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Citations to this article

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.
I Miyajima, … , J P Kinet, S J Galli
I Miyajima, … , J P Kinet, S J Galli
Published March 1, 1997
Citation Information: J Clin Invest. 1997;99(5):901-914. https://doi.org/10.1172/JCI119255.
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Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

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Abstract

We attempted to elicit active anaphylaxis to ovalbumin, or passive IgE- or IgG1-dependent anaphylaxis, in mice lacking either the Fc epsilonRI alpha chain or the FcR gamma chain common to Fc epsilonRI and Fc gammaRI/III, or in mice lacking mast cells (KitW/ KitW-v mice), and compared the responses to those in the corresponding wild-type mice. We found that the FcR gamma chain is required for the death, as well as for most of the pathophysiological changes, associated with active anaphylaxis or IgE- or IgG1-dependent passive anaphylaxis. Moreover, some of the physiological changes associated with either active, or IgG1-dependent passive, anaphylactic responses were significantly greater in Fc epsilonRI alpha chain -/- mice than in the corresponding normal mice. Finally, while both KitW/KitW-v and congenic +/+ mice exhibited fatal active anaphylaxis, mast cell-deficient mice exhibited weaker physiological responses than the corresponding wild-type mice in both active and IgG1-dependent passive systemic anaphylaxis. Our findings strongly suggest that while IgE antibodies and Fc epsilonRI may influence the intensity and/or kinetics of some of the pathophysiological changes associated with active anaphylaxis in the mouse, the mortality associated with this response can be mediated largely by IgG1 antibodies and Fc gammaRIII.

Authors

I Miyajima, D Dombrowicz, T R Martin, J V Ravetch, J P Kinet, S J Galli

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LM Bartnikas, MF Gurish, OT Burton, S Leisten, E Janssen, HC Oettgen, J Beaupré, CN Lewis, KF Austen, S Schulte, JL Hornick, RS Geha, MK Oyoshi
Journal of Allergy and Clinical Immunology 2013
Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice
LL Reber, T Marichal, K Mukai, Y Kita, SM Tokuoka, A Roers, K Hartmann, H Karasuyama, KC Nadeau, M Tsai, SJ Galli
Journal of Allergy and Clinical Immunology 2013
A beneficial role for immunoglobulin E in host defense against honeybee venom
T Marichal, P Starkl, LL Reber, J Kalesnikoff, HC Oettgen, M Tsai, M Metz, SJ Galli
Immunity 2013
Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis
MV Khodoun, ZY Kucuk, RT Strait, D Krishnamurthy, K Janek, CD Clay, SC Morris, FD Finkelman
Journal of Allergy and Clinical Immunology 2013
Protective and pathological roles of mast cells and basophils
D Voehringer
Nature Reviews Immunology 2013
Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica
J Ratelade, N Asavapanumas, AM Ritchie, S Wemlinger, JL Bennett, AS Verkman
Acta Neuropathologica 2013
IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis: Cellular immune response
W Lübben, A Turqueti-Neves, A Okhrimenko, C Stöberl, V Schmidt, K Pfeffer, S Dehnert, S Wünsche, S Storsberg, S Paul, S Bauer, G Riethmüller, D Voehringer, P Yu
European Journal of Immunology 2013
Immune response phenotype of allergic versus clinically tolerant pigs in a neonatal swine model of allergy
J Schmied, P Rupa, S Garvie, B Wilkie
Veterinary Immunology and Immunopathology 2013
Assessment of the respiratory sensitization potential of proteins using an enhanced mouse intranasal test (MINT)
SM Krieger, DR Boverhof, MR Woolhiser, JA Hotchkiss
Food and Chemical Toxicology 2013
A BALB/c mouse model for assessing the potential allergenicity of proteins: comparison of allergen dose, sensitization frequency, timepoint and sex
C Chen, N Sun, Y Li, X Jia
Food and Chemical Toxicology 2013
Current challenges and opportunities in nonclinical safety testing of biologics
S Kronenberg, A Baumann, L Haan, HJ Hinton, J Moggs, FP Theil, I Wakefield, T Singer
Drug Discovery Today 2013
An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis
JS Zhou, A Sandomenico, V Severino, OT Burton, A Darling, HC Oettgen, M Ruvo
Molecular BioSystems 2013
Antiallergic and Antiarthritic Effects of Stem Bark Extract of Glyphaea brevis (Spreng) Monachino (Tiliaceae) in Murine Models
DD Obiri, N Osafo, RE Abotsi
ISRN Pharmacology 2013
IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection
M Matsumoto, Y Sasaki, K Yasuda, T Takai, M Muramatsu, T Yoshimoto, K Nakanishi, JF Urban
Infection and immunity 2013
Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?
