BACKGROUND Coronavirus disease 19 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen clearance; however, in some patients an excessive and aberrant host immune response can lead to an acute respiratory distress syndrome. The comprehension of the mechanisms that regulate pathogen elimination, immunity, and pathology is essential to better characterize disease progression and widen the spectrum of therapeutic options.METHODS We performed a flow cytometric characterization of immune cell subsets from 30 patients with COVID-19 and correlated these data with clinical outcomes.RESULTS Patients with COVID-19 showed decreased numbers of circulating T, B, and NK cells and exhibited a skewing of CD8+ T cells toward a terminally differentiated/senescent phenotype. In agreement, CD4+ T and CD8+ T, but also NK cells, displayed reduced antiviral cytokine production capability. Moreover, a reduced cytotoxic potential was identified in patients with COVID-19, particularly in those who required intensive care. The latter group of patients also showed increased serum IL-6 levels that inversely correlated to the frequency of granzyme A–expressing NK cells. Off-label treatment with tocilizumab restored the cytotoxic potential of NK cells.CONCLUSION The association between IL-6 serum levels and the impairment of cytotoxic activity suggests the possibility that targeting this cytokine may restore antiviral mechanisms.FUNDING This study was supported by funds from the Department of Experimental and Clinical Medicine of University of Florence (the ex-60% fund and the “Excellence Departments 2018–2022 Project”) derived from Ministero dell’Istruzione, dell’Università e della Ricerca (Italy).
Alessio Mazzoni, Lorenzo Salvati, Laura Maggi, Manuela Capone, Anna Vanni, Michele Spinicci, Jessica Mencarini, Roberto Caporale, Benedetta Peruzzi, Alberto Antonelli, Michele Trotta, Lorenzo Zammarchi, Luca Ciani, Leonardo Gori, Chiara Lazzeri, Andrea Matucci, Alessandra Vultaggio, Oliviero Rossi, Fabio Almerigogna, Paola Parronchi, Paolo Fontanari, Federico Lavorini, Adriano Peris, Gian Maria Rossolini, Alessandro Bartoloni, Sergio Romagnani, Francesco Liotta, Francesco Annunziato, Lorenzo Cosmi
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H Koay, N Gherardin, T Nguyen, W Zhang, J Habel, R Seneviratna, F James, N Holmes, O Smibert, C Gordon, J Trubiano, K Kedzierska, D Godfrey |
Immunity | 2022 |
The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome
R Ganesh, S Grach, A Ghosh, D Bierle, B Salonen, N Collins, A Joshi, N Boeder, C Anstine, M Mueller, E Wight, I Croghan, A Badley, R Carter, R Hurt |
Mayo Clinic Proceedings | 2022 |
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications
M Al-Nesf, H Abdesselem, I Bensmail, S Ibrahim, W Saeed, S Mohammed, A Razok, H Alhussain, R Aly, M Maslamani, K Ouararhni, M Khatib, A Hssain, A Omrani, S Al-Kaabi, A Khal, A Al-Thani, W Samsam, A Farooq, J Al-Suwaidi, M Al-Maadheed, H Al-Siddiqi, A Butler, J Decock, V Mohamed-Ali, F Al-Ejeh |
Nature Communications | 2022 |
The crucial role of prolactin-lactogenic hormone in Covid-19
H Al-Kuraishy, A Al-Gareeb, M Butnariu, G Batiha |
Molecular and Cellular Biochemistry | 2022 |
New Discovery of Myeloid-Derived Suppressor Cell’s Tale on Viral Infection and COVID-19
S Park, D Nam, H Seong, Y Hahn |
Frontiers in immunology | 2022 |
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19
, M Xu, D Song, T Yue, Y Wang, P Zhang, Y Zhong, M Zhang, T Lam, N Faria, E Clercq, G Li |
Immunity & Ageing | 2022 |
SARS-CoV-2 Immunization Orchestrates the Amplification of IFNγ-Producing T Cell and NK Cell Persistence
L Sala, S Gandini, A Bruno, R Allevi, M Gallazzi, P Senesi, M Palano, P Meregalli, E Longhi, C Sommese, L Luzi, E Trabucchi |
Frontiers in immunology | 2022 |
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Q Hammer, J Dunst, W Christ, F Picarazzi, M Wendorff, P Momayyezi, O Huhn, H Netskar, K Maleki, M García, T Sekine, E Sohlberg, V Azzimato, M Aouadi, F Degenhardt, A Franke, F Spallotta, M Mori, J Michaëlsson, N Björkström, T Rückert, C Romagnani, A Horowitz, J Klingström, H Ljunggren, K Malmberg |
Cell Reports | 2022 |
Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2
K Piadel, A Haybatollahi, A Dalgleish, P Smith |
Journal of General Virology | 2022 |
Hematopoietic responses to SARS-CoV-2 infection
S Elahi |
Cellular and Molecular Life Sciences | 2022 |
Open-label use of an aliphatic polyamine immunomodulator in patients hospitalized with COVID-19
S Efimov, N Matsiyeuskaya, O Boytsova, L Akhieva, E Kuntsevich, A Troshina, E Kvasova, A Tikhonov, N Khomyakova, F Harrison, J Rossi, T Hardman |
Drugs in Context | 2022 |
SARS-CoV-2 Associated Immune Dysregulation and COVID-Associated Pulmonary Aspergilliosis (CAPA): A Cautionary Tale
D Worku |
International journal of molecular sciences | 2022 |
SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine
S Gupta, S Agrawal, A Sandoval, H Su, M Tran, Y Demirdag |
Journal of Clinical Immunology | 2022 |
Long‐term SARS‐CoV‐2‐specific and cross‐reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology
I Laurén, S Havervall, H Ng, Martin, A Pettke, N GreilertNorin, L Gabrielsson, A Chourlia, C AmoêdoLeite, V Josyula, M Eltahir, I Kerzeli, A Falk, J Hober, W Christ, A Wiberg, M Hedhammar, H Tegel, J Burman, F Xu, E Pin, A Månberg, J Klingström, G Christoffersson, S Hober, P Nilsson, M Philipson, P Dönnes, R Lindsay, C Thålin, S Mangsbo |
Immunity, Inflammation and Disease | 2022 |
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
J Sabbatinelli, G Matacchione, A Giuliani, D Ramini, M Rippo, A Procopio, M Bonafè, F Olivieri |
Mechanisms of Ageing and Development | 2022 |
COVID-19 infection as a new risk factor for penile Mondor disease
K Balawender, A Pliszka, A Surowiec, S Rajda |
BMC urology | 2022 |
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques
M Aid, S Vidal, C Piedra-Mora, S Ducat, C Chan, S Bondoc, A Colarusso, C Starke, M Nekorchuk, K Busman-Sahay, J Estes, A Martinot, D Barouch, A Bukreyev |
PLoS pathogens | 2022 |
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection
A Romano, N Parrinello, M Barchitta, R Manuele, F Puglisi, A Maugeri, A Barbato, A Triolo, C Giallongo, D Tibullo, L Ferla, C Botta, S Siragusa, C Iacobello, A Montineri, G Volti, A Agodi, G Palumbo, F Raimondo |
Scientific Reports | 2022 |
Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection
N Albayrak, C Cano, S Karimi, D Dogahe, A Praet, A Godefroid, V Marmol, D Grimaldi, B Bondue, J Vooren, F Mascart, V Corbière |
Frontiers in immunology | 2022 |
Apparent Association of Insulin With Interleukin-6 (IL-6) in Severe COVID-19 Patients Having Chronic Disease Comorbidities
F Nouh, H Othman, E Gwarsha, A Elbadry, A Alabdali, I Barassi, S Elamary, A Elbadry, F Elshaari |
Cureus | 2022 |
Dynamic response landscape of immune cells identified immune dysfunction which predicts disease progression in COVID-19 infected patients
X Deng, Y Zhang, M Li, X Tang, J Shen, Y Chen, Y Zhao, Q Wen, X Wu, M Li, J Li, W Xu, W Li, Z Xiao, D Xian, F Du |
International journal of biological sciences | 2022 |
