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Bo Zhou, Rong Tian
Published August 20, 2018
Citation Information: J Clin Invest. 2018;128(9):3716-3726. https://doi.org/10.1172/JCI120849.
Citation Information: J Clin Invest. 2018;128(9):3716-3726. https://doi.org/10.1172/JCI120849.
Abstract
Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative metabolism in mitochondria is the main energy source of the heart, and the inability to generate and transfer energy has long been considered the primary mechanism linking mitochondrial dysfunction and contractile failure. However, the role of mitochondria in heart failure is now increasingly recognized to be beyond that of a failed power plant. In this Review, we summarize recent evidence demonstrating vicious cycles of pathophysiological mechanisms during the pathological remodeling of the heart that drive mitochondrial contributions from being compensatory to being a suicide mission. These mechanisms include bottlenecks of metabolic flux, redox imbalance, protein modification, ROS-induced ROS generation, impaired mitochondrial Ca2+ homeostasis, and inflammation. The interpretation of these findings will lead us to novel avenues for disease mechanisms and therapy.
Authors
Bo Zhou, Rong Tian
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Citations to this article (413)
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Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca2+ pathways in heart failure
Wan S, Cui Z, Wu L, Zhang F, Liu T, Hu J, Tian J, Yu B, Liu F, Kou J, Li F |
Redox Biology | 2023 |
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Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy
Marino F, Salerno N, Scalise M, Salerno L, Torella A, Molinaro C, Chiefalo A, Filardo A, Siracusa C, Panuccio G, Ferravante C, Giurato G, Rizzo F, Torella M, Donniacuo M, De Angelis A, Viglietto G, Urbanek K, Weisz A, Torella D, Cianflone E |
International journal of molecular sciences | 2023 |
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Mitochondrial Dysfunction: The Hidden Player in the Pathogenesis of Atherosclerosis?
Ciccarelli G, Conte S, Cimmino G, Maiorano P, Morrione A, Giordano A |
International journal of molecular sciences | 2023 |
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Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis
Wen SY, Ali A, Huang IC, Liu JS, Chen PY, Padma Viswanadha V, Huang CY, Kuo WW |
Aging | 2023 |
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A FRET-based respirasome assembly screen identifies spleen tyrosine kinase as a target to improve muscle mitochondrial respiration and exercise performance in mice
Kobayashi A, Azuma K, Takeiwa T, Kitami T, Horie K, Ikeda K, Inoue S |
Nature Communications | 2023 |
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Therapeutic Use and Molecular Aspects of Ivabradine in Cardiac Remodeling: A Review
Kamisah Y, Che Hassan HH |
International journal of molecular sciences | 2023 |
|
Obesity-associated cardiometabolic complications in polycystic ovary syndrome: The potential role of sodium-glucose cotransporter-2 inhibitors
Pruett JE, Romero DG, Yanes Cardozo LL |
Frontiers in Endocrinology | 2023 |
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Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation–Contraction Coupling
Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A |
International journal of molecular sciences | 2023 |
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NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice.
Murakami Y, Wei FY, Kawamura Y, Horiguchi H, Kadomatsu T, Miyata K, Miura K, Oike Y, Ando Y, Ueda M, Tomizawa K, Chujo T |
Communications biology | 2023 |
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Understanding the Mechanisms and Treatment of Heart Failure: Quantitative Systems Pharmacology Models with a Focus on SGLT2 Inhibitors and Sex-Specific Differences
Ndiaye JF, Nekka F, Craig M |
Pharmaceutics | 2023 |
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Evaluation of Coenzyme Q10 (CoQ10) Deficiency and Therapy in Mouse Models of Cardiomyopathy.
Pu TT, Wu W, Liang PD, Du JC, Han SL, Deng XL, Du XJ |
Journal of Cardiovascular Pharmacology | 2023 |
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Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension.
Pugnaloni F, Capolupo I, Patel N, Giliberti P, Dotta A, Bagolan P, Kipfmueller F |
International journal of molecular sciences | 2023 |
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Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative Stress Involving Gliflozins and Sirtuins.
Sanz RL, Inserra F, García Menéndez S, Mazzei L, Ferder L, Manucha W |
Current Hypertension Reports | 2023 |
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Multiple targets related to mitochondrial function unveiled by metabolomics and proteomics profiles of hearts from atrial fibrillation patients
Liu W, Hu B, Wang Y, Zhang X, Zhu M, Shi Y, Guo C, Zhang Y |
Frontiers in physiology | 2023 |
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Effect of L-carnitine in Ameliorating Lipopolysaccharide-Induced Cardiomyocyte Injury via MAPK Signaling.
Zhang L, Xiu L, Wang T, Zhao D |
Molecular Biotechnology | 2023 |
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Association of thiamine administration and prognosis in critically ill patients with heart failure.
Yang R, Huang J, Zhao Y, Wang J, Niu D, Ye E, Yue S, Hou X, Cui L, Wu J |
Frontiers in pharmacology | 2023 |
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Cardiotoxicity of chloroquine and hydroxychloroquine through mitochondrial pathway.
Seydi E, Karbalay M, Naderpour S, Arjmand A, Pourahmad J |
2023 | |
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Targeting Mitochondrial Metabolism to Save the Failing Heart.
Schenkl C, Heyne E, Doenst T, Schulze PC, Nguyen TD |
2023 | |
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Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction
Ragni M, Greco CM, Felicetta A, Ren SV, Kunderfranco P, Ruocco C, Carullo P, Larcher V, Tedesco L, Severi I, Giordano A, Cinti S, Valerio A, Sun H, Wang Y, Gao C, Condorelli G, Nisoli E |
Cardiovascular Research | 2023 |
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Novel insights into the phenotype and long-term D-gal treatment in PGM1-CDG: a case series.
Radenkovic S, Johnsen C, Schulze A, Lail G, Guilder L, Schwartz K, Schultz M, Mercimek-Andrews S, Boyer S, Morava E |
2023 | |
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Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges.
Ritterhoff J, Tian R |
Nature reviews. Cardiology | 2023 |
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Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites.
Diaz-Espinosa J, Stringer KA, Rosania GR |
Metabolites | 2023 |
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Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies.
Huang Y, Zhou B |
Biomedicines | 2023 |
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Different heart failure phenotypes of valvular heart disease: the role of mitochondrial dysfunction
Zhang S, Liu C, Zhang Y, Wu Z, Feng K, Lai Y, Pei J, Guan T |
Frontiers in Cardiovascular Medicine | 2023 |
|
Repurposing Dihydroartemisinin to Combat Oral Squamous Cell Carcinoma, Associated with Mitochondrial Dysfunction and Oxidative Stress
Shi S, Luo H, Ji Y, Ouyang H, Wang Z, Wang X, Hu R, Wang L, Wang Y, Xia J, Cheng B, Bao B, Li X, Liao G, Xu B |
Oxidative medicine and cellular longevity | 2023 |
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Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy.
Chella Krishnan K, El Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gerdes Gyuricza I, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker B, James DE, Lusis AJ |
eLife | 2023 |
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Impact of polyphenols on heart failure and cardiac hypertrophy: clinical effects and molecular mechanisms
Hedayati N, Yaghoobi A, Salami M, Gholinezhad Y, Aghadavood F, Eshraghi R, Aarabi MH, Homayoonfal M, Asemi Z, Mirzaei H, Hajijafari M, Mafi A, Rezaee M |
Frontiers in Cardiovascular Medicine | 2023 |
|
Shengxian decoction protects against chronic heart failure in a rat model via energy regulation mechanisms.
Yang ZQ, Han YY, Gao F, Tian JY, Bai R, Guo QH, Liu XC |
2023 | |
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Myocardial capacity of mitochondrial oxidative phosphorylation in response to prolonged electromagnetic stress
Savchenko L, Martinelli I, Marsal D, Zhdan V, Tao J, Kunduzova O |
Frontiers in Cardiovascular Medicine | 2023 |
|
Dual-omics reveals temporal differences in acute sympathetic stress-induced cardiac inflammation following α(1) and β-adrenergic receptors activation.
Zhang D, Zhao MM, Wu JM, Wang R, Xue G, Xue YB, Shao JQ, Zhang YY, Dong ED, Li ZY, Xiao H |
Acta Pharmacologica Sinica | 2023 |
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The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease
Stojanovic D, Stojanovic M, Milenkovic J, Velickov A, Ignjatovic A, Milojkovic M |
Cells | 2023 |
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Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration
Yu F, Cong S, Yap EP, Hausenloy DJ, Ramachandra CJ |
International journal of molecular sciences | 2023 |
|
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats
Samuelsson AM, Bartolomaeus TU, Anandakumar H, Thowsen I, Nikpey E, Han J, Marko L, Finne K, Tenstad O, Eckstein J, Berndt N, Kühne T, Kedziora S, Sultan I, Skogstrand T, Karlsen TV, Nurmi H, Forslund SK, Bollano E, Alitalo K, Muller DN, Wiig H |
Cardiovascular Research | 2023 |
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Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling
Peng K, Zeng C, Gao Y, Liu B, Li L, Xu K, Yin Y, Qiu Y, Zhang M, Ma F, Wang Z |
Acta pharmaceutica Sinica. B | 2023 |
|
Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca2+ overload
Zhang N, Yu H, Liu T, Zhou Z, Feng B, Wang Y, Qian Z, Hou X, Zou J |
Redox Biology | 2023 |
|
Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.