MA Brown, JK Hatfield
Frontiers in immunology 2012
Mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis
M Costanza, MP Colombo, R Pedotti
International journal of molecular sciences 2012
Mast Cells and Company
F Jönsson, M Daëron
Frontiers in immunology 2012
New models for analyzing mast cell functions in vivo
LL Reber, T Marichal, SJ Galli
Trends in Immunology 2012
Properties of mouse and human IgG receptors and their contribution to disease models
P Bruhns
Blood 2012
Intestinal Mast Cell Levels Control Severity of Oral Antigen-Induced Anaphylaxis in Mice
R Ahrens, H Osterfeld, D Wu, CY Chen, M Arumugam, K Groschwitz, R Strait, Y Wang, FD Finkelman, SP Hogan
The American Journal of Pathology 2012
Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity
SP Hogan, YH Wang, R Strait, FD Finkelman
Seminars in Immunopathology 2012
Fcγ Receptors Inhibit Mouse and Human Basophil Activation
L Cassard, F Jönsson, S Arnaud, M Daëron
Journal of immunology (Baltimore, Md. : 1950) 2012
The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
JW Williams, MY Tjota, AI Sperling
Journal of allergy 2012
Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma
SK Norton, DS Wijesinghe, A Dellinger, J Sturgill, Z Zhou, S Barbour, C Chalfant, DH Conrad, CL Kepley
Journal of Allergy and Clinical Immunology 2012
Human FcγRIIA induces anaphylactic and allergic reactions
F Jönsson, DA Mancardi, W Zhao, Y Kita, B Iannascoli, H Khun, N Rooijen, T Shimizu, LB Schwartz, M Daëron, P Bruhns
Blood 2012
CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; Part II : CD 200/CD200R Potential Clinical Applications
D Holmannová, M Koláčková, K Kondělková, P Kuneš, J Krejsek, C Andrýs
Acta Medica (Hradec Kralove, Czech Republic) 2012
Human Fc RIIA at center stage
T Kawakami
Blood 2012
The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling
NA Pullen, YT Falanga, JK Morales, JJ Ryan
Frontiers in immunology 2012
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis
YT Falanga, NS Chaimowitz, N Charles, FD Finkelman, NA Pullen, S Barbour, K Dholaria, T Faber, M Kolawole, B Huang, S Odom, J Rivera, J Carlyon, DH Conrad, S Spiegel, CA Oskeritzian, JJ Ryan
Journal of immunology (Baltimore, Md. : 1950) 2012
Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction
MA Nader
Inflammopharmacology 2012
Anti-allergic effect of a chloroform-soluble extract of <i>Cinnamomum cambodianum</i> in bone marrow-derived mast cells
HS Chae, P Khiev, HK Lee, SR Oh, YW Chin
Immunopharmacology and Immunotoxicology 2012
Anti-allergic effects of nilotinib on mast cell–mediated anaphylaxis like reactions
DS El-Agamy
European Journal of Pharmacology 2012
Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate
T Shindo, Y Kanazawa, Y Saito, K Kojima, M Ohsawa, R Teshima
The Journal of Toxicological Sciences 2012
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction
G Jin, T Matsushita, Y Hamaguchi, DL Huu, T Ishii, M Hasegawa, K Obata, H Karasuyama, K Takehara, M Fujimoto
Journal of Dermatological Science 2012
Mast cells and IgE activation do not alter the development of oral tolerance in a murine model
MC Tunis, W Dawicki, KR Carson, J Wang, JS Marshall
Journal of Allergy and Clinical Immunology 2012
Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells
HH Song, HS Chae, SR Oh, HK Lee, YW Chin
The American journal of Chinese medicine 2012
Les IgG, leurs récepteurs et les neutrophiles : acteurs de la réaction anaphylactique ?
P Bruhns
Revue Française d'Allergologie 2012
Comparisons of serum total IgE, IgG, and IgG1 levels in patients with and without echinococcosis-induced anaphylactic shock
Y Li, H Zheng, M Gu, X Cao, H Wen, Z Liu, T Liu
The American journal of tropical medicine and hygiene 2012
The role of sphingosine 1-phosphate in immunity and sepsis
MH Gräler
American Journal of Clinical and Experimental Immunology 2012
Neutrophils as Inducers of Anaphylaxis
Friederike Jönsson, David A. Mancardi, Yoshihiro Kita, Hajime Karasuyama, Bruno Iannascoli, Nico van Rooijen, Takao Shimizu, Marc Daëron, Pierre Bruhns
Journal of Clinical Investigation 2011
Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis
MV Khodoun, R Strait, L Armstrong, N Yanase, FD Finkelman
Proceedings of the National Academy of Sciences 2011
Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases
OT Burton, HC Oettgen
Immunological Reviews 2011
Mast Cells as Cellular Sensors in Inflammation and Immunity
W Beghdadi, LC Madjene, M Benhamou, N Charles, G Gautier, P Launay, U Blank
Frontiers in immunology 2011
Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria
A Porcherie, C Mathieu, R Peronet, E Schneider, J Claver, PH Commere, H Kiefer-Biasizzo, H Karasuyama, G Milon, M Dy, JP Kinet, J Louis, U Blank, S Mécheri
Journal of Experimental Medicine 2011
Antigen-fixed leukocytes tolerize Th2 responses in mouse models of allergy
CB Smarr, CL Hsu, AJ Byrne, SD Miller, PJ Bryce
Journal of immunology (Baltimore, Md. : 1950) 2011
Basophils Are the Major Producers of IL-4 during Primary Helminth Infection
N van Panhuys, M Prout, E Forbes, B Min, WE Paul, GL Gros
Journal of immunology (Baltimore, Md. : 1950) 2011
Nonredundant Roles of Basophils in Immunity
H Karasuyama, K Mukai, K Obata, Y Tsujimura, T Wada
Annual Review of Immunology 2011
[An unexpected role for neutrophils in anaphylaxis]
F Jönsson, DA Mancardi, M Daëron, P Bruhns
médecine/sciences 2011
Neutrophils give us a shock
CA Lowell
Journal of Clinical Investigation 2011
Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm
J Manikandan, N Kothandaraman, MP Hande, PN Pushparaj
Cellular and Molecular Life Sciences 2011
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice
K Arias, DK Chu, K Flader, F Botelho, T Walker, N Arias, AA Humbles, AJ Coyle, HC Oettgen, HD Chang, NV Rooijen, S Waserman, M Jordana
Journal of Allergy and Clinical Immunology 2011
Newly appreciated roles for basophils in allergy and protective immunity
H Karasuyama, K Obata, T Wada, Y Tsujimura, K Mukai
Allergy 2011
Mesenteric lymph node transcriptome profiles in BALB/c mice sensitized to three common food allergens
M Husain, HJ Boermans, NA Karrow
BMC Genomics 2011
Environmental cigarette smoke exposure modulates IgE levels of Pb-exposed children
PM Lutz, EA Kelty, TD Brown, TJ Wilson, G Brock, R Neal
Toxicology 2011
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee
Annual Reports in Medicinal Chemistry Volume 46 2011
Effects of Lactobacillus rhamnosus GG supplementation on cow's milk allergy in a mouse model
CL Thang, B Baurhoo, JI Boye, BK Simpson, X Zhao
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2011
Demographic and Clinical Characteristics of Patients with Anaphylactic Shock after Surgery for Cystic Echinococcosis
Y Li, X Cao, L Chen, H Zheng, Z Liu
The American journal of tropical medicine and hygiene 2011
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock
Ana Olivera, Christoph Eisner, Yoshiaki Kitamura, Sandra Dillahunt, Laura Allende, Galina Tuymetova, Wendy Watford, Francoise Meylan, Susanne Diesner, Lingli Li, Jurgen Schnermann, Richard Proia, Juan Rivera
Journal of Clinical Investigation 2010
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions
K Hitomi, S Tahara-Hanaoka, S Someya, A Fujiki, H Tada, T Sugiyama, S Shibayama, K Shibuya, A Shibuya
Nature Immunology 2010
IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling
CB Mathias, SA Hobson, M Garcia-Lloret, G Lawson, D Poddighe, EJ Freyschmidt, W Xing, MF Gurish, TA Chatila, HC Oettgen
Journal of Allergy and Clinical Immunology 2010
Basophils and the T helper 2 environment can promote the development of lupus nephritis
N Charles, D Hardwick, E Daugas, GG Illei, J Rivera
Nature Medicine 2010
PAS-1, an Ascaris suum Protein, Modulates Allergic Airway Inflammation via CD8+ γδTCR+ and CD4+ CD25+ FoxP3+ T Cells
CA de Araújo, A Perini, MA Martins, MS Macedo, MF Macedo-Soares
Scandinavian Journal of Immunology 2010
Murine B cells regulate serum IgE levels in a CD23-dependent manner
LE Cheng, ZE Wang, RM Locksley
Journal of immunology (Baltimore, Md. : 1950) 2010
Inhibitory effect of glycoprotein isolated from Opuntia ficus-indica var. saboten MAKINO on activities of allergy-mediators in compound 48/80-stimulated mast cells
KT Lim
Cellular Immunology 2010
IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen
R Ishikawa, Y Tsujimura, K Obata, Y Kawano, Y Minegishi, H Karasuyama
Biochemical and Biophysical Research Communications 2010
Forsythia suspensa extract alleviates hypersensitivity induced by soybean β-conglycinin in weaned piglets
Y Hao, D Li, X Piao, X Piao
Journal of Ethnopharmacology 2010
Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops
GS Ladics, LM Knippels, AH Penninks, GA Bannon, RE Goodman, C Herouet-Guicheney
Regulatory Toxicology and Pharmacology 2010
Anaphylaxis and Hypersensitivity Reactions
MC Castells
2010
Suppression of IgE B Cells and IgE Binding to Fc RI by Gene Therapy with Single-Chain Anti-IgE
T Ota, M Aoki-Ota, BH Duong, D Nemazee
Journal of immunology (Baltimore, Md. : 1950) 2009
Co-operation between mast cells and neurons is essential for antigen-mediated bronchoconstriction1
JM Cyphert, M Kovarova, IC Allen, JM Hartney, DL Murphy, J Wess, BH Koller
Journal of immunology (Baltimore, Md. : 1950) 2009
Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy
N Schmitz, K Dietmeier, M Bauer, M Maudrich, S Utzinger, S Muntwiler, P Saudan, MF Bachmann
Journal of Experimental Medicine 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
IgE Influences the Number and Function of Mature Mast Cells, but Not Progenitor Recruitment in Allergic Pulmonary Inflammation
CB Mathias, EJ Freyschmidt, B Caplan, T Jones, D Poddighe, W Xing, KL Harrison, MF Gurish, HC Oettgen
Journal of immunology (Baltimore, Md. : 1950) 2009
Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction
K Nishida, A Hasegawa, S Nakae, K Oboki, H Saito, S Yamasaki, T Hirano
Journal of Experimental Medicine 2009
Rheumatoid Arthritis
IA Ku, JB Imboden, PY Hsue, P Ganz
Circulation Journal 2009
Mechanisms of mast cell signaling in anaphylaxis
DD Metcalfe, RD Peavy, AM Gilfillan
Journal of Allergy and Clinical Immunology 2009
Newly discovered roles for basophils: a neglected minority gains new respect
H Karasuyama, K Mukai, Y Tsujimura, K Obata
Nature Reviews Immunology 2009
Inhibition of allergic responses by CD40 gene silencing
M Suzuki, X Zheng, X Zhang, TE Ichim, H Sun, N Kubo, M Beduhn, A Shunnar, B Garcia, WP Min
Allergy 2009
Anaphylaxis to a self-peptide in the absence of mast cells or histamine
S Musio, P Pedotti, R Mantegazza, H Ohtsu, L Boon, L Steinman, SJ Galli, R Pedotti
Laboratory Investigation 2009
Mast Cells
HP Kiener, PA Nigrovic, DM Lee
Rheumatoid Arthritis 2009
Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model
SH Kim, SB Park, SM Kang, H Jeon, JP Lim, TK Kwon, WH Park, HM Kim, TY Shin
Food and Chemical Toxicology 2009
Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses
B Wagner, WH Miller, HN Erb, DP Lunn, DF Antczak
Veterinary Immunology and Immunopathology 2009
Middleton's Allergy: Principles and Practice
RP Schleimer
Middleton's Allergy: Principles and Practice 2009
Kelley's Textbook of Rheumatology
J Degroot, AM Zuurmond, PP Tak
Kelley's Textbook of Rheumatology 2009
Importance of basophil activation testing in insect venom allergy
M Kosnik, P Korosec
Allergy Asthma & Clinical Immunology 2009
Ailanthus altissima swingle has anti-anaphylactic effect and inhibits inflammatory cytokine expression via suppression of nuclear factor-kappaB activation
TH Kang, IY Choi, SJ Kim, PD Moon, JU Seo, JJ Kim, NH An, SH Kim, MH Kim, JY Um, SH Hong, HM Kim, HJ Jeong
In vitro cellular & developmental biology. Animal 2009
Cancer and IgE
ML Penichet, E Jensen-Jarolim
2009
CD4+CD25+ regulatory T cells specific for a thymus-expressed antigen prevent the development of anaphylaxis to self
S Scabeni, M Lapilla, S Musio, B Gallo, E Ciusani, L Steinman, R Mantegazza, R Pedotti
Journal of immunology (Baltimore, Md. : 1950) 2008
IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
EE Forbes, K Groschwitz, JP Abonia, EB Brandt, E Cohen, C Blanchard, R Ahrens, L Seidu, A McKenzie, R Strait, FD Finkelman, PS Foster, KI Matthaei, ME Rothenberg, SP Hogan
Journal of Experimental Medicine 2008
Sialic Acid Residues Are Essential for the Anaphylactic Activity of Murine IgG1 Antibodies
SR Silva, A Casabuono, JF Jacysyn, BC Favoretto, I Fernandes, MS Macedo, AS Couto, EL Faquim-Mauro
Journal of immunology (Baltimore, Md. : 1950) 2008
Using guinea pigs in studies relevant to asthma and COPD
BJ Canning, Y Chou
Pulmonary Pharmacology & Therapeutics 2008
VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways
N Tiwari, CC Wang, C Brochetta, G Ke, F Vita, Z Qi, J Rivera, MR Soranzo, G Zabucchi, W Hong, U Blank
Blood 2008
Basophils Play a Pivotal Role in Immunoglobulin-G-Mediated but Not Immunoglobulin-E-Mediated Systemic Anaphylaxis
Y Tsujimura, K Obata, K Mukai, H Shindou, M Yoshida, H Nishikado, Y Kawano, Y Minegishi, T Shimizu, H Karasuyama
Immunity 2008
FcγRIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitis
D Zeyrek, R Tanac, S Altinoz, A Berdeli, F Gulen, H Koksoy, E Demir
Pediatric Allergy and Immunology 2008
Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice
KC Medeiros, CA Figueiredo, TB Figueredo, KR Freire, FA Santos, NM Alcantara-Neves, TM Silva, MR Piuvezam
Journal of Ethnopharmacology 2008
Hypothesis: hemolytic transfusion reactions represent an alternative type of anaphylaxis
EA Hod, SA Sokol, JC Zimring, SL Spitalnik
International journal of clinical and experimental pathology 2008
Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection
K Shin, GF Watts, HC Oettgen, DS Friend, AD Pemberton, MF Gurish, DM Lee
Journal of immunology (Baltimore, Md. : 1950) 2008
Basophils Are Back!
