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Citations to this article

Potential role of iron in repair of inflammatory demyelinating lesions
Nathanael J. Lee, … , Steven Jacobson, Daniel S. Reich
Nathanael J. Lee, … , Steven Jacobson, Daniel S. Reich
Published September 9, 2019
Citation Information: J Clin Invest. 2019;129(10):4365-4376. https://doi.org/10.1172/JCI126809.
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Research Article Neuroscience Article has an altmetric score of 31

Potential role of iron in repair of inflammatory demyelinating lesions

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Abstract

Inflammatory destruction of iron-rich myelin is characteristic of multiple sclerosis (MS). Although iron is needed for oligodendrocytes to produce myelin during development, its deposition has also been linked to neurodegeneration and inflammation, including in MS. We report perivascular iron deposition in multiple sclerosis lesions that was mirrored in 72 lesions from 13 marmosets with experimental autoimmune encephalomyelitis. Iron accumulated mainly inside microglia/macrophages from 6 weeks after demyelination. Consistently, expression of transferrin receptor, the brain’s main iron-influx protein, increased as lesions aged. Iron was uncorrelated with inflammation and postdated initial demyelination, suggesting that iron is not directly pathogenic. Iron homeostasis was at least partially restored in remyelinated, but not persistently demyelinated, lesions. Taken together, our results suggest that iron accumulation in the weeks after inflammatory demyelination may contribute to lesion repair rather than inflammatory demyelination per se.

Authors

Nathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Govind Nair, Nicholas J. Luciano, Emily C. Leibovitch, Cecil C. Yen, Tracey A. Rouault, Afonso C. Silva, Steven Jacobson, Daniel S. Reich

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 2 4 5 7 4 5 1 28
Citation information
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Citations to this article (28)

