archives of Allergy and Immunology 2021
Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements
M Meggyes, DU Nagy, T Balassa, K Godony, A Peterfalvi, L Szereday, B Polgar
Biomolecules 2021
Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients
Q Chen, B Yu, Y Yang, J Huang, Y Liang, J Zhou, L Li, X Peng, B Cheng, Y Lin
International Immunopharmacology 2021
Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability
N Gligorijević, D Stanić-Vučinić, M Radomirović, M Stojadinović, U Khulal, O Nedić, TĆ Veličković
Molecules (Basel, Switzerland) 2021
Endothelial cell, myeloid, and adaptive immune responses in SARS‐CoV‐2 infection
N Degauque, A Haziot, S Brouard, N Mooney
The FASEB Journal 2021
TREC/KREC Levels in Young COVID-19 Patients
MB Khadzhieva, EV Kalinina, SS Larin, DA Sviridova, AS Gracheva, JV Chursinova, VA Stepanov, IV Redkin, LS Avdeikina, AG Rumyantsev, AN Kuzovlev, LE Salnikova
Diagnostics 2021
Innate lymphoid cells (ILC) in SARS-CoV-2 infection
A Kumar, W Cao, K Endrias, SV Kuchipudi, SK Mittal, S Sambhara
Molecular Aspects of Medicine 2021
Immune profiling of COVID-19: preliminary findings and implications for the pandemic
HT Maecker
Journal for ImmunoTherapy of Cancer 2021
Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider
A Najm, A Alunno, X Mariette, B Terrier, GD Marco, J Emmel, L Mason, DG McGonagle, PM Machado
RMD Open 2021
Adaptive immune responses to SARS-CoV-2
D Forthal
Advanced Drug Delivery Reviews 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection
A Synowiec, A Szczepański, E Barreto-Duran, LK Lie, K Pyrc
Clinical microbiology reviews 2021
Mild and Asymptomatic COVID-19 Convalescents Present Long-Term Endotype of Immunosuppression Associated With Neutrophil Subsets Possessing Regulatory Functions
I Siemińska, K Węglarczyk, M Surmiak, D Kurowska-Baran, M Sanak, M Siedlar, J Baran
Frontiers in immunology 2021
EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19
A Alunno, A Najm, PM Machado, H Bertheussen, GR Burmester, F Carubbi, GD Marco, R Giacomelli, O Hermine, JD Isaacs, I Koné-Paut, C Magro-Checa, I McInnes, PL Meroni, L Quartuccio, AV Ramanan, M Ramos-Casals, JR Carrio, H Schulze-Koops, TA Stamm, SW Tas, B Terrier, DG McGonagle, X Mariette
Annals of the rheumatic diseases 2021
Gamma Delta T Cells and Their Involvement in COVID-19 Virus Infections
G von Massow, S Oh, A Lam, K Gustafsson
Frontiers in immunology 2021
Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators
D Ricci, MP Etna, F Rizzo, S Sandini, M Severa, EM Coccia
International journal of molecular sciences 2021
Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients
E Martín-Sánchez, JJ Garcés, C Maia, S Inogés, AL de Cerio, F Carmona-Torre, M Marin-Oto, F Alegre, E Molano, M Fernandez-Alonso, C Perez, C Botta, A Zabaleta, AB Alcaide, MF Landecho, M Rua, T Pérez-Warnisher, L Blanco, S Sarvide, A Vilas-Zornoza, D Alignani, C Moreno, I Pineda, M Sogbe, J Argemi, B Paiva, JR Yuste
Frontiers in immunology 2021
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19
R Wendt, MT Lingitz, M Laggner, M Mildner, D Traxler, A Graf, P Krotka, B Moser, K Hoetzenecker, S Kalbitz, C Lübbert, J Beige, HJ Ankersmit
Biology : open access journal 2021
Severe Acute Respiratory Syndrome Coronavirus 2: Manifestations of Disease and Approaches to Treatment and Prevention in Humans
ME Watson, K Inagaki, JB Weinberg
Comparative medicine 2021
Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities
CF Chu, F Sabath, S Fibi-Smetana, S Sun, R Öllinger, E Noeßner, YY Chao, L Rinke, E Winheim, R Rad, AB Krug, L Taher, CE Zielinski
Frontiers in immunology 2021
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
J Lim, KJ Puan, LW Wang, KW Teng, CY Loh, KP Tan, G Carissimo, YH Chan, CM Poh, CY Lee, SW Fong, NK Yeo, RS Chee, SN Amrun, ZW Chang, MZ Tay, A Torres-Ruesta, NL Fernandez, W How, AK Andiappan, W Lee, K Duan, SY Tan, G Yan, S Kalimuddin, DC Lye, YS Leo, SW Ong, BE Young, L Renia, LF Ng, B Lee, O Rötzschke
Frontiers in immunology 2021
Binding of phosphatidylserine‐positive microparticles by PBMCs classifies disease severity in COVID‐19 patients