Antibody profiles in COVID ‐19 convalescent plasma prepared with amotosalen/ UVA pathogen reduction treatment
A Bagri, R Assis, C Tsai, G Simmons, Z Mei, M Goetz, M Gatmaitan, M Stone, C Germanio, R Martinelli, O Darst, J Rioveros, P Robinson, D Ward, A Ziman, D Seftel, S Khan, M Busch, P Felgner, L Corash |
Transfusion | 2022 |
Differences in Characteristics of T-Cell Immunity to SARS-CoV-2 in Clinically Healthy Subjects
N Sushentseva, O Popov, I Polkovnikova, S Alpako, S Shcherbak |
Bulletin of Experimental Biology and Medicine | 2022 |
From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
Zhao M, Tian C, Cong S, Di X, Wang K |
Frontiers in immunology | 2022 |
Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors
Rovito R, Augello M, Ben-Haim A, Bono V, d\u2019Arminio Monforte A, Marchetti G |
Frontiers in immunology | 2022 |
Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2
Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A, Devadas S |
Frontiers in immunology | 2022 |
Exploring the Utility of NK Cells in COVID-19
Deng X, Terunuma H, Nieda M |
Biomedicines | 2022 |
Adaptive Immune Responses and Immunity to SARS-CoV-2
Primorac D, Vrdoljak K, Brlek P, Pavelić E, Molnar V, Matišić V, Erceg Ivkošić I, Parčina M |
Frontiers in immunology | 2022 |
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness
Morrell ED, Bhatraju PK, Sathe NA, Lawson J, Mabrey L, Holton SE, Presnell SR, Wiedeman A, Acosta-Vega C, Mitchem MA, Liu T, Chai XY, Sahi S, Brager C, Orlov M, Sakr SS, Sader A, Lum DM, Koetje N, Garay A, Barnes E, Cromer G, Bray MK, Pipavath S, Fink SL, Evans L, Long SA, West TE, Wurfel MM, Mikacenic C |
AJP Lung Cellular and Molecular Physiology | 2022 |
Molecular mechanisms involved in pathogenicity of SARS-CoV-2: Immune evasion and implications for therapeutic strategies
Latifi-Pupovci H |
Biomedicine & Pharmacotherapy | 2022 |
What Inhibits Natural Killers’ Performance in Tumour
Papak I, Chruściel E, Dziubek K, Kurkowiak M, Urban-Wójciuk Z, Marjański T, Rzyman W, Marek-Trzonkowska N |
International journal of molecular sciences | 2022 |
NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients
Dizaji Asl K, Mazloumi Z, Majidi G, Kalarestaghi H, Sabetkam S, Rafat A |
Cell Biochemistry and Function | 2022 |
The deciphering of the immune cells and marker signature in COVID‐19 pathogenesis: An update
Jasim SA, Mahdi RS, Bokov DO, Najm MA, Sobirova GN, Bafoyeva ZO, Taifi A, Alkadir OK, Mustafa YF, Mirzaei R, Karampoor S |
Journal of Medical Virology | 2022 |
Tocilizumab Accelerates Recovery in Patients With Severe COVID-19 Pneumonia on Venovenous Extracorporeal Membrane Oxygenation
Lewis TC, Arnouk S, Toy B, Geraci TC, Carillo JA, Chang SH, Moazami N, Kon ZN, Smith DE |
ASAIO Journal | 2022 |
Connecting the dots between inflammatory cascades of obesity and COVID-19 in light of mortal consequences—a review
Mal P, Mukherjee T, Upadhyay AK, Mohanty S, Pattnaik AK |
Environmental Science and Pollution Research | 2022 |
Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
Medeiros T, Guimarães GM, Carvalho FR, Alves LS, Faustino R, Campi-Azevedo AC, Peruhype-Magalhães V, Teixeira-Carvalho A, de Souza Gomes M, Rodrigues do Amaral L, Martins-Filho OA, Lugon JR, Almeida JR, Silva AA |
Cytokine | 2022 |
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA Vaccine
Al-Attiyah R, Safar HA, Botras L, Botras M, Al-Kandari F, Chehadeh W, Mustafa AS |
Frontiers in immunology | 2022 |
Lymphocyte Population Changes at Two Time Points during the Acute Period of COVID-19 Infection
Scalia G, Raia M, Gelzo M, Cacciapuoti S, Rosa AD, Pinchera B, Scotto R, Tripodi L, Mormile M, Fabbrocini G, Gentile I, Parrella R, Castaldo G, Scialò F |
Journal of Clinical Medicine | 2022 |
Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 Evolution
Garcinuño S, Gil-Etayo FJ, Mancebo E, López-Nevado M, Lalueza A, Díaz-Simón R, Pleguezuelo DE, Serrano M, Cabrera-Marante O, Allende LM, Paz-Artal E, Serrano A |
International journal of molecular sciences | 2022 |
Age-dependent NK cell dysfunctions in severe COVID-19 patients
Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumé, Mattia Lanfranchi, Isabella Quinti, Cinzia Milito, Paolo Palange, Ilaria Menichini, Silvano Sozzani, Luigi Frati, Angela Gismondi, Angela Santoni, Helena Stabile |
Frontiers in immunology | 2022 |
Where do T cell subsets stand in SARS-CoV-2 infection: an update
Tarique M, Suhail M, Naz H, Muhammad N, Tabrez S, Zughaibi TA, Abuzenadah AM, Hashem AM, Shankar H, Saini C, Sharma A |
Frontiers in Cellular and Infection Microbiology | 2022 |
SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination
Vespa S, Simeone P, Catitti G, Buca D, De Bellis D, Pierdomenico L, Pieragostino D, Cicalini I, Del Boccio P, Natale L, Owens T, Khorooshi R, De Laurenzi V, Stuppia L, Lanuti P |
International journal of molecular sciences | 2022 |
Alum/CpG Adjuvanted Inactivated COVID-19 Vaccine with Protective Efficacy against SARS-CoV-2 and Variants
Zhang Y, Zheng X, Sheng W, Liang H, Zhao Y, Zhu X, Yang R, Zhang Y, Dong X, Li W, Pei F, Ding L, Chang Z, Deng L, Yuan G, Yang Z, Zhu D, Yang X, Wang H |
Human vaccines | 2022 |
Clinical Effect of Early administration of Tocilizumab Following the Initiation of Corticosteroid Therapy for Patients with COVID-19
Kawamata ( T, Tanino ( Y, Nikaido ( T, Minemura ( H, Sato ( Y, Togawa ( R, Watanabe ( N, Yamada ( R, Sato ( R, Onuma ( T, Tomita ( H, Saito ( M, Rikimaru ( M, Suzuki ( Y, Tsukada ( Y, Nakamura ( K, Kanemitsu ( K, Iseki ( K, Shibata ( Y |
Journal of Infection and Chemotherapy | 2022 |
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key
Khare K, Pandey R |
Frontiers in immunology | 2022 |
Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2.
Lee KS, Russ BP, Wong TY, Horspool AM, Winters MT, Barbier M, Bevere JR, Martinez I, Damron FH, Cyphert HA |
iScience | 2022 |
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike
Gatineau J, Nidercorne C, Dupont A, Puiffe ML, Cohen JL, Molinier-Frenkel V, Niedergang F, Castellano F |
Frontiers in immunology | 2022 |
Heterogenous CD8+ T Cell Maturation and ‘Polarization’ in Acute and Convalescent COVID-19 Patients
Kudryavtsev IV, Arsentieva NA, Korobova ZR, Isakov DV, Rubinstein AA, Batsunov OK, Khamitova IV, Kuznetsova RN, Savin TV, Akisheva TV, Stanevich OV, Lebedeva AA, Vorobyov EA, Vorobyova SV, Kulikov AN, Sharapova MA, Pevtsov DE, Totolian AA |
Viruses | 2022 |
SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows
Solimando AG, Marziliano D, Ribatti D |
Biomedicines | 2022 |
The function of myeloid-derived suppressor cells in COVID-19 lymphopenia
Li T, Zheng F, Cheng F |
International Immunopharmacology | 2022 |
Neutrophil-Lymphocyte Ratio Predicting Case Severity in SARS-CoV-2 Infection: A Review
Agarwal S |
Cureus | 2022 |
Impact of SARS-CoV-2 infection on the profiles and responses of innate immune cells after recovery
Ruenjaiman V, Sodsai P, Kueanjinda P, Bunrasmee W, Klinchanhom S, Reantragoon R, Tunvirachaisakul C, Manothummetha K, Mejun N, Liengswangwong K, Torvorapanit P, Paitoonpong L, Putcharoen O, Palaga T, Hirankarn N |
Journal of Microbiology, Immunology and Infection | 2022 |
Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19.
