Research Article
V Modur, Y Li, G A Zimmerman, S M Prescott, T M McIntyre
Title and authors | Publication | Year |
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IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus-infected cells and correlates to severity in HFRS.
Maleki KT, Niemetz L, Christ W, Wigren Byström J, Thunberg T, Ahlm C, Klingström J |
PLoS pathogens | 2025 |
Balancing the Scales: The Dual Role of Interleukins in Bone Metastatic Microenvironments
Dawalibi A, Alosaimi AA, Mohammad KS |
International journal of molecular sciences | 2024 |
Exploring the Role of Hormones and Cytokines in Osteoporosis Development
Umur E, Bulut SB, Yiğit P, Bayrak E, Arkan Y, Arslan F, Baysoy E, Kaleli-Can G, Ayan B |
Biomedicines | 2024 |
Relationship between Vitreous IL-6 Levels, Gender Differences and C-Reactive Protein (CRP) in a Blood Sample of Posterior Uveitis.
Sakai A, Tagami M, Katsuyama-Yoshikawa A, Misawa N, Haruna Y, Azumi A, Honda S |
Journal of Clinical Medicine | 2023 |
The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective.
Banerjee D, Tian R, Cai S |
Current Cardiology Reports | 2023 |
Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements.
Millrine D, Cardus Figueras A, Uceda Fernandez J, Andrews R, Szomolay B, Cossins BC, Rice CM, Li J, Tyrrell VJ, McLeod L, Holmans P, O'Donnell VB, Taylor PR, Turner SJ, Jenkins BJ, Jones GW, Topley N, Williams NM, Jones SA |
Journal of immunology (Baltimore, Md. : 1950) | 2023 |
The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
Xu J, Yu L, Liu F, Wan L, Deng Z |
Frontiers in immunology | 2023 |
Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection.
Funderburg NT, Shive CL, Chen Z, Tatsuoka C, Bowman ER, Longenecker CT, McComsey GA, Clagett BM, Dorazio D, Freeman ML, Sieg SF, Moisi D, Anthony DD, Jacobson JM, Stein SL, Calabrese LH, Landay A, Flexner C, Crawford KW, Capparelli EV, Rodriguez B, Lederman MM |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2023 |
Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass.
Titova OE, Brunius C, Warensjö Lemming E, Stattin K, Baron JA, Byberg L, Michaëlsson K, Larsson SC |
International Journal of Obesity | 2023 |
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome.
Shahini A, Shahini A |
Journal of Cell Communication and Signaling | 2022 |
Meprin β expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney injury.
Abousaad S, Ahmed F, Abouzeid A, Ongeri EM |
Physiological Reports | 2022 |
High Intensity Interval Training Leads to Similar Inflammatory Activation as Seen With Traditional Training in Chronic Heart Failure.
Taylor AG, Ignaszewski AI, Bredin SSD, Hill JS, Shellington EM, Warburton DER |
Frontiers in Cardiovascular Medicine | 2022 |
Bothrops moojeni snake venom induces an inflammatory response in preadipocytes: Insights into a new aspect of envenomation.
Maia-Marques R, Teixeira DS, Janovits PM, DeOcesano-Pereira C, Leiguez E, Teixeira C |
PLoS neglected tropical diseases | 2022 |
Systemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia
Preuss SF, Grieshober D, Augustin HG |
Annual Review of Physiology | 2022 |
Influences of the IL-6 cytokine family on bone structure and function
NA Sims |
Cytokine | 2021 |
Making sense of IL‐6 signalling cues in pathophysiology
D Millrine, RH Jenkins, ST Hughes, SA Jones |
FEBS Letters | 2021 |
Unravelling the broader complexity of IL-6 involvement in health and disease
RH Jenkins, ST Hughes, AC Figueras, SA Jones |
Cytokine | 2021 |
On the role of bacterial metalloproteases in COVID-19 associated cytokine storm.