L Rausch, K Lutz, M Schifferer, E Winheim, R Gruber, EF Oesterhaus, L Rinke, JC Hellmuth, C Scherer, M Muenchhoff, C Mandel, M BergweltBaildon, M Simons, T Straub, AB Krug, J Kranich, T Brocker
Journal of Extracellular Vesicles 2021
Perforin, COVID‐19 and a possible pathogenic auto‐inflammatory feedback loop
L Cunningham, I Kimber, D Basketter, P Simmonds, S McSweeney, C Tziotzios, JP McFadden
Scandinavian Journal of Immunology 2021
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19
J Shi, J Zhou, X Zhang, W Hu, JF Zhao, S Wang, FS Wang, JY Zhang
Frontiers in immunology 2021
COVID-19 in immunocompromised patients: A systematic review of cancer, hematopoietic cell and solid organ transplant patients
JA Belsky, BP Tullius, MG Lamb, R Sayegh, JR Stanek, JJ Auletta
Journal of Infection 2021
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients
A Sacconi, CD Vitis, L de Latouliere, S di Martino, FD Nicola, F Goeman, C Mottini, F Paolini, M DAscanio, A Ricci, A Tafuri, P Marchetti, AD Napoli, LD Biase, A Negro, C Napoli, P Anibaldi, V Salvati, D Duffy, B Terrier, M Fanciulli, C Capalbo, S Sciacchitano, G Blandino, G Piaggio, R Mancini, G Ciliberto
Cell Death and Disease 2021
Mast cells: Therapeutic targets for COVID ‐19 and beyond
HY Lam, V Tergaonkar, AP Kumar, KS Ahn
IUBMB Life 2021
An Overview on the Epidemiology and Immunology of COVID-19
M Meskini, MR Rami, P Maroofi, S Ghosh, SD Siadat, M Sheikhpour
Journal of Infection and Public Health 2021
Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
HE Jung, HK Lee
Viruses 2021
What we know and still ignore on COVID‐19 immune pathogenesis and a proposal based on the experience of allergic disorders
E Maggi, BG Azzarone, GW Canonica, L Moretta
Allergy 2021
Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
Juan Matute, Benjamin Finander, David Pepin, Xinbin Ai, Neal Smith, Jonathan Li, Andrea Edlow, Alexandra Villani, Paul Lerou, Brian Kalish
Research square 2021
Hemophagocytic histiocytosis in severe SARS‐CoV‐2 infection: A bone marrow study
H Dandu, G Yadav, HS Malhotra, S Pandey, R Sachu, K Dubey
International Journal of Laboratory Hematology 2021
Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis
R Chu, C van Eeden, S Suresh, WI Sligl, M Osman, JW Tervaert
International journal of molecular sciences 2021
NK and T Cell Immunological Signatures in Hospitalized Patients with COVID-19
L Bergantini, M d'Alessandro, P Cameli, D Cavallaro, S Gangi, B Cekorja, P Sestini, E Bargagli
Cells 2021
Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study
E Kalicińska, D Szymczak, A Zińczuk, B Adamik, J Smiechowicz, T Skalec, D Nowicka-Suszko, M Biernat, A Bogucka-Fedorczuk, J Rybka, A Martuszewski, W Gozdzik, K Simon, T Wróbel
Cells 2021
Manifestations and mechanisms of central nervous system damage caused by SARS-CoV-2
F Yang, H Zhao, H Liu, X Wu, Y Li
Brain Research Bulletin 2021
Cytokine Storms in the Course of COVID-19 and Haemophagocytic Lymphohistiocytosis in Pregnant and Postpartum Women
A Obuchowska, A Standyło, K Obuchowska, Ż Kimber-Trojnar, B Leszczyńska-Gorzelak
Biomolecules 2021
Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities
M Emadi-Baygi, M Ehsanifard, N Afrashtehpour, M Norouzi, Z Joz-Abbasalian
Frontiers in immunology 2021
Single-cell immunology of SARS-CoV-2 infection
Y Tian, LN Carpp, HE Miller, M Zager, EW Newell, R Gottardo
Nature Biotechnology 2021
Early Response of CD8+ T Cells in COVID-19 Patients
D Ramljak, M Vukoja, M Curlin, K Vukojevic, M Barbaric, U Glamoclija, B Purisevic, O Peric, V Soljic
Journal of Personalized Medicine 2021
Severe Type of COVID-19: Pathogenesis, Warning Indicators and Treatment
K Shi, Y Liu, Q Zhang, C Ran, J Hou, Y Zhang, X Wang
Chinese Journal of Integrative Medicine 2021
Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates
H Zhao, TC Wang, XF Li, NN Zhang, L Li, C Zhou, YQ Deng, TS Cao, G Yang, RT Li, YJ Huang, YG Li, YM Zhang, FX Li, YR Zhou, YH Jiang, , SH Sun, ML Cheng, KP Gu, M Zhang, QQ Ma, X Yang, B Ying, YW Gao, CF Qin
Signal Transduction and Targeted Therapy 2021
Lymphopenia: A useful predictor of COVID-19 disease severity and mortality
KU Toori, MA Qureshi, A Chaudhry
Pakistan Journal of Medical Sciences 2021
Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
