Research Article
P A Rufo, D Merlin, M Riegler, M H Ferguson-Maltzman, B L Dickinson, C Brugnara, S L Alper, W I Lencer
Title and authors | Publication | Year |
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Mg2+ is the major activator of calcium-sensing receptor in the intestine and its supplementation can treat secretory diarrhea
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Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells
Oak AA, Chu T, Yottasan P, Chhetri PD, Zhu J, Du Bois J, Cil O |
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Multicomponent crystals of clotrimazole: a combined theoretical and experimental study
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CrystEngComm | 2021 |
Inhibition of CFTR-mediated intestinal chloride secretion by a fungus-derived arthropsolide A: Mechanism of action and anti-diarrheal efficacy
N Akrimajirachoote, S Satitsri, U Sommart, V Rukachaisirikul, C Muanprasat |
European Journal of Pharmacology | 2020 |
Studies of Epithelial Transporters and Ion Channels: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 3
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2020 | |
Development of a Cell-Based Assay for Identifying K Ca 3.1 Inhibitors Using Intestinal Epithelial Cell Lines
C Jakakul, P Kanjanasirirat, C Muanprasat |
SLAS Discovery | 2020 |
Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
J van der Horst, IA Greenwood, TA Jepps |
Frontiers in physiology | 2020 |
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea
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JCI Insight | 2019 |
KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility
MS Valero, M Ramón-Gimenez, J Lozano-Gerona, P Delgado-Wicke, P Calmarza, A Oliván-Viguera, V López, ÁL Garcia-Otín, S Valero, E Pueyo, KL Hamilton, H Miura, R Köhler |
International journal of molecular sciences | 2019 |
Dexamethasone reduces airway epithelial Cl− secretion by rapid non-genomic inhibition of KCNQ1, KCNN4 and KATP K+ channels
D Hynes, BJ Harvey |
Steroids | 2019 |
The Role of Ion Transporters in the Pathophysiology of Infectious Diarrhea
S Das, R Jayaratne, KE Barrett |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2018 |
Enterocyte K + ion permeability and fluid secretion: missing the correct channel or missing the point?: Letters
ML Lucas |
The Journal of Physiology | 2018 |
Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis
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Molecular and Cellular Endocrinology | 2018 |
Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore
HM Nguyen, V Singh, B Pressly, DP Jenkins, H Wulff, V Yarov-Yarovoy |
Molecular pharmacology | 2017 |
Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide
AS Vanhove, S Hang, V Vijayakumar, AC Wong, J Asara, PI Watnick, BK Coombes |
PLoS pathogens | 2017 |
Pathogen-induced secretory diarrhea and its prevention
S Anand, S Mandal, P Patil, SK Tomar |
European Journal of Clinical Microbiology & Infectious Diseases | 2016 |
Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea
Y Jiang, B Yu, H Yang, T Ma |
Frontiers in pharmacology | 2016 |
K+ Channel Inhibition Differentially Regulates Migration of Intestinal Epithelial Cells in Inflamed vs. Non-Inflamed Conditions in a PI3K/Akt-Mediated Manner
S Zundler, M Caioni, M Müller, U Strauch, C Kunst, G Woelfel, MM Zegers |
PloS one | 2016 |
Secretory diarrhoea: mechanisms and emerging therapies
JR Thiagarajah, M Donowitz, AS Verkman |
Nature Reviews Gastroenterology & Hepatology | 2015 |
Electrophysiological Studies into the Safety of the Anti-diarrheal Drug Clotrimazole during Oral Rehydration Therapy
WS Lexmond, PA Rufo, E Fiebiger, WI Lencer, JM Vinetz |
PLoS neglected tropical diseases | 2015 |
Ion Channels and Transporters of Epithelia in Health and Disease
KL Hamilton, DC Devor |
Ion Channels and Transporters of Epithelia in Health and Disease | 2015 |
Inhibition of cAMP-Activated Intestinal Chloride Secretion by Diclofenac: Cellular Mechanism and Potential Application in Cholera
P Pongkorpsakol, N Pathomthongtaweechai, P Srimanote, S Soodvilai, V Chatsudthipong, C Muanprasat, J Li |
PLoS neglected tropical diseases | 2014 |