Földvári-Nagy L, Schnabel T, Dörnyei G, Korcsmáros T, Lenti K |
Cell communication and signaling : CCS | 2021 |
Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction
MJ George, NH Jasmin, VT Cummings, A Richard-Loendt, F Launchbury, K Woollard, T Turner-Stokes, AI Diaz, M Lythgoe, DJ Stuckey, AD Hingorani, DW Gilroy |
JACC: Basic to Translational Science | 2021 |
The determinant role of IL-6 in the establishment of inflammation leading to spontaneous preterm birth
E Prairie, F Côté, M Tsakpinoglou, M Mina, C Quiniou, K Leimert, D Olson, S Chemtob |
Cytokine & Growth Factor Reviews | 2021 |
Preeclampsia Status Controls Interleukin-6 and Soluble IL-6 Receptor Release from Neutrophils and Endothelial Cells: Relevance to Increased Inflammatory Responses
Y Wang, Y Gu, JS Alexander, DF Lewis |
Pathophysiology | 2021 |
Preeclampsia Status Controls Interleukin-6 and Soluble IL-6 Receptor Release from Neutrophils and Endothelial Cells: Relevance to Increased Inflammatory Responses.
Wang Y, Gu Y, Alexander JS, Lewis DF |
2021 | |
Dynamics of Immune Activation in Viral Diseases
PV Bramhachari |
2020 | |
IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms
A Valin, MJ Rey, C Municio, A Usategui, M Romero, J Fernández-Felipe, JD Cañete, FJ Blanco, Y Ruano, G Criado, JL Pablos |
2020 | |
Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans
D van Keulen, MG Pouwer, V Emilsson, LP Matic, EJ Pieterman, U Hedin, V Gudnason, LL Jennings, K Holmstrøm, BS Nielsen, G Pasterkamp, JH Lindeman, AJ van Gool, MD Gelpke, HM Princen, D Tempel, A Cignarella |
PloS one | 2019 |
Role of Inflammatory Cell Subtypes in Heart Failure
D Strassheim, EC Dempsey, E Gerasimovskaya, K Stenmark, V Karoor |
Journal of Immunology Research | 2019 |
Characteristics of Impaired Dendritic Cell Function in Patients With Hepatitis B Virus Infection
A Yonejima, E Mizukoshi, T Tamai, H Nakagawa, M Kitahara, T Yamashita, K Arai, T Terashima, N Iida, K Fushimi, H Okada, T Yamashita, Y Sakai, M Honda, S Kaneko |
Hepatology | 2019 |
Influence of mineral waters on in vitro proliferation, antioxidant response and cytokine production in a human lung fibroblasts cell line
LM Melgar-Sánchez, I García-Ruiz, V Pardo-Marqués, MT Agulló-Ortuño, I Martínez-Galán |
International Journal of Biometeorology | 2019 |
Exposure to a single immobilization or lipopolysaccharide challenge increases expression of genes implicated in the development of Alzheimer’s disease in the mice brain cortex
A Padova, I Rokytova, B Mravec, R Kvetnansky, P Vargovic |
Endocrine Regulations | 2019 |
IL-6 trans -signalling mediates trabecular, but not cortical, bone loss after ovariectomy
L Lazzaro, BA Tonkin, IJ Poulton, NE McGregor, W Ferlin, NA Sims |
Bone | 2018 |
Physiological effects of modulating the interleukin-6 axis
G Schett |
Rheumatology | 2018 |
Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells
M Valle, J Dworshak, A Sharma, A Ibrahim, M Al-Shabrawey, S Sharma |
Experimental Eye Research | 2018 |
CRP genetic variants are associated with mortality and depressive symptoms in chronic heart failure patients
S Kittel-Schneider, M Kaspar, D Berliner, H Weber, J Deckert, G Ertl, S Störk, C Angermann, A Reif |
Brain, Behavior, and Immunity | 2018 |
Potential Role of Humoral IL-6 Cytokine in Mediating Pro-Inflammatory Endothelial Cell Response in Amyotrophic Lateral Sclerosis
S Garbuzova-Davis, J Ehrhart, P Sanberg, C Borlongan |
International journal of molecular sciences | 2018 |
Subclinical Inflammation in Heart Failure: A Neutrophil Perspective
B Vulesevic, MG Sirois, BG Allen, S de Denus, M White |