SK Henne, LM Hochfeld, C., MM Nöthen, S HeilmannHeimbach
2021
Hypertension and its management in COVID-19 patients: The assorted view
GE Batiha, A Gari, N Elshony, HM Shaheen, MB Abubakar, SB Adeyemi, HM Al-kuraishy
2021
Prognostic Nutritional Index and CRP, age, platelet count, albumin level score in predicting mortality and intensive care unit admission for COVID-19
M Bayram, O Yildirim, RS Ozmen, B Soylu, AS Dundar, AR Koksal, I Ekinci, M Akarsu, O Tabak
Biomarkers in Medicine 2021
Immune characterization of a Colombian family cluster with SARS-CoV-2 infection
W Aguilar-Jiménez, L Flórez-Álvarez, DS Rincón, D Marín-Palma, A Sánchez-Martínez, J Martínez, MI Zapata, JD Loaiza, C Cárdenas, F Guzmán, PA Velilla, NA Taborda, W Zapata, JC Hernández, FJ Díaz, MT Rugeles
Biomédica 2021
Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19
S Hashimoto, K Yoshizaki, K Uno, H Kitajima, T Arai, Y Tamura, H Morishita, H Matsuoka, Y Han, S Minamoto, T Hirashima, T Yamada, Y Kashiwa, M Kameda, S Yamaguchi, Y Tsuchihashi, M Iwahashi, E Nakayama, T Shioda, T Nagai, T Tanaka
Frontiers in Medicine 2021
Peptides Derived From S and N Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Induce T Cell Responses: A Proof of Concept for T Cell Vaccines
YS Lee, SH Hong, HJ Park, HY Lee, JY Hwang, SY Kim, JW Park, KS Choi, JK Seong, SI Park, SM Lee, KA Hwang, JW Yun, JH Nam
Frontiers in microbiology 2021
Computational simulations to dissect the cell immune response dynamics for severe and critical cases of SARS-CoV-2 infection
R Blanco-Rodríguez, X Du, E Hernández-Vargas
Computer Methods and Programs in Biomedicine 2021
Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls
A Mert, H Vahaboğlu, F Arslan, A Batirel, KT Saraçoğlu, A Bastug, A Çağatay, İ Irmak, GT Dizman, İ Ertenli, LN Altunal, BE Sengel, M Bayram, A Omma, S Amikishiyev, A Aypak, C Bes, S Bolukçu, S Içten, A Topeli, M Bektaş, BY Arslan, S Öztürk, Ş Çomoğlu, S Aydin, O Küçükşahin, OC Içaçan, B Ince, S Aghamuradov, MY Mutlu, F Şimşek, S Emre, C Ustun, P Ergen, Ö Aydin, MM Koç, ÖG Sevindik, Z Odabaşı, V Korten, H Bodur, R Güner, S Ünal, M Kocak, A Gül
Rheumatology International 2021
Balancing Potential Benefits and Risks of Bruton Tyrosine Kinase Inhibitor Therapies in Multiple Sclerosis During the COVID-19 Pandemic
MS Weber, JA Nicholas, MR Yeaman
Neurology: Neuroimmunology & Neuroinflammation 2021
High‑dose intravenous immunoglobulins as a therapeutic option in critical illness polyneuropathy accompanying SARS‑CoV‑2 infection: A case‑based review of the literature (Review)
A Stoian, Z Bajko, S Maier, R Cioflinc, B Grigorescu, A Moțățăianu, L Bărcuțean, R Balașa, M Stoian
Experimental and therapeutic medicine 2021
Dynamics of host immune responses to SARS-CoV-2
R Taherkhani, S Taherkhani, F Farshadpour
World journal of clinical cases 2021
Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients
DA Rodríguez-Serrano, E Roy-Vallejo, ND Cruz, AM Ramírez, SC Rodríguez-García, N Arevalillo-Fernández, JM Galván-Román, LF García-Rodrigo, L Vega-Piris, MC Llano, DA Méndez, BG de Marcos, JH Santos, AS Azofra, EÁ Pérez-Urria, P Rodriguez-Cortes, L Esparcia, A Marcos-Jimenez, S Sánchez-Alonso, I Llorente, J Soriano, CS Fernández, R García-Vicuña, J Ancochea, J Sanz, C Muñoz-Calleja, R de la Cámara, AC Berlanga, I González-Álvaro, L Cardeñoso, RM Hernández, M Orts, C Figueroa, C Román, A Planas, LD Arganda, PM Vives, GD Nieto, A Cecconi, A Benedicto, AR González, J Jiménez-Borreguero, C del Arco, JM Aguilar, N Villalba, M Negro, E Contreras, A del Rey, C Santiago, M Junquera, R Caminero, FJ Val, S González, M Caño, I López, A von Wernitz, I Guerra, J Sorando, L Chao, MJ Cárdenas, V Espiga, A Pizarro, ÁF Álvarez, B Aguado, J Cannata, J Ortiz, A Morell, E Ramírez, AI Zurriaga, MP Abanades, SR García, TG Aranda, M Ruiz, CM Nieto, JM Serra, F Sánchez-Madrid, I Sánchez-Cerrillo, P Martínez-Fleta, C López-Sanz, L Gabrie, L del Campo Guerola, E Fernández, R Tejedor, PA Haro, MT Genao, BQ Dorado, DJ Jiménez, MA González, P Villamayor, I de los Santos, E Sánchez, F Moldenhauer, P Casado, J Curbelo, A Gutiérrez, A Bautista, NR Giménez, A Fernández, LG Fraile, P Parra, B Moyano, A Barrios, P Gil, IG Polo, DR de Asúa, B Sánchez, C Sáez, M Ciudad, MF Rico, CA Román, EM Rodríguez, D Navas, M del Carmen Cuevas Torresano, DD García, TA Cavero, AG Blanco, MA Chong, AG Cobos, AM Torres, T Alonso, P Landete, J Soriano, C Cisneros, EG Castillo, C Valenzuela, FJ Pérez, RM Girón, J Aspa, C Marcos, E Zamora, G Iturricastillo, MB Mayo, ER Garrido, S Castañeda, C Fernández-Díaz, EG Tomero, NG Castañeda, AM Ortiz, C Valero, M Uriarte, N Montes, IG Sanz, FE Viamontes, JD Valdueza