Molecular Mechanisms of Calcium-sensing Receptor-mediated Calcium Signaling in the Modulation of Epithelial Ion Transport and Bicarbonate Secretion
R Xie, X Dong, C Wong, V Vallon, B Tang, J Sun, S Yang, H Dong |
The Journal of biological chemistry | 2014 |
The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma
J Wang, L Jia, Z Kuang, T Wu, Y Hong, X Chen, WK Leung, J Xia, B Cheng |
PloS one | 2014 |
WIPO Re:Search: Catalyzing Collaborations to Accelerate Product Development for Diseases of Poverty
R Ramamoorthi, KM Graef, A Krattiger, JC Dent |
Chemical Reviews | 2014 |
Blood-Brain Barrier KCa3.1 Channels: Evidence for a Role in Brain Na Uptake and Edema in Ischemic Stroke
YJ Chen, BK Wallace, N Yuen, DP Jenkins, H Wulff, ME O'Donnell |
Stroke; a journal of cerebral circulation | 2014 |
The In Vitro and In Vivo Antitumor Effects of Clotrimazole on Oral Squamous Cell Carcinoma
J Wang, L Jia, Z Kuang, T Wu, Y Hong, X Chen, WK Leung, J Xia, B Cheng, AR Amin |
PloS one | 2014 |
The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea
IA Sheikh, H Koley, MK Chakrabarti, KM Hoque |
The Journal of biological chemistry | 2013 |
NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease
D Strøbæk, DT Brown, DP Jenkins, YJ Chen, N Coleman, Y Ando, P Chiu, S Jørgensen, J Demnitz, H Wulff, P Christophersen |
British Journal of Pharmacology | 2013 |
An alternative explanation for the occurrence of short circuit current increases in the small intestine following challenge by bacterial enterotoxins
ML Lucas |
Medical Hypotheses | 2013 |
Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators
DP Jenkins, W Yu, BM Brown, LD Løjkner, H Wulff |
ASSAY and Drug Development Technologies | 2013 |
The Epac1 Signaling Pathway Regulates Cl− Secretion via Modulation of Apical KCNN4c Channels in Diarrhea*
IA Sheikh, H Koley, MK Chakrabarti, KM Hoque |
The Journal of biological chemistry | 2013 |
The Epac1 Signaling Pathway Regulates Cl − Secretion via Modulation of Apical KCNN4c Channels in Diarrhea
IA Sheikh, H Koley, MK Chakrabarti, KM Hoque |
The Journal of biological chemistry | 2013 |
Zinc sulphate attenuates chloride secretion in human colonic mucosae in vitro
M Medani, VA Bzik, A Rogers, D Collins, R Kennelly, DC Winter, DJ Brayden, AW Baird |
European Journal of Pharmacology | 2012 |
Cyclic AMP-induced K+ secretion occurs independently of Cl- secretion in rat distal colon
GI Sandle, VM Rajendran |
American journal of physiology. Cell physiology | 2012 |
Cyclic AMP-induced K + secretion occurs independently of Cl − secretion in rat distal colon
GI Sandle, VM Rajendran |
American journal of physiology. Cell physiology | 2012 |
Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels
R Alzamora, F O'Mahony, WH Ko, TW Yip, D Carter, M Irnaten, BJ Harvey |
Frontiers in physiology | 2011 |
Lack of Restoration in Vivo by K+-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge
ML Lucas, LC Gilligan, CC Whitelaw, PJ Wynne, JD Morrison |
Journal of Tropical Medicine | 2011 |
Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon
R Alzamora, F O’Mahony, BJ Harvey |
Steroids | 2011 |
Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line
KM Basalingappa, VM Rajendran, WF Wonderlin |
American journal of physiology. Gastrointestinal and liver physiology | 2011 |
Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line
KM Basalingappa, VM Rajendran, WF Wonderlin |
AJP Gastrointestinal and Liver Physiology | 2011 |
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport
P Preston, L Wartosch, D Günzel, M Fromm, P Kongsuphol, J Ousingsawat, K Kunzelmann, J Barhanin, R Warth, TJ Jentsch |
The Journal of biological chemistry | 2010 |
Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells
JC Eby, WP Ciesla, W Hamman, GM Donato, RJ Pickles, EL Hewlett, WI Lencer |
The Journal of biological chemistry | 2010 |
Therapeutic potential of KCa3.1 blockers: an overview of recent advances, and promising trends
H Wulff, NA Castle |
Expert Review of Clinical Pharmacology | 2010 |
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon
NS Kumar, SK Singh, VM Rajendran |
AJP Gastrointestinal and Liver Physiology | 2010 |
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
HJ Binder |
Annual Review of Physiology | 2010 |
