Foxp3+ T lymphocytes: immune regulators within the lung allograft
Elizabeth A. Lendermon, John F. McDyer
Elizabeth A. Lendermon, John F. McDyer
Published December 18, 2018
Citation Information: J Clin Invest. 2019;129(2):494-495. https://doi.org/10.1172/JCI126517.
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Commentary

Foxp3+ T lymphocytes: immune regulators within the lung allograft

Abstract

Antibody-mediated rejection (AMR) has emerged as an important cause of lung graft failure. In the current issue of the JCI, a study by Li et al. identifies a critical role of Foxp3+ T cells residing within lung allografts in the regulation of AMR. This study not only provides new insights into the nature of lung allografts as a primary site where T and B cell priming and immune regulation can occur, but also introduces the mouse orthotopic lung transplant as a model for studying the immunobiology of AMR. Because AMR can be so difficult to effectively treat in lung transplant recipients, the development of an animal model is a major advance in understanding the immunopathogenesis of AMR.

Authors

Elizabeth A. Lendermon, John F. McDyer

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Figure 1

Foxp3+ T lymphocytes in BALT regulate B and T cell alloimmune responses in the lung allograft.

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Foxp3+ T lymphocytes in BALT regulate B and T cell alloimmune responses ...
Lung allografts are primary sites where T and B cell priming and immune regulation can occur. Foxp3+ T cells residing within lung allografts regulate AMR. Preserving the presence of Foxp3+ regulatory CD4+ T cells may be important in the prevention and resolution of ALI from any cause in lung transplantation.