The Canadian journal of cardiology | 2018 |
Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice
D van Keulen, MG Pouwer, G Pasterkamp, AJ van Gool, MD Gelpke, HM Princen, D Tempel, M Bader |
PloS one | 2018 |
Maestro endothelium conducts the neutrophils
R Grieshaber-Bouyer, PA Nigrovic |
Blood | 2018 |
Interleukin 6: The biology behind the therapy
SA Jones, T Takeuchi, D Aletaha, J Smolen, EH Choy, I McInnes |
2018 | |
Circulating levels of sgp130 and sex hormones in male patients with coronary atherosclerotic disease
Y Cui, W Dai, Y Li |
Atherosclerosis | 2017 |
Interleukin-6 as a Multifunctional Regulator: Inflammation, Immune Response, and Fibrosis
E Choy, S Rose-John |
Journal of Scleroderma and Related Disorders | 2017 |
Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation
J Lokau, M Agthe, C Garbers |
Mediators of Inflammation | 2016 |
Cytokines and persistent viral infections
JC Beltra, H Decaluwe |
Cytokine | 2016 |
Crocin attenuate Tumor Necrosis Factor-alpha (TNF-α) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta
S Samarghandian, M Azimi-Nezhad, T Farkhondeh |
Cytokine | 2016 |
Effects of neuromyelitis optica–IgG at the blood–brain barrier in vitro
Y Takeshita, B Obermeier, AC Cotleur, SF Spampinato, F Shimizu, E Yamamoto, Y Sano, TJ Kryzer, VA Lennon, T Kanda, RM Ransohoff |
Neurology: Neuroimmunology & Neuroinflammation | 2016 |
IL-6 as a keystone cytokine in health and disease
CA Hunter, SA Jones |
Nature Immunology | 2015 |
The varying faces of IL-6: From cardiac protection to cardiac failure
JA Fontes, NR Rose, D Čiháková |
Cytokine | 2015 |
Novel Anti-Inflammatory Therapies for the Treatment of Atherosclerosis
R Khan, V Spagnoli, JC Tardif, PL L’Allier |
Atherosclerosis | 2015 |
Muscular interleukin-6 differentially regulates skeletal muscle adaptation to high-fat diet in a sex-dependent manner
J Guerra, B Ferrer, M Giralt, G Comes, J Carrasco, A Molinero, AL Serrano, J Hidalgo |
Cytokine | 2015 |
Podocytes Regulate Neutrophil Recruitment by Glomerular Endothelial Cells via IL-6–Mediated Crosstalk
SJ Kuravi, HM McGettrick, SC Satchell, MA Saleem, L Harper, JM Williams, GE Rainger, CO Savage |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
IL-6 as a target in autoimmune disease and inflammation
M Hashizume, Y Ohsugi |
Folia Pharmacologica Japonica | 2014 |
Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice
L Yao, T Yago, B Shao, Z Liu, R Silasi-Mansat, H Setiadi, F Lupu, RP McEver |
Blood | 2013 |
The Role of IL-6 Trans -Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model
LH Wei, CH Chou, MW Chen, S Rose-John, ML Kuo, SU Chen, YS Yang |
The Journal of clinical endocrinology and metabolism | 2013 |
Soluble TNF and IL-6 receptors: Indicators of vascular health in women without cardiovascular disease
M Cortez-Cooper, E Meaders, J Stallings, S Haddow, B Kraj, G Sloan, KK McCully, JG Cannon |
Vascular medicine (London, England) | 2013 |
Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia
Z Zhang, Y Gao, L Zhang, L Jia, P Wang, L Zhang, H Li |
Hypertension in Pregnancy | 2013 |
Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice
N Ahuja, A Andres-Hernando, C Altmann, R Bhargava, J Bacalja, RG Webb, Z He, CL Edelstein, S Faubel |
American journal of physiology. Renal physiology | 2012 |
Role of interleukin-6 in hemopoietic and non-hemopoietic synergy mediating TLR4-triggered late murine ileus and endotoxic shock
BM Buchholz, RS Chanthaphavong, TR Billiar, AJ Bauer |
Neurogastroenterology and Motility | 2012 |
Interleukin-6, a major cytokine in the central nervous system