Koves TR, Zhang GF, Davidson MT, Chaves AB, Crown SB, Johnson JM, Slentz DH, Grimsrud PA, Muoio DM |
Cell Metabolism | 2023 |
|
IFN-γ and androgens disrupt mitochondrial function in murine myocytes.
Fenimore JM, Springer DA, Romero ME, Edmondson EF, McVicar DW, Yanpallewar S, Sanford M, Spindel T, Engle E, Meyer TJ, Valencia JC, Young HA |
The Journal of Pathology | 2023 |
|
Bile acid binds heart failure and inflammation.
Tong D, Hill JA |
Nature metabolism | 2023 |
|
Sacubitril/valsartan mitigates cardiac remodeling, systolic dysfunction, and preserves mitochondrial quality in a rat model of mitral regurgitation.
Tantisuwat L, Saengklub N, Boonpala P, Kumphune S, Panyasing Y, Kalandakanond-Thongsong S, Kijtawornrat A |
Scientific Reports | 2023 |
|
Comparison of SGLT2 inhibitors with DPP-4 inhibitors combined with metformin in patients with acute myocardial infarction and diabetes mellitus
Lyu YS, Oh S, Kim JH, Kim SY, Jeong MH |
Cardiovascular Diabetology | 2023 |
|
Metabolic Approaches for the Treatment of Dilated Cardiomyopathy
Spoladore R, Pinto G, Daus F, Pezzini S, Kolios D, Fragasso G |
Journal of Cardiovascular Development and Disease | 2023 |
|
mt-Ty 5'tiRNA regulates skeletal muscle cell proliferation and differentiation.
Cao J, Wang X, Advani V, Lu YW, Malizia AP, Singh GB, Huang ZP, Liu J, Wang C, Oliveira EM, Mably JD, Chen K, Wang DZ |
Cell Proliferation | 2023 |
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Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of Panax ginseng
Cao X, Yao F, Zhang B, Sun X |
Frontiers in pharmacology | 2023 |
|
Fetal metabolic adaptations to cardiovascular stress in twin-twin transfusion syndrome
Parchem JG, Fan H, Mann LK, Chen Q, Won JH, Gross SS, Zhao Z, Taegtmeyer H, Papanna R |
iScience | 2023 |
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Computational Modeling of Substrate-Dependent Mitochondrial Respiration and Bioenergetics in the Heart and Kidney Cortex and Outer Medulla
Sadri S, Zhang X, Audi SH, Cowley Jr. AW, Dash RK |
2023 | |
|
Mitochondrial Dysfunction in Cardiotoxicity Induced by BCR-ABL1 Tyrosine Kinase Inhibitors -Underlying Mechanisms, Detection, Potential Therapies.
Sun S, Qin J, Liao W, Gao X, Shang Z, Luo D, Xiong S |
Cardiovascular Toxicology | 2023 |
|
Mitochondrial heterogeneity in diseases.
Chen L, Zhou M, Li H, Liu D, Liao P, Zong Y, Zhang C, Zou W, Gao J |
Signal Transduction and Targeted Therapy | 2023 |
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Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy
Renaud D, Scholl-Bürgi S, Karall D, Michel M |
Metabolites | 2023 |
|
The Impact of Pharmacotherapy for Heart Failure on Oxidative Stress-Role of New Drugs, Flozins.
Bodnar P, Mazurkiewicz M, Chwalba T, Romuk E, Ciszek-Chwalba A, Jacheć W, Wojciechowska C |
Biomedicines | 2023 |
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Investigation of Cobalt(III) Cage Complexes as Inhibitors of the Mitochondrial Calcium Uniporter
Bigham NP, Wilson JJ |
European Journal of Inorganic Chemistry | 2023 |
|
TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy
Li Y, Zhu L, Cai MX, Wang ZL, Zhuang M, Tan CY, Xie TH, Yao Y, Wei TT |
Cell Death and Disease | 2023 |
|
Exploring the effects and mechanisms of Guizhigancao Decoction on heart failure using an integrated approach based on experimental support and network pharmacology strategy.
Qu J, Wang J, Zheng B, Jiang X, Liu J, Chen J |
Journal of traditional and complementary medicine | 2023 |
|
Thiamine administration may increase survival benefit in critically ill patients with myocardial infarction
Yue S, Wang J, Zhao Y, Ye E, Niu D, Huang J, Li X, Hu Y, Hou X, Wu J |
Frontiers in Nutrition | 2023 |
|
New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
Sharma AK, Singh S, Bhat M, Gill K, Zaid M, Kumar S, Shakya A, Tantray J, Jose D, Gupta R, Yangzom T, Sharma RK, Sahu SK, Rathore G, Chandolia P, Singh M, Mishra A, Raj S, Gupta A, Agarwal M, Kifayat S, Gupta A, Gupta P, Vashist A, Vaibhav P, Kathuria N, Yadav V, Singh RP, Garg A |
Scientific Reports | 2023 |
|
Pyroptosis in Cardiovascular Diseases: Pumping Gasdermin on the Fire
Yarovinsky TO, Su M, Chen C, Xiang Y, Tang WH, Hwa J |
Seminars in Immunology | 2023 |
|
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy
Xu H, Wang X, Yu W, Sun S, Wu NN, Ge J, Ren J, Zhang Y |
JACC: Basic to Translational Science | 2023 |
|
Circulating and Cardiac Tissue miRNAs in Children with Dilated Cardiomyopathy
Hailu FT, Karimpour-Fard A, Neltner B, Stauffer BL, Lipshultz S, Miyamoto SD, Sucharov CC |
Journal of Cardiovascular Development and Disease | 2023 |
|
Moderate- and High-Intensity Endurance Training Alleviate Diabetes-Induced Cardiac Dysfunction in Rats
D\u2019Haese S, Verboven M, Evens L, Deluyker D, Lambrichts I, Eijnde B, Hansen D, Bito V |
Nutrients | 2023 |
|
Variations in Intracellular Organometallic Reaction Frequency Captured by Single-Molecule Fluorescence Microscopy
Nguyen D, Yan G, Chen TY, Do LH |
Angewandte Chemie (International ed. in English) | 2023 |
|
Effects of ROS Pathway Inhibitors and NADH and FADH2 Linked Substrates on Mitochondrial Bioenergetics and ROS Emission in the Heart and Kidney Cortex and Outer Medulla
Sadri S, Tomar N, Yang C, Audi SH, Cowley AW Jr, Dash RK |
Archives of Biochemistry and Biophysics | 2023 |
|
Heart Failure And Type 2 Diabetes Mellitus: Neurohumoral, Histological And Molecular Interconnections
Ushakov A, Ivanchenko V, Gagarina A |
Current cardiology reviews | 2023 |
|
The roles of tissue-resident macrophages in sepsis-associated organ dysfunction
Gao Y, Tian X, Zhang X, Milebe Nkoua GD, Chen F, Liu Y, Chai Y |
Heliyon | 2023 |
|
Status of Mitochondrial Oxidative Phosphorylation during the Development of Heart Failure
Bhullar SK, Dhalla NS |
Antioxidants | 2023 |
|
Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure
Qian K, Tang J, Ling YJ, Zhou M, Yan XX, Xie Y, Zhu LJ, Nirmala K, Sun KY, Qin ZH, Sheng R |
EBioMedicine | 2023 |
|
Cardioprotective effects of Moku-boi-to and its impact on AngII-induced cardiomyocyte hypertrophy
Tagashira H, Abe F, Sato-Numata K, Aizawa K, Hirasawa K, Kure Y, Iwata D, Numata T |
Frontiers in Cell and Developmental Biology | 2023 |
|
RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy.
Krumbein M, Oberman F, Cinnamon Y, Golomb M, May D, Vainer G, Belzer V, Meir K, Fridman I, Haybaeck J, Poelzl G, Kehat I, Beeri R, Kessler SM, Yisraeli JK |
Communications biology | 2023 |
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S14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.