SJ Galli, CB Franco
Immunity 2008
Basophils enhance immunological memory responses
A Denzel, UA Maus, MR Gomez, C Moll, M Niedermeier, C Winter, R Maus, S Hollingshead, DE Briles, LA Kunz-Schughart, Y Talke, M Mack
Nature Immunology 2008
High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice
D Shiva, T Matsumoto, MJ Kremenik, Y Kato, H Yano
Immunology Letters 2008
Novel vaccination for allergy through gene silencing of CD40 using small interfering RNA
M Suzuki, X Zheng, X Zhang, M Li, C Vladau, TE Ichim, H Sun, LR Min, B Garcia, WP Min
Journal of immunology (Baltimore, Md. : 1950) 2008
Dissociation of experimental allergic encephalomyelitis protective effect and allergic side reactions in tolerization with neuroantigen
FS Lichtenegger, S Kuerten, S Faas, BO Boehm, M Tary-Lehmann, PV Lehmann
Journal of immunology (Baltimore, Md. : 1950) 2007
Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
PA Nigrovic, BA Binstadt, PA Monach, A Johnsen, M Gurish, Y Iwakura, C Benoist, D Mathis, DM Lee
Proceedings of the National Academy of Sciences 2007
Mast cells in the promotion and limitation of chronic inflammation
M Metz, MA Grimbaldeston, S Nakae, AM Piliponsky, M Tsai, SJ Galli
Immunological Reviews 2007
Inhibitory Effects of Phyto Extract Mixture (PEM381) on Type I Allergic Reaction
KB Kim, EG Lee, OH Chai, CH Song, JM Jeong
Journal of the Korean Society of Food Science and Nutrition 2007
Effects of Phyto-Extract Mixture (PEM381) in Type I Allergic Reaction-Induced Mice
KB Kim, JS Park, JM Jeong
Journal of the Korean Society of Food Science and Nutrition 2007
Inhibition of pathologic inflammation by leukocyte Ig-like receptor B4 and related inhibitory receptors
HR Katz
Immunological Reviews 2007
Effects of Triterpenoid-Rich Extracts of <i>Ganoderma tsugae</i> on Airway Hyperreactivity and Th2 Responses in vivo
ML Chen, BF Lin
International Archives of Allergy and Immunology 2007
Role of mast cell degranulation in the neural correlates of the immediate allergic reaction in a murine model of asthma
FA Costa-Pinto, AS Basso, M Russo
Brain, Behavior, and Immunity 2007
Anaphylaxis: Lessons from mouse models
FD Finkelman
Journal of Allergy and Clinical Immunology 2007
Oral allergy syndrome and anaphylactic reactions in BALB/c mice caused by soybean glycinin and β-conglycinin
X Liu, J Feng, ZR Xu, YZ Wang, JX Liu
Clinical & Experimental Allergy 2007
Immunotherapy with CpG DNA conjugated with T-cell epitope peptide of an allergenic Cry j 2 protein is useful for control of allergic conditions in mice
M Suzuki, N Ohta, WP Min, T Matsumoto, R Min, X Zhang, K Toida, S Murakami
International Immunopharmacology 2007
Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes
SH Kim, S Lee, IK Kim, TK Kwon, JY Moon, WH Park, TY Shin
Food and Chemical Toxicology 2007
The FcγRIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitis
F Gulen, R Tanac, S Altinoz, A Berdeli, D Zeyrek, H Koksoy, E Demir
Clinical Biochemistry 2007
The roles of mast cells and Kupffer cells in rat systemic anaphylaxis
T Shibamoto, T Shimo, S Cui, W Zhang, H Takano, Y Kurata, H Tsuchida
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2007
Large defects of type I allergic response in telomerase reverse transcriptase knockout mice
A Ujike-Asai, A Okada, Y Du, M Maruyama, X Yuan, F Ishikawa, Y Motoo, K Isobe, H Nakajima
Journal of leukocyte biology 2007
Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses
J Sun, K Arias, D Alvarez, R Fattouh, T Walker, S Goncharova, B Kim, S Waserman, J Reed, AJ Coyle, M Jordana
Journal of immunology (Baltimore, Md. : 1950) 2007
CD4 + T Cell-Specific Deletion of IL-4 Receptor α Prevents Ovalbumin-Induced Anaphylaxis by an IFN-γ-Dependent Mechanism
N Nieuwenhuizen, DB Herbert, AL Lopata, F Brombacher
Journal of immunology (Baltimore, Md. : 1950) 2007
Mast cells can promote the development of multiple features of chronic asthma in mice
Mang Yu, Mindy Tsai, See-Ying Tam, Carol Jones, James Zehnder and Stephen J. Galli
Journal of Clinical Investigation 2006
Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses
MA Grimbaldeston, M Metz, M Yu, M Tsai, SJ Galli
Current Opinion in Immunology 2006
Critical Role of the Fc Receptor γ-Chain on APCs in the Development of Allergen-Induced Airway Hyperresponsiveness and Inflammation
K Kitamura, K Takeda, T Koya, N Miyahara, T Kodama, A Dakhama, T Takai, A Hirano, M Tanimoto, M Harada, EW Gelfand
Journal of immunology (Baltimore, Md. : 1950) 2006
Current Protocols in Pharmacology
JP Renninger
Current Protocols in Pharmacology 2006
A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses
CM Pucheu-Haston, D Shuster, T Olivry, P Brianceau, P Lockwood, T McClanahan, RW Malefyt, JD Mattson, B Hammerberg
Immunology 2006
Particularities of the vasculature can promote the organ specificity of autoimmune attack
BA Binstadt, PR Patel, H Alencar, PA Nigrovic, DM Lee, U Mahmood, R Weissleder, D Mathis, C Benoist
Nature Immunology 2006
Action of Dracocephalum argunense on Mast Cell-Mediated Allergy Model
SH Kim, SH Kim, SH Kim, JY Moon, WH Park, CH Kim, TY Shin
Biological & Pharmaceutical Bulletin 2006
Artemisia iwayomogiInhibits Immediate-Type Allergic Reaction and Inflammatory Cytokine Secretion
TY Shin, JS Park, SH Kim
Immunopharmacology and Immunotoxicology 2006