Scientific Reports 2021
Therapeutic use of specific tumour necrosis factor inhibitors in inflammatory diseases including COVID-19
S Patel, M Wadhwa
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2021
Delivery Routes for COVID-19 Vaccines
JH Park, HK Lee
Human vaccines 2021
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
K Renner, T Schwittay, S Chaabane, J Gottschling, C Müller, C Tiefenböck, JN Salewski, F Winter, S Buchtler, S Balam, MV Malfertheiner, M Lubnow, D Lunz, B Graf, F Hitzenbichler, F Hanses, H Poeck, M Kreutz, E Orsó, R Burkhardt, T Niedermair, C Brochhausen, A Gessner, B Salzberger, M Mack
Nature Communications 2021
Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
A Gangaev, SL Ketelaars, OI Isaeva, S Patiwael, A Dopler, K Hoefakker, SD Biasi, L Gibellini, C Mussini, G Guaraldi, M Girardis, CM Ormeno, PJ Hekking, NM Lardy, M Toebes, R Balderas, TN Schumacher, H Ovaa, A Cossarizza, P Kvistborg
Nature Communications 2021
Innate immune sensing of coronavirus and viral evasion strategies
Y Kasuga, B Zhu, KJ Jang, JS Yoo
Experimental & molecular medicine 2021
Role of the Immune Microenvironment in SARS-CoV-2 Infection
CH Ye, WL Hsu, GR Peng, WC Yu, WC Lin, SY Hu, SH Yu
Cell Transplantation 2021
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu
Cell Discovery 2021
Gastrointestinal Microenvironment and the Gut-Lung Axis in the Immune Responses of Severe COVID-19
Y Yang, W Huang, Y Fan, GQ Chen
Frontiers in Molecular Biosciences 2021
The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review
S Huang, S Zhao, H Luo, Z Wu, J Wu, H Xia, X Chen
BMC Pulmonary Medicine 2021
The effect of azoximer bromide (Polyoxidonium®) in patients hospitalized with coronavirus disease (COVID-19): an open-label, multicentre, interventional clinical study
SV Efimov, NV Matsiyeuskaya, OV Boytsova, LY Akhieva, EI Kvasova, F Harrison, YS Karpova, A Tikhonov, NF Khomyakova, T Hardman, JF Rossi
Drugs in Context 2021
Cytotoxic T-lymphocyte elicited vaccine against SARS-CoV-2 employing immunoinformatics framework
N Kumar, N Admane, A Kumari, D Sood, S Grover, VK Prajapati, R Chandra, A Grover
Scientific Reports 2021
Immune Response Failure in Paucisymptomatic Long-Standing SARS-CoV-2 Spreaders
S Corrao, F Gervasi, FD Bernardo, C Argano
Clinics and Practice 2021
Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis – Author’s reply
T Kashour, IM Tleyjeh
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2021
Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques
PD Yadav, R Ella, S Kumar, DR Patil, S Mohandas, AM Shete, KM Vadrevu, G Bhati, G Sapkal, H Kaushal, S Patil, R Jain, G Deshpande, N Gupta, K Agarwal, M Gokhale, B Mathapati, S Metkari, C Mote, D Nyayanit, DY Patil, BS Prasad, A Suryawanshi, M Kadam, A Kumar, S Daigude, S Gopale, T Majumdar, D Mali, P Sarkale, S Baradkar, P Gawande, Y Joshi, S Fulari, H Dighe, S Sharma, R Gunjikar, A Kumar, K Kalele, VK Srinivas, RR Gangakhedkar, KM Ella, P Abraham, S Panda, B Bhargava
Nature Communications 2021
Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19
W Sayah, I Berkane, I Guermache, M Sabri, FZ Lakhal, SY Rahali, A Djidjeli, LL mahammed, F Merah, B Belaid, L Berkani, NZ Lazli, L Kheddouci, A Kadi, M Ouali, R Khellafi, D Mekideche, A Kheliouen, RM Hamidi, S Ayoub, NB Raaf, F Derrar, M Gharnaout, I Allam, R Djidjik
Cytokine 2021
An Overview of Nucleic Acid Testing for the Novel Coronavirus SARS-CoV-2
H Wang, G Li, J Zhao, Y Li, Y Ai
Frontiers in Medicine 2021
Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients
C Bao, X Tao, W Cui, Y Hao, S Zheng, B Yi, T Pan, KH Young, W Qian
Experimental Hematology and Oncology 2021
Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors?
