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Citations to this article

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.
M Moroi, … , M C Fishman, P L Huang
M Moroi, … , M C Fishman, P L Huang
Published March 15, 1998
Citation Information: J Clin Invest. 1998;101(6):1225-1232. https://doi.org/10.1172/JCI1293.
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Research Article Article has an altmetric score of 3

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.

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Abstract

To begin to dissect atherogenesis as a complex genetic disorder affected by genetic makeup and environment, we have (a) generated a reproducible mouse model of neointimal growth; (b) evaluated the effect of disruption of a single gene, endothelial nitric oxide synthase, believed to be central to intimal growth, and (c) examined the modifying effects of gender and pregnancy upon the vascular response. Cuff placement around the femoral artery causes reproducible intimal growth. We assessed the response to injury by quantitative morphometry, measuring the intimal to medial (I/M) volume ratio. In wild-type mice, cuff placement causes pronounced intimal proliferation without affecting the media, resulting in I/M ratios of 31% (SV129 males) and 27% (C57BL/6 males). eNOS mutant male mice have a much greater degree of intimal growth (I/M ratio of 70%). Female mice show less intimal response than do males, although eNOS mutant female mice still have more response than do wild-type females. Most dramatic, however, is the effect of pregnancy, which essentially abolishes the intimal response to injury, even overriding the effect of eNOS mutation. We conclude that eNOS deficiency is a genetic predisposition to intimal proliferation that is enhanced by male gender, and that may be overridden by pregnancy.

Authors

M Moroi, L Zhang, T Yasuda, R Virmani, H K Gold, M C Fishman, P L Huang

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1995 Total
Citations: 4 2 4 4 5 7 8 6 7 4 6 9 3 12 27 10 10 7 12 13 8 20 19 18 18 3 1 247
Citation information
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Citations to this article in year 2008 (10)

Title and authors Publication Year
Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling
P Wohlfart, H Xu, A Endlich, A Habermeier, EI Closs, T Hübschle, C Mang, H Strobel, T Suzuki, H Kleinert, U Förstermann, H Ruetten, H Li
The Journal of pharmacology and experimental therapeutics 2008
Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis
R Lukowski, P Weinmeister, D Bernhard, S Feil, M Gotthardt, J Herz, S Massberg, A Zernecke, C Weber, F Hofmann, R Feil
Arteriosclerosis, thrombosis, and vascular biology 2008
Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection
HH Kim, N Sawada, G Soydan, HS Lee, Z Zhou, SK Hwang, C Waeber, MA Moskowitz, JK Liao
Journal of Cerebral Blood Flow & Metabolism 2008
Spontaneous Myocardial Infarction and Nitric Oxide Synthase
M Tsutsui, S Nakata, H Shimokawa, Y Otsuji, N Yanagihara
Trends in Cardiovascular Medicine 2008
Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice
VW Liu, PL Huang
Cardiovascular Research 2008
Intimal hyperplasia in murine models
DY Hui
Current drug targets 2008
Diabetic eNOS knockout mice develop distinct macro- and microvascular complications
S Mohan, RL Reddick, N Musi, DA Horn, B Yan, TJ Prihoda, M Natarajan, SL Abboud-Werner
Laboratory Investigation 2008
Colchicine Inhibits Intimal Hyperplasia and Leukocyte VEGF Expression in Dogs
HM Atta, MA El-Rehany, SR Raheim, R Fouad, AM Galal
Journal of Surgical Research 2008
Translational Therapeutics of Dipyridamole
HH Kim, JK Liao
Arteriosclerosis, thrombosis, and vascular biology 2008
Vascular remodeling and mobilization of bone marrow-derived cells in cuff-induced vascular injury in LDL receptor knockout mice:
Y XU, H ARAI, T MURAYAMA, T KITA, M YOKODE
Chinese Medical Journal 2008

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