Zhao Q, Cai MM, Li D, Zhao BY, Zhou SS, Wu ZR, Shi YJ, Su L |
Heliyon | 2023 |
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Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway
Du L, Lu H, Wang Z, Liu C, Xiao Y, Guo Z, Li Y |
Molecules (Basel, Switzerland) | 2023 |
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Protective Effect of Uridine on Structural and Functional Rearrangements in Heart Mitochondria after a High-Dose Isoprenaline Exposure Modelling Stress-Induced Cardiomyopathy in Rats
Belosludtseva NV, Pavlik LL, Mikheeva IB, Talanov EY, Serov DA, Khurtin DA, Belosludtsev KN, Mironova GD |
International journal of molecular sciences | 2023 |
|
Differences in Levels of Mitochondrial DNA Content at Various Stages of Canine Myxomatous Mitral Valve Disease
Chirathanaphirom S, Chuammitri P, Pongkan W, Manachai N, Chantawong P, Boonsri B, Boonyapakorn C |
2023 | |
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C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes
Jin S, Lee CJ, Lim G, Park S, Lee SH, Chung JH, Oh J, Kang SM |
BMB Reports | 2023 |
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Ventricular differences in mitochondrial Ca(2+) dynamics in murine and porcine hearts.
Sung JH, Chapoy Villanueva H, Feng F, Araque Igualador A, Prins KW, Liu JC |
Journal of Molecular and Cellular Cardiology | 2023 |
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Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease
Fuchs MA, Burke EJ, Latic N, Murray S, Li H, Sparks M, Abraham D, Zhang H, Rosenberg P, Hänzelmann S, Hausmann F, Huber T, Erben R, Fisher-Wellman K, Bursac N, Wolf M, Grabner A |
Research square | 2023 |
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Raising NAD+ level stimulates short-chain dehydrogenase/reductase proteins to alleviate heart failure independent of mitochondrial protein deacetylation
Walker MA, Chen H, Yadav A, Ritterhoff J, Villet O, McMillen T, Wang Y, Purcell H, Djukovic D, Raftery D, Isoherranen N, Tian R |
Circulation | 2023 |
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Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.
Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker JK, Jensen BC, Pei L, Burris T, Zhang L |
Circulation | 2023 |
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Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure.
Meng S, Yu Y, Yu S, Zhu S, Shi M, Xiang M, Ma H |
Journal of Cardiovascular Translational Research | 2023 |
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Molecular mechanisms underlying sarcopenia in heart failure.
Rutledge CA |
2023 | |
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Regulatory mechanisms of long non-coding RNAs on mitochondrial function in congestive heart failure
Li C, Zhou M, Song X, Huang S, Guo Z |
Non-coding RNA Research | 2023 |
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Upregulation of Mitochondrial ATPase Inhibitory Factor 1 (ATPIF1) Mediates Increased Glycolysis in Mouse Hearts
Bo Zhou, Arianne Caudal, Xiaoting Tang, Juan D Chavez, Timothy S. McMillen, Andrew Keller, Outi Villet, Mingyue Zhao, Yaxin Liu, Julia Ritterhoff, Pei Wang, Stephen C Kolwicz Jr., Wang Wang, James E. Bruce, Rong Tian |
Journal of Clinical Investigation | 2022 |
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Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction
Dan Wu, Bo Tan, Yuanyuan Sun, Qingxun Hu |
Redox Biology | 2022 |
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MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction
R Song, C Dasgupta, C Mulder, L Zhang |
Circulation | 2022 |
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Study on diverse pathological characteristics of heart failure in different stages based on proteomics
J Liu, H Lian, J Yu, J Wu, X Chen, P wang, L tian, Y Yang, J Yang, D Li, S Guo |
Journal of Cellular and Molecular Medicine | 2022 |
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Old and Novel Therapeutic Approaches in the Management of Hyperglycemia, an Important Risk Factor for Atherosclerosis
M Janjusevic, A Fluca, G Gagno, A Pierri, L Padoan, A Sorrentino, A Beltrami, G Sinagra, A Aleksova |
International journal of molecular sciences | 2022 |
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Mitochondrial Dysfunction: An Emerging Link in the Pathophysiology of Cardiorenal Syndrome
S Shi, B Zhang, Y Li, X Xu, J Lv, Q Jia, R Chai, W Xue, Y Li, Y Wang, H Wu, Q Song, Y Hu |
Frontiers in Cardiovascular Medicine | 2022 |
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Intermedin1–53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1α in Cardiac Fibrosis
L Zhang, J Zhang, Y Hou, W Lu, X Ni, F Lin, X Liu, X Wang, Y Yu, M Jia, C Tang, L Han, S Chai, Y Qi |
Inflammation | 2022 |
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Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy
N Sayles, N Southwell, K McAvoy, K Kim, A Pesini, C Anderson, C Quinzii, S Cloonan, H Kawamata, G Manfredi |
Cell Reports | 2022 |
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The Oxidative Balance Orchestrates the Main Keystones of the Functional Activity of Cardiomyocytes
M Bevere, C Morabito, M Mariggiò, S Guarnieri, D Giustarini |
Oxidative Medicine & Cellular Longevity | 2022 |
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The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes
CS Abdullah, R Aishwarya, S Alam, NS Remex, M Morshed, S Nitu, S Miriyala, M Panchatcharam, B Hartman, J King, MA Bhuiyan, J Traylor, CG Kevil, AW Orr, S Bhuiyan |
Mitochondrion | 2022 |
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Dietary supplementation with inosine-5′-monophosphate improves the functional, energetic, and antioxidant status of liver and muscle growth in pigs
L Bonagurio, A Murakami, C Moreira, J Comar, P Pozza |
Scientific Reports | 2022 |
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Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway
C Zhang, M Han, X Zhang, H Tong, X Sun, G Sun |
Journal of inflammation research | 2022 |
|
Protective Effect of Trimetazidine on Potassium Ion Homeostasis in Myocardial Tissue in Mice with Heart Failure
K Yang, Y Xue, M Yu, H Jiao, Y Li, X Wei, W Liu, Y Sun, N Chen, L Song, T Yu, K Chen, D Guo, Z Song |
BioMed Research International | 2022 |
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Somatic Mutations in Cardiovascular Disease
J Heimlich, A Bick |
Circulation research | 2022 |
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Alterations of sodium-hydrogen exchanger 1 function in response to SGLT2 inhibitors: what is the evidence?
S Wichaiyo, N Saengklub |
Heart Failure Reviews | 2022 |
|
Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation
M Liu, Y Wu |
Frontiers in Cardiovascular Medicine | 2022 |
|
The Role of Oxidative Stress in the Aging Heart
L Pagan, M Gomes, M Gatto, G Mota, K Okoshi, M Okoshi |
Antioxidants | 2022 |
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New Insights in Early Detection of Anticancer Drug-Related Cardiotoxicity Using Perfusion and Metabolic Imaging
F Cadour, F Thuny, J Sourdon |
Frontiers in Cardiovascular Medicine | 2022 |
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The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction—Victim of Its Environment?