Current Topics in Membranes
TC Wagenknecht, Z Liu |
Structure and Function of Calcium Release Channels | 2010 |
Disruption of the K + Channel β-Subunit KCNE3 Reveals an Important Role in Intestinal and Tracheal Cl − Transport
P Preston, L Wartosch, D Günzel, M Fromm, P Kongsuphol, J Ousingsawat, K Kunzelmann, J Barhanin, R Warth, TJ Jentsch |
The Journal of biological chemistry | 2010 |
Selective Translocation of the Bordetella pertussis Adenylate Cyclase Toxin across the Basolateral Membranes of Polarized Epithelial Cells
JC Eby, WP Ciesla, W Hamman, GM Donato, RJ Pickles, EL Hewlett, WI Lencer |
The Journal of biological chemistry | 2010 |
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon
NS Kumar, SK Singh, VM Rajendran |
AJP Gastrointestinal and Liver Physiology | 2010 |
Cholesterol-dependent regulation of adenosine A2A receptor-mediated anion secretion in colon epithelial cells
RS Lam, D Nahirney, M Duszyk |
Experimental Cell Research | 2009 |
Ceramide activates JNK to inhibit a cAMP-gated K + conductance and Cl – secretion in intestinal epithelia
DE Saslowsky, N Tanaka, KP Reddy, WI Lencer |
The FASEB Journal | 2009 |
Potassium channels as drug targets for therapeutic intervention in respiratory diseases
A Nardi, J Demnitz, ML Garcia, R Polosa |
Expert Opinion on Therapeutic Patents | 2008 |
Modeling of the Inhibition of the Intermediate‐Conductance Ca2+‐Activated K+Channel (IKCa1) by Some Triarylmethanes Using Quantum Chemical Properties Derived FromAb InitioCalculations
M Fernández, J Caballero |
QSAR & Combinatorial Science | 2008 |
Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents
M Tian, MQ Dong, SW Chiu, CP Lau, GR Li |
British Journal of Pharmacology | 2006 |
The distribution of intermediate-conductance, calcium-activated, potassium (IK) channels in epithelial cells
N Thompson-Vest, Y Shimizu, B Hunne, JB Furness |
Journal of Anatomy | 2006 |
Expression and Modulation of the Intermediate- Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Glioblastoma GL-15 Cells
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Biochemical Pharmacology | 2006 |
Physiology of the Gastrointestinal Tract
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Physiology of the Gastrointestinal Tract | 2006 |
DCEBIO stimulates Cl − secretion in the mouse jejunum
KL Hamilton, M Kiessling |
American journal of physiology. Cell physiology | 2006 |
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H Dong, A Smith, M Hovaida, JY Chow |
AJP Gastrointestinal and Liver Physiology | 2006 |
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ST Halm, T Liao, DR Halm |
American journal of physiology. Cell physiology | 2006 |
Phosphatidylinositol 3-Phosphate Indirectly Activates KCa3.1 via 14 Amino Acids in the Carboxy Terminus of KCa3.1
S Srivastava, P Choudhury, Z Li, GX Liu, V Nadkarni, K Ko, WA Coetzee, EY Skolnik |
Molecular biology of the cell | 2006 |
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function
TJ Jentsch, T Maritzen, AA Zdebik |
Journal of Clinical Investigation | 2005 |
Inhibition of tumor growth and prolonged survival of rats with intracranial gliomas following administration of clotrimazole
MH Khalid, Y Tokunaga, AJ Caputy, E Walters |
Journal of Neurosurgery | 2005 |
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HM Jones, KL Hamilton, DC Devor |
The Journal of biological chemistry | 2005 |
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
KM Hoque, VM Rajendran, HJ Binder |
AJP Gastrointestinal and Liver Physiology | 2005 |
Vibrio cholerae Infection of Drosophila melanogaster Mimics the Human Disease Cholera
NS Blow, RN Salomon, K Garrity, I Reveillaud, A Kopin, FR Jackson, PI Watnick, DS Schneider |
PLoS pathogens | 2005 |
Pathways for K+ Efflux in Isolated Surface and Crypt Colonic Cells. Activation by Calcium
JR del Castillo, L Burguillos |
The Journal of Membrane Biology | 2005 |
Calcium-dependent regulation of secretion in biliary epithelial cells: The role of apamin-sensitive SK channels
AP Feranchak, RB Doctor, M Troetsch, K Brookman, SM Johnson, JG Fitz |
Gastroenterology | 2004 |
Potassium currents regulating secretion from Brunner's glands in guinea pig duodenum
J Kovac, B Moore, S Vanner |