Wang M, Chang W, Zhang L, Zhang Y |
International journal of biological sciences | 2022 |
Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review
Tziastoudi M, Cholevas C, Stefanidis I, Theoharides TC |
Annals of Clinical and Translational Neurology | 2022 |
Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
Bychinin MV, Klypa TV, Mandel IA, Yusubalieva GM, Baklaushev VP, Kolyshkina NA, Troitsky AV |
Scientific Reports | 2022 |
Generation of Cytotoxic T Cells and Dysfunctional CD8 T Cells in Severe COVID-19 Patients
Gozzi-Silva SC, Oliveira LD, Alberca RW, Pereira NZ, Yoshikawa FS, Pietrobon AJ, Yendo TM, de Souza Andrade MM, Ramos YA, Brito CA, Oliveira EA, Beserra DR, Orfali RL, Aoki V, Duarte AJ, Sato MN |
Cells | 2022 |
Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes
Messing M, Sekhon MS, Hughes MR, Stukas S, Hoiland RL, Cooper J, Ahmed N, Hamer MS, Li Y, Shin SB, Tung LW, Wellington CL, Sin DD, Leslie KB, McNagny KM |
Frontiers in immunology | 2022 |
Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives
Zhu Q, Xu Y, Wang T, Xie F |
Frontiers in immunology | 2022 |
Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19
Valenzuela-Fernández A, Cabrera-Rodriguez R, Ciuffreda L, Perez-Yanes S, Estevez-Herrera J, González-Montelongo R, Alcoba-Florez J, Trujillo-González R, García-Martínez de Artola D, Gil-Campesino H, Díez-Gil O, Lorenzo-Salazar JM, Flores C, Garcia-Luis J |
Frontiers in Bioengineering and Biotechnology | 2022 |
Immunosenescence and inflamm-ageing in COVID-19
Zinatizadeh MR, Zarandi PK, Ghiasi M, Kooshki H, Mohammadi M, Amani J, Rezaei N |
Ageing Research Reviews | 2022 |
Impact of fluvoxamine on outpatient treatment of COVID-19 in Honduras in a prospective observational real-world study
Pineda E, Singh J, Pineda MV, Umanzor JG, Baires F, Benitez LG, Burgos C, Sekhon AK, Crisp N, Lewis AS, Radwanski J, Bermudez M, Barjun KS, Diaz O, Palou E, Escalante RE, Hernandez CI, Stevens ML, Eberhard D, Sierra M, Alvarado T, Videa O, Sierra-Hoffman M, Valerio-Pascua F |
Frontiers in pharmacology | 2022 |
Current Developments in the Preclinical and Clinical use of Natural Killer T cells
Kratzmeier C, Singh S, Asiedu EB, Webb TJ |
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy | 2022 |
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Khoo WH, Jackson K, Phetsouphanh C, Zaunders JJ, Alquicira-Hernandez J, Yazar S, Ruiz-Diaz S, Singh M, Dhenni R, Kyaw W, Tea F, Merheb V, Lee FX, Burrell R, Howard-Jones A, Koirala A, Zhou L, Yuksel A, Catchpoole DR, Lai CL, Vitagliano TL, Rouet R, Christ D, Tang B, West NP, George S, Gerrard J, Croucher PI, Kelleher AD, Goodnow CG, Sprent JD, Powell JE, Brilot F, Nanan R, Hsu PS, Deenick EK, Britton PN, Phan TG |
Clinical Immunology | 2022 |
CD4+ T-Cell Dysfunction in Severe COVID-19 Disease Is Tumor Necrosis Factor-α/Tumor Necrosis Factor Receptor 1–Dependent
Popescu I, Snyder ME, Iasella CJ, Hannan SJ, Koshy R, Burke R, Das A, Brown MJ, Lyons EJ, Lieber SC, Chen X, Sembrat JC, Bhatt P, Deng E, An X, Linstrum K, Kitsios G, Konstantinidis I, Saul M, Kass DJ, Alder JK, Chen BB, Lendermon EA, Kilaru S, Johnson B, Pilewski JM, Kiss JE, Wells AH, Morris A, McVerry BJ, McMahon DK, Triulzi DJ, Chen K, Sanchez PG, McDyer JF |
American journal of respiratory and critical care medicine | 2022 |
High activation levels maintained in receptor‐binding domain–specific memory B cells in people with severe coronavirus disease 2019
Gupta M, Balachandran H, Louie RH, Li H, Agapiou D, Keoshkerian E, Christ D, Rawlinson W, Mina MM, Post JJ, Hudson B, Gilroy N, Konecny P, Bartlett AW, Sasson SC, Ahlenstiel G, Dwyer D, Lloyd AR, Martinello M, Luciani F, Bull RA |
Immunology and Cell Biology | 2022 |
Immune profile of children diagnosed with multisystem inflammatory syndrome associated with SARS-CoV-2 infection (MIS-C)
Gowin E, Dworacki G, Siewert B, Wysocki J, Januszkiewicz-Lewandowska D |
2022 | |
High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56+CD57+PD-1+ Natural Killer Cells, SARS-CoV-2-Specific Memory CD4+ and CD8+ T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients
Srivastava R, Dhanushkodi N, Prakash S, Coulon PG, Vahed H, Zayou L, Quadiri A, BenMohamed L |
2022 | |
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of healthcare workers
Magali Noval Rivas, Joseph E. Ebinger, Min Wu, Nancy Sun, Jonathan Braun, Kimia Sobhani, Jennifer E. Van Eyk, Susan Cheng, Moshe Arditi |
Journal of Clinical Investigation | 2021 |
An immune-based biomarker signature is associated with mortality in COVID-19 patients
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle Fink, Adriana A. de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura R. Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily Gliniewicz, Elana R. Shaw, Dana Kahle, Andre T. Rastegar, Michael A Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S Lionakis, Luigi D Notarangelo |
JCI Insight | 2021 |
Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19
B Liao, Z Liu, L Tang, L Li, Q Gan, H Shi, Q Jiao, Y Guan, M Xie, , H Zhao, W Chen, Y Liu, L Li, Y Wang, Y Cao, Y Shi, Y Li, C Lei |
International journal of medical sciences | 2021 |
Major reduction of NKT cells in patients with severe COVID-19 pneumonia
MA Zingaropoli, V Perri, P Pasculli, FC Dezza, P Nijhawan, G Savelloni, GL Torre, C D'Agostino, F Mengoni, M Lichtner, MR Ciardi, CM Mastroianni |
Clinical Immunology | 2021 |
Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
G Meoni, V Ghini, L Maggi, A Vignoli, A Mazzoni, L Salvati, M Capone, A Vanni, L Tenori, P Fontanari, F Lavorini, A Peris, A Bartoloni, F Liotta, L Cosmi, C Luchinat, F Annunziato, P Turano, K Subbarao |
PLoS pathogens | 2021 |
SARS‐CoV‐2‐specific serological and functional T cell immune responses during acute and early COVID‐19 convalescence in solid organ transplant patients
A Favà, L Donadeu, N Sabé, V Pernin, J GonzálezCostello, L Lladó, M Meneghini, X Charmetant, E GarcíaRomero, A Cachero, A Torija, R RodriguezUrquia, E Crespo, I Teubel, E Melilli, N Montero, A Manonelles, R Preyer, K Strecker, A Ovize, JJ Lozano, J Sidorova, JM Cruzado, ML Quintrec, O Thaunat, O Bestard |
American Journal of Transplantation | 2021 |
The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes
G Tang, M Huang, Y Luo, W Liu, Q Lin, L Mao, S Wu, Z Xiong, H Hou, Z Sun, F Wang |
Frontiers in immunology | 2021 |
Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
JD Matute, B Finander, D Pepin, X Ai, NP Smith, JZ Li, AG Edlow, AC Villani, PH Lerou, BT Kalish |
Pediatric Research | 2021 |
T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19
O Zenarruzabeitia, G Astarloa-Pando, I Terrén, A Orrantia, R Pérez-Garay, I Seijas-Betolaza, J Nieto-Arana, N Imaz-Ayo, S Pérez-Fernández, E Arana-Arri, F Borrego |
Frontiers in immunology | 2021 |
Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19
J Yang, M Zhong, E Zhang, K Hong, Q Yang, D Zhou, J Xia, YQ Chen, M Sun, B Zhao, J Xiang, Y Liu, Y Han, M Xu, , C Huang, Y Shang, H Yan, J Wu |
Journal of Molecular Cell Biology | 2021 |
High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses
M Xie, J Yunis, Y Yao, J Shi, Y Yang, P Zhou, K Liang, Y Wan, A Mehdi, Z Chen, N Wang, S Xu, M Zhou, M Yu, K Wang, Y Tao, Y Zhou, X Li, X Liu, X Yu, Y Wei, Z Liu, J Sprent, D Yu |
IBMS BoneKEy | 2021 |
Autoimmunity and COVID-19 – The microbiotal connection
N Katz-Agranov, G Zandman-Goddard |
Autoimmunity Reviews | 2021 |
Anti-VEGF agents: As appealing targets in the setting of COVID-19 treatment in critically ill patients
A Sahebnasagh, SM Nabavi, HR Kashani, S Abdollahian, S Habtemariam, A Rezabakhsh |
International Immunopharmacology | 2021 |
SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias, D Furman, DA Winer, E Verdin |
2021 | |
The Effect of Unconventional Cytokine Combinations on NK-Cell Responses to Viral Infection
DE Ochayon, SN Waggoner |
Frontiers in immunology | 2021 |
SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise
R Duerr, KM Crosse, AM Valero-Jimenez, M Dittmann |
Microorganisms | 2021 |
Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice
M Ghasemzadeh, A Ghasemzadeh, E Hosseini |
Human Immunology | 2021 |
Activation or exhaustion of CD8+ T cells in patients with COVID-19