A Rocca, R van Heeswijk, J Richiardi, P Meyer, R Hullin |
Cells | 2022 |
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Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway
Y Yu, W Chen, M Yu, J Liu, H Sun, P Yang |
Frontiers in Cardiovascular Medicine | 2022 |
|
Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure
A Wang, W Zhao, K Yan, P Huang, H Zhang, Z Zhang, D Zhang, X Ma |
Frontiers in pharmacology | 2022 |
|
Whole Blood Metabolite Profiles Reflect Changes in Energy Metabolism in Heart Failure
C Beuchel, J Dittrich, J Pott, S Henger, F Beutner, B Isermann, M Loeffler, J Thiery, U Ceglarek, M Scholz |
Metabolites | 2022 |
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Mitochondrial Ca2+ Homeostasis: Emerging Roles and Clinical Significance in Cardiac Remodeling
D Zhang, F Wang, P Li, Y Gao |
International journal of molecular sciences | 2022 |
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Mitochondrial Determinants of Anti-Cancer Drug-Induced Cardiotoxicity
C Rocca, E Francesco, T Pasqua, M Granieri, A Bartolo, M Cantafio, M Muoio, M Gentile, A Neri, T Angelone, G Viglietto, N Amodio |
Biomedicines | 2022 |
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Sericin-mediated improvement of dysmorphic cardiac mitochondria from hypercholesterolaemia is associated with maintaining mitochondrial dynamics, energy production, and mitochondrial structure
K Rujimongkon, S Ampawong, D Isarangkul, O Reamtong, P Aramwit |
Pharmaceutical Biology | 2022 |
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Involvement of Oxidative Stress in the Development of Subcellular Defects and Heart Disease
N Dhalla, V Elimban, M Bartekova, A Adameova |
Biomedicines | 2022 |
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Ageing Increases Cardiac Electrical Remodelling in Rats and Mice via NOX4/ROS/CaMKII-Mediated Calcium Signalling
X Luo, W Yu, Z Liu, Z Pu, T Liu, Y Li, W Liu, M Lei, X Tan, T Chen, T Li |
Oxidative Medicine & Cellular Longevity | 2022 |
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Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer
L Shen, X Zhan, C Angeloni |
Oxidative Medicine & Cellular Longevity | 2022 |
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The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro
K Merches, L Breunig, J Fender, T Brand, V Bätz, S Idel, L Kollipara, Y Reinders, A Sickmann, A Mally, K Lorenz |
Archives of Toxicology | 2022 |
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Mitochondrial Transplantation Ameliorates the Development and Progression of Osteoarthritis
A Lee, J Woo, S Lee, H Na, K Cho, Y Lee, J Lee, S Kim, S Park, S Kim, M Cho |
Immune Network | 2022 |
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Association of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor Use With Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus Patients With Stabilized Acute Myocardial Infarction: A Propensity Score Matching Study
T Chang, C Lu, H Huang, R Chou, C Chang, C Liu, P Huang, S Lin |
Frontiers in Cardiovascular Medicine | 2022 |
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EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia
D Eberhardt, S Lee, X Yin, A Balynas, E Rekate, J Kraiss, M Lang, M Walsh, M Streiff, A Corbin, Y Li, K Funai, F Sachse, D Chaudhuri |
Journal of Molecular and Cellular Cardiology | 2022 |
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Prognosis and diastolic dysfunction predictors in patients with heart failure and recovered ejection fraction
T Takada, K Matsuura, Y Minami, T Abe, A Yoshida, M Kishihara, S Watanabe, S Shirotani, K Jujo, N Hagiwara |
Scientific Reports | 2022 |
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Animal Models to Study Cardiac Arrhythmias
Blackwell DJ, Schmeckpeper J, Knollmann BC |
Circulation research | 2022 |
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Mitochondrial Calcium: Effects of Its Imbalance in Disease
Matuz-Mares D, González-Andrade M, Araiza-Villanueva MG, Vilchis-Landeros MM, Vázquez-Meza H |
Antioxidants | 2022 |
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The Legend of ATP: From Origin of Life to Precision Medicine
Chu XY, Xu YY, Tong XY, Wang G, Zhang HY |
Metabolites | 2022 |
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Mechanism and Protective Effect of Smilax glabra Roxb on the Treatment of Heart Failure via Network Pharmacology Analysis and Vitro Verification
Long Y, Li Z, Huang C, Lu Z, Qiu K, He M, Fang Z, Ding B, Yuan X, Zhu W |
Frontiers in pharmacology | 2022 |
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Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure
Ni L, Miao P, Jiang J, Wan F, Li J, Ai M, Kong L, Tu S |
PloS one | 2022 |
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PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure.
Chen L, Qin Y, Liu B, Gao M, Li A, Li X, Gong G |
Frontiers in Cell and Developmental Biology | 2022 |
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New Progress in the Molecular Regulations and Therapeutic Applications in Cardiac Oxidative Damage Caused by Pressure Overload
Shi X, Dorsey A, Qiu H |
Antioxidants | 2022 |
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Genetically Encoded ATP Biosensors for Direct Monitoring of Cellular ATP Dynamics
White D III, Yang Q |
Cells | 2022 |
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Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload
Guo AH, Baliira R, Skinner ME, Kumar S, Andren A, Zhang L, Goldsmith RS, Michan S, Davis NJ, Maccani MW, Day SM, Sinclair DA, Brody MJ, Lyssiotis CA, Stein AB, Lombard DB |
Scientific Reports | 2022 |
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Cell-Target-Specific Anti-Inflammatory Effect of Empagliflozin: In Vitro Evidence in Human Cardiomyocytes.
Giannattasio S, Citarella A, Trocchianesi S, Filardi T, Morano S, Lenzi A, Ferretti E, Crescioli C |
Frontiers in Molecular Biosciences | 2022 |
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Diet-Induced Hypercholesterolemia Leads to Cardiac Dysfunction and Alterations in the Myocardial Proteome.
Szabó MR, Pipicz M, Sárközy M, Bruszel B, Szabó Z, Csont T |
International journal of molecular sciences | 2022 |
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Metabolic Regulation of Cardiac Regeneration
Duan X, Liu X, Zhan Z |
Frontiers in Cardiovascular Medicine | 2022 |
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Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation
Tang X, Wang Z, Hu S, Zhou B |
Pharmaceutics | 2022 |
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Neospora caninum infection induced mitochondrial dysfunction in caprine endometrial epithelial cells via downregulating SIRT1
Tao DL, Zhao SS, Chen JM, Chen X, Yang X, Song JK, Liu Q, Zhao GH |
Parasites & vectors | 2022 |
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Adrenergic receptor regulation of mitochondrial function in cardiomyocytes
Sandroni PB, Fisher-Wellman KH, Jensen BC |
Journal of Cardiovascular Pharmacology | 2022 |
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Could SGLT2 Inhibitors Improve Exercise Intolerance in Chronic Heart Failure?
Voorrips SN, Saucedo-Orozco H, Sánchez-Aguilera PI, De Boer RA, Van der Meer P, Westenbrink BD |
International journal of molecular sciences | 2022 |
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Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels
Mengozzi A, Costantino S, Paneni F, Duranti E, Nannipieri M, Mancini R, Lai M, La Rocca V, Puxeddu I, Antonioli L, Fornai M, Ghionzoli M, Georgiopoulos G, Ippolito C, Bernardini N, Ruschitzka F, Pugliese NR, Taddei S, Virdis* A, Masi S |
Circulation research | 2022 |
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Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
Tong WH, Ollivierre H, Noguchi A, Ghosh MC, Springer DA, Rouault TA |
Heliyon | 2022 |
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Mitochondrial dysfunction in heart failure and its therapeutic implications
Liu M, Lv J, Pan Z, Wang D, Zhao L, Guo X |
Frontiers in Cardiovascular Medicine | 2022 |
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VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR.
Rosenberg P |
Cell Calcium | 2022 |
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Benzoylaconine improves mitochondrial function in oxygen-glucose deprivation and reperfusion-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis.
Chen L, Yan L, Zhang W |
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology | 2022 |
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Novel Targets for a Combination of Mechanical Unloading with Pharmacotherapy in Advanced Heart Failure.
Jedrzejewska A, Braczko A, Kawecka A, Hellmann M, Siondalski P, Slominska E, Kutryb-Zajac B, Yacoub MH, Smolenski RT |
International journal of molecular sciences | 2022 |
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Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease.
Xie LH, Fefelova N, Pamarthi SH, Gwathmey JK |
Cells | 2022 |
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Corticosteroid Receptors in Cardiac Health and Disease.
Ivy JR, Gray GA, Holmes MC, Denvir MA, Chapman KE |
Advances in experimental medicine and biology | 2022 |
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Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy
Wang Q, Su H, Liu J |
Oxidative medicine and cellular longevity | 2022 |
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Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced right ventricular failure
Banerjee S, Hong J, Umar S |
Frontiers in Cardiovascular Medicine | 2022 |
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The cardioprotective effects and mechanisms of naringenin in myocardial ischemia based on network pharmacology and experiment verification
Yang Y, Qi J, Zhang M, Chen P, Liu Y, Sun X, Chu L |
Frontiers in pharmacology | 2022 |
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Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Preventing Mitochondrial Function Injury
Ji Y, Jin D, Qi J, Wang X, Zhang C, An P, Luo Y, Luo J |
International journal of molecular sciences | 2022 |
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Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization.