FcγRIIa, Not FcγRIIb, Is Constitutively and Functionally Expressed on Skin-Derived Human Mast Cells
W Zhao, CL Kepley, PA Morel, LM Okumoto, Y Fukuoka, LB Schwartz
Journal of immunology (Baltimore, Md. : 1950) 2006
Pathophysiology of Urticaria
A Hennino, F Bérard, I Guillot, N Saad, A Rozières, JF Nicolas
Clinical Reviews in Allergy & Immunology 2006
Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle
JP Abonia, DS Friend, WG Austen, FD Moore, MC Carroll, R Chan, J Afnan, A Humbles, C Gerard, P Knight, Y Kanaoka, S Yasuda, N Morokawa, KF Austen, RL Stevens, MF Gurish
Journal of immunology (Baltimore, Md. : 1950) 2005
Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis
CE Smith, TN Eagar, JL Strominger, SD Miller
Proceedings of the National Academy of Sciences 2005
Rapidly changing perspectives about mast cells at mucosal surfaces
H Vliagoftis, AD Befus
Immunological Reviews 2005
MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
SJ Galli, J Kalesnikoff, MA Grimbaldeston, AM Piliponsky, CM Williams, M Tsai
Annual Review of Immunology 2005
Elicitation of allergic asthma by immunoglobulin free light chains
AD Kraneveld, M Kool, AH van Houwelingen, P Roholl, A Solomon, DS Postma, FP Nijkamp, FA Redegeld
Proceedings of the National Academy of Sciences 2005
The allergy adjuvant effect of particles - genetic factors influence antibody and cytokine responses
UC Nygaard, A Aase, M Løvik
BMC Immunology 2005
Peanut-lupine antibody cross-reactivity is not associated to cross-allergenicity in peanut-sensitized mouse strains
A Lifrani, M Dubarry, M Rautureau, N Aattouri, PN Boyaka, D Tomé
International Immunopharmacology 2005
Dietary unripe apple polyphenol inhibits the development of food allergies in murine models
H Akiyama, Y Sato, T Watanabe, MH Nagaoka, Y Yoshioka, T Shoji, T Kanda, K Yamada, M Totsuka, R Teshima, J Sawada, Y Goda, T Maitani
FEBS Letters 2005
Comparison of asthma phenotypes using different sensitizing protocols in mice
YS Chang, YK Kim, JW Bahn, SH Kim, HW Park, TB Kim, SH Cho, KU Min, YY Kim
The Korean Journal of Internal Medicine 2005
Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice
YS Chang, YK Kim, JW Bahn, SH Kim, HW Park, TB Kim, SH Cho, KU Min, YY Kim
The Korean Journal of Internal Medicine 2005
Anti-Allergic Effects of Artemisia iwayomogi on Mast Cell-Mediated Allergy Model
SH Kim, CH Choi, SY Kim, JS Eun, TY Shin
Experimental biology and medicine (Maywood, N.J.) 2005
Amomum xanthiodes Inhibits Mast Cell-Mediated Allergic Reactions Through the Inhibition of Histamine Release and Inflammatory Cytokine Production
SH Kim, TY Shin
Experimental biology and medicine (Maywood, N.J.) 2005
Mast Cell Survival and Activation by IgE in the Absence of Antigen: A Consideration of the Biologic Mechanisms and Relevance
T Kawakami, J Kitaura
Journal of immunology (Baltimore, Md. : 1950) 2005
Identification of Antigen-Capturing Cells as Basophils
M Mack, MA Schneider, C Moll, J Cihak, H Brühl, JW Ellwart, MP Hogarth, M Stangassinger, D Schlöndorff
Journal of immunology (Baltimore, Md. : 1950) 2005
Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies
MF Macedo-Soares, DM Itami, C Lima, A Perini, EL Faquim-Mauro, MA Martins, MS Macedo
Journal of Allergy and Clinical Immunology 2004
WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells
A Kettner, L Kumar, IM Antón, Y Sasahara, M la Fuente, VI Pivniouk, H Falet, JH Hartwig, RS Geha
Journal of Experimental Medicine 2004
Allergen-independent immunostimulatory sequence oligodeoxynucleotide therapy attenuates experimental allergic rhinitis
CS Rhee, L Libet, D Chisholm, K Takabayashi, S Baird, TD Bigby, CH Lee, AA Horner, E Raz
Immunology 2004
Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis
NF Neel, BM Creasy, JN Rankin, EM Pierce, ME McCoy, RH Daner, JA Fowler, JC Daniel, CS Lantz
Immunology Letters 2004
Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
FD Finkelman, T Shea-Donohue, SC Morris, L Gildea, R Strait, KB Madden, L Schopf, JF Urban
Immunological Reviews 2004
Animal Models for the Study of Allergy
R Helm
Handbook of Laboratory Animal Science Second Edition Animal Models Volume III 2004
Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume III
R Helm
Handbook of Laboratory Animal Science, Second Edition: Animal Models, Volume III 2004
Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology, Third Edition
E Guigné, J Revuz, JC Roujeau
Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology, Third Edition 2004
Basophils initiate IL-4 production during a memory T-dependent response
MV Khodoun, T Orekhova, C Potter, S Morris, FD Finkelman
Journal of Experimental Medicine 2004
Mast Cell-Independent Mechanisms of Immediate Hypersensitivity: A Role for Platelets
DC Cara, KV Ebbert, DM McCafferty
Journal of immunology (Baltimore, Md. : 1950) 2004
The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity
D Artis, A Villarino, M Silverman, W He, EM Thornton, S Mu, S Summer, TM Covey, E Huang, H Yoshida, G Koretzky, M Goldschmidt, GD Wu, F de Sauvage, HR Miller, CJ Saris, P Scott, CA Hunter
Journal of immunology (Baltimore, Md. : 1950) 2004
Mast cells are required for experimental oral allergen-induced diarrhea
Eric B. Brandt, Richard T. Strait, Dan Hershko, Quan Wang, Emily E. Muntel, Troy A. Scribner, Nives Zimmermann, Fred D. Finkelman, Marc E. Rothenberg.
