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Citations to this article

Potentiation of the immune response in HIV-1+ individuals.
T Schmitz, … , W W Bachovchin, B T Huber
T Schmitz, … , W W Bachovchin, B T Huber
Published March 15, 1996
Citation Information: J Clin Invest. 1996;97(6):1545-1549. https://doi.org/10.1172/JCI118577.
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Research Article Article has an altmetric score of 3

Potentiation of the immune response in HIV-1+ individuals.

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Abstract

T cells from HIV-1+ individuals have a defect in mounting an antigen specific response. HIV-1 Tat has been implicated as the causative agent of this immunosuppression. We have previously shown that HIV-1 Tat inhibits antigen specific proliferation of normal T cells in vitro by binding to the accessory molecule CD26, a dipeptidase expressed on the surface of activated T cells. We now demonstrate that the defective in vitro recall antigen response in HIV-1 infected individuals can be restored by the addition of soluble CD26, probably by serving as a decoy receptor for HIV-1 Tat. The restored response is comparable to that of an HIV-1- individual, suggesting that early in HIV infection there is a block in the memory cell response, rather than deletion of these cells.

Authors

T Schmitz, R Underwood, R Khiroya, W W Bachovchin, B T Huber

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Total citations by year

Year: 2024 2019 2016 2015 2011 2010 2009 2007 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 1 1 1 1 1 1 1 1 2 1 2 1 5 2 2 1 24
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (1)

Title and authors Publication Year
Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors
EJ Verspohl
Pharmacology & Therapeutics 2009

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Referenced in 17 patents
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