Andelova N, Waczulikova I, Kunstek L, Talian I, Ravingerova T, Jasova M, Suty S, Ferko M |
Scientific Reports | 2022 |
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SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
Zhu JY, Wang G, Huang X, Lee H, Lee JG, Yang P, van de Leemput J, Huang W, Kane MA, Yang P, Han Z |
2022 | |
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Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy
Hu J, Liu T, Fu F, Cui Z, Lai Q, Zhang Y, Yu B, Liu F, Kou J, Li F |
Journal of Translational Medicine | 2022 |
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Inhibition of mitochondrial respiration has fundamentally different effects on proliferation, cell survival and stress response in immature versus differentiated cardiomyocyte cell lines
Grün B, Tirre M, Pyschny S, Singh V, Kehl HG, Jux C, Drenckhahn JD |
Frontiers in Cell and Developmental Biology | 2022 |
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Oxidative-Damaged Mitochondria Activate GABARAPL1-Induced NLRP3 Inflammasomes in an Autophagic-Exosome Manner after Acute Myocardial Ischemia
Zhang T, Hou D, He J, Zeng X, Liu R, Liu L, Li T, Xiao Y, Ma R, Huang H, Duan C |
Oxidative medicine and cellular longevity | 2022 |
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A novel mutation in human EMD gene and mitochondrial dysfunction in emerin knockdown cardiomyocytes
Du Z, Zhu T, Lin M, Bao Y, Qiao J, Lv G, Xie Y, Li Q, Quan J, Xu C, Xie Y, Wang L, Yang W, Wang S, Wu L, Yin T, Xie Y |
Journal of Cellular and Molecular Medicine | 2022 |
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Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca2+ signalling in heart failure
Voglhuber J, Holzer M, Radulović S, Thai PN, Djalinac N, Matzer I, Wallner M, Bugger H, Zirlik A, Leitinger G, Dedkova EN, Bers DM, Ljubojevic-Holzer S |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2022 |
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Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex
Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF |
Molecular Cell | 2022 |
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Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data
Ye L, Ngan DK, Xu T, Liu Z, Zhao J, Sakamuru S, Zhang L, Zhao T, Xia M, Simeonov A, Huang R |
Toxicology and Applied Pharmacology | 2022 |
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PINK1 Phosphorylates Drp1S616 to Improve Mitochondrial Fission and Inhibit the Progression of Hypertension-Induced HFpEF
Shou J, Huo Y |
International journal of molecular sciences | 2022 |
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Thermoneutrality induces vascular dysfunction and impaired metabolic function in male Wistar rats: a new model of vascular disease.
Keller AC, Chun JH, Knaub LA, Henckel MM, Hull SE, Scalzo RL, Pott GB, Walker LA, Reusch JEB |
Journal of Hypertension | 2022 |
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Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors.
Prandi FR, Barone L, Lecis D, Belli M, Sergi D, Milite M, Lerakis S, Romeo F, Barillà F |
Biomolecules | 2022 |
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Cuproptosis, the novel therapeutic mechanism for heart failure: a narrative review.
Yuan HJ, Xue YT, Liu Y |
Cardiovascular diagnosis and therapy | 2022 |
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Research progress on the relationship between mitochondrial function and heart failure: A bibliometric study from 2002 to 2021.
Qi X, Zhu Z, Wang Y, Wen Z, Jiang Z, Zhang L, Pang Y, Lu J |
Frontiers in Molecular Biosciences | 2022 |
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Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure.
Donnarumma E, Kohlhaas M, Vimont E, Kornobis E, Chaze T, Gianetto QG, Matondo M, Moya-Nilges M, Maack C, Wai T |
Nature Communications | 2022 |
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Methylmercury Toxicity During Heart Development: A Combined Analysis of Morphological and Functional Parameters.
Ronconi-Krüger N, Pinheiro J, Simioni C, Nazari EM |
Cardiovascular Toxicology | 2022 |
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Human induced pluripotent stem cells for studying mitochondrial diseases in the heart
Caudal A, Ren L, Tu C, Wu JC |
FEBS Letters | 2022 |
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Advances in the study of nicotinamide adenine dinucleotide phosphate oxidase in myocardial remodeling.
Miao R, Wang L, Chen Z, Ge S, Li L, Zhang K, Chen Y, Guo W, Duan X, Zhu M, Zhao G, Lin F |
Frontiers in Cardiovascular Medicine | 2022 |
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A circular network of purine metabolism as coregulators of dilated cardiomyopathy.
Wang G, Zou R, Liu L, Wang Z, Zou Z, Tan S, Xu W, Fan X |
Journal of Translational Medicine | 2022 |
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Baseline mitochondrial DNA copy number and heart failure incidence and its role in overall and heart failure mortality in middle-aged women
Sundquist K, Sundquist J, Wang X, Palmer K, Memon AA |
Frontiers in Cardiovascular Medicine | 2022 |
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Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full Losses
Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J |
Oxidative medicine and cellular longevity | 2022 |
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Mitochondrial mutations in protein coding genes of respiratory chain including complexes IV, V, and mt-tRNA genes are associated risk factors for congenital heart disease
Heidari MM, Khatami M, Kamalipour A, Kalantari M, Movahed M, Emmamy MH, Hadadzadeh M, Bragança J, Namnabat M, Mazrouei B |
EXCLI journal | 2022 |
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Peripheral Blood Mononuclear Cells Mitochondrial Respiration and Superoxide Anion after Heart Transplantation
Alfatni A, Charles AL, Sauer F, Riou M, Goupilleau F, Talha S, Meyer A, Andres E, Kindo M, Mazzucotelli JP, Epailly E, Geny B |
Journal of Clinical Medicine | 2022 |
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Iron Deficiency and Deranged Myocardial Energetics in Heart Failure.
Tkaczyszyn M, Górniak KM, Lis WH, Ponikowski P, Jankowska EA |
International journal of environmental research and public health | 2022 |
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Kinetic Mathematical Modeling of Oxidative Phosphorylation in Cardiomyocyte Mitochondria
Tseng WW, Wei AC |
Cells | 2022 |
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iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation
Guo Y, Wen J, He A, Qu C, Peng Y, Luo S, Wang X |
Journal of Advanced Research | 2022 |
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Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction
Wang DD, Airhart SE, Zhou B, Shireman LM, Jiang S, Melendez Rodriguez C, Kirkpatrick JN, Shen DD, Tian R, O\u2019Brien KD |
JACC: Basic to Translational Science | 2022 |
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Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure.
Rasicci DV, Ge J, Milburn GN, Wood NB, Pruznak AM, Lang CH, Previs MJ, Campbell KS, Yengo CM |
American journal of physiology. Heart and circulatory physiology | 2022 |
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Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling
Huang C, Sharma A, Thakur R, Rai D, Katiki M, Germano JD, Song Y, Singh S, Sin J, Sengstock D, Andres AM, Murali R, Mentzer RM Jr, Gottlieb RA, Piplani H |
Matrix biology : journal of the International Society for Matrix Biology | 2022 |
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Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction.
Spielmann N, Schenkl C, Komlódi T, da Silva-Buttkus P, Heyne E, Rohde J, Amarie OV, Rathkolb B, Gnaiger E, Doenst T, Fuchs H, Gailus-Durner V, de Angelis MH, Szibor M |
Mammalian genome : official journal of the International Mammalian Genome Society | 2022 |
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DELE1 is protective for mitochondrial cardiomyopathy.
Huynh H, Zhu S, Lee S, Bao Y, Pang J, Nguyen A, Gu Y, Chen C, Ouyang K, Evans SM, Fang X |
Journal of Molecular and Cellular Cardiology | 2022 |
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The HF-AF ENERGY Trial: Nicotinamide Riboside for the Treatment of Atrial Fibrillation in Heart Failure Patients.
Pool L, Knops P, Manintveld OC, Brugts JJ, Theuns DAMJ, Brundel BJJM, de Groot NMS |
Cardiovascular Drugs and Therapy | 2022 |
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Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure with a Preserved Ejection Fraction: A Meta-Analysis of Randomized Controlled Trials
Lou Y, Yang Q, Zhang W, Yu Y, Huang J |
2022 | |
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Mitochondrial lysine acylation and cardiometabolic stress: Truth or consequence?