M Erta, A Quintana, J Hidalgo |
International journal of biological sciences | 2012 |
Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression
WY Cheung, CA Simmons, L You |
Bone | 2012 |
Time course of inflammatory cytokines in acute ischemic stroke patients and their relation to inter-alfa trypsin inhibitor heavy chain 4 and outcome
AR Nayak, RS Kashyap, D Kabra, HJ Purohit, GM Taori, HF Daginawala |
Annals of Indian Academy of Neurology | 2012 |
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
Anti-inflammatory effect of IL-6 receptor blockade in corneal alkali burn
T Sakimoto, S Sugaya, A Ishimori, M Sawa |
Experimental Eye Research | 2012 |
Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice
N Ahuja, A Andres-Hernando, C Altmann, R Bhargava, J Bacalja, RG Webb, Z He, CL Edelstein, S Faubel |
American journal of physiology. Renal physiology | 2012 |
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Simon Jones, Jürgen Scheller, Stefan Rose-John |
Journal of Clinical Investigation | 2011 |
Elevated Maternal Soluble Gp130 and IL-6 Levels and Reduced Gp130 and SOCS-3 Expressions in Women Complicated With Preeclampsia
Y Wang, DF Lewis, Y Gu, S Zhao, LJ Groome |
Hypertension | 2011 |
Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures
D Bingham, CM John, SS Panter, GA Jarvis |
Brain Research Bulletin | 2011 |
IL-6/IL-6 receptor system and its role in physiological and pathological conditions
M Mihara, M Hashizume, H Yoshida, M Suzuki, M Shiina |
Clinical Science | 2011 |
Crawling Phagocytes Recruited in the Brain Vasculature after Pertussis Toxin Exposure through IL6, ICAM1 and ITGαM: Crawling Phagocytes in the Brain Vasculature
JF Richard, M Roy, J Audoy-Rémus, P Tremblay, L Vallières |
Brain Pathology | 2011 |
The Role of Interleukin 6 in the Pathophysiology of Rheumatoid Arthritis
S Srirangan, EH Choy |
Therapeutic Advances in Musculoskeletal Diseases | 2010 |
Lack of Knowledge: Breast Cancer and the Soluble Interleukin-6 Receptor
H Knüpfer, R Preiss |
Breast care (Basel, Switzerland) | 2010 |
Rapamycin inhibits cholangiocyte regeneration by blocking interleukin-6-induced activation of signal transducer and activator of transcription 3 after liver transplantation
LP Chen, QH Zhang, G Chen, YY Qian, BY Shi, JH Dong |
Liver Transplantation | 2010 |
Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients
KH Oh, JY Jung, MO Yoon, A Song, H Lee, H Ro, YH Hwang, DK Kim, P Margetts, C Ahn |
Nephrology Dialysis Transplantation | 2010 |
Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice
MN Manjavachi, EM Motta, DM Marotta, DF Leite, JB Calixto |
PAIN | 2010 |
Current Topics in Membranes
TC Wagenknecht, Z Liu |
Structure and Function of Calcium Release Channels | 2010 |
The role of Interleukin 6 in the pathophysiology of rheumatoid arthritis
S Srirangan, EH Choy |
Therapeutic Advances in Musculoskeletal Diseases | 2010 |
High habitual dietary α-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations in male twins
J Dai, TR Ziegler, RM Bostick, AK Manatunga, DP Jones, J Goldberg, A Miller, G Vogt, PW Wilson, L Jones, L Shallenberger, V Vaccarino |
The American journal of clinical nutrition | 2010 |
The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice
L Kugathasan, JB Ray, Y Deng, E Rezaei, DJ Dumont, DJ Stewart |
Journal of Experimental Medicine | 2009 |
Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor
JM Dayer, E Choy |
Rheumatology | 2009 |
Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A
N Okiyama, T Sugihara, Y Iwakura, H Yokozeki, N Miyasaka, H Kohsaka |