MS Rha, EC Shin |
Cellular and Molecular Immunology | 2021 |
A scoping review of the pathophysiology of COVID-19
PE Marik, J Iglesias, J Varon, P Kory |
International journal of immunopathology and pharmacology | 2021 |
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
EA Thompson, K Cascino, AA Ordonez, W Zhou, A Vaghasia, A Hamacher-Brady, NR Brady, IH Sun, R Wang, AZ Rosenberg, M Delannoy, R Rothman, K Fenstermacher, L Sauer, K Shaw-Saliba, EM Bloch, AD Redd, AA Tobian, M Horton, K Smith, A Pekosz, FR DAlessio, S Yegnasubramanian, H Ji, AL Cox, JD Powell |
Cell Reports | 2021 |
Edible and Herbal Plants for the Prevention and Management of COVID-19
S Li, CS Cheng, C Zhang, GY Tang, HY Tan, HY Chen, N Wang, AY Lai, Y Feng |
Frontiers in pharmacology | 2021 |
Myeloid cells in COVID-19 microenvironment
G Qin, S Liu, L Yang, W Yu, Y Zhang |
Signal Transduction and Targeted Therapy | 2021 |
Directing T-Cell Immune Responses for Cancer Vaccination and Immunotherapy
PL Smith, K Piadel, AG Dalgleish |
Human vaccines | 2021 |
Immune System Disequilibrium—Neutrophils, Their Extracellular Traps, and COVID-19-Induced Sepsis
C Keane, M Coalter, I Martin-Loeches |
Frontiers in Medicine | 2021 |
Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches
A Hasan, E Al-Ozairi, Z Al-Baqsumi, R Ahmad, F Al-Mulla |
ImmunoTargets and Therapy | 2021 |
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
J Hazeldine, J M. |
Frontiers in immunology | 2021 |
Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection
X Wang, G Xu, X Liu, Y Liu, S Zhang, Z Zhang |
Cellular and Molecular Immunology | 2021 |
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
P Wang, SY Lau, S Deng, P Chen, BW Mok, AJ Zhang, AC Lee, KH Chan, RC Tam, H Xu, R Zhou, W Song, L Liu, KK To, JF Chan, Z Chen, KY Yuen, H Chen |
Nature Communications | 2021 |
COVID-19 in Immunosuppressed Children
E Nicastro, L Verdoni, LR Bettini, G Zuin, A Balduzzi, G Montini, A Biondi, L D'Antiga |
Frontiers in Pediatrics | 2021 |
Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects
S Yu, C Di, S Chen, M Guo, J Yan, Z Zhu, L Liu, R Feng, Y Xie, R Zhang, J Chen, M Wang, D Wei, H Fang, T Yin, J Huang, S Chen, H Lu, J Zhu, J Qu |
Cell Research | 2021 |
A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
JG Yeo, JY Leong, SH Tay, KD Nadua, DE Anderson, AJ Lim, XW Ng, SL Poh, D Guo, KN Yaung, P Kumar, M Wasser, SN Hazirah, N Sutamam, CJ Chua, M Qui, R Foo, AM Gamage, KT Yeo, L Ramakrishna, T Arkachaisri, BE Young, DC Lye, LF Wang, CY Chong, NW Tan, J Li, KQ Kam, F Ginhoux, KC Thoon, JK Chan, CF Yung, S Albani |
Frontiers in immunology | 2021 |
Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 Infection
A Lin, WH Yan |
Frontiers in immunology | 2021 |
Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System
J Roberts, AL Pritchard, AT Treweeke, AG Rossi, N Brace, P Cahill, SM MacRury, J Wei, IL Megson |
Frontiers in Cardiovascular Medicine | 2021 |
Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial
P Tebas, SP Yang, JD Boyer, EL Reuschel, A Patel, A Christensen-Quick, VM Andrade, MP Morrow, K Kraynyak, J Agnes, M Purwar, A Sylvester, J Pawlicki, E Gillespie, I Maricic, FI Zaidi, KY Kim, Y Dia, D Frase, P Pezzoli, K Schultheis, TR Smith, SJ Ramos, T McMullan, K Buttigieg, MW Carroll, J Ervin, MC Diehl, E Blackwood, MP Mammen, J Lee, MJ Dallas, AS Brown, JE Shea, JJ Kim, DB Weiner, KE Broderick, LM Humeau |
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The Journal of Clinical Investigation in the time of COVID-19
A Casadevall, S Jackson, GL Semenza, GF Tomaselli, RS Ahima |
Journal of Clinical Investigation | 2021 |
Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
A Mazzoni, L Salvati, L Maggi, F Annunziato, L Cosmi |
Seminars in Immunology | 2021 |
T Cells: Warriors of SARS-CoV-2 Infection
P de Candia, F Prattichizzo, S Garavelli, G Matarese |
Trends in Immunology | 2021 |
Pattern Recognition Proteins: First Line of Defense Against Coronaviruses
CA Labarrere, GS Kassab |
Frontiers in immunology | 2021 |
Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review
A Peddapalli, M Gehani, AM Kalle, SR Peddapalli, AE Peter, S Sharad |
Viruses | 2021 |
SARS-CoV-2 and Plasma Hypercoagulability
E Steadman, M Fandaros, W Yin |
Cellular and Molecular Bioengineering | 2021 |
Basophils and Mast Cells in COVID-19 Pathogenesis
G Murdaca, MD Gioacchino, M Greco, M Borro, F Paladin, C Petrarca, S Gangemi |
Cells | 2021 |
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AM Zahran, ZA Zahran, YH Mady, EE Mahran, A Rashad, A Makboul, KA Nasif, AA Abdelmaksoud, O El-Badawy |
Multidisciplinary Respiratory Medicine | 2021 |
Implications of Laboratory Tests in Disease Grading and Death Risk Stratification of COVID-19: A Retrospective Study in Wuhan, China
Y Bai, E Wang, S Zhao, J Li, Y Zhu, Y Zhang, L Cao, H Liu, Y Dong, F Wang, G Liang, L Liu |
Frontiers in Medicine | 2021 |
T cell response to SARS-CoV-2 infection in humans: A systematic review
M Shrotri, MC van Schalkwyk, N Post, D Eddy, C Huntley, D Leeman, S Rigby, SV Williams, WH Bermingham, P Kellam, J Maher, AM Shields, G Amirthalingam, SJ Peacock, SA Ismail, SR Walsh |
PloS one | 2021 |
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MF Osuchowski, MS Winkler, T Skirecki, S Cajander, M Shankar-Hari, G Lachmann, G Monneret, F Venet, M Bauer, FM Brunkhorst, S Weis, A Garcia-Salido, M Kox, JM Cavaillon, F Uhle, MA Weigand, SB Flohé, WJ Wiersinga, R Almansa, A de la Fuente, I Martin-Loeches, C Meisel, T Spinetti, JC Schefold, C Cilloniz, A Torres, EJ Giamarellos-Bourboulis, R Ferrer, M Girardis, A Cossarizza, MG Netea, T van der Poll, JF Bermejo-Martín, I Rubio |
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T cell counts and IL‐6 concentration in blood of North African COVID‐19 patients are two independent prognostic factors for severe disease and death
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Journal of leukocyte biology | 2021 |
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I Kos, B Balensiefer, V Lesan, D KadduMulindwa, L Thurner, K Christofyllakis, JT Bittenbring, M Ahlgrimm, M Seiffert, S Wagenpfeil, Y Bewarder, F Neumann, T Rixecker, S Smola, A Link, M Krawczyk, F Lammert, PM Lepper, R Bals, S Stilgenbauer, M Bewarder |
European Journal of Immunology | 2021 |
SARS-CoV-2-specific T cells in infection and vaccination
A Bertoletti, NL Bert, M Qui, AT Tan |
Cellular and Molecular Immunology | 2021 |
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
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Immune Network | 2021 |
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Heliyon | 2021 |
Immune checkpoint inhibition in COVID-19: risks and benefits
PS Pezeshki, N Rezaei |
Expert Opinion on Biological Therapy | 2021 |
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue
TC Theoharides, C Cholevas, K Polyzoidis, A Politis |
BioFactors (Oxford, England) | 2021 |
Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, Including Response to SARS-CoV-2, in Autism Spectrum Disorder
TC Theoharides |
Journal of Personalized Medicine | 2021 |
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
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Nature | 2021 |
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19
DM Kim, Y Kim, JW Seo, J Lee, U Park, NY Ha, J Koh, H Park, JW Lee, HJ Ro, NR Yun, DY Kim, SH Yoon, YS Na, DS Moon, SC Lim, CM Kim, K Jeon, JG Kang, NY Jang, H Jeong, J Kim, S Cheon, KM Sohn, JY Moon, S Kym, SR Han, MS Lee, HJ Kim, WY Park, JY Choi, HW Shin, HY Kim, CH Cho, YK Jeon, YS Kim, NH Cho |
Cell Reports | 2021 |
Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients
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Frontiers in immunology | 2021 |
Abnormality in the NK-cell population is prolonged in severe COVID-19 patients
G Leem, S Cheon, H Lee, SJ Choi, S Jeong, ES Kim, HW Jeong, H Jeong, SH Park, YS Kim, EC Shin |
Journal of Allergy and Clinical Immunology | 2021 |
Impaired response to first SARS‐CoV ‐2 dose vaccination in myeloproliferative neoplasm patients receiving ruxolitinib
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American Journal of Hematology | 2021 |