Title and authors Publication Year
Association of Iron Deposition in Early-Stage Multiple Sclerosis Lesion with Remyelination Capacity in 3T MRI
Hyeong-Geol Shin, Woojun Kim, Jung Lee, Hyun-soo Lee, Yoonho Nam, Jiwoong Kim, Xu Li, Peter Zijl, Peter Calabresi, Jongho Lee, Jinhee Jang
NeuroImage. Clinical 2025
Characteristics of TSPO expression in marmoset EAE
Falk I, Maric D, Leibovitch E, Sati P, Lefeuvre J, Luciano NJ, Guy J, Ha SK, Owen DR, Aigbirhio F, Matthews PM, Reich DS, Jacobson S
Journal of Neuroinflammation 2025
Myelin endocytosis by brain blood vessel endothelial cells causes endothelial iron overload and oligodendroglial iron hunger in hypoperfusion-induced white matter injury
Yuxin Liu, Xinmei Kang, Jiahao Lin, Yixin Liu, Sanxin Liu, Chunyi Li, Xiaohui Deng, Huipeng Huang, Tiemei Li, Shisi Wang, Danli Lu, Yuxuan Jiang, Zhengqi Lu, Wei Cai, Tingting Lu
CNS neuroscience & therapeutics 2024
Exploring Potential Mechanisms Accounting for Iron Accumulation in the Central Nervous System of Patients with Alzheimer's Disease.
LeVine SM
Cells 2024
Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder
Heij J, van der Zwaag W, Knapen T, Caan MW, Forstman B, Veltman DJ, van Wingen G, Aghajani M
Translational Psychiatry 2024
Towards Treating Multiple Sclerosis Progression
Häusler D, Weber MS
Pharmaceuticals 2024
Inflammation in multiple sclerosis: consequences for remyelination and disease progression.
Klotz L, Antel J, Kuhlmann T
Nature reviews. Neurology 2023
In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis.
Donadieu M, Lee NJ, Gaitán MI, Ha SK, Luciano NJ, Roy S, Ineichen B, Leibovitch EC, Yen CC, Pham DL, Silva AC, Johnson M, Jacobson S, Sati P, Reich DS
eLife 2023
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS
Jhelum P, Zandee S, Ryan F, Zarruk JG, Michalke B, Venkataramani V, Curran L, Klement W, Prat A, David S
Acta Neuropathologica Communications 2023
A 4D transcriptomic map for the evolution of multiple sclerosis-like lesions in the marmoset brain
Lin JP, Brake A, Donadieu M, Lee A, Kawaguchi R, Sati P, Geschwind DH, Jacobson S, Schafer DP, Reich DS
2023
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1β-Induced Iron Regulatory Protein 1.
Yang J, Du C, Li Y, Liu R, Jing C, Xie J, Wang J
Neurochemical Research 2023
A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology
M Mishra, J Wang, R Mirzaei, R Chan, H Melo, P Zhang, C Ling, A Bruccoleri, L Tang, V Yong
Cells 2022
Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis
J Luoqian, W Yang, X Ding, Q Tuo, Z Xiang, Z Zheng, Y Guo, L Li, P Guan, S Ayton, B Dong, H Zhang, H Hu, P Lei
Cellular and Molecular Immunology 2022
Hepcidin (rs10421768), Transferrin (rs3811647, rs1049296) and Transferrin Receptor 2 (rs7385804) Gene Polymorphism Might Be Associated with the Origin of Multiple Sclerosis
Stachowska L, Koziarska D, Karakiewicz B, Kotwas A, Knyszyńska A, Folwarski M, Dec K, Stachowska E, Hawryłkowicz V, Kulaszyńska M, Sołek-Pastuszka J, Skonieczna-Żydecka K
International journal of environmental research and public health 2022
Iron-Induced Oxidative Stress in Human Diseases
Kawabata T
Cells 2022
Spatial-temporal changes of iron deposition and iron metabolism after traumatic brain injury in mice
Cheng H, Wang N, Ma X, Wang P, Dong W, Chen Z, Wu M, Wang Z, Wang L, Guan D, Zhao R
Frontiers in molecular neuroscience 2022
Iron metabolism mediates microglia susceptibility in ferroptosis
Jiao L, Li X, Luo Y, Wei J, Ding X, Xiong H, Liu X, Lei P
Frontiers in cellular neuroscience 2022
A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis
Rahmanzadeh R, Galbusera R, Lu PJ, Bahn E, Weigel M, Barakovic M, Franz J, Nguyen TD, Spincemaille P, Schiavi S, Daducci A, La Rosa F, Absinta M, Sati P, Cuadra MB, Radue EW, Leppert D, Kuhle J, Kappos L, Brück W, Reich DS, Stadelmann C, Wang Y, Granziera C
Annals of Neurology 2022
Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease
B Rossi, B Santos-Lima, E Terrabuio, E Zenaro, G Constantin
Frontiers in immunology 2021
Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System
DC Ivan, S Walthert, K Berve, J Steudler, G Locatelli
Frontiers in immunology 2021
Diversity and Function of Glial Cell Types in Multiple Sclerosis
L Schirmer, DP Schafer, T Bartels, DH Rowitch, PA Calabresi
Trends in Immunology 2021
Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis
HY Yong, VW Yong
Nature Reviews Neurology 2021
The Chemical Biology of Ferroptosis in the Central Nervous System
RR Ratan
Cell Chemical Biology 2020
The Role of Iron Metabolism in Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients
A Knyszyńska, A Radecka, P Zabielska, J Łuczak, B Karakiewicz, A Lubkowska
International journal of environmental research and public health 2020
High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis
A Miedema, MH Wijering, BJ Eggen, SM Kooistra
Frontiers in molecular neuroscience 2020
Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis
Q Ma, A Matsunaga, B Ho, JR Oksenberg, A Didonna
Journal of Neuroinflammation 2020
Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives
J MartinsMacedo, AC Lepore, HS Domingues, AJ Salgado, ED Gomes, L Pinto
Glia 2020
Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction
Khodanovich, Pishchelko, Glazacheva, Pan, Akulov, Svetlik, Tyumentseva, Ananina, Yarnykh
Cells 2019

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