Muoio DM, Williams AS, Grimsrud PA |
Current opinion in physiology | 2022 |
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Carboxylate-Capped Analogues of Ru265 are MCU Inhibitor Prodrugs
Bigham NP, Huang Z, Spivey J, Woods JJ, MacMillan SN, Wilson JJ |
Inorganic chemistry | 2022 |
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Diabetic Cardiomyopathy: Pathophysiology and Novel Therapies
Laksono S, Hosea GT, Nurusshofa Z |
The Brown Journal of Hospital Medicine | 2022 |
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Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone
Peter Siska, Sonja-Maria Decking, Nathalie Babl, Carina Matos, Christina Bruss, Katrin Singer, Jana Klitzke, Marian Schön, Jakob Simeth, Josef Koestler, Heiko Siegmund, Ines Ugele, Michael G. Paulus, Alexander Dietl, Kristina Kolodova, Louisa Steines, Katharina Freitag, Alice Peuker, Gabriele Schönhammer, Johanna Raithel, Bernhard Graf, Florian Geismann, Matthias Lubnow, Matthias Mack, Peter Hau, Christopher Bohr, Ralph Burkhardt, Andre Gessner, Bernd Salzberger, Ralf Wagner, Frank Hanses, Florian Hitzenbichler, Daniel Heudobler, Florian Lüke, Tobias Pukrop, Wolfgang Herr, Daniel Wolff, Rainer Spang, Hendrik Poeck, Petra Hoffmann, Jonathan Jantsch, Christoph Brochhausen, Dirk Lunz, Michael Rehli, Marina Kreutz, Kathrin Renner |
Journal of Clinical Investigation | 2021 |
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NAD + Repletion Reverses Heart Failure With Preserved Ejection Fraction
D Tong, GG Schiattarella, N Jiang, F Altamirano, PA Szweda, A Elnwasany, DI Lee, H Yoo, DA Kass, LI Szweda, S Lavandero, E Verdin, TG Gillette, JA Hill |
Circulation research | 2021 |
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Mitochondria in Focus: From Function to Therapeutic Strategies in Chronic Lung Diseases
D de Assis Fernandes Caldeira, DJ Weiss, PR Rocco, PL Silva, FF Cruz |
Frontiers in immunology | 2021 |
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Relevance of mitochondrial dysfunction in heart disease associated with insulin resistance conditions
N de las Heras, V Lahera |
Pflügers Archiv - European Journal of Physiology | 2021 |
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Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease
M Zhang, G Wang, T Peng |
Cells | 2021 |
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Prediction of single-cell mechanisms for disease progression in hypertrophic remodelling by a trans-omics approach
M Hamano, S Nomura, M Iida, I Komuro, Y Yamanishi |
Scientific Reports | 2021 |
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Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function
M Gesper, AB Nonnast, N Kumowski, R Stoehr, K Schuett, N Marx, BA Kappel |
Frontiers in Medicine | 2021 |
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Mitochondrial Medicine: Genetic Underpinnings and Disease Modeling Using Induced Pluripotent Stem Cell Technology
PK Kargaran, D Mosqueira, T Kozicz |
Frontiers in Cardiovascular Medicine | 2021 |
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Reverse Remodeling With Left Ventricular Assist Devices
D Burkhoff, VK Topkara, G Sayer, N Uriel |
Circulation research | 2021 |
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Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
RS Najjar, RG Feresin |
International journal of molecular sciences | 2021 |
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TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes
X Zhou, A Li, P Lin, J Zhou, J Ma |
Pflügers Archiv - European Journal of Physiology | 2021 |
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Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review
V Mollace, GM Rosano, SD Anker, AJ Coats, P Seferovic, R Mollace, A Tavernese, M Gliozzi, V Musolino, C Carresi, J Maiuolo, R Macrì, F Bosco, M Chiocchi, F Romeo, M Metra, M Volterrani |
Nutrients | 2021 |
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Metabolic Remodeling and Implicated Calcium and Signal Transduction Pathways in the Pathogenesis of Heart Failure
AH Chaanine |
International journal of molecular sciences | 2021 |
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Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart
D Barriales, I Martín-Ruiz, A Carreras-González, M Montesinos-Robledo, M Azkargorta, I Iloro, I Escobés, T Martín-Mateos, E Atondo, A Palacios, M Gonzalez-Lopez, L Bárcena, AR Cortázar, D Cabrera, A Peña-Cearra, SM van Liempd, JM Falcón-Pérez, MA Pascual-Itoiz, JM Flores, L Abecia, A Pellon, ML Martínez-Chantar, AM Aransay, A Pascual, F Elortza, E Berra, JL Lavín, H Rodríguez, J Anguita, CL Stallings |
PLoS Biology | 2021 |
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Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy
MY Ho, CY Wang |
Cells | 2021 |
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Cardiac Energy Metabolism in Heart Failure
GD Lopaschuk, QG Karwi, R Tian, AR Wende, ED Abel |
Circulation research | 2021 |
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Creatine deficiency and heart failure
AD Franco, G Ambrosio, L Baroncelli, T Pizzorusso, A Barison, I Olivotto, FA Recchia, CM Lombardi, M Metra, YF Chen, C Passino, M Emdin, G Vergaro |
Heart Failure Reviews | 2021 |
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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy
S Zhu, Z Chen, M Zhu, Y Shen, LJ Leon, L Chi, S Spinozzi, C Tan, Y Gu, A Nguyen, Y Zhou, W Feng, FM Vaz, X Wang, AB Gustafsson, SM Evans, O Kunfu, |
Circulation. Heart failure | 2021 |
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TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes
J Liu, T Wen, K Dong, X He, H Zhou, J Shen, Z Fu, G Hu, W Ma, J Li, W Wang, L Wang, BN Akerberg, J Xu, I Osman, Z Zheng, W Wang, Q Du, WT Pu, M Xiang, W Chen, H Su, W Zhang, J Zhou |
Cell Death and Differentiation | 2021 |
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Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice
W Wu, M Ziemann, K Huynh, G She, ZD Pang, Y Zhang, T Duong, H Kiriazis, TT Pu, RY Bai, JJ Li, Y Zhang, MX Chen, J Sadoshima, XL Deng, PJ Meikle, XJ Du |
Theranostics | 2021 |
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BGP-15 Protects against Heart Failure by Enhanced Mitochondrial Biogenesis and Decreased Fibrotic Remodelling in Spontaneously Hypertensive Rats
O Horvath, K Ordog, K Bruszt, L Deres, F Gallyas, B Sumegi, K Toth, R Halmosi, PF Martinez |
Oxidative Medicine & Cellular Longevity | 2021 |
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Proarrhythmic Electrical Remodeling by Noncardiomyocytes at Interfaces With Cardiomyocytes Under Oxidative Stress
Y Zhao, S Iyer, M Tavanaei, NT Nguyen, A Lin, TP Nguyen |
Frontiers in physiology | 2021 |
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Cardiac Remodeling During Pregnancy With Metabolic Syndrome: Prologue of Pathological Remodeling
Y Yang, J Kurian, G Schena, J Johnson, H Kubo, JG Travers, C Kang, AM Lucchese, DM Eaton, M Lv, N Li, LG Leynes, D Yu, F Yang, TA McKinsey, R Kishore, M Khan, S Mohsin, SR Houser |
Circulation | 2021 |
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mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology
AA Elorza, JP Soffia |
Frontiers in Cell and Developmental Biology | 2021 |
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Therapeutic potential and recent advances on targeting mitochondrial dynamics in cardiac hypertrophy: A concise review
LH Aung, JC Jumbo, Y Wang, P Li |
Molecular Therapy — Nucleic Acids | 2021 |
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
AA Cluntun, R Badolia, S Lettlova, KM Parnell, TS Shankar, NA Diakos, KA Olson, I Taleb, SM Tatum, JA Berg, CN Cunningham, TV Ry, AJ Bott, AT Krokidi, S Fogarty, S Skedros, WI Swiatek, X Yu, B Luo, S Merx, S Navankasattusas, JE Cox, GS Ducker, WL Holland, SH McKellar, J Rutter, SG Drakos |
Cell Metabolism | 2021 |
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Melatonin Reduces Oxidative Stress in the Right Ventricle of Newborn Sheep Gestated under Chronic Hypoxia
A Gonzaléz-Candia, PV Arias, SA Aguilar, EG Figueroa, RV Reyes, G Ebensperger, AJ Llanos, EA Herrera |
Antioxidants | 2021 |
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Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome
JN Peoples, N Ghazal, DM Duong, KR Hardin, JR Manning, NT Seyfried, V Faundez, JQ Kwong |
American journal of physiology. Cell physiology | 2021 |
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Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
L Koklesova, M Samec, A Liskova, K Zhai, D Büsselberg, FA Giordano, P Kubatka, O Golunitschaja |
The EPMA Journal | 2021 |
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Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease
M Ouarhache, S Marquet, AF Frade, AM Ferreira, B Ianni, RR Almeida, JP Nunes, LR Ferreira, VO Rigaud, D Cândido, C Mady, RC Zaniratto, P Buck, M Torres, F Gallardo, P Andrieux, S Bydlowsky, D Levy, L Abel, CS Cardoso, OR Santos-Junior, LC Oliveira, CD Oliveira, MD Nunes, A Cobat, J Kalil, AL Ribeiro, EC Sabino, E Cunha-Neto, C Chevillard |