T Çınar, Mİ Hayıroğlu, V Çiçek, Ş Kılıç, S Asal, S Yavuz, M Selçuk, E Yalçınkaya, N Keser, AL Orhan
Heart & lung : the journal of critical care 2021
Haemophagocytic syndrome and COVID-19
S Retamozo, P Brito-Zerón, A Sisó-Almirall, A Flores-Chávez, MJ Soto-Cárdenas, M Ramos-Casals
Clinical Rheumatology 2021
PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19
MS Rha, HW Jeong, JH Ko, SJ Choi, IH Seo, JS Lee, M Sa, AR Kim, EJ Joo, JY Ahn, JH Kim, KH Song, ES Kim, DH Oh, MY Ahn, HK Choi, JH Jeon, JP Choi, HB Kim, YK Kim, SH Park, WS Choi, JY Choi, KR Peck, EC Shin
Immunity 2021
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant
RS Abraham, JM Marshall, HS Kuehn, CM Rueda, A Gibbs, W Guider, C Stewart, SD Rosenzweig, H Wang, S Jean, M Peeples, T King, WG Hunt, JR Honegger, O Ramilo, PJ Mustillo, A Mejias, MI Ardura, M Shimamura
Journal of Allergy and Clinical Immunology 2021
Combination of cycle threshold time, absolute lymphocyte count and neutrophil:lymphocyte ratio is predictive of hypoxia in patients with SARS-CoV-2 infection
V Abeysuriya, S Seneviratne, A de Silva, R Mowjood, S Mowjood, T de Silva, P de Mel, C de Mel, L Chandrasena, R Wijesinha, A Fernando, S de Mel
Transactions of the Royal Society of Tropical Medicine and Hygiene 2021
Expansion of CD56dimCD16neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 Patients
J Casado, E Moraga, P Vizcarra, H Velasco, A Martín-Hondarza, J Haemmerle, S Gómez, C Quereda, A Vallejo
Viruses 2021
An update on host immunity correlates and prospects of re-infection in COVID-19
N Negi, S Maurya, R Singh, B Das
International Reviews of Immunology 2021
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
K Ying, R Zhai, T Pyrkov, A Shindyapina, M Mariotti, P Fedichev, X Shen, V Gladyshev
2021
Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology
A Codd, S Hanna, E Compeer, F Richter, E Pring, E Gea-Mallorquí, M Borsa, O Moon, D Scourfield, D Ahern, H Almuttaqi, D Alonzi, A Alrubayyi, G Alsaleh, V Bart, V Batchelor, R Bayliss, D Berthold, J Bezbradica, T Bharuchq, H Borrmann, M Borsa, R Borst, J Brun, S Burnell, L Capitani, A Cavounidis, L Chapman, A Chauveau, L Cifuentes, A Codd, E Compeer, C Coveney, A Cross, S Danielli, L Davies, C Dendrou, S Dimonte, R Durairaj, L Dustin, A Dyer, C Fielding, F Fischer, A Gallimore, S Galloway, A Gammage, E Gea-Mallorquí, A Godkin, S Hanna, C Heuberger, S Hulin-Curtis, F Issa, E Jones, R Jones, K Ladell, S Lauder, K Liddiard, P Ligoxygakis, F Lu, B MacLachlan, S Maleki-Toyserkani, E Mann, A Marzeda, R Matthews, J Mazet, A Milicic, E Mitchell, O Moon, V Nguyen, M O'Hanlon, C Pavillet, D Peppa, A Pires, E Pring, M Quastel, S Reed, J Rehwinkel, N Richmond, F Richter, A Robinson, P Rodrigues, P Sabberwal, A Sami, R Peres, Q Sattentau, B Schonfeldova, D Scourfield, T Selvakumar, F Shepherd, C Shorten, A Simon, A Smith, A Crespo, M Tellier, E Thornton, L Uhl, E van Grinsven, A Wann, R Williams, J Wilson, D Zhou, Z Zhu, A Gallimore, A Milicic
2021
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
Rouphael N, Maecker H, Montgomery RR, Diray-Arce J, Kleinstein SH, Altman MC, Bosinger SE, Eckalbar W, Guan L, Hough CL, Krammer F, Langelier C, Levy O, McEnaney K, Peters B, Rahman A, Rajan JV, Sigelman S, Steen H, van Bakel H, Ward A, Wilson MR, Woodruff P, Zamecnik CR, Augustine AD, Ozonoff A, Reed EF, Becker PM, Higuita NA, Altman MC, Atkinson MA, Baden LR, Becker PM, Bime C, Brakenridge SC, Calfee CS, Cairns CB, Corry D, Davis MM, Augustine AD, Ehrlich LI, Haddad EK, Erle DJ, Fernandez-Sesma A, Hafler DA, Hough CL, Kheradmand F, Kleinstein SH, Kraft M, Levy O, McComsey GA, Melamed E, Messer W, Metcalf J, Montgomery RR, Nadeau KC, Ozonoff A, Peters B, Pulendran B, Reed EF, Rouphael N, Sarwal M, Schaenman J, Sekaly R, Shaw AC, Simon V
