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Citations to this article

HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.
M Roederer, … , L A Herzenberg, L A Herzenberg
M Roederer, … , L A Herzenberg, L A Herzenberg
Published April 1, 1997
Citation Information: J Clin Invest. 1997;99(7):1555-1564. https://doi.org/10.1172/JCI119318.
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HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.

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Abstract

In this report, we demonstrate that the T cell tropic strain of HIV, LAI, does not replicate in naive CD4 T cells stimulated by cross-linking CD3 and CD28. In contrast, LAI replicates well in memory CD4 T cells stimulated in the same way. Unlike this physiologically relevant stimulation, PHA stimulates productive LAI replication in both naive and memory T cells. These studies were conducted with highly purified (FACS-isolated) subsets of CD4 T cells identified by expression of both CD45RA and CD62L. Remixing of purified T cells showed that naive T cells do not suppress LAI replication in memory T cells and that memory T cells do not restore LAI expression in naive T cells. The suppression of productive LAI replication in naive T cells is not due to differential expression of viral coreceptors, nor is it due to inhibition of activation of the important HIV transcription factors, nuclear factor-kappaB and activator protein-1. The inherent resistance of naive T cells to productive HIV infection, coupled with their proliferative advantage as demonstrated here, provides a sound basis for proposed clinical therapies using ex vivo expansion and reinfusion of CD4 T cells from HIV-infected adults.

Authors

M Roederer, P A Raju, D K Mitra, L A Herzenberg, L A Herzenberg

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Year: 2020 2018 2016 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 Total
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