Journal of Clinical Immunology | 2021 |
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Characterizing a long-term chronic heart failure model by transcriptomic alterations and monitoring of cardiac remodeling
Y Zhu, Q Wang, H Lin, K Chen, C Zheng, L Chen, S Ma, W Liao, J Bin, Y Liao |
Aging | 2021 |
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Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway
Z Zhong, Y Tian, X Luo, J Zou, L Wu, J Tian |
Frontiers in Bioengineering and Biotechnology | 2021 |
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Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish
DD Park, BM Gahr, J Krause, W Rottbauer, T Zeller, S Just |
International journal of molecular sciences | 2021 |
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Modulation of Mitochondrial Quality Control Processes by BGP-15 in Oxidative Stress Scenarios: From Cell Culture to Heart Failure
O Horvath, K Ordog, K Bruszt, N Kalman, D Kovacs, B Radnai, F Gallyas, K Toth, R Halmosi, L Deres, H Zhou |
Oxidative Medicine & Cellular Longevity | 2021 |
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MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases
GQ Zhang, SQ Wang, Y Chen, LY Fu, YN Xu, L Li, L Tao, XC Shen |
Frontiers in pharmacology | 2021 |
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Functional and Adaptive Significance of Promoter Mutations That Affect Divergent Myocardial Expressions of TRIM72 in Primates
Y Feng, H Xu, J Liu, N Xie, L Gao, Y He, Y Yao, F Lv, Y Zhang, J Lu, W Zhang, CY Li, X Hu, Z Yang, RP Xiao, A Yoder |
Molecular Biology and Evolution | 2021 |
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Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy
R Zou, J Tao, J Qiu, W Shi, M Zou, W Chen, W Li, N Zhou, S Wang, L Ma, X Chen, Y Chen |
Oxidative Medicine & Cellular Longevity | 2021 |
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Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency, and diastolic function early in life
JM do Carmo, AC Omoto, X Dai, SP Moak, GS Mega, X Li, Z Wang, AJ Mouton, JE Hall, AA da Silva |
American journal of physiology. Heart and circulatory physiology | 2021 |
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Far-infrared rays enhance mitochondrial biogenesis and GLUT3 expression under low glucose conditions in rat skeletal muscle cells
Y Seo, YW Kim, D Lee, D Kim, K Kim, T Kim, C Baek, Y Lee, J Lee, H Lee, G Jang, W Jeong, J Choi, D Hwang, JS Suh, SW Kim, HK Kim, J Han, H Bang, JH Kim, T Zhou, JH Ko |
The Korean Journal of Physiology & Pharmacology | 2021 |
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Cardioprotective effects of early intervention with sacubitril/valsartan on pressure overloaded rat hearts
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Scientific Reports | 2021 |
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Quantification of Myocardial Mitochondrial Membrane Potential Using PET
M Pelletier-Galarneau, FJ Detmer, Y Petibon, M Normandin, C Ma, NM Alpert, GE Fakhri |
Current Cardiology Reports | 2021 |
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Hotspot and Frontier Analysis of Exercise Training Therapy for Heart Failure Complicated With Depression Based on Web of Science Database and Big Data Analysis
Y Wang, Y Jia, M Li, S Jiao, H Zhao |
Frontiers in Cardiovascular Medicine | 2021 |
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Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice
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The Journal of biological chemistry | 2021 |
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Iron deficiency without anaemia: a diagnosis that matters
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Clinical Medicine | 2021 |
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Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction
Z Zhou, Z Liu, X Gao, Q Long |
Journal of Bioenergetics and Biomembranes | 2021 |
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Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics
M Schmid, CN Toepfer |
Biology Open | 2021 |
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Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene
S Huo, W Shi, H Ma, D Yan, P Luo, J Guo, C Li, J Lin, C Zhang, S Li, J Lv, L Lin, H Zhou |
Oxidative Medicine & Cellular Longevity | 2021 |
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Impairment of IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity and Mortality
SY Aghdam, D Kenchegowda, GP Holmes-Hampton, M Moroni, SP Ghosh |
International journal of molecular sciences | 2021 |
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Beta3-Adrenergic Receptor Activation Alleviates Cardiac Dysfunction in Cardiac Hypertrophy by Regulating Oxidative Stress
M Zhang, Y Xu, J Chen, C Qin, J Liu, D Guo, R Wang, J Hu, Q Zou, J Yang, Z Wang, X Niu, Y Chen |
Oxidative Medicine & Cellular Longevity | 2021 |
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SGLT2 Inhibition on Cardiac Mitochondrial Function: Searching for a Sweet Spot
KT Sawicki, I BenSahra, EM McNally |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2021 |
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MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca 2+ Leak
T Liu, N Yang, A Sidor, B ORourke |
Circulation research | 2021 |
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Quantitative Proteomics Reveal That Metabolic Improvement Contributes to the Cardioprotective Effect of T89 on Isoproterenol-Induced Cardiac Injury
XH Wei, X Guo, CS Pan, H Li, YC Cui, L Yan, JY Fan, JN Deng, BH Hu, X Chang, SY He, LL Yan, K Sun, CS Wang, JY Han |
Frontiers in physiology | 2021 |
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Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing
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Cell Discovery | 2021 |
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The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases
J Liu, L Zhong, R Guo, H Zhou |
Oxidative Medicine & Cellular Longevity | 2021 |
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Yiqi Huoxue preserves heart function by upregulating the Sigma‑1 receptor in rats with myocardial infarction
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Experimental and therapeutic medicine | 2021 |
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Cloning of Mn-SOD gene and its mRNA expression difference and antioxidant enzyme activities under hypoxia stress of cobia Rachycentron canadum
JD Zhang, HJ Li, E Amenyogbe, WZ Wang, JS Huang, G Chen |
Molecular Biology Reports | 2021 |
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Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy
S Wang, Y Cui, M Xiong, M Li, P Wang, J Cui, X Du, Y Chen, T Zhang |
Journal of inflammation research | 2021 |
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Proteomic Analysis Reveals the Protective Effects of Yiqi Fumai Lyophilized Injection on Chronic Heart Failure by Improving Myocardial Energy Metabolism
X Han, Y Zhang, O Qiao, H Ji, X Zhang, W Wang, X Li, J Wang, D Li, A Ju, C Liu, W Gao |
Frontiers in pharmacology | 2021 |
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Sunitinib-induced cardiac hypertrophy and the endothelin axis
J Sourdon, C Facchin, A Certain, T Viel, B Robin, F Lager, C Marchiol, D Balvay, T Yoganathan, J Favier, PL Tharaux, N Dhaun, G Renault, B Tavitian |
Theranostics | 2021 |
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Oral N-acetylcysteine as an adjunct to standard medical therapy improved heart function in cases with stable class II and III systolic heart failure
A Yazdi, N Khansari, M Mehrpooya, Y Mohammadi, S Zareie |
Irish Journal of Medical Science | 2021 |
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Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
J Chen, J Zhong, L Wang, Y Chen |
Frontiers in Cardiovascular Medicine | 2021 |
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Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results
TM Szabo, A Frigy, EE Nagy |
International journal of molecular sciences | 2021 |
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The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool
JW Wegener, A Wagdi, E Wagner, DM Katschinski, G Hasenfuss, T Bruegmann, SE Lehnart |
Frontiers in physiology | 2021 |
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Inside the pathophysiological mechanisms of cardiometabolic diseases: the other pandemic to fight
MR Choi |
Pflügers Archiv - European Journal of Physiology | 2021 |
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The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases
L Liu, Y Li, Q Chen |
Frontiers in physiology | 2021 |
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Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?