Science Immunology 2021
Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial*
Tom J, Bao M, Tsai L, Qamra A, Summers D, Carrasco-Triguero M, McBride J, Rosenberger CM, Lin CJ, Stubbings W, Blyth KG, Carratalà J, François B, Benfield T, Haslem D, Bonfanti P, van der Leest CH, Rohatgi N, Wiese L, Luyt CE, Kheradmand F, Rosas IO, Cai F
Critical Care Medicine 2021
Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution
De Cassai A, Longhini F, Romagnoli S, Cavaliere F, Caroleo A, Foti L, Furlani E, Gianoli S, Monteleone F, Saraco G, Villa G, Conti G, Navalesi P
2021
The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role
Bertoletti A, Tan AT, Le Bert N
2021
Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults.
Lewis SA, Sureshchandra S, Zulu MZ, Doratt B, Jankeel A, Ibraim IC, Pinski AN, Rhoades NS, Curtis M, Jiang X, Tifrea D, Zaldivar F, Shen W, Edwards RA, Chow D, Cooper D, Amin A, Messaoudi I
2021
Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques
Hasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith B, Meade-White K, Shupert WL, Hawman DW, Feldmann H
2021
Rationale for Randomized Clinical Trials Investigating the Potential of BCG Vaccination in Preventing COVID-19 Infection
Noval Rivas M, Rosser CJ, Arditi M
Bladder Cancer 2021
SARS-CoV-2 specific T-cell responses and correlations with COVID-19 patient predisposition
Arne Sattler, Stefan Angermair, Helena Stockmann, Katrin Moira Heim, Dmytro Khadzhynov, Sascha Treskatsch, Fabian Halleck, Martin E. Kreis, Katja Kotsch
Journal of Clinical Investigation 2020
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation
Gunjan L. Shah, Susan DeWolf, Yeon Joo Lee, Roni Tamari, Parastoo B. Dahi, Jessica A. Lavery, Josel D. Ruiz, Sean M. Devlin, Christina Cho, Jonathan U. Peled, Ioannis Politikos, Michael Scordo, N. Esther Babady, Tania Jain, Santosha Vardhana, Anthony F. Daniyan, Craig S. Sauter, Juliet N. Barker, Sergio A. Giralt, Cheryl Goss, Peter Maslak, Tobias M. Hohl, Mini Kamboj, Lakshmi Ramanathan, Marcel R.M. van den Brink, Esperanza B. Papadopoulos, Genovefa A. Papanicolaou, Miguel-Angel Perales
Journal of Clinical Investigation 2020
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19
Y Rodríguez, L Novelli, M Rojas, MD Santis, Y Acosta-Ampudia, DM Monsalve, C Ramírez-Santana, A Costanzo, WM Ridgway, AA Ansari, ME Gershwin, C Selmi, JM Anaya
Journal of Autoimmunity 2020
Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics
A Ritter, NN Kreis, F Louwen, J Yuan
International journal of molecular sciences 2020
A gendered magnifying glass on COVID-19
L Salvati, B Biagioni, E Vivarelli, P Parronchi
Clinical and Molecular Allergy 2020
Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies
M Market, L Angka, AB Martel, D Bastin, O Olanubi, G Tennakoon, DM Boucher, J Ng, M Ardolino, RC Auer
Frontiers in immunology 2020
Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeutics
V Kumar
International Immunopharmacology 2020
The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection
O Gallo, LG Locatello, A Mazzoni, L Novelli, F Annunziato
Mucosal Immunology 2020
Can Natural Killer Cells Be a Principal Player in Anti-SARS-CoV-2 Immunity?