Journal of Clinical Investigation 2003
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus
R Pedotti, M Sanna, M Tsai, J DeVoss, L Steinman, H McDevitt, SJ Galli
BMC Immunology 2003
gammadelta T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation
L Svensson, B Lilliehöök, R Larsson, A Bucht
Immunology 2003
THEBIOLOGY OFIGEAND THEBASIS OFALLERGICDISEASE
HJ Gould, BJ Sutton, AJ Beavil, RL Beavil, N McCloskey, HA Coker, D Fear, L Smurthwaite
Annual Review of Immunology 2003
Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
R Pedotti, JJ DeVoss, S Youssef, D Mitchell, J Wedemeyer, R Madanat, H Garren, P Fontoura, M Tsai, SJ Galli, RA Sobel, L Steinman
Proceedings of the National Academy of Sciences 2003
Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases
R Pedotti, JJ de Voss, L Steinman, SJ Galli
Trends in Immunology 2003
IL-4 selectively enhances FcγRIII expression and signaling on mouse mast cells
HJ Chong, LA Bouton, DP Bailey, H Wright, C Ramirez, A Gharse, C Oskeritzian, HZ Xia, J Zhu, WE Paul, C Kepley, LB Schwartz, JJ Ryan
Cellular Immunology 2003
Animal Models of Allergen and Virus-Induced Asthma
J Schwarze, E Gelfand
Respiratory Infections in Allergy and Asthma 2003
Advances in mechanisms of allergy
BS Bochner, Q Hamid
Journal of Allergy and Clinical Immunology 2003
Lung Biology in Health and Disease
N Zamel
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential 2003
Evaluation of the immune response to CRA and FRA recombinant antigens of Trypanosoma cruzi in C57BL/6 mice
VR Pereira, VM de Lorena, M Nakazawa, AP da Silva, U Montarroyos, R Correa-Oliveira, Y de Miranda Gomes
Revista da Sociedade Brasileira de Medicina Tropical 2003
Cutting Edge: Both Activating and Inhibitory Fc Receptors Expressed on Mast Cells Regulate Experimental Allergic Encephalomyelitis Disease Severity
M Robbie-Ryan, MB Tanzola, VH Secor, MA Brown
Journal of immunology (Baltimore, Md. : 1950) 2003
IgE-Mediated Activation of NK Cells Through FcγRIII
N Arase, H Arase, S Hirano, T Yokosuka, D Sakurai, T Saito
Journal of immunology (Baltimore, Md. : 1950) 2003
Anti-Peptide Autoantibodies and Fatal Anaphylaxis with Insulin Self-Peptides B:9-23 and B:13-23
Edwin Liu, Hiroaki Moriyama, Norio Abiru, Dongmei Miao, Liping Yu, Robert M. Taylor, Fred D. Finkelman, George S. Eisenbarth
Journal of Clinical Investigation 2002
Cytokines Regulate Development of Human Mast Cells from Hematopoietic Progenitors
T Nakahata, H Toru
International Journal of Hematology 2002
Analyzing the Roles of Mast Cells and Basophils in Host Defense and Other Biological Responses
SJ Galli, J Wedemeyer, M Tsai
International Journal of Hematology 2002
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
C Lock, G Hermans, R Pedotti, A Brendolan, E Schadt, H Garren, A Langer-Gould, S Strober, B Cannella, J Allard, P Klonowski, A Austin, N Lad, N Kaminski, SJ Galli, JR Oksenberg, CS Raine, R Heller, L Steinman
Nature Medicine 2002
Inhibitory receptors and allergy
HR Katz
Current Opinion in Immunology 2002
FcγRI (CD64) Contributes Substantially to Severity of Arthritis, Hypersensitivity Responses, and Protection from Bacterial Infection
A Ioan-Facsinay, SJ Kimpe, SM Hellwig, PL Lent, FM Hofhuis, HH Ojik, C Sedlik, SA Silveira, J Gerber, YF Jong, R Roozendaal, LA Aarden, WB Berg, T Saito, D Mosser, S Amigorena, S Izui, GJ Ommen, M Vugt, JG de Winkel, JS Verbeek
Immunity 2002
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions
H Konishi, H Tsutsui, T Murakami, S Yumikura-Futatsugi, KI Yamanaka, M Tanaka, Y Iwakura, N Suzuki, K Takeda, S Akira, K Nakanishi, H Mizutani
Proceedings of the National Academy of Sciences 2002
Accumulation of platelets in the lung and liver and their degranulation following antigen-challenge in sensitized mice
A Yoshida, M Ohba, X Wu, T Sasano, M Nakamura, Y Endo
British Journal of Pharmacology 2002
Murine models for natural rubber latex allergy assessment
BJ Meade, M Woolhiser
Methods 2002
Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model
K Shida, R Takahashi, E Iwadate, K Takamizawa, H Yasui, T Sato, S Habu, S Hachimura, S Kaminogawa
Clinical & Experimental Allergy 2002
Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen
T Nakada, K Watanabe, T Matsumoto, K Santa, K Triizuka, T Hanawa
International Immunopharmacology 2002