J Piquereau, S Boitard, R Ventura-Clapier, M Mericskay |
International journal of molecular sciences | 2021 |
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A Novel Small Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics
H He, T Baka, J Balschi, A Motani, K Nguyen, Q Liu, R Slater, B Rock, C Wang, C Hale, G Karamanlidis, J Hartman, F Malik, J Reagan, I Luptak |
Circulation. Heart failure | 2021 |
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The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy
Beak JY, Kang HS, Huang W, Deshmukh R, Hong SJ, Kadakia N, Aghajanian A, Gerrish K, Jetten A, Jensen B |
The Journal of biological chemistry | 2021 |
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Boosting mitochondrial metabolism with dietary supplements in heart failure
O\u2019Brien KD, Tian R |
Nature reviews. Cardiology | 2021 |
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Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure
Bo Zhou, Dennis D. Wang, Yanhua Qiu, Sophia Airhart, Yaxin Liu, April Stempien-Otero, Kevin D. O’Brien, Rong Tian. |
Journal of Clinical Investigation | 2020 |
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Blood-based bioenergetics: An emerging translational and clinical tool
A Braganza, GK Annarapu, S Shiva |
Molecular Aspects of Medicine | 2020 |
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Targeting the Mitochondria in Heart Failure
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JACC: Basic to Translational Science | 2020 |
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Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin
JM Quiles, ÅB Gustafsson |
Frontiers in physiology | 2020 |
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Energy metabolism disorders and potential therapeutic drugs in heart failure
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Acta pharmaceutica Sinica. B | 2020 |
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NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death
W Xu, L Li, L Zhang |
Frontiers in physiology | 2020 |
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Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure
J Li, S Agvanian, K Zhou, RM Shaw, TT Hong |
Frontiers in physiology | 2020 |
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The Physiological and Pathological Roles of Mitochondrial Calcium Uptake in Heart
L Lai, H Qiu |
International journal of molecular sciences | 2020 |
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Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications
H Xu, S Cui, Y Zhang, J Ren |
Acta Pharmacologica Sinica | 2020 |
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Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
CM Oh, D Ryu, S Cho, Y Jang |
Korean Circulation Journal | 2020 |
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Changes in Myocardial Metabolism Preceding Sudden Cardiac Death
J Snyder, R Zhai, AI Lackey, PY Sato |
Frontiers in physiology | 2020 |
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Mitochondrial ion channels as targets for cardioprotection
DJ Hausenloy, R Schulz, H Girao, BR Kwak, DD Stefani, R Rizzuto, P Bernardi, FD Lisa |
Journal of Cellular and Molecular Medicine | 2020 |
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Metabolic Modulation of Macrophage Function Post Myocardial Infarction
M Zhao, DD Wang, X Liu, R Tian |
Frontiers in physiology | 2020 |
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MicroRNA‐574 regulates FAM210A expression and influences pathological cardiac remodeling
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EMBO Molecular Medicine | 2020 |
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Macrophage activation as an archetype of mitochondrial repurposing
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Molecular Aspects of Medicine | 2020 |
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Irisin attenuates myocardial ischemia/reperfusion‐induced cardiac dysfunction by regulating ER‐mitochondria interaction through a mitochondrial ubiquitin ligase‐dependent mechanism
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Clinical and Translational Medicine | 2020 |
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Cardiac Complications of Propionic and Other Inherited Organic Acidemias
KC Park, S Krywawych, E Richard, LR Desviat, P Swietach |
Frontiers in Cardiovascular Medicine | 2020 |
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Molecular Perspectives of Mitochondrial Adaptations and Their Role in Cardiac Proteostasis
S Alam, CS Abdullah, R Aishwarya, M Morshed, S Bhuiyan |
Frontiers in physiology | 2020 |
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Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors
GD Lopaschuk, S Verma |
JACC: Basic to Translational Science | 2020 |
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Age-associated arterial calcification: the current pursuit of aggravating and mitigating factors
A Chakrabarti, DR Goldstein, NR Sutton |
Current Opinion in Lipidology | 2020 |
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Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats
JD Pandya, M Valdez, JE Royland, RC MacPhail, PG Sullivan, PR Kodavanti |
Journal of Aging Research | 2020 |
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Mitochondrial Transfer and Regulators of Mesenchymal Stromal Cell Function and Therapeutic Efficacy
A Mohammadalipour, SP Dumbali, PL Wenzel |
Frontiers in Cell and Developmental Biology | 2020 |
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Mitochondrial Dysfunction in Diabetic Cardiomyopathy: The Possible Therapeutic Roles of Phenolic Acids
FF Jubaidi, S Zainalabidin, V Mariappan, SB Budin |
International journal of molecular sciences | 2020 |
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Pyrroloquinoline quinone can prevent chronic heart failure by regulating mitochondrial function
X Xu, C Chen, WJ Lu, YL Su, JY Shi, YC Liu, L Wang, CX Xiao, X Wu, Q Lu |
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Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload
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Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice
M Beauchemin, R Geguchadze, AR Guntur, K Nevola, PT Le, D Barlow, M Rue, CP Vary, CW Lary, KJ Motyl, KL Houseknecht |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2020 |
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Tead1 is essential for mitochondrial function in cardiomyocytes
R Liu, R Jagannathan, L Sun, F Li, P Yang, J Lee, V Negi, EM Perez-Garcia, S Shiva, VK Yechoor, M Moulik |
American journal of physiology. Heart and circulatory physiology | 2020 |
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Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway
N Nuamnaichati, S Mangmool, N Chattipakorn, W Parichatikanond |
Frontiers in pharmacology | 2020 |
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Valosin-Containing Protein, a Calcium-Associated ATPase Protein, in Endoplasmic Reticulum and Mitochondrial Function and Its Implications for Diseases
X Sun, H Qiu |
International journal of molecular sciences | 2020 |
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SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy
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Redox Biology | 2020 |
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Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias
HM Aitken-Buck, J Krause, T Zeller, PP Jones, RR Lamberts |
Frontiers in physiology | 2020 |
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tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
J Cao, DB Cowan, DZ Wang |
Frontiers in pharmacology | 2020 |
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Mitochondrial Pathobiology and Metabolic Remodeling in Progression to Overt Systolic Heart Failure
AH Chaanine, TH LeJemtel, P Delafontaine |
Journal of Clinical Medicine | 2020 |
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Cardiovascular Problems in the Fragile X Premutation
N Tassanakijpanich, J Cohen, R Cohen, UN Srivatsa, RJ Hagerman |
Frontiers in Genetics | 2020 |
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Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress
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Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases
A Alfatni, M Riou, AL Charles, A Meyer, C Barnig, E Andres, A Lejay, S Talha, B Geny |
Journal of Clinical Medicine | 2020 |
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CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction
E Aplak, C von Montfort, L Haasler, D Stucki, B Steckel, AS Reichert, W Stahl, P Brenneisen, P Mukhopadhyay |
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Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology
A Kunovac, QA Hathaway, MV Pinti, AD Taylor, JM Hollander |
American journal of physiology. Heart and circulatory physiology | 2020 |
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Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide
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Heart Failure Reviews | 2020 |
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Mitochondria: Potential Targets for Osteoarthritis
X Mao, P Fu, L Wang, C Xiang |
Frontiers in Medicine | 2020 |
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Stress-mediated generation of deleterious ROS in healthy individuals - role of cytochrome c oxidase
R Ramzan, S Vogt, B Kadenbach |
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Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy
N Yang, QW Guan, FH Chen, QX Xia, , HH Zhou, XY Mao, N Cárdenas-Rodríguez |
Oxidative Medicine & Cellular Longevity | 2020 |
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Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to Improve Mitochondrial Dysfunction
T Ni, N Lin, X Huang, W Lu, Z Sun, J Zhang, H Lin, J Chi, H Guo |
Frontiers in pharmacology | 2020 |
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Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement
AD Lorenzo, G Iannuzzo, A Parlato, G Cuomo, C Testa, M Coppola, G DAmbrosio, DA Oliviero, S Sarullo, G Vitale, C Nugara, FM Sarullo, F Giallauria |
Journal of Clinical Medicine | 2020 |
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Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol
Y Ni, J Deng, X Liu, Q Li, J Zhang, H Bai, J Zhang |
Journal of Cellular and Molecular Medicine | 2020 |
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Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells
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Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning
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Annals of the New York Academy of Sciences | 2020 |
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Redox Biology | 2020 |
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Metabolism, Epigenetics, and Causal Inference in Heart Failure
TH Kimball, TM Vondriska |
Trends in endocrinology and metabolism: TEM | 2020 |
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Regulation of energy metabolism by combination therapy attenuates cardiac metabolic remodeling in heart failure
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International journal of biological sciences | 2020 |
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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure
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Circulation research | 2020 |
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Protective Effects of Euthyroidism Restoration on Mitochondria Function and Quality Control in Cardiac Pathophysiology
F Forini, G Nicolini, C Kusmic, G Iervasi |
International journal of molecular sciences | 2019 |
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Pathophysiology of Calcium Mediated Ventricular Arrhythmias and Novel Therapeutic Options with Focus on Gene Therapy
Paar, Jirak, Larbig, Zagidullin, Brandt, Lichtenauer, Hoppe, Motloch |
International journal of molecular sciences | 2019 |
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Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop
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Circulation | 2019 |
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Both gain and loss of Nampt function promote pressure overload-induced heart failure
J Byun, S Oka, N Imai, CY Huang, G Ralda, P Zhai, Y Ikeda, S Ikeda, J Sadoshima |
American journal of physiology. Heart and circulatory physiology | 2019 |
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Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2019 |
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Intrinsic Effects of Gold Nanoparticles on Oxygen–Glucose Deprivation/Reperfusion Injury in Rat Cortical Neurons
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Neurochemical Research | 2019 |
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Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients
R Shirakawa, T Yokota, T Nakajima, S Takada, M Yamane, T Furihata, S Maekawa, H Nambu, T Katayama, A Fukushima, A Saito, N Ishimori, F Dela, S Kinugawa, T Anzai |
Scientific Reports | 2019 |
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Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
N Tarasova, P Vishnyakova, Y Logashina, A Elchaninov |
International journal of molecular sciences | 2019 |
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DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure
ME Pepin, S Drakos, CM Ha, M Tristani-Firouzi, CH Selzman, JC Fang, AR Wende, O Wever-Pinzon |
American journal of physiology. Heart and circulatory physiology | 2019 |
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Comprehensive Analysis and Co-Expression Network of mRNAs and lncRNAs in Pressure Overload-Induced Heart Failure
S Chen, Q Ma, Y Xue, J Zhang, G Yang, T Wang, A Ma, L Bai |
Frontiers in Genetics | 2019 |
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Metabolic Alterations in Cardiomyocytes of Patients with Duchenne and Becker Muscular Dystrophies
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Journal of Clinical Medicine | 2019 |
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The New Promise of Mitochondrial Transplantation for Myocardial Recovery
WH Tang |
JACC: Basic to Translational Science | 2019 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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