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Ioana Agache, Cezmi A. Akdis
Published March 11, 2019
Citation Information: J Clin Invest. 2019;129(4):1493-1503. https://doi.org/10.1172/JCI124611.
Citation Information: J Clin Invest. 2019;129(4):1493-1503. https://doi.org/10.1172/JCI124611.
Abstract
A rapidly developing paradigm for modern health care is a proactive and individualized response to patients’ symptoms, combining precision diagnosis and personalized treatment. Precision medicine is becoming an overarching medical discipline that will require a better understanding of biomarkers, phenotypes, endotypes, genotypes, regiotypes, and theratypes of diseases. The 100-year-old personalized allergen-specific management of allergic diseases has particularly contributed to early awareness in precision medicine. Polyomics, big data, and systems biology have demonstrated a profound complexity and dynamic variability in allergic disease between individuals, as well as between regions. Escalating health care costs together with questionable efficacy of the current management of allergic diseases facilitated the emergence of the endotype-driven approach. We describe here a precision medicine approach that stratifies patients based on disease mechanisms to optimize management of allergic diseases.
Authors
Ioana Agache, Cezmi A. Akdis
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Citations to this article (118)
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TLR5 Activation Exacerbates Airway Inflammation in Asthma
GS Whitehead, S Hussain, R Fannin, CS Trempus, CL Innes, SH Schurman, DN Cook, S Garantziotis |
Lung | 2020 |
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Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment
MD Martinis, MM Sirufo, M Suppa, DD Silvestre, L Ginaldi |
International journal of molecular sciences | 2020 |
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Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock
SC Brakenridge, Z Wang, M Cox, S Raymond, R Hawkins, D Darden, G Ghita, B Brumback, J Cuschieri, RV Maier, FA Moore, AM Mohr, PA Efron, LL Moldawer |
The journal of trauma and acute care surgery | 2020 |
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Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach
Y Fukuda, K Akimoto, T Homma, JR Baker, K Ito, PJ Barnes, H Sagara |
Journal of Clinical Medicine | 2020 |
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Allergen Immunotherapy in Children User’s Guide
M AlvaroLozano, CA Akdis, M Akdis, C Alviani, E Angier, S Arasi, L ArztGradwohl, D Barber, R Bazire, O Cavkaytar, P Comberiati, S Dramburg, SR Durham, AO Eifan, L Forchert, S Halken, M Kirtland, UC Kucuksezer, JA Layhadi, PM Matricardi, A Muraro, C Ozdemir, GB Pajno, O Pfaar, E Potapova, C Riggioni, G Roberts, PR del Río, MH Shamji, GJ Sturm, M VazquezOrtiz |
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology | 2020 |
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TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells
N Ogasawara, JA Poposki, AI Klingler, BK Tan, KE Hulse, WW Stevens, AT Peters, LC Grammer, KC Welch, SS Smith, DB Conley, K Takano, T Himi, RC Kern, RP Schleimer, A Kato |
Journal of Allergy and Clinical Immunology | 2020 |
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Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemiea, b, c: Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H
L Klimek, O Pfaar, M Worm, T Eiwegger, J Hagemann, M Ollert, E Untersmayr, K Hoffmann-Sommergruber, A Vultaggio, I Agache, S Bavbek, A Bossios, I Casper, S Chan, A Chatzipetrou, C Vogelberg, D Firinu, P Kauppi, A Kolios, A Kothari, A Matucci, O Palomares, Z Szépfalusi, W Pohl, W Hötzenecker, A Rosenkranz, KC Bergmann, T Bieber, R Buhl, J Buters, U Darsow, T Keil, J Kleine-Tebbe, S Lau, M Maurer, H Merk, R Mösges, J Saloga, P Staubach, U Jappe, C Rabe, U Rabe, C Vogelmeier, T Biedermann, K Jung, W Schlenter, J Ring, A Chaker, W Wehrmann, S Becker, L Freudelsperger, N Mülleneisen, K Nemat, W Czech, H Wrede, R Brehler, T Fuchs, PV Tomazic, W Aberer, AF Wagner, F Horak, S Wöhrl, V Niederberger-Leppin, I Pali-Schöll, R Roller-Wirnsberger, O Spranger, R Valenta, M Akdis, PM Matricardi, F Spertini, N Khaltaev, JP Michel, L Nicod, P Schmid-Grendelmeier, M Idzko, E Hamelmann, T Jakob, T Werfel, M Wagenmann, C Taube, E Jensen-Jarolim, S Korn, F Hentges, J Schwarze, L OMahony, E Knol, S del Giacco, T Chivato, J Bousquet, T Zuberbier, C Akdis, M Jutel |