Pathways of anaphylaxis in the mouse
RT Strait, SC Morris, M Yang, XW Qu, FD Finkelman
Journal of Allergy and Clinical Immunology 2002
The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis
Y Makabe-Kobayashi, Y Hori, T Adachi, S Ishigaki-Suzuki, Y Kikuchi, Y Kagaya, K Shirato, A Nagy, A Ujike, T Takai, T Watanabe, H Ohtsu
Journal of Allergy and Clinical Immunology 2002
IgE and Anti-IgE Therapy in Asthma and Allergic Disease
D Dombrowicz, A Capron, M Capro
IgE and Anti-IgE Therapy in Asthma and Allergic Disease: Pathogenesis and Novel Therapeutic Strategies 2002
IgE and Anti-IgE Therapy in Asthma and Allergic Disease: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness and Airflow Obstruction
J Tepper, D Tumas
IgE and Anti-IgE Therapy in Asthma and Allergic Disease: Pathogenesis and Novel Therapeutic Strategies 2002
Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses
FA Redegeld, MW van der Heijden, M Kool, BM Heijdra, J Garssen, AD Kraneveld, HV Loveren, P Roholl, T Saito, JS Verbeek, J Claassens, AS Koster, FP Nijkamp
Nature Medicine 2002
IgE-Dependent Mast Cell Activation Potentiates Airway Responses in Murine Asthma Models
SI Mayr, RI Zuberi, M Zhang, J de Sousa-Hitzler, K Ngo, Y Kuwabara, L Yu, WP Fung-Leung, FT Liu
Journal of immunology (Baltimore, Md. : 1950) 2002
Role of STAT6 in IgE Receptor/FcεRI-Mediated Late Phase Allergic Responses of Mast Cells
R Malaviya, FM Uckun
Journal of immunology (Baltimore, Md. : 1950) 2002
Early Phase Bronchoconstriction in the Mouse Requires Allergen-Specific IgG
JR Crosby, G Cieslewicz, M Borchers, E Hines, P Carrigan, JJ Lee, NA Lee
Journal of immunology (Baltimore, Md. : 1950) 2002
CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4′-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O -Demethylation
FM Uckun, J Thoen, H Chen, E Sudbeck, C Mao, R Malaviya, XP Liu, CL Chen
Drug Metabolism and Disposition 2002
IgE regulation and roles in asthma pathogenesis
HC Oettgen, RS Geha
Journal of Allergy and Clinical Immunology 2001
New insights into the role of cytokines in asthma
JC Renauld
Journal of clinical pathology 2001
Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice
M Daheshia, DS Friend, MJ Grusby, KF Austen, HR Katz
Journal of Experimental Medicine 2001
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction
T Yuasa, M Ono, T Watanabe, T Takai
Journal of Experimental Medicine 2001
Lyn Is Essential for Fc  Receptor III-Mediated Systemic Anaphylaxis but Not for the Arthus Reaction
T Yuasa, M Ono, T Watanabe, T Takai
Journal of Experimental Medicine 2001
Examination of oral sensitization with ovalbumin in Brown Norway rats and three strains of mice
H Akiyama, R Teshima, J Sakushima, H Okunuki, Y Goda, J Sawada, M Toyoda
Immunology Letters 2001
DNA-based vaccination for the treatment of food allergy
MD Nguyen, N Cinman, J Yen, AA Horner
Allergy 2001
IGG FCRECEPTORS
JV Ravetch, S Bolland
Annual Review of Immunology 2001
Anti-IgE efficacy in murine asthma models is dependent on the method of allergen sensitization
DB Tumas, B Chan, W Werther, T Wrin, J Vennari, N Desjardin, RL Shields, P Jardieu
Journal of Allergy and Clinical Immunology 2001
Activating and Inhibitory Immunoglobulin-like Receptors
MD Cooper, T Takai, JV Ravetch
2001
Neutralizing antiviral antibody responses
R M Zinkernagel, A LaMarre, A Ciurea, L Hunziker, A F Ochsenbein, K D McCoy, T Fehr, M F Bachmann, U Kalinke, H Hengartner
Advances in immunology 2001
Roles of mast cells and basophils in innate and acquired immunity
J Wedemeyer, M Tsai, SJ Galli
Current Opinion in Immunology 2000
Mast cells and basophils
SJ Galli
Current Opinion in Hematology 2000
Induction of active systemic anaphylaxis by oral sensitization with ovalbumin in mast-cell-deficient mice
H Okunuki, R Teshima, J Sakushima, H Akiyama, Y Goda, M Toyoda, J Sawada
Immunology Letters 2000
The immunologic basis for intestinal food allergy
SH Murch
Current Opinion in Gastroenterology 2000
Serum IgE response to orally ingested antigen: A novel IgE response model with allergen-specific T-cell receptor transgenic mice
K Shida, S Hachimura, A Ametani, M Ishimori, M Ling, M Hashiguchi, Y Ueda, T Sato, Y Kumagai, K Takamizawa, S Habu, S Kaminogawa
Journal of Allergy and Clinical Immunology 2000
Glucocorticoids enhance IgE synthesis. Are we heading towards new paradigms?