Regulation of the expression of proinflammatory cytokines induced by SARS-CoV-2
XN Zhang, LJ Wu, X Kong, BY Zheng, Z Zhang, ZW He |
World journal of clinical cases | 2021 |
Immune memory in convalescent patients with asymptomatic or mild COVID-19
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Cell Discovery | 2021 |
Immunological Characteristics of Non-Intensive Care Hospitalized COVID-19 Patients: A Preliminary Report
S Corrao, F Gervasi, FD Bernardo, G Natoli, M Raspanti, N Catalano, C Argano |
Journal of Clinical Medicine | 2021 |
Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
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International Immunopharmacology | 2021 |
SARS-CoV-2-Associated T-Cell Responses in the Presence of Humoral Immunodeficiency
S Gupta, H Su, T Narsai, S Agrawal |
International Archives of Allergy and Immunology | 2021 |
Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements
M Meggyes, DU Nagy, T Balassa, K Godony, A Peterfalvi, L Szereday, B Polgar |
Biomolecules | 2021 |
Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients
Q Chen, B Yu, Y Yang, J Huang, Y Liang, J Zhou, L Li, X Peng, B Cheng, Y Lin |
International Immunopharmacology | 2021 |
Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability
N Gligorijević, D Stanić-Vučinić, M Radomirović, M Stojadinović, U Khulal, O Nedić, TĆ Veličković |
Molecules (Basel, Switzerland) | 2021 |
Endothelial cell, myeloid, and adaptive immune responses in SARS‐CoV‐2 infection
N Degauque, A Haziot, S Brouard, N Mooney |
The FASEB Journal | 2021 |
TREC/KREC Levels in Young COVID-19 Patients
MB Khadzhieva, EV Kalinina, SS Larin, DA Sviridova, AS Gracheva, JV Chursinova, VA Stepanov, IV Redkin, LS Avdeikina, AG Rumyantsev, AN Kuzovlev, LE Salnikova |
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Innate lymphoid cells (ILC) in SARS-CoV-2 infection
A Kumar, W Cao, K Endrias, SV Kuchipudi, SK Mittal, S Sambhara |
Molecular Aspects of Medicine | 2021 |
Immune profiling of COVID-19: preliminary findings and implications for the pandemic
HT Maecker |
Journal for ImmunoTherapy of Cancer | 2021 |
Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider
A Najm, A Alunno, X Mariette, B Terrier, GD Marco, J Emmel, L Mason, DG McGonagle, PM Machado |
RMD Open | 2021 |
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Advanced Drug Delivery Reviews | 2021 |
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A Synowiec, A Szczepański, E Barreto-Duran, LK Lie, K Pyrc |
Clinical microbiology reviews | 2021 |
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I Siemińska, K Węglarczyk, M Surmiak, D Kurowska-Baran, M Sanak, M Siedlar, J Baran |
Frontiers in immunology | 2021 |
EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19
A Alunno, A Najm, PM Machado, H Bertheussen, GR Burmester, F Carubbi, GD Marco, R Giacomelli, O Hermine, JD Isaacs, I Koné-Paut, C Magro-Checa, I McInnes, PL Meroni, L Quartuccio, AV Ramanan, M Ramos-Casals, JR Carrio, H Schulze-Koops, TA Stamm, SW Tas, B Terrier, DG McGonagle, X Mariette |
Annals of the rheumatic diseases | 2021 |
Gamma Delta T Cells and Their Involvement in COVID-19 Virus Infections
G von Massow, S Oh, A Lam, K Gustafsson |
Frontiers in immunology | 2021 |
Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators
D Ricci, MP Etna, F Rizzo, S Sandini, M Severa, EM Coccia |
International journal of molecular sciences | 2021 |
Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients
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Frontiers in immunology | 2021 |
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19
R Wendt, MT Lingitz, M Laggner, M Mildner, D Traxler, A Graf, P Krotka, B Moser, K Hoetzenecker, S Kalbitz, C Lübbert, J Beige, HJ Ankersmit |
Biology : open access journal | 2021 |
Severe Acute Respiratory Syndrome Coronavirus 2: Manifestations of Disease and Approaches to Treatment and Prevention in Humans
ME Watson, K Inagaki, JB Weinberg |
Comparative medicine | 2021 |
Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities
CF Chu, F Sabath, S Fibi-Smetana, S Sun, R Öllinger, E Noeßner, YY Chao, L Rinke, E Winheim, R Rad, AB Krug, L Taher, CE Zielinski |
Frontiers in immunology | 2021 |
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
J Lim, KJ Puan, LW Wang, KW Teng, CY Loh, KP Tan, G Carissimo, YH Chan, CM Poh, CY Lee, SW Fong, NK Yeo, RS Chee, SN Amrun, ZW Chang, MZ Tay, A Torres-Ruesta, NL Fernandez, W How, AK Andiappan, W Lee, K Duan, SY Tan, G Yan, S Kalimuddin, DC Lye, YS Leo, SW Ong, BE Young, L Renia, LF Ng, B Lee, O Rötzschke |
Frontiers in immunology | 2021 |
Binding of phosphatidylserine‐positive microparticles by PBMCs classifies disease severity in COVID‐19 patients
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Journal of Extracellular Vesicles | 2021 |
Perforin, COVID‐19 and a possible pathogenic auto‐inflammatory feedback loop
L Cunningham, I Kimber, D Basketter, P Simmonds, S McSweeney, C Tziotzios, JP McFadden |
Scandinavian Journal of Immunology | 2021 |
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19
J Shi, J Zhou, X Zhang, W Hu, JF Zhao, S Wang, FS Wang, JY Zhang |
Frontiers in immunology | 2021 |
COVID-19 in immunocompromised patients: A systematic review of cancer, hematopoietic cell and solid organ transplant patients
JA Belsky, BP Tullius, MG Lamb, R Sayegh, JR Stanek, JJ Auletta |
Journal of Infection | 2021 |
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients
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Mast cells: Therapeutic targets for COVID ‐19 and beyond
HY Lam, V Tergaonkar, AP Kumar, KS Ahn |
IUBMB Life | 2021 |
An Overview on the Epidemiology and Immunology of COVID-19
M Meskini, MR Rami, P Maroofi, S Ghosh, SD Siadat, M Sheikhpour |
Journal of Infection and Public Health | 2021 |
Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 Infection
HE Jung, HK Lee |
Viruses | 2021 |
What we know and still ignore on COVID‐19 immune pathogenesis and a proposal based on the experience of allergic disorders
E Maggi, BG Azzarone, GW Canonica, L Moretta |
Allergy | 2021 |
Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
Juan Matute, Benjamin Finander, David Pepin, Xinbin Ai, Neal Smith, Jonathan Li, Andrea Edlow, Alexandra Villani, Paul Lerou, Brian Kalish |
Research square | 2021 |
Hemophagocytic histiocytosis in severe SARS‐CoV‐2 infection: A bone marrow study
H Dandu, G Yadav, HS Malhotra, S Pandey, R Sachu, K Dubey |
International Journal of Laboratory Hematology | 2021 |
Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis
R Chu, C van Eeden, S Suresh, WI Sligl, M Osman, JW Tervaert |
International journal of molecular sciences | 2021 |
NK and T Cell Immunological Signatures in Hospitalized Patients with COVID-19
L Bergantini, M d'Alessandro, P Cameli, D Cavallaro, S Gangi, B Cekorja, P Sestini, E Bargagli |
Cells | 2021 |
Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study
E Kalicińska, D Szymczak, A Zińczuk, B Adamik, J Smiechowicz, T Skalec, D Nowicka-Suszko, M Biernat, A Bogucka-Fedorczuk, J Rybka, A Martuszewski, W Gozdzik, K Simon, T Wróbel |
Cells | 2021 |
Manifestations and mechanisms of central nervous system damage caused by SARS-CoV-2
F Yang, H Zhao, H Liu, X Wu, Y Li |
Brain Research Bulletin | 2021 |
Cytokine Storms in the Course of COVID-19 and Haemophagocytic Lymphohistiocytosis in Pregnant and Postpartum Women
A Obuchowska, A Standyło, K Obuchowska, Ż Kimber-Trojnar, B Leszczyńska-Gorzelak |
Biomolecules | 2021 |
Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities
M Emadi-Baygi, M Ehsanifard, N Afrashtehpour, M Norouzi, Z Joz-Abbasalian |
Frontiers in immunology | 2021 |
Single-cell immunology of SARS-CoV-2 infection
Y Tian, LN Carpp, HE Miller, M Zager, EW Newell, R Gottardo |
Nature Biotechnology | 2021 |
Early Response of CD8+ T Cells in COVID-19 Patients
D Ramljak, M Vukoja, M Curlin, K Vukojevic, M Barbaric, U Glamoclija, B Purisevic, O Peric, V Soljic |
Journal of Personalized Medicine | 2021 |
Severe Type of COVID-19: Pathogenesis, Warning Indicators and Treatment
K Shi, Y Liu, Q Zhang, C Ran, J Hou, Y Zhang, X Wang |
Chinese Journal of Integrative Medicine | 2021 |
Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates
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Signal Transduction and Targeted Therapy | 2021 |
Lymphopenia: A useful predictor of COVID-19 disease severity and mortality
KU Toori, MA Qureshi, A Chaudhry |
Pakistan Journal of Medical Sciences | 2021 |
Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
SK Henne, LM Hochfeld, C., MM Nöthen, S HeilmannHeimbach |
2021 | |
Hypertension and its management in COVID-19 patients: The assorted view
GE Batiha, A Gari, N Elshony, HM Shaheen, MB Abubakar, SB Adeyemi, HM Al-kuraishy |
2021 | |
Prognostic Nutritional Index and CRP, age, platelet count, albumin level score in predicting mortality and intensive care unit admission for COVID-19
M Bayram, O Yildirim, RS Ozmen, B Soylu, AS Dundar, AR Koksal, I Ekinci, M Akarsu, O Tabak |
Biomarkers in Medicine | 2021 |
Immune characterization of a Colombian family cluster with SARS-CoV-2 infection
W Aguilar-Jiménez, L Flórez-Álvarez, DS Rincón, D Marín-Palma, A Sánchez-Martínez, J Martínez, MI Zapata, JD Loaiza, C Cárdenas, F Guzmán, PA Velilla, NA Taborda, W Zapata, JC Hernández, FJ Díaz, MT Rugeles |
Biomédica | 2021 |
Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19
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Frontiers in Medicine | 2021 |
Peptides Derived From S and N Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 Induce T Cell Responses: A Proof of Concept for T Cell Vaccines
YS Lee, SH Hong, HJ Park, HY Lee, JY Hwang, SY Kim, JW Park, KS Choi, JK Seong, SI Park, SM Lee, KA Hwang, JW Yun, JH Nam |
Frontiers in microbiology | 2021 |
Computational simulations to dissect the cell immune response dynamics for severe and critical cases of SARS-CoV-2 infection
R Blanco-Rodríguez, X Du, E Hernández-Vargas |
Computer Methods and Programs in Biomedicine | 2021 |
Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls
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Rheumatology International | 2021 |
Balancing Potential Benefits and Risks of Bruton Tyrosine Kinase Inhibitor Therapies in Multiple Sclerosis During the COVID-19 Pandemic
MS Weber, JA Nicholas, MR Yeaman |
Neurology: Neuroimmunology & Neuroinflammation | 2021 |
High‑dose intravenous immunoglobulins as a therapeutic option in critical illness polyneuropathy accompanying SARS‑CoV‑2 infection: A case‑based review of the literature (Review)
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Experimental and therapeutic medicine | 2021 |
Dynamics of host immune responses to SARS-CoV-2
R Taherkhani, S Taherkhani, F Farshadpour |
World journal of clinical cases | 2021 |
Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients
DA Rodríguez-Serrano, E Roy-Vallejo, ND Cruz, AM Ramírez, SC Rodríguez-García, N Arevalillo-Fernández, JM Galván-Román, LF García-Rodrigo, L Vega-Piris, MC Llano, DA Méndez, BG de Marcos, JH Santos, AS Azofra, EÁ Pérez-Urria, P Rodriguez-Cortes, L Esparcia, A Marcos-Jimenez, S Sánchez-Alonso, I Llorente, J Soriano, CS Fernández, R García-Vicuña, J Ancochea, J Sanz, C Muñoz-Calleja, R de la Cámara, AC Berlanga, I González-Álvaro, L Cardeñoso, RM Hernández, M Orts, C Figueroa, C Román, A Planas, LD Arganda, PM Vives, GD Nieto, A Cecconi, A Benedicto, AR González, J Jiménez-Borreguero, C del Arco, JM Aguilar, N Villalba, M Negro, E Contreras, A del Rey, C Santiago, M Junquera, R Caminero, FJ Val, S González, M Caño, I López, A von Wernitz, I Guerra, J Sorando, L Chao, MJ Cárdenas, V Espiga, A Pizarro, ÁF Álvarez, B Aguado, J Cannata, J Ortiz, A Morell, E Ramírez, AI Zurriaga, MP Abanades, SR García, TG Aranda, M Ruiz, CM Nieto, JM Serra, F Sánchez-Madrid, I Sánchez-Cerrillo, P Martínez-Fleta, C López-Sanz, L Gabrie, L del Campo Guerola, E Fernández, R Tejedor, PA Haro, MT Genao, BQ Dorado, DJ Jiménez, MA González, P Villamayor, I de los Santos, E Sánchez, F Moldenhauer, P Casado, J Curbelo, A Gutiérrez, A Bautista, NR Giménez, A Fernández, LG Fraile, P Parra, B Moyano, A Barrios, P Gil, IG Polo, DR de Asúa, B Sánchez, C Sáez, M Ciudad, MF Rico, CA Román, EM Rodríguez, D Navas, M del Carmen Cuevas Torresano, DD García, TA Cavero, AG Blanco, MA Chong, AG Cobos, AM Torres, T Alonso, P Landete, J Soriano, C Cisneros, EG Castillo, C Valenzuela, FJ Pérez, RM Girón, J Aspa, C Marcos, E Zamora, G Iturricastillo, MB Mayo, ER Garrido, S Castañeda, C Fernández-Díaz, EG Tomero, NG Castañeda, AM Ortiz, C Valero, M Uriarte, N Montes, IG Sanz, FE Viamontes, JD Valdueza |
Scientific Reports | 2021 |
Therapeutic use of specific tumour necrosis factor inhibitors in inflammatory diseases including COVID-19
S Patel, M Wadhwa |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2021 |
Delivery Routes for COVID-19 Vaccines
JH Park, HK Lee |
Human vaccines | 2021 |
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
K Renner, T Schwittay, S Chaabane, J Gottschling, C Müller, C Tiefenböck, JN Salewski, F Winter, S Buchtler, S Balam, MV Malfertheiner, M Lubnow, D Lunz, B Graf, F Hitzenbichler, F Hanses, H Poeck, M Kreutz, E Orsó, R Burkhardt, T Niedermair, C Brochhausen, A Gessner, B Salzberger, M Mack |
Nature Communications | 2021 |
Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
A Gangaev, SL Ketelaars, OI Isaeva, S Patiwael, A Dopler, K Hoefakker, SD Biasi, L Gibellini, C Mussini, G Guaraldi, M Girardis, CM Ormeno, PJ Hekking, NM Lardy, M Toebes, R Balderas, TN Schumacher, H Ovaa, A Cossarizza, P Kvistborg |
Nature Communications | 2021 |
Innate immune sensing of coronavirus and viral evasion strategies
Y Kasuga, B Zhu, KJ Jang, JS Yoo |
Experimental & molecular medicine | 2021 |
Role of the Immune Microenvironment in SARS-CoV-2 Infection
CH Ye, WL Hsu, GR Peng, WC Yu, WC Lin, SY Hu, SH Yu |
Cell Transplantation | 2021 |
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu |
Cell Discovery | 2021 |
Gastrointestinal Microenvironment and the Gut-Lung Axis in the Immune Responses of Severe COVID-19
Y Yang, W Huang, Y Fan, GQ Chen |
Frontiers in Molecular Biosciences | 2021 |
The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review
S Huang, S Zhao, H Luo, Z Wu, J Wu, H Xia, X Chen |
BMC Pulmonary Medicine | 2021 |
The effect of azoximer bromide (Polyoxidonium®) in patients hospitalized with coronavirus disease (COVID-19): an open-label, multicentre, interventional clinical study
SV Efimov, NV Matsiyeuskaya, OV Boytsova, LY Akhieva, EI Kvasova, F Harrison, YS Karpova, A Tikhonov, NF Khomyakova, T Hardman, JF Rossi |
Drugs in Context | 2021 |
Cytotoxic T-lymphocyte elicited vaccine against SARS-CoV-2 employing immunoinformatics framework
N Kumar, N Admane, A Kumari, D Sood, S Grover, VK Prajapati, R Chandra, A Grover |
Scientific Reports | 2021 |
Immune Response Failure in Paucisymptomatic Long-Standing SARS-CoV-2 Spreaders
S Corrao, F Gervasi, FD Bernardo, C Argano |
Clinics and Practice | 2021 |
Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis – Author’s reply
T Kashour, IM Tleyjeh |
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases | 2021 |
Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques
PD Yadav, R Ella, S Kumar, DR Patil, S Mohandas, AM Shete, KM Vadrevu, G Bhati, G Sapkal, H Kaushal, S Patil, R Jain, G Deshpande, N Gupta, K Agarwal, M Gokhale, B Mathapati, S Metkari, C Mote, D Nyayanit, DY Patil, BS Prasad, A Suryawanshi, M Kadam, A Kumar, S Daigude, S Gopale, T Majumdar, D Mali, P Sarkale, S Baradkar, P Gawande, Y Joshi, S Fulari, H Dighe, S Sharma, R Gunjikar, A Kumar, K Kalele, VK Srinivas, RR Gangakhedkar, KM Ella, P Abraham, S Panda, B Bhargava |
Nature Communications | 2021 |
Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19
W Sayah, I Berkane, I Guermache, M Sabri, FZ Lakhal, SY Rahali, A Djidjeli, LL mahammed, F Merah, B Belaid, L Berkani, NZ Lazli, L Kheddouci, A Kadi, M Ouali, R Khellafi, D Mekideche, A Kheliouen, RM Hamidi, S Ayoub, NB Raaf, F Derrar, M Gharnaout, I Allam, R Djidjik |
Cytokine | 2021 |
An Overview of Nucleic Acid Testing for the Novel Coronavirus SARS-CoV-2
H Wang, G Li, J Zhao, Y Li, Y Ai |
Frontiers in Medicine | 2021 |
Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients
C Bao, X Tao, W Cui, Y Hao, S Zheng, B Yi, T Pan, KH Young, W Qian |
Experimental Hematology and Oncology | 2021 |
Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors?
