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Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation.

R Sehmi, … , P M O'Byrne, J A Denburg

R Sehmi, … , P M O'Byrne, J A Denburg

Published November 15, 1997
Citation Information: J Clin Invest. 1997;100(10):2466-2475. https://doi.org/10.1172/JCI119789.

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Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells JW Upham, R Sehmi, LM Hayes, K Howie, J Lundahl, JA Denburg	Journal of Allergy and Clinical Immunology	2002
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Systemic aspects of allergic disease: the role of the bone marrow MM Cyr, JA Denburg	Current Opinion in Immunology	2001
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Lung Biology in Health and Disease: Pathogenesis and Clinical Management R Ballard	Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential	2001
In Vitro and In Vivo Inhibition of Interleukin (IL)-5–Mediated Eosinopoiesis by Murine IL-5R α Antisense Oligonucleotide E Lach-Trifilieff, RA McKay, BP Monia, JG Karras, C Walker	American journal of respiratory cell and molecular biology	2001
An Increase in Circulating Mast Cell Colony-Forming Cells in Asthma HH Mwamtemi, K Koike, T Kinoshita, S Ito, S Ishida, Y Nakazawa, Y Kurokawa, K Shinozaki, K Sakashita, K Takeuchi, M Shiohara, T Kamijo, Y Yasui, A Ishiguro, Y Kawano, K Kitano, H Miyazaki, T Kato, S Sakuma, A Komiyama	Journal of immunology (Baltimore, Md. : 1950)	2001
Mechanisms of eosinophil-associated inflammation GJ Gleich	Journal of Allergy and Clinical Immunology	2000
IL-5: biology and potential therapeutic applications JK Weltman, AS Karim	Expert Opinion on Investigational Drugs	2000
Molecular pathology of allergic disease I: Lower airway disease QA Hamid, EM Minshall	Journal of Allergy and Clinical Immunology	2000
Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin E(2) MI Elsas, D Joseph, L Lintomen, ES Maximiano, M Bodstein, PX Elsas, BB Vargaftig	British Journal of Pharmacology	2000
Haemopoietic mechanisms in nasal polyposis and asthma JA Denburg	Thorax	2000
Selective upregulation of a functional beta7 integrin on differentiating eosinophils J Lundahl, R Sehmi, L Hayes, K Howie, JA Denburg	Allergy	2000
Role for cysteinyl leukotriene receptor antagonist therapy in asthma and their potential role in allergic rhinitis based on the concept of “one linked airway disease” EO Meltzer	Annals of Allergy Asthma & Immunology	2000
Eosinophilopoiesis J Denburg	Respiratory Medicine	2000
IL-5 production by bone marrow stromal cells: Implications for eosinophilia associated with asthma MB Hogan, D Piktel, KS Landreth	Journal of Allergy and Clinical Immunology	2000
Molecular pathology of allergic disease P Christodoulopoulos, L Cameron, S Durham, Q Hamid	Journal of Allergy and Clinical Immunology	2000
Systemic activation of basophils and eosinophils: Markers and consequences BS Bochner	Journal of Allergy and Clinical Immunology	2000
Recruitment of T cells to the lung in response to antigen challenge QA Hamid, LA Cameron	Journal of Allergy and Clinical Immunology	2000
Systemic aspects of allergic disease: Bone marrow responses JA Denburg, R Sehmi, H Saito, J Pil-Seob, MD Inman, PM O’Byrne	Journal of Allergy and Clinical Immunology	2000
The effects of inhaled budesonide on circulating eosinophil progenitors and their expression of cytokines after allergen challenge in subjects with atopic asthma GM Gauvreau, LJ Wood, R Sehmi, RM Watson, SC Dorman, RP Schleimer, JA Denburg, PM O'Byrne	American journal of respiratory and critical care medicine	2000
Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils AS Gounni, B Gregory, E Nutku, F Aris, K Latifa, E Minshall, J North, J Tavernier, R Levit, N Nicolaides, D Robinson, Q Hamid	Blood	2000
Engagement of the CrkL Adapter in Interleukin-5 Signaling in Eosinophils J Du, YM Alsayed, F Xin, SJ Ackerman, LC Platanias	The Journal of biological chemistry	2000