Arthritis & Rheumatism | 2009 |
Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells
HM McGettrick, E Smith, A Filer, S Kissane, M Salmon, CD Buckley, GE Rainger, GB Nash |
European Journal of Immunology | 2009 |
NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats
HH Wei, XC Lu, DA Shear, A Waghray, C Yao, FC Tortella, JR Dave |
Journal of Neuroinflammation | 2009 |
Principles of Cancer Biotherapy
RK Oldham, RO Dillman |
2009 | |
Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy
CL Klein, TS Hoke, WF Fang, CJ Altmann, IS Douglas, S Faubel |
Kidney International | 2008 |
Effects of IL-1β and IL-6 on tissue-type plasminogen activator expression in vascular endothelial cells
P Larsson, E Ulfhammer, L Karlsson, M Bokarewa, K Wåhlander, S Jern |
Thrombosis Research | 2008 |
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier
RA Linker, F Lühder, KJ Kallen, DH Lee, B Engelhardt, S Rose-John, R Gold |
Journal of Neuroimmunology | 2008 |
Serum interleukin-6 receptor in polymyalgia rheumatica: A potential marker of relapse/recurrence risk
L Pulsatelli, L Boiardi, E Pignotti, P Dolzani, T Silvestri, P Macchioni, F Cantini, C Salvarani, A Facchini, R Meliconi |
Arthritis & Rheumatism | 2008 |
Principles of Bone Biology
CJ Rosen, T Niu |
Principles of Bone Biology | 2008 |
Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice
N Mzhavia, S Yu, S Ikeda, TT Chu, I Goldberg, HM Dansky |
Diabetes | 2008 |
Oncostatin M Receptor-β Signaling Limits Monocytic Cell Recruitment in Acute Inflammation
E Hams, CS Colmont, V Dioszeghy, VJ Hammond, CA Fielding, AS Williams, M Tanaka, A Miyajima, PR Taylor, N Topley, SA Jones |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Regulation of a lymphocyte–endothelial–IL-6 trans-signaling axis by fever-range thermal stress: Hot spot of immune surveillance
TD Vardam, L Zhou, MM Appenheimer, Q Chen, WC Wang, H Baumann, SS Evans |
Cytokine | 2007 |
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
A Chalaris, B Rabe, K Paliga, H Lange, T Laskay, CA Fielding, SA Jones, S Rose-John, J Scheller |
Blood | 2007 |
Type 2 diabetes and cardiovascular disease: getting to the fat of the matterThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum
KB Goralski, CJ Sinal |
Canadian Journal of Physiology and Pharmacology | 2007 |
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
S Rose-John, GH Waetzig, J Scheller, J Grötzinger, D Seegert |
Expert Opinion on Therapeutic Targets | 2007 |
sIL-6R: more than an agonist?
H Knüpfer, R Preiss |
Immunology and Cell Biology | 2007 |
Modulation of immune response by head injury
MC Morganti-Kossmann, L Satgunaseelan, N Bye, T Kossmann |
Injury | 2007 |
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
PJ Richards, MA Nowell, S Horiuchi, RM McLoughlin, CA Fielding, S Grau, N Yamamoto, M Ehrmann, S Rose-John, AS Williams, N Topley, SA Jones |
Arthritis & Rheumatism | 2006 |
Human T-cell leukemia virus type-I Tax induces expression of interleukin-6 receptor (IL-6R): Shedding of soluble IL-6R and activation of STAT3 signaling
S Horiuchi, N Yamamoto, MZ Dewan, Y Takahashi, A Yamashita, T Yoshida, MA Nowell, PJ Richards, SA Jones, N Yamamoto |
International Journal of Cancer | 2006 |
Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
JR McColm, P Geisen, LJ Peterson, ME Hartnett |
Experimental Eye Research | 2006 |
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism
Q Chen, DT Fisher, KA Clancy, JM Gauguet, WC Wang, E Unger, S Rose-John, UH von Andrian, H Baumann, SS Evans |
Nature Immunology | 2006 |
Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population
JC Galicia, H Tai, Y Komatsu, Y Shimada, I Ikezawa, H Yoshie |
Journal of Clinical Periodontology | 2006 |
Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1
CM Lin, H Chang, YH Chen, SY Li, IH Wu, JH Chiu |
International Immunopharmacology | 2006 |
Serum levels of IL-6 and its soluble receptor, TNF-α and chemokine RANTES in scorpion envenomed children: Their relation to scorpion envenomation outcome
AH Abdel-Haleem, AR Meki, HA Noaman, ZT Mohamed |
Toxicon | 2006 |
Hurdles to Lymphocyte Trafficking in the Tumor Microenvironment: Implications for Effective Immunotherapy
DT Fisher, Q Chen, MM Appenheimer, J Skitzki, WC Wang, K Odunsi, SS Evans |
Immunological Investigations | 2006 |
Regulation of NF-κB-dependent Gene Expression by the POU Domain Transcription Factor Oct-1
NG Paz, S Simeonidis, C Leo, DW Rose, T Collins |
The Journal of biological chemistry | 2006 |
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
RM McLoughlin, BJ Jenkins, D Grail, AS Williams, CA Fielding, CR Parker, M Ernst, N Topley, SA Jones |
Proceedings of the National Academy of Sciences | 2005 |
Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6
SA Jones |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium
F Lally, E Smith, A Filer, MA Stone, JS Shaw, GB Nash, CD Buckley, GE Rainger |
Arthritis & Rheumatism | 2005 |
Pathological role of IL-6 in the experimental allergic bronchial asthma in mice.
Doganci A, Sauer K, Karwot R, Finotto S |
Clinical Reviews in Allergy & Immunology | 2005 |
Review:IL-6 Transsignaling: TheIn VivoConsequences
SA Jones, PJ Richards, J Scheller, S Rose-John |
Journal of Interferon & Cytokine Research | 2005 |
Review: IL-6 Transsignaling: The In Vivo Consequences
SA Jones, PJ Richards, J Scheller, S Rose-John |
Journal of Interferon & Cytokine Research | 2005 |
Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock
C Martínez, Y Juarranz, C Abad, A Arranz, BG Miguel, F Rosignoli, J Leceta, RP Gomariz |
Journal of leukocyte biology | 2005 |
Resolving Peritoneal Inflammation: Flicking the Right “Switches”
R McLoughlin |
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis | 2005 |
Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: Exacerbation of joint inflammation in STAT-1 gene-knockout mice
AS de Hooge, FA van de Loo, MI Koenders, MB Bennink, OJ Arntz, T Kolbe, WB van den Berg |
Arthritis & Rheumatism | 2004 |
Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs
SW Lindemann, CC Yost, MM Denis, TM McIntyre, AS Weyrich, GA Zimmerman |
Proceedings of the National Academy of Sciences | 2004 |
Differential Regulation of Neutrophil-Activating Chemokines by IL-6 and Its Soluble Receptor Isoforms
RM McLoughlin, SM Hurst, MA Nowell, DA Harris, S Horiuchi, LW Morgan, TS Wilkinson, N Yamamoto, N Topley, SA Jones |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Phenytoin treatment reduces atherosclerosis in mice through mechanisms independent of plasma HDL-cholesterol concentration
C Trocho, JC Escolà-Gil, V Ribas, S Benı́tez, JM Martı́n-Campos, N Rotllan, L Osaba, J Ordóñez-Llanos, F González-Sastre, F Blanco-Vaca |
Atherosclerosis | 2004 |
Interleukin-6 and Cardiovascular Diseases
T Kanda, T Takahashi |
Japanese Heart Journal | 2004 |
Central Role of IL-6 Receptor Signal-Transducing Chain gp130 in Activation of L-Selectin Adhesion by Fever-Range Thermal Stress
Q Chen, WC Wang, R Bruce, H Li, DM Schleider, MJ Mulbury, MD Bain, PK Wallace, H Baumann, SS Evans |
Immunity | 2004 |
Cytokine-Related Aging Process