T Çınar, Mİ Hayıroğlu, V Çiçek, Ş Kılıç, S Asal, S Yavuz, M Selçuk, E Yalçınkaya, N Keser, AL Orhan |
Heart & lung : the journal of critical care | 2021 |
Haemophagocytic syndrome and COVID-19
S Retamozo, P Brito-Zerón, A Sisó-Almirall, A Flores-Chávez, MJ Soto-Cárdenas, M Ramos-Casals |
Clinical Rheumatology | 2021 |
PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19
MS Rha, HW Jeong, JH Ko, SJ Choi, IH Seo, JS Lee, M Sa, AR Kim, EJ Joo, JY Ahn, JH Kim, KH Song, ES Kim, DH Oh, MY Ahn, HK Choi, JH Jeon, JP Choi, HB Kim, YK Kim, SH Park, WS Choi, JY Choi, KR Peck, EC Shin |
Immunity | 2021 |
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant
RS Abraham, JM Marshall, HS Kuehn, CM Rueda, A Gibbs, W Guider, C Stewart, SD Rosenzweig, H Wang, S Jean, M Peeples, T King, WG Hunt, JR Honegger, O Ramilo, PJ Mustillo, A Mejias, MI Ardura, M Shimamura |
Journal of Allergy and Clinical Immunology | 2021 |
Combination of cycle threshold time, absolute lymphocyte count and neutrophil:lymphocyte ratio is predictive of hypoxia in patients with SARS-CoV-2 infection
V Abeysuriya, S Seneviratne, A de Silva, R Mowjood, S Mowjood, T de Silva, P de Mel, C de Mel, L Chandrasena, R Wijesinha, A Fernando, S de Mel |
Transactions of the Royal Society of Tropical Medicine and Hygiene | 2021 |
Expansion of CD56dimCD16neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 Patients
J Casado, E Moraga, P Vizcarra, H Velasco, A Martín-Hondarza, J Haemmerle, S Gómez, C Quereda, A Vallejo |
Viruses | 2021 |
An update on host immunity correlates and prospects of re-infection in COVID-19
N Negi, S Maurya, R Singh, B Das |
International Reviews of Immunology | 2021 |
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
K Ying, R Zhai, T Pyrkov, A Shindyapina, M Mariotti, P Fedichev, X Shen, V Gladyshev |
2021 | |
Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology
A Codd, S Hanna, E Compeer, F Richter, E Pring, E Gea-Mallorquí, M Borsa, O Moon, D Scourfield, D Ahern, H Almuttaqi, D Alonzi, A Alrubayyi, G Alsaleh, V Bart, V Batchelor, R Bayliss, D Berthold, J Bezbradica, T Bharuchq, H Borrmann, M Borsa, R Borst, J Brun, S Burnell, L Capitani, A Cavounidis, L Chapman, A Chauveau, L Cifuentes, A Codd, E Compeer, C Coveney, A Cross, S Danielli, L Davies, C Dendrou, S Dimonte, R Durairaj, L Dustin, A Dyer, C Fielding, F Fischer, A Gallimore, S Galloway, A Gammage, E Gea-Mallorquí, A Godkin, S Hanna, C Heuberger, S Hulin-Curtis, F Issa, E Jones, R Jones, K Ladell, S Lauder, K Liddiard, P Ligoxygakis, F Lu, B MacLachlan, S Maleki-Toyserkani, E Mann, A Marzeda, R Matthews, J Mazet, A Milicic, E Mitchell, O Moon, V Nguyen, M O'Hanlon, C Pavillet, D Peppa, A Pires, E Pring, M Quastel, S Reed, J Rehwinkel, N Richmond, F Richter, A Robinson, P Rodrigues, P Sabberwal, A Sami, R Peres, Q Sattentau, B Schonfeldova, D Scourfield, T Selvakumar, F Shepherd, C Shorten, A Simon, A Smith, A Crespo, M Tellier, E Thornton, L Uhl, E van Grinsven, A Wann, R Williams, J Wilson, D Zhou, Z Zhu, A Gallimore, A Milicic |
2021 | |
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
Rouphael N, Maecker H, Montgomery RR, Diray-Arce J, Kleinstein SH, Altman MC, Bosinger SE, Eckalbar W, Guan L, Hough CL, Krammer F, Langelier C, Levy O, McEnaney K, Peters B, Rahman A, Rajan JV, Sigelman S, Steen H, van Bakel H, Ward A, Wilson MR, Woodruff P, Zamecnik CR, Augustine AD, Ozonoff A, Reed EF, Becker PM, Higuita NA, Altman MC, Atkinson MA, Baden LR, Becker PM, Bime C, Brakenridge SC, Calfee CS, Cairns CB, Corry D, Davis MM, Augustine AD, Ehrlich LI, Haddad EK, Erle DJ, Fernandez-Sesma A, Hafler DA, Hough CL, Kheradmand F, Kleinstein SH, Kraft M, Levy O, McComsey GA, Melamed E, Messer W, Metcalf J, Montgomery RR, Nadeau KC, Ozonoff A, Peters B, Pulendran B, Reed EF, Rouphael N, Sarwal M, Schaenman J, Sekaly R, Shaw AC, Simon V |
Science Immunology | 2021 |
Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial*
Tom J, Bao M, Tsai L, Qamra A, Summers D, Carrasco-Triguero M, McBride J, Rosenberger CM, Lin CJ, Stubbings W, Blyth KG, Carratalà J, François B, Benfield T, Haslem D, Bonfanti P, van der Leest CH, Rohatgi N, Wiese L, Luyt CE, Kheradmand F, Rosas IO, Cai F |
Critical Care Medicine | 2021 |
Research on SARS-COV-2 pandemic: a narrative review focused on the Italian contribution
De Cassai A, Longhini F, Romagnoli S, Cavaliere F, Caroleo A, Foti L, Furlani E, Gianoli S, Monteleone F, Saraco G, Villa G, Conti G, Navalesi P |
2021 | |
The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role
Bertoletti A, Tan AT, Le Bert N |
2021 | |
Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults.
Lewis SA, Sureshchandra S, Zulu MZ, Doratt B, Jankeel A, Ibraim IC, Pinski AN, Rhoades NS, Curtis M, Jiang X, Tifrea D, Zaldivar F, Shen W, Edwards RA, Chow D, Cooper D, Amin A, Messaoudi I |
2021 | |
Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques
Hasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith B, Meade-White K, Shupert WL, Hawman DW, Feldmann H |
2021 | |
Rationale for Randomized Clinical Trials Investigating the Potential of BCG Vaccination in Preventing COVID-19 Infection
Noval Rivas M, Rosser CJ, Arditi M |
Bladder Cancer | 2021 |
SARS-CoV-2 specific T-cell responses and correlations with COVID-19 patient predisposition
Arne Sattler, Stefan Angermair, Helena Stockmann, Katrin Moira Heim, Dmytro Khadzhynov, Sascha Treskatsch, Fabian Halleck, Martin E. Kreis, Katja Kotsch |
Journal of Clinical Investigation | 2020 |
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation
Gunjan L. Shah, Susan DeWolf, Yeon Joo Lee, Roni Tamari, Parastoo B. Dahi, Jessica A. Lavery, Josel D. Ruiz, Sean M. Devlin, Christina Cho, Jonathan U. Peled, Ioannis Politikos, Michael Scordo, N. Esther Babady, Tania Jain, Santosha Vardhana, Anthony F. Daniyan, Craig S. Sauter, Juliet N. Barker, Sergio A. Giralt, Cheryl Goss, Peter Maslak, Tobias M. Hohl, Mini Kamboj, Lakshmi Ramanathan, Marcel R.M. van den Brink, Esperanza B. Papadopoulos, Genovefa A. Papanicolaou, Miguel-Angel Perales |
Journal of Clinical Investigation | 2020 |
Autoinflammatory and autoimmune conditions at the crossroad of COVID-19
Y Rodríguez, L Novelli, M Rojas, MD Santis, Y Acosta-Ampudia, DM Monsalve, C Ramírez-Santana, A Costanzo, WM Ridgway, AA Ansari, ME Gershwin, C Selmi, JM Anaya |
Journal of Autoimmunity | 2020 |
Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics
A Ritter, NN Kreis, F Louwen, J Yuan |
International journal of molecular sciences | 2020 |
A gendered magnifying glass on COVID-19
L Salvati, B Biagioni, E Vivarelli, P Parronchi |
Clinical and Molecular Allergy | 2020 |
Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies
M Market, L Angka, AB Martel, D Bastin, O Olanubi, G Tennakoon, DM Boucher, J Ng, M Ardolino, RC Auer |
Frontiers in immunology | 2020 |
Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeutics
V Kumar |
International Immunopharmacology | 2020 |
The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection
O Gallo, LG Locatello, A Mazzoni, L Novelli, F Annunziato |
Mucosal Immunology | 2020 |
Can Natural Killer Cells Be a Principal Player in Anti-SARS-CoV-2 Immunity?