AJP Gastrointestinal and Liver Physiology | 2004 |
Defects of Secretion in Cystic Fibrosis
C Schultz |
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Blockage of Intermediate-Conductance Ca 2+ -Activated K + Channels Inhibit Human Pancreatic Cancer Cell Growth in Vitro
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Molecular pharmacology | 2004 |
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling
PA Rufo, PW Lin, A Andrade, L Jiang, L Rameh, C Flexner, SL Alper, WI Lencer |
American journal of physiology. Cell physiology | 2003 |
Function of K+ Channels in the Intestinal Epithelium
R Warth, J Barhanin |
The Journal of Membrane Biology | 2003 |
Encyclopedia of Gastroenterology
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Encyclopedia of Gastroenterology | 2003 |
Ion Channels in Digestive Health and Disease:
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Journal of Pediatric Gastroenterology and Nutrition | 2003 |
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WJ Joiner, S Basavappa, S Vidyasagar, K Nehrke, S Krishnan, HJ Binder, EL Boulpaep, VM Rajendran |
AJP Gastrointestinal and Liver Physiology | 2003 |
Electrogenic ion transport in mammalian colon involves an ammonia-sensitive apical membrane K+ conductance
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Digestive Diseases and Sciences | 2003 |
K+ channels as therapeutic drug targets
AD Wickenden |
Pharmacology & Therapeutics | 2002 |
The Ca2+-activated K+channel of intermediate conductance:a possible target for immune suppression
BS Jensen, M Hertz, P Christophersen, LS Madsen |
Expert Opinion on Therapeutic Targets | 2002 |
Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease
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Physiological reviews | 2002 |
The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis
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Defective regulatory volume decrease in human cystic fibrosis tracheal cells because of altered regulation of intermediate conductance Ca2+-dependent potassium channels
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Proceedings of the National Academy of Sciences | 2001 |
Modulation of Mouse Paneth Cell α-Defensin Secretion by mIKCa1, a Ca 2+ -activated, Intermediate Conductance Potassium Channel
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The Journal of biological chemistry | 2001 |
Delineation of the Clotrimazole/TRAM-34 Binding Site on the Intermediate Conductance Calcium-activated Potassium Channel, IKCa1
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The Journal of biological chemistry | 2001 |
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Annual Review of Physiology | 2000 |
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Biochimica et Biophysica Acta (BBA) - Biomembranes | 2000 |
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
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Proceedings of the National Academy of Sciences | 2000 |
Clotrimazole inhibits smooth muscle cell proliferation and has a vasodilator effect on resistance arteries
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Fundamental & Clinical Pharmacology | 2000 |
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant
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Proceedings of the National Academy of Sciences | 2000 |
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Nature | 2000 |
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AJP Gastrointestinal and Liver Physiology | 2000 |
Structure-guided Transformation of Charybdotoxin Yields an Analog That Selectively Targets Ca2+-activated over Voltage-gated K+ Channels
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The Journal of biological chemistry | 1999 |
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AJP Gastrointestinal and Liver Physiology | 1999 |
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The Journal of Physiology | 1998 |
Clotrimazole inhibits the growth of Plasmodium falciparum in vitro
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Transactions of the Royal Society of Tropical Medicine and Hygiene | 1998 |
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