In the HXB and BXH recombinant inbred strains derived from the spontaneously hypertensive rat and the normotensive Brown Norway rat, we determined the strain distribution patterns of 500 genetic markers to scan the rodent genome for quantitative trait loci regulating cardiac mass and blood pressure. The markers spanned approximately 1,139 cM of the genome and were tested for correlations with left ventricular mass adjusted for body weight, and with systolic, diastolic, and mean arterial pressures. The marker for the dopamine 1A receptor (Drd1a) on chromosome 17 showed the strongest correlation with left ventricular heart weight (P = .00038, r = -0.59) and the relationship to heart weight was independent of blood pressure. The markers showing the strongest correlations with systolic, diastolic, and mean arterial pressure were D19Mit7 on chromosome 19 (P = .0012, r = .55), D2N35 on chromosome 2 (P = .0008, r = .56), and Il6 on chromosome 4 (P = .0018, r = .53), respectively. These studies demonstrate that the HXB and BXH strains can be effectively used for genome scanning studies of complex traits and have revealed several chromosome regions that may be involved in the genetic control of blood pressure and cardiac mass in the rat.
M Pravenec, D Gauguier, J J Schott, J Buard, V Kren, V Bila, C Szpirer, J Szpirer, J M Wang, H Huang
Title and authors | Publication | Year |
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Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
D Gauguier |
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics | 2005 |
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
N Hubner, CA Wallace, H Zimdahl, E Petretto, H Schulz, F Maciver, M Mueller, O Hummel, J Monti, V Zidek, A Musilova, V Kren, H Causton, L Game, G Born, S Schmidt, A Müller, SA Cook, TW Kurtz, J Whittaker, M Pravenec, TJ Aitman |
Nature Genetics | 2005 |
Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony
T Watanabe, Y Iizuka, YQ Liang, H Inomata, T Gotoda, K Yanai, M Isobe, N Kato |
Biochemical and Biophysical Research Communications | 2005 |
Genetic analysis of complex cardiovascular traits in the spontaneously hypertensive rat: Genetic analysis of complex cardiovascular traits
M Pravenec, V Křen |
Experimental Physiology | 2005 |
Influence of elevated renin substrate on angiotensin II and arterial blood pressure in conscious mice: Renin substrate in mice
BC Cholewa, DL Mattson |
Experimental Physiology | 2005 |
Sex-specific effects of dual ET-1/ANG II receptor (Dear) variants in Dahl salt-sensitive/resistant hypertension rat model
Y Kaneko, VL Herrera, T Didishvili, N Ruiz-Opazo |
Physiological genomics | 2005 |
A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate
J Dutil, V Eliopoulos, ÉL Marchand, AM Devlin, J Tremblay, K Prithiviraj, P Hamet, A Migneault, D deBlois, AY Deng |
Physiological genomics | 2005 |
Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17
M Grondin, V Eliopoulos, R Lambert, Y Deng, A Ariyarajah, M Moujahidine, J Dutil, S Charron, AY Deng |
Physiological genomics | 2005 |
Dynamic genetic architecture of metabolic syndrome attributes in the rat
O Seda, F Liska, D Krenova, L Kazdova, L Sedova, T Zima, J Peng, K Pelinkova, J Tremblay, P Hamet, V Kren |
Physiological genomics | 2005 |
Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2
V Eliopoulos, J Dutil, Y Deng, M Grondin, AY Deng |
Physiological genomics | 2005 |
Identification of Quantitative Trait Loci for Cardiac Hypertrophy in Two Different Strains of the Spontaneously Hypertensive Rat
H INOMATA, T WATANABE, Y IIZUKA, YQ LIANG, T MASHIMO, T NABIKA, K IKEDA, K YANAI, T GOTODA, Y YAMORI, M ISOBE, N KATO |
Hypertension Research | 2005 |