JE Morley, RN Baumgartner |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2004 |
Chlamydia Pneumoniae Seropositivity and Cardiovascular Risk Factors: The InCHIANTI Study
P Blanc, AM Corsi, A Gabbuti, C Peduzzi, F Meacci, F Olivieri, F Lauretani, M Francesco, L Ferrucci |
Journal of the American Geriatrics Society | 2004 |
Regulation of CX3CL1/Fractalkine Expression in Endothelial Cells
T Imaizumi, H Yoshida, K Satoh |
Journal of Atherosclerosis and Thrombosis | 2004 |
Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced
JC Galicia, H Tai, Y Komatsu, Y Shimada, K Akazawa, H Yoshie |
Genes and Immunity | 2004 |
Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow
A Bernardo, C Ball, L Nolasco, JF Moake, J Dong |
Blood | 2004 |
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
MA Nowell, PJ Richards, S Horiuchi, N Yamamoto, S Rose-John, N Topley, AS Williams, SA Jones |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential
JH der Thüsen, J Kuiper, TJ Berkel, EA Biessen |
Pharmacological reviews | 2003 |
Role of soluble gp130 in the tumour necrosis factor-alpha expression and its production by peripheral blood mononuclear cells
E Jablonskaca, W Puzewska, M Marcinczyk, J Jablonski |
Mediators of Inflammation | 2003 |
The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover
PK Wong, IK Campbell, PJ Egan, M Ernst, IP Wicks |
Arthritis & Rheumatism | 2003 |
The potential role of peroxisome proliferator–activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis
J Plutzky |
The American Journal of Cardiology | 2003 |
Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3
U Eriksson, MO Kurrer, N Schmitz, SC Marsch, A Fontana, HP Eugster, M Kopf |
Circulation | 2003 |
Interleukin-11 and Interleukin-6 Protect Cultured Human Endothelial Cells from H 2 O 2 -Induced Cell Death
AB Waxman, K Mahboubi, RG Knickelbein, LL Mantell, N Manzo, JS Pober, JA Elias |
American journal of respiratory cell and molecular biology | 2003 |
Effect of soluble interleukin-6 receptor alpha and interleukin-6 secreted by polymorphonuclear leukocytes on tumor necrosis factor-alpha expression and its production by peripheral blood mononuclear cells
E Jablonska |
Mediators of Inflammation | 2002 |
Production of growth related oncogene protein-α in human umbilical vein endothelial cells stimulated with soluble interleukin-6 receptor-α: role of signal transducers, janus kinase 2 and mitogen-activated kinase kinase
T Matsumiya, T Imaizumi, H Itaya, T Shibata, H Yoshida, H Sakaki, H Kimura, K Satoh |
Life Sciences | 2002 |
Soluble Interleukin 6 Receptor (sIL-6R) Mediates Colonic Tumor Cell Adherence to the Vascular Endothelium: A Mechanism for Metastatic Initiation?
JF Dowdall, DC Winter, E Andrews, WE Laug, JH Wang, HP Redmond |
Journal of Surgical Research | 2002 |
The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex
D Aasland, B Oppmann, J Grötzinger, S Rose-John, KJ Kallen |
Journal of Molecular Biology | 2002 |
The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex
SA Jones, S Rose-John |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2002 |
The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases
Karl-Josef Kallen |
Biochimica et Biophysica Acta | 2002 |
Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein
S Verma, SH Li, MV Badiwala, RD Weisel, PW Fedak, RK Li, B Dhillon, DA Mickle |
Circulation | 2002 |
A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain Polyunsaturated Fatty Acids
UN Das |
2002 | |
Mediators of Acute Lung Injury: A Review
JM Sethi, AB Waxman |
Clinical Pulmonary Medicine | 2001 |
Is obesity an inflammatory condition?
