Citations to this article

Potentiation of the immune response in HIV-1+ individuals.
T Schmitz, … , W W Bachovchin, B T Huber
T Schmitz, … , W W Bachovchin, B T Huber
Published March 15, 1996
Citation Information: J Clin Invest. 1996;97(6):1545-1549. https://doi.org/10.1172/JCI118577.
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Potentiation of the immune response in HIV-1+ individuals.

Abstract

T cells from HIV-1+ individuals have a defect in mounting an antigen specific response. HIV-1 Tat has been implicated as the causative agent of this immunosuppression. We have previously shown that HIV-1 Tat inhibits antigen specific proliferation of normal T cells in vitro by binding to the accessory molecule CD26, a dipeptidase expressed on the surface of activated T cells. We now demonstrate that the defective in vitro recall antigen response in HIV-1 infected individuals can be restored by the addition of soluble CD26, probably by serving as a decoy receptor for HIV-1 Tat. The restored response is comparable to that of an HIV-1- individual, suggesting that early in HIV infection there is a block in the memory cell response, rather than deletion of these cells.

Authors

T Schmitz, R Underwood, R Khiroya, W W Bachovchin, B T Huber

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Citations to this article (24)

Title and authors Publication Year
Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and Pathogenesis.
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Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease
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Soluble CD26 / Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding
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Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors
EJ Verspohl 		Pharmacology & Therapeutics 2009
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An evaluation of serum soluble CD30 levels and serum CD26 (DPPIV) enzyme activity as markers of type 2 and type 1 cytokines in HIV patients receiving highly active antiretroviral therapy
NM Keane, P Price, S Lee, SF Stone, MA French 		Clinical & Experimental Immunology 2001
CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes: CD26: Receptor and Peptidase
MD Gorrell, V Gysbers, GW McCaughan 		Scandinavian Journal of Immunology 2001
Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer
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Decreased Dipeptidyl Peptidase IV Enzyme Activity of Plasma Soluble CD26 and Its Inverse Correlation with HIV-1 RNA in HIV-1 Infected Individuals
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CD26, let it cut or cut it down
ID Meester, S Korom, JV Damme, S Scharpé 		Immunology Today 1999
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P Proost, S Struyf, D Schols, G Opdenakker, S Sozzani, P Allavena, A Mantovani, K Augustyns, G Bal, A Haemers, AM Lambeir, S Scharpé, JV Damme, ID Meester 		The Journal of biological chemistry 1999
Increased Rate of HIV-1 Entry and Its Cytopathic Effect in CD4+/CXCR4+T Cells Expressing Relatively High Levels of CD26
C Callebaut, E Jacotot, J Blanco, B Krust, AG Hovanessian 		Experimental Cell Research 1998
Specific and Irreversible Cyclopeptide Inhibitors of Dipeptidyl Peptidase IV Activity of the T-Cell Activation Antigen CD26
C Nguyen, J Blanco, JP Mazaleyrat, B Krust, C Callebaut, E Jacotot, AG Hovanessian, M Wakselman 		Journal of Medicinal Chemistry 1998
The N-terminal Structure of HIV-1 Tat Is Required for Suppression of CD26-dependent T Cell Growth
S Wrenger, T Hoffmann, J Faust, C Mrestani-Klaus, W Brandt, K Neubert, M Kraft, S Olek, R Frank, S Ansorge, D Reinhold 		The Journal of biological chemistry 1997
Cellular Peptidases in Immune Functions and Diseases
S Ansorge, J Langner 		1997
Dipeptidyl-Peptidase IV-beta, a Novel form of Cell-Surface-Expressed Protein with Dipeptidyl-Peptidase IV Activity
E Jacotot, C Callebaut, J Blanco, B Krust, K Neubert, A Barth, AG Hovanessian 		European Journal of Biochemistry 1996

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