F Ahmed, DH Jo, SH Lee
Frontiers in immunology 2020
COVID-19: The Emerging Immunopathological Determinants for Recovery or Death
T Ahmad, R Chaudhuri, MC Joshi, A Almatroudi, AH Rahmani, SM Ali
Frontiers in microbiology 2020
On the genetics and immunopathogenesis of COVID-19
CO Jacob
Clinical Immunology 2020
Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020
C Manickam, S Sugawara, RK Reeves, TC Hobman
PLoS pathogens 2020
T cell phenotypes in COVID-19 - a living review
SJ Hanna, AS Codd, E Gea-Mallorqui, DO Scourfield, FC Richter, K Ladell, M Borsa, EB Compeer, OR Moon, SA Galloway, S Dimonte, L Capitani, FR Shepherd, JD Wilson, LF Uhl, DJ Ahern, H Almuttaqi, DS Alonzi, A Alrubayyi, G Alsaleh, VM Bart, V Batchelor, R Bayliss, DL Berthold, JS Bezbradica, T Bharuchq, H Borrmann, M Borsa, R Borst, J Brun, S Burnell, L Capitani, A Cavounidis, L Chapman, A Chauveau, L Cifuentes, AS Codd, EB Compeer, C Coveney, A Cross, S Danielli, LC Davies, CA Dendrou, S Dimonte, RR Durairaj, LB Dustin, A Dyer, C Fielding, F Fischer, A Gallimore, S Galloway, A Gammage, E Gea-Mallorquí, A Godkin, SJ Hanna, C Heuberger, S Hulin-Curtis, F Issa, E Jones, R Jones, K Ladell, SN Lauder, K Liddiard, P Ligoxygakis, F Lu, B MacLachlan, S Maleki-Toyserkani, EH Mann, AM Marzeda, RJ Matthews, JM Mazet, A Milicic, E Mitchell, O Moon, VD Nguyen, M O'Hanlon, CE Pavillet, D Peppa, A Pires, E Pring, M Quastel, S Reed, J Rehwinkel, N Richmond, FC Richter, AJ Robinson, PR Rodrigues, P Sabberwal, A Sami, RS Peres, Q Sattentau, B Schonfeldova, DO Scourfield, TA Selvakumar, FR Shepherd, C Shorten, AK Simon, AL Smith, AT Crespo, M Tellier, E Thornton, LF Uhl, E van Grinsven, AK Wann, R Williams, JD Wilson, D Zhou, Z Zhu, AM Gallimore, A Milicic
2020
Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection
J Yang, E Zhang, M Zhong, Q Yang, K Hong, T Shu, D Zhou, J Xiang, J Xia, , D Zhang, C Huang, Y Shang, H Yan
Virologica Sinica 2020
T cell responses in patients with COVID-19
Z Chen, EJ Wherry
Nature Reviews Immunology 2020
Natural killer cell immunotypes related to COVID-19 disease severity
C Maucourant, I Filipovic, A Ponzetta, S Aleman, M Cornillet, L Hertwig, B Strunz, A Lentini, B Reinius, D Brownlie, A Cuapio, EH Ask, RM Hull, A Haroun-Izquierdo, M Schaffer, J Klingström, E Folkesson, M Buggert, JK Sandberg, LI Eriksson, O Rooyackers, HG Ljunggren, KJ Malmberg, J Michaëlsson, N Marquardt, Q Hammer, K Strålin, NK Björkström
Science Immunology 2020
Threading the Pieces Together: Integrative Perspective on SARS-CoV-2
A Kanakan, N Mishra, JS Vasudevan, S Sahni, A Khan, S Sharma, R Pandey
Pathogens 2020
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?