Evidence for Local Eosinophil Differentiation Within Allergic Nasal Mucosa: Inhibition with Soluble IL-5 Receptor L Cameron, P Christodoulopoulos, F Lavigne, Y Nakamura, D Eidelman, A McEuen, A Walls, J Tavernier, E Minshall, R Moqbel, Q Hamid	Journal of immunology (Baltimore, Md. : 1950)	2000
Eosinophilopoiesis in A Murine Model of Allergic Airway Eosinophilia: Involvement of Bone Marrow IL-5 and IL-5 Receptor α M Tomaki, LL Zhao, J Lundahl, M Sjöstrand, M Jordana, A Lindén, P OByrne, J Lötvall	Journal of immunology (Baltimore, Md. : 1950)	2000
Interleukin 5 regulates the isoform expression of its own receptor α-subunit J Tavernier, JV der Heyden, A Verhee, G Brusselle, XV Ostade, J Vandekerckhove, J North, SM Rankin, AB Kay, DS Robinson	Blood	2000
Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from patients with atopic asthma compared with atopic and nonatopic control subjects K Zeibecoglou, S Ying, T Yamada, J North, J Burman, J Bungre, Q Meng, AB Kay, DS Robinson	Journal of Allergy and Clinical Immunology	1999
Increased progenitor cell proliferation in the peripheral blood of patients with bronchial asthma: The role of nitric oxide CH Wang, WY Hsieh, LY Shih, HC Lin, CY Liu, KF Chung, HP Kuo	Journal of Allergy and Clinical Immunology	1999
Cytokines in asthma KF Chung, PJ Barnes	Thorax	1999
Interleukin-5 and allergic inflammation OB yrne, W ood	Clinical & Experimental Allergy	1999
The nose, the lung and the bone marrow in allergic inflammation J Denburg	Allergy	1999
Allergen challenge primes for IL-5 mRNA production and abrogates beta-adrenergic function in peripheral blood T lymphocytes from asthmatics BORGER, JONKER, VELLENGA, POSTMA, DE MONCHY, KAUFFMAN	Clinical & Experimental Allergy	1999
Interaction between haemopoietic regulation and airway inflammation PM O'byrne, GM Gauvreau, LJ Wood	Clinical & Experimental Allergy	1999
Bone marrow in atopy and asthma: hematopoietic mechanisms in allergic inflammation JA Denburg	Immunology Today	1999
An inhaled corticosteroid, budesonide, reduces baseline but not allergen-induced increases in bone marrow inflammatory cell progenitors in asthmatic subjects LJ Wood, R Sehmi, GM Gauvreau, RM Watson, R Foley, JA Denburg, PM O'byrne	American journal of respiratory and critical care medicine	1999
CD34 + /Interleukin-5R α Messenger RNA + Cells in the Bronchial Mucosa in Asthma: Potential Airway Eosinophil Progenitors DS Robinson, R Damia, K Zeibecoglou, S Molet, J North, T Yamada, AB Kay, Q Hamid	American journal of respiratory cell and molecular biology	1999
Allergic Networks Regulating Eosinophilia PS Foster	American journal of respiratory cell and molecular biology	1999
Immunolocalization of CD34 in Nasal Polyposis: Effect of Topical Corticosteroids YK Kim, M Uno, DL Hamilos, L Beck, B Bochner, R Schleimer, JA Denburg	American journal of respiratory cell and molecular biology	1999
Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia J Wang, K Palmer, J Lŏtvall, S Milan, XF Lei, KI Matthaei, J Gauldie, MD Inman, M Jordana, Z Xing	Journal of Clinical Investigation	1998
Hemopoietic progenitors and cytokines in allergic inflammation JA Denburg	Allergy	1998
Pharmacologic modulation of airway inflammation PM O'Byrne, GM Gauvreau, LJ Wood	Allergy	1998
Inhibition by the anti-mitotic drug doxorubicin of platelet-activating-factor-induced late eosinophil accumulation in rats S Perez, J Machado, R Cordeiro, M Martins, R Borojevic, P Silva	European Journal of Pharmacology	1998
Enhanced Expression of GM-CSF in Differentiating Eosinophils of Atopic and Atopic Asthmatic Subjects GM Gauvreau, PM O'Byrne, R Moqbel, J Velazquez, RM Watson, KJ Howie, JA Denburg	American journal of respiratory cell and molecular biology	1998
The mechanism of IL-5 signal transduction T Adachi, R Alam	American journal of physiology. Cell physiology	1998

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