Allergo Journal | 2020 |
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Delirium Severity Trajectories and Outcomes in ICU Patients. Defining a Dynamic Symptom Phenotype
H Lindroth, BA Khan, JS Carpenter, S Gao, AJ Perkins, SH Khan, S Wang, RN Jones, MA Boustani |
Annals of the American Thoracic Society | 2020 |
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The Effects of Indoor Pollutants Exposure on Allergy and Lung Inflammation: An Activation State of Neutrophils and Eosinophils in Sputum
KN Isa, Z Hashim, J Jalaludin, LT Than, JH Hashim |
International journal of environmental research and public health | 2020 |
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Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic
L Klimek, O Pfaar, M Worm, T Eiwegger, J Hagemann, M Ollert, E Untersmayr, K Hoffmann-Sommergruber, A Vultaggio, I Agache, S Bavbek, A Bossios, I Casper, S Chan, A Chatzipetrou, C Vogelberg, D Firinu, P Kauppi, A Kolios, A Kothari, A Matucci, O Palomares, Z Szépfalusi, W Pohl, W Hötzenecker, AR Rosenkranz, KC Bergmann, T Bieber, R Buhl, J Buters, U Darsow, T Keil, J Kleine-Tebbe, S Lau, M Maurer, H Merk, R Mösges, J Saloga, P Staubach, U Jappe, KF Rabe, U Rabe, C Vogelmeier, T Biedermann, K Jung, W Schlenter, J Ring, A Chaker, W Wehrmann, S Becker, L Freudelsperger, N Mülleneisen, K Nemat, W Czech, H Wrede, R Brehler, T Fuchs, PV Tomazic, W Aberer, AH Fink-Wagner, F Horak, S Wöhrl, V Niederberger-Leppin, I Pali-Schöll, W Pohl, R Roller-Wirnsberger, O Spranger, R Valenta, M Akdis, PM Matricardi, F Spertini, N Khaltaev, JP Michel, L Nicod, P Schmid-Grendelmeier, M Idzko, E Hamelmann, T Jakob, T Werfel, M Wagenmann, C Taube, E Jensen-Jarolim, S Korn, F Hentges, J Schwarze, L OMahony, EF Knol, S del Giacco, TC Pérez, J Bousquet, A Bedbrook, T Zuberbier, C Akdis, M Jutel |
2020 | |
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Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)
N Berghi, M Dumitru, D Vrinceanu, R Ciuluvica, A Simioniuc-Petrescu, R Caragheorgheopol, C Tucureanu, R Cornateanu, C Giurcaneanu |
Experimental and therapeutic medicine | 2020 |
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Considerations on biologicals for patients with allergic disease in times of the COVID‐19 pandemic: An EAACI statement
Vultaggio A, Agache I, Akdis CA, Akdis M, Bavbek S, Bossios A, Bousquet J, Boyman O, Chaker AM, Chan S, Chatzipetrou A, Feleszko W, Firinu D, Jutel M, Kauppi P, Klimek L, Kolios A, Kothari A, Kowalski ML, Matucci A, Palomares O, Pfaar O, Rogala B, Untersmayr E, Eiwegger T |
Allergy | 2020 |
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Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.
Venter C, Agostoni C, Arshad SH, Ben-Abdallah M, Du Toit G, Fleischer DM, Greenhawt M, Glueck DH, Groetch M, Lunjani N, Maslin K, Maiorella A, Meyer R, Antonella M, Netting MJ, Ibeabughichi Nwaru B, Palmer DJ, Palumbo MP, Roberts G, Roduit C, Smith P, Untersmayr E, Vanderlinden LA, O'Mahony L |
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology | 2020 |
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Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
M Battaglia, S Ahmed, MS Anderson, MA Atkinson, D Becker, PJ Bingley, E Bosi, TM Brusko, LA DiMeglio, C Evans-Molina, SE Gitelman, CJ Greenbaum, PA Gottlieb, KC Herold, MJ Hessner, M Knip, L Jacobsen, JP Krischer, SA Long, M Lundgren, EF McKinney, NG Morgan, RA Oram, T Pastinen, MC Peters, A Petrelli, X Qian, MJ Redondo, BO Roep, D Schatz, D Skibinski, M Peakman |
Diabetes care | 2019 |
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Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
A Kivihall, A Aab, J Soja, K Sładek, M Sanak, A Altraja, B Jakiela, G Bochenek, A Rebane |
Clinical and Translational Allergy | 2019 |
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Hot Topic: Precision Medicine for Asthma—Has the Time Come?
X Li |
Current Allergy and Asthma Reports | 2019 |
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