F Ahmed, DH Jo, SH Lee |
Frontiers in immunology | 2020 |
COVID-19: The Emerging Immunopathological Determinants for Recovery or Death
T Ahmad, R Chaudhuri, MC Joshi, A Almatroudi, AH Rahmani, SM Ali |
Frontiers in microbiology | 2020 |
On the genetics and immunopathogenesis of COVID-19
CO Jacob |
Clinical Immunology | 2020 |
Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020
C Manickam, S Sugawara, RK Reeves, TC Hobman |
PLoS pathogens | 2020 |
T cell phenotypes in COVID-19 - a living review
SJ Hanna, AS Codd, E Gea-Mallorqui, DO Scourfield, FC Richter, K Ladell, M Borsa, EB Compeer, OR Moon, SA Galloway, S Dimonte, L Capitani, FR Shepherd, JD Wilson, LF Uhl, DJ Ahern, H Almuttaqi, DS Alonzi, A Alrubayyi, G Alsaleh, VM Bart, V Batchelor, R Bayliss, DL Berthold, JS Bezbradica, T Bharuchq, H Borrmann, M Borsa, R Borst, J Brun, S Burnell, L Capitani, A Cavounidis, L Chapman, A Chauveau, L Cifuentes, AS Codd, EB Compeer, C Coveney, A Cross, S Danielli, LC Davies, CA Dendrou, S Dimonte, RR Durairaj, LB Dustin, A Dyer, C Fielding, F Fischer, A Gallimore, S Galloway, A Gammage, E Gea-Mallorquí, A Godkin, SJ Hanna, C Heuberger, S Hulin-Curtis, F Issa, E Jones, R Jones, K Ladell, SN Lauder, K Liddiard, P Ligoxygakis, F Lu, B MacLachlan, S Maleki-Toyserkani, EH Mann, AM Marzeda, RJ Matthews, JM Mazet, A Milicic, E Mitchell, O Moon, VD Nguyen, M O'Hanlon, CE Pavillet, D Peppa, A Pires, E Pring, M Quastel, S Reed, J Rehwinkel, N Richmond, FC Richter, AJ Robinson, PR Rodrigues, P Sabberwal, A Sami, RS Peres, Q Sattentau, B Schonfeldova, DO Scourfield, TA Selvakumar, FR Shepherd, C Shorten, AK Simon, AL Smith, AT Crespo, M Tellier, E Thornton, LF Uhl, E van Grinsven, AK Wann, R Williams, JD Wilson, D Zhou, Z Zhu, AM Gallimore, A Milicic |
2020 | |
Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection
J Yang, E Zhang, M Zhong, Q Yang, K Hong, T Shu, D Zhou, J Xiang, J Xia, , D Zhang, C Huang, Y Shang, H Yan |
Virologica Sinica | 2020 |
T cell responses in patients with COVID-19
Z Chen, EJ Wherry |
Nature Reviews Immunology | 2020 |
Natural killer cell immunotypes related to COVID-19 disease severity
C Maucourant, I Filipovic, A Ponzetta, S Aleman, M Cornillet, L Hertwig, B Strunz, A Lentini, B Reinius, D Brownlie, A Cuapio, EH Ask, RM Hull, A Haroun-Izquierdo, M Schaffer, J Klingström, E Folkesson, M Buggert, JK Sandberg, LI Eriksson, O Rooyackers, HG Ljunggren, KJ Malmberg, J Michaëlsson, N Marquardt, Q Hammer, K Strålin, NK Björkström |
Science Immunology | 2020 |
Threading the Pieces Together: Integrative Perspective on SARS-CoV-2
A Kanakan, N Mishra, JS Vasudevan, S Sahni, A Khan, S Sharma, R Pandey |
Pathogens | 2020 |
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?
JM Berthelot, F Lioté, Y Maugars, J Sibilia |
Frontiers in immunology | 2020 |
Pulmonary vascular improvement in severe COVID-19 patients treated with tocilizumab
L Salvati, M Occhipinti, L Gori, L Ciani, A Mazzoni, L Maggi, M Capone, P Parronchi, F Liotta, V Miele, F Annunziato, F Lavorini, L Cosmi |
Immunology Letters | 2020 |
Quantitative and qualitative alterations of circulating myeloid cells and plasmacytoid DC in SARS‐CoV‐2 infection
B Peruzzi, S Bencini, M Capone, A Mazzoni, L Maggi, L Salvati, A Vanni, C Orazzini, C Nozzoli, A Morettini, L Poggesi, F Pieralli, A Peris, A Bartoloni, AM Vannucchi, F Liotta, R Caporale, L Cosmi, F Annunziato |
Immunology | 2020 |
Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome
LY Chen, RL Hoiland, S Stukas, CL Wellington, MS Sekhon |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2020 |
Natural Killer Cell Dysfunction and Its Role in COVID-19
C van Eeden, L Khan, MS Osman, JW Tervaert |
International journal of molecular sciences | 2020 |
COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment
A Arastehfar, A Carvalho, FL van de Veerdonk, JD Jenks, P Koehler, R Krause, OA Cornely, DS Perlin, C Lass-Flörl, M Hoenigl |
Journal of Fungi | 2020 |
The immune system view of the coronavirus SARS-CoV-2
I Celardo, L Pace, L Cifaldi, C Gaudio, V Barnaba |
Biology direct | 2020 |
Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions
EA Meyerowitz, P Sen, SR Schoenfeld, TG Neilan, MJ Frigault, JH Stone, AY Kim, MK Mansour |
Clinical Infectious Diseases | 2020 |
Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset
JF Gutiérrez-Bautista, A Rodriguez-Nicolas, A Rosales-Castillo, P Jiménez, F Garrido, P Anderson, F Ruiz-Cabello, MÁ López-Ruz |
Frontiers in immunology | 2020 |
First Report of Tocilizumab Use in a Cohort of Latin American Patients Hospitalized for Severe COVID-19 Pneumonia
O Valenzuela, S Ibáñez, MC Poli, P Roessler, M Aylwin, G Roizen, M Iruretagoyena, V Agar, J Donoso, M Fierro, J Montes |
Frontiers in Medicine | 2020 |
The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic review
AG Kaye, R Siegel |
PeerJ | 2020 |
Long-Term Existence of SARS-CoV-2 in COVID-19 Patients: Host Immunity, Viral Virulence, and Transmissibility
X Wang, K Huang, H Jiang, L Hua, W Yu, D Ding, K Wang, X Li, Z Zou, M Jin, S Xu |
Virologica Sinica | 2020 |
Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome
A Sacchi, G Grassi, V Bordoni, P Lorenzini, E Cimini, R Casetti, E Tartaglia, L Marchioni, N Petrosillo, F Palmieri, G DOffizi, S Notari, M Tempestilli, MR Capobianchi, E Nicastri, M Maeurer, A Zumla, F Locatelli, A Antinori, G Ippolito, C Agrati |
Cell Death and Disease | 2020 |
Continuous tracking of COVID-19 patients' immune status
J Guan, X Wei, S Qin, X Liu, Y Jiang, Y Chen, Y Chen, H Lu, J Qian, Z Wang, X Lin |
International Immunopharmacology | 2020 |
Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study
BJ Webb, ID Peltan, P Jensen, D Hoda, B Hunter, A Silver, N Starr, W Buckel, N Grisel, E Hummel, G Snow, D Morris, E Stenehjem, R Srivastava, SM Brown |
2020 | |
Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series
S Mori, T Ai, Y Otomo, Y Taniyama |
PloS one | 2020 |
No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
GW Jones, MP Monopoli, L Campagnolo, A Pietroiusti, L Tran, B Fadeel |
Nanomedicine | 2020 |
Compassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: a prospective observational study
AM Vannucchi, B Sordi, A Morettini, C Nozzoli, L Poggesi, F Pieralli, A Bartoloni, A Atanasio, F Miselli, C Paoli, GG Loscocco, A Fanelli, O Para, A Berni, I Tassinari, L Zammarchi, L Maggi, A Mazzoni, V Scotti, G Falchetti, D Malandrino, F Luise, G Millotti, S Bencini, M Capone, MP Piccinni, F Annunziato, P Guglielmelli, F Mannelli, G Coltro, D Fantoni, M Borella, E Ravenda, B Peruzzi, R Caporale, L Cosmi, F Liotta, L Lombardelli, F Logiodice, A Vanni, L Salvati, C Lazzeri, M Bonizzoli, A Peris, G Cianchi, A Bosi, M Pucatti, P Fontanari, S Benemei, MM Cerinic, L Turco |
Leukemia | 2020 |
COVID-19 and Obesity: Dangerous Liaisons
G Caci, A Albini, M Malerba, DM Noonan, P Pochetti, R Polosa |
Journal of Clinical Medicine | 2020 |
SARS-CoV-2: characteristics and current advances in research
Y Yang, Z Xiao, K Ye, X He, B Sun, Z Qin, J Yu, J Yao, Q Wu, Z Bao, W Zhao |
Virology Journal | 2020 |
Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids
Y Miao, L Fan, JY Li |
Frontiers in immunology | 2020 |
Lymphopenia during the COVID-19 infection: What it shows and what can be learned
S Tavakolpour, T Rakhshandehroo, EX Wei, M Rashidian |
Immunology Letters | 2020 |
A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2
Riggioni C, Comberiati P, Giovannini M, Agache I, Akdis M, Alves\u2010Correia M, Antó JM, Arcolaci A, Azkur AK, Azkur D, Beken B, Boccabella C, Bousquet J, Breiteneder H, Carvalho D, De las Vecillas L, Diamant Z, Eguiluz\u2010Gracia I, Eiwegger T, Eyerich S, Fokkens W, Gao Y, Hannachi F, Johnston SL, Jutel M, Karavelia A, Klimek L, Moya B, Nadeau KC, O'Hehir R, O'Mahony L, Pfaar O, Sanak M, Schwarze J, Sokolowska M, Torres MJ, van de Veen W, van Zelm MC, Wang DY, Zhang L, Jiménez\u2010Saiz R, Akdis CA |
Allergy | 2020 |
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AA, Horton M, Smith K, Pekosz A, D\u2019Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD |
2020 |