SS Salvi, KS Babu, ST Holgate
Clinical & Experimental Allergy 2000
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
CM Williams, SJ Galli
Journal of Allergy and Clinical Immunology 2000
DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice
AA Horner, MD Nguyen, A Ronaghy, N Cinman, S Verbeek, E Raz
Journal of Allergy and Clinical Immunology 2000
Mechanism for the Isotype Dependence of Antibody-Mediated Toxicity in Cryptococcus neoformans- Infected Mice
N Lendvai, XW Qu, W Hsueh, A Casadevall
Journal of immunology (Baltimore, Md. : 1950) 2000
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis
Jonathan M. Spergel, Emiko Mizoguchi, Hans Oettgen, Atul K. Bhan, Raif S. Geha
Journal of Clinical Investigation 1999
IgE in asthma and atopy: cellular and molecular connections
HC Oettgen, RS Geha
Journal of Clinical Investigation 1999
Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis
T Yuasa, S Kubo, T Yoshino, A Ujike, K Matsumura, M Ono, JV Ravetch, T Takai
Journal of Experimental Medicine 1999
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells
VI Pivniouk, TR Martin, JM Lu-Kuo, HR Katz, HC Oettgen, RS Geha
Journal of Clinical Investigation 1999
Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG
A Ujike, Y Ishikawa, M Ono, T Yuasa, T Yoshino, M Fukumoto, JV Ravetch, T Takai
Journal of Experimental Medicine 1999
Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus
KJ Seidl, JP Manis, A Bottaro, J Zhang, L Davidson, A Kisselgof, H Oettgen, FW Alt
Proceedings of the National Academy of Sciences 1999
Deletion of Fc  Receptor IIB Renders H-2b Mice Susceptible to Collagen-induced Arthritis
T Yuasa, S Kubo, T Yoshino, A Ujike, K Matsumura, M Ono, JV Ravetch, T Takai
Journal of Experimental Medicine 1999
Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
A Ujike, Y Ishikawa, M Ono, T Yuasa, T Yoshino, M Fukumoto, JV Ravetch, T Takai
Journal of Experimental Medicine 1999
IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
JF Urban, N Noben-Trauth, DD Donaldson, KB Madden, SC Morris, M Collins, FD Finkelman
Journal of immunology (Baltimore, Md. : 1950) 1999
Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice
B Nieswandt, B Echtenacher, FP Wachs, J Schröder, JE Gessner, RE Schmidt, GE Grau, DN Männel
Blood 1999
Inhibition of murine IgE and immediate cutaneous hypersensitivity responses to ovalbumin by the immunomodulatory agent leflunomide
ER Jarman, A Kuba, E Montermann, RR Bartlett, AB Reske-Kunz
Clinical & Experimental Immunology 1999
Induction and regulation of the IgE response
DB Corry, F Kheradmand
Nature 1999
Targeting Janus Kinase 3 in Mast Cells Prevents Immediate Hypersensitivity Reactions and Anaphylaxis
R Malaviya, DM Zhu, I Dibirdik, FM Uckun
The Journal of biological chemistry 1999
Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice
C L Chen, R Malaviya, C Navara, H Chen, B Bechard, G Mitcheltree, X P Liu, F M Uckun
Pharmaceutical Research 1999
DIVERGENT ROLES FOR FcRECEPTORS AND COMPLEMENT IN VIVO
JV Ravetch, RA Clynes
Annual Review of Immunology 1998
IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice
H Wakayama, Y Hasegawa, T Kawabe, H Saito, H Kikutani, K Shimokata
Clinical & Experimental Immunology 1998
Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells
AV Shaji, SK Kulkarni, JN Agrewala
Clinical & Experimental Immunology 1998
Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice
IH Choi, YM Shin, JS Park, MS Lee, EH Han, OH Chai, SY Im, TY Ha, HK Lee
Journal of Experimental Medicine 1998
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice
DB Corry, G Grünig, H Hadeiba, VP Kurup, ML Warnock, D Sheppard, DM Rennick, RM Locksley
Molecular Medicine 1998
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor
S Ishii, T Kuwaki, T Nagase, K Maki, F Tashiro, S Sunaga, WH Cao, K Kume, Y Fukuchi, K Ikuta, J Miyazaki, M Kumada, T Shimizu
Journal of Experimental Medicine 1998
Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses
D Dombrowicz, S Lin, V Flamand, AT Brini, BH Koller, JP Kinet
Immunity 1998
Enzymatically Active Papain Preferentially Induces an Allergic Response in Mice
L Chambers, A Brown, DI Pritchard, S Sreedharan, K Brocklehurst, NA Kalsheker
Biochemical and Biophysical Research Communications 1998
Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
S Ishii, T Kuwaki, T Nagase, K Maki, F Tashiro, S Sunaga, WH Cao, K Kume, Y Fukuchi, K Ikuta, J Miyazaki, M Kumada, T Shimizu
Journal of Experimental Medicine 1998
Immunoglobulin E-dependent Active Fatal Anaphylaxis in Mast Cell-deficient Mice
IH Choi, YM Shin, JS Park, MS Lee, EH Han, OH Chai, SY Im, TY Ha, HK Lee
Journal of Experimental Medicine 1998
Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
DB Corry, HG Folkesson, ML Warnock, DJ Erle, MA Matthay, JP Wiener-Kronish, RM Locksley
Journal of immunology (Baltimore, Md. : 1950) 1998
Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis
R Clynes, C Dumitru, JV Ravetch
Science 1998
Gastric inflammation during systemic anaphylaxis: neutrophil recruitment in stomach wall of mice does not require mast cell participation
G T Furuta, Z S Wang, B K Wershil
Digestive Diseases and Sciences 1998
Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains
D Dombrowicz, V Flamand, I Miyajima, JV Ravetch, SJ Galli, JP Kinet
Journal of Clinical Investigation 1997
IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions
M Yamaguchi, CS Lantz, HC Oettgen, IM Katona, T Fleming, I Miyajima, JP Kinet, SJ Galli
Journal of Experimental Medicine 1997
Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells
SJ Galli
Journal of Experimental Medicine 1997
Bronchial asthma: lessons from murine models
GJ Gleich, H Kita
Proceedings of the National Academy of Sciences 1997
Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
PD Mehlhop, M de Rijn, AB Goldberg, JP Brewer, VP Kurup, TR Martin, HC Oettgen
Proceedings of the National Academy of Sciences 1997
The role of FcR in immunity: Lessons from gene targeting in mice
JS Verbeek, WL Hazenbos, PJ Capel, JG de Winkel
Research in Immunology 1997
Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice
M Korsgren, JS ält, O Korsgren, F Sundler, CG Persson
Journal of Experimental Medicine 1997
Impaired mast cell-dependent natural immunity in complement C3-deficient mice
AP Prodeus, X Zhou, M Maurer, SJ Galli, MC Carroll
Nature 1997
Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts
C M Kokron, F A Bonilla, H C Oettgen, N Ramesh, R S Geha, F Pandolfi
Journal of Clinical Immunology 1997
Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice
A Oshiba, E Hamelmann, K Takeda, KL Bradley, JE Loader, GL Larsen, EW Gelfand
Journal of Clinical Investigation 1996
Allergic conjunctivitis and dry eye
H Fujishima, I Toda, J Shimazaki, K Tsubota
The British journal of ophthalmology 1996
Allergen-specific IgG1 and IgG3 through Fc gamma RII induce eosinophil degranulation
M Kaneko, MC Swanson, GJ Gleich, H Kita
Journal of Clinical Investigation 1995

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