UN Das |
Nutrition | 2001 |
IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation
SM Hurst, TS Wilkinson, RM McLoughlin, S Jones, S Horiuchi, N Yamamoto, S Rose-John, GM Fuller, N Topley, SA Jones |
Immunity | 2001 |
Soluble Interleukin-6 Receptor α Inhibits the Cytokine-Induced Fractalkine/CX3CL1 Expression in Human Vascular Endothelial Cells in Culture
T Matsumiya, T Imaizumi, K Fujimoto, X Cui, T Shibata, W Tamo, M Kumagai, K Tanji, H Yoshida, H Kimura, K Satoh |
Experimental Cell Research | 2001 |
SIGNALING THROUGH CD31 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS:
PC Evans, ER Taylor, PJ Kilshaw |
Transplantation | 2001 |
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
SA Jones, S Horiuchi, N Topley, N Yamamoto, GM Fuller |
The FASEB Journal | 2001 |
Physiology of Inflammation
K Ley |
2001 | |
Involvement of IL-6, Apart from Its Role in Immunity, in Mediating a Chronic Response during Experimental Arthritis
AS de Hooge, FA van de Loo, OJ Arntz, WB van Berg |
The American Journal of Pathology | 2000 |
Polymorphonuclears: structure, function, and mechanisms of involvement in skin diseases
P Driesch |
Clinics in Dermatology | 2000 |
URINARY SOLUBLE IL-6 RECEPTOR LEVELS AFTER CARDIOPULMONARY BYPASS
AG Sutherland, DJ Deehan |
Cytokine | 2000 |
Cytokine signaling-regulation of the immune response in normal and critically ill states:
A Oberholzer, C Oberholzer, LL Moldawer |
Critical Care Medicine | 2000 |
INTERLEUKIN-13 PROTECTS ENDOTHELIAL CELLS FROM APOPTOSIS AND ACTIVATION: Association with the Protective Genes A20 and A1
PC Evans, PJ Kilshaw |
Transplantation | 2000 |
Cellular Mechanisms in Airways Inflammation
CP Page, KH Banner, D Spina |
2000 | |
Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum–infected erythrocytes to microvascular endothelial cells under flow
BG Yipp, S Anand, T Schollaardt, KD Patel, S Looareesuwan, M Ho |
Blood | 2000 |
New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?
KJ Kallen, PR Galle, S Rose-John |
Expert Opinion on Investigational Drugs | 1999 |
C-reactive protein: a physiological activator of interleukin 6 receptor shedding
SA Jones, D Novick, S Horiuchi, N Yamamoto, AJ Szalai, GM Fuller |
Journal of Experimental Medicine | 1999 |
Selective Proteolytic Cleavage of IL-2 Receptor and IL-6 Receptor Ligand Binding Chains by Neutrophil-Derived Serine Proteases at Foci of Inflammation
U Bank, D Reinhold, C Schneemilch, D Kunz, HJ Synowitz, S Ansorge |
Journal of Interferon & Cytokine Research | 1999 |
Interleukin-6 expression and regulation in astrocytes
NJ van Wagoner, EN Benveniste |
Journal of Neuroimmunology | 1999 |
Adhesion molecule expression and regulation on cells of the central nervous system
SJ Lee, EN Benveniste |
Journal of Neuroimmunology | 1999 |
Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors
P März, U Otten, S Rose-John |
European Journal of Neuroscience | 1999 |
C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding
SA Jones, D Novick, S Horiuchi, N Yamamoto, AJ Szalai, GM Fuller |
Journal of Experimental Medicine | 1999 |
Divergent inducible expression of P-selectin and E-selectin in mice and primates
L Yao, H Setiadi, L Xia, Z Laszik, FB Taylor, RP McEver |
Blood | 1999 |
Endothelial Activation in ARDS
GA Zimmerman, KH Albertine, HJ Carveth, EA Gill, CK Grissom, JR Hoidal, T Imaizumi, CG Maloney, TM McIntyre, JR Michael, JF Orme, SM Prescott, MS Topham |
Chest | 1999 |
Biology of the Arterial Wall
BI Levy, A Tedgui |
1999 | |
Cytokine Actions in the Central Nervous System
EN Benveniste |
Cytokine & Growth Factor Reviews | 1998 |
Shedding of the soluble IL-6 receptor is triggered by Ca2+ mobilization, while basal release is predominantly the product of differential mRNA splicing in THP-1 cells
SA Jones, S Horiuchi, D Novick, N Yamamoto, GM Fuller |
European Journal of Immunology | 1998 |