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Usage Information

Mitochondrial fidelity and metabolic agility control immune cell fate and function
Michael N. Sack
Michael N. Sack
Published July 30, 2018
Citation Information: J Clin Invest. 2018;128(9):3651-3661. https://doi.org/10.1172/JCI120845.
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Review Series

Mitochondrial fidelity and metabolic agility control immune cell fate and function

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Abstract

Remodeling of mitochondrial metabolism plays an important role in regulating immune cell fate, proliferation, and activity. Furthermore, given their bacterial ancestry, disruption in mitochondrial fidelity leading to extravasation of their content initiates and amplifies innate immune surveillance with a myriad of physiologic and pathologic consequences. Investigations into the role of mitochondria in the immune system have come to the fore, and appreciation of mitochondrial function and quality control in immune regulation has enhanced our understanding of disease pathogenesis and identified new targets for immune modulation. This mitochondria-centered Review focuses on the role of mitochondrial metabolism and fidelity, as well as the role of the mitochondria as a structural platform, for the control of immune cell polarity, activation, and signaling. Mitochondria-linked disease and mitochondrially targeted therapeutic strategies to manage these conditions are also discussed.

Authors

Michael N. Sack

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,145 82
PDF 158 23
Figure 260 3
Citation downloads 103 0
Totals 1,666 108
Total Views 1,774
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