JM Berthelot, F Lioté, Y Maugars, J Sibilia
Frontiers in immunology 2020
Pulmonary vascular improvement in severe COVID-19 patients treated with tocilizumab
L Salvati, M Occhipinti, L Gori, L Ciani, A Mazzoni, L Maggi, M Capone, P Parronchi, F Liotta, V Miele, F Annunziato, F Lavorini, L Cosmi
Immunology Letters 2020
Quantitative and qualitative alterations of circulating myeloid cells and plasmacytoid DC in SARS‐CoV‐2 infection
B Peruzzi, S Bencini, M Capone, A Mazzoni, L Maggi, L Salvati, A Vanni, C Orazzini, C Nozzoli, A Morettini, L Poggesi, F Pieralli, A Peris, A Bartoloni, AM Vannucchi, F Liotta, R Caporale, L Cosmi, F Annunziato
Immunology 2020
Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome
LY Chen, RL Hoiland, S Stukas, CL Wellington, MS Sekhon
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2020
Natural Killer Cell Dysfunction and Its Role in COVID-19
C van Eeden, L Khan, MS Osman, JW Tervaert
International journal of molecular sciences 2020
COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment
A Arastehfar, A Carvalho, FL van de Veerdonk, JD Jenks, P Koehler, R Krause, OA Cornely, DS Perlin, C Lass-Flörl, M Hoenigl
Journal of Fungi 2020
The immune system view of the coronavirus SARS-CoV-2
I Celardo, L Pace, L Cifaldi, C Gaudio, V Barnaba
Biology direct 2020
Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions
EA Meyerowitz, P Sen, SR Schoenfeld, TG Neilan, MJ Frigault, JH Stone, AY Kim, MK Mansour
Clinical Infectious Diseases 2020
Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset
JF Gutiérrez-Bautista, A Rodriguez-Nicolas, A Rosales-Castillo, P Jiménez, F Garrido, P Anderson, F Ruiz-Cabello, MÁ López-Ruz
Frontiers in immunology 2020
First Report of Tocilizumab Use in a Cohort of Latin American Patients Hospitalized for Severe COVID-19 Pneumonia
O Valenzuela, S Ibáñez, MC Poli, P Roessler, M Aylwin, G Roizen, M Iruretagoyena, V Agar, J Donoso, M Fierro, J Montes
Frontiers in Medicine 2020
The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic review
AG Kaye, R Siegel
PeerJ 2020
Long-Term Existence of SARS-CoV-2 in COVID-19 Patients: Host Immunity, Viral Virulence, and Transmissibility
X Wang, K Huang, H Jiang, L Hua, W Yu, D Ding, K Wang, X Li, Z Zou, M Jin, S Xu
Virologica Sinica 2020
Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome
A Sacchi, G Grassi, V Bordoni, P Lorenzini, E Cimini, R Casetti, E Tartaglia, L Marchioni, N Petrosillo, F Palmieri, G DOffizi, S Notari, M Tempestilli, MR Capobianchi, E Nicastri, M Maeurer, A Zumla, F Locatelli, A Antinori, G Ippolito, C Agrati
Cell Death and Disease 2020
Continuous tracking of COVID-19 patients' immune status
J Guan, X Wei, S Qin, X Liu, Y Jiang, Y Chen, Y Chen, H Lu, J Qian, Z Wang, X Lin
International Immunopharmacology 2020
Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study
BJ Webb, ID Peltan, P Jensen, D Hoda, B Hunter, A Silver, N Starr, W Buckel, N Grisel, E Hummel, G Snow, D Morris, E Stenehjem, R Srivastava, SM Brown
2020
Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series
S Mori, T Ai, Y Otomo, Y Taniyama
PloS one 2020
No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
GW Jones, MP Monopoli, L Campagnolo, A Pietroiusti, L Tran, B Fadeel
Nanomedicine 2020
Compassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: a prospective observational study
AM Vannucchi, B Sordi, A Morettini, C Nozzoli, L Poggesi, F Pieralli, A Bartoloni, A Atanasio, F Miselli, C Paoli, GG Loscocco, A Fanelli, O Para, A Berni, I Tassinari, L Zammarchi, L Maggi, A Mazzoni, V Scotti, G Falchetti, D Malandrino, F Luise, G Millotti, S Bencini, M Capone, MP Piccinni, F Annunziato, P Guglielmelli, F Mannelli, G Coltro, D Fantoni, M Borella, E Ravenda, B Peruzzi, R Caporale, L Cosmi, F Liotta, L Lombardelli, F Logiodice, A Vanni, L Salvati, C Lazzeri, M Bonizzoli, A Peris, G Cianchi, A Bosi, M Pucatti, P Fontanari, S Benemei, MM Cerinic, L Turco
Leukemia 2020
COVID-19 and Obesity: Dangerous Liaisons
G Caci, A Albini, M Malerba, DM Noonan, P Pochetti, R Polosa
Journal of Clinical Medicine 2020
SARS-CoV-2: characteristics and current advances in research
Y Yang, Z Xiao, K Ye, X He, B Sun, Z Qin, J Yu, J Yao, Q Wu, Z Bao, W Zhao
Virology Journal 2020
Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids
Y Miao, L Fan, JY Li
Frontiers in immunology 2020
Lymphopenia during the COVID-19 infection: What it shows and what can be learned
S Tavakolpour, T Rakhshandehroo, EX Wei, M Rashidian
Immunology Letters 2020
A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2
Riggioni C, Comberiati P, Giovannini M, Agache I, Akdis M, Alves\u2010Correia M, Antó JM, Arcolaci A, Azkur AK, Azkur D, Beken B, Boccabella C, Bousquet J, Breiteneder H, Carvalho D, De las Vecillas L, Diamant Z, Eguiluz\u2010Gracia I, Eiwegger T, Eyerich S, Fokkens W, Gao Y, Hannachi F, Johnston SL, Jutel M, Karavelia A, Klimek L, Moya B, Nadeau KC, O'Hehir R, O'Mahony L, Pfaar O, Sanak M, Schwarze J, Sokolowska M, Torres MJ, van de Veen W, van Zelm MC, Wang DY, Zhang L, Jiménez\u2010Saiz R, Akdis CA
Allergy 2020
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AA, Horton M, Smith K, Pekosz A, D